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The map label for this gene is pncB [H]

Identifier: 203284534

GI number: 203284534

Start: 684011

End: 685486

Strand: Reverse

Name: pncB [H]

Synonym: BDU_639

Alternate gene names: 203284534

Gene position: 685486-684011 (Counterclockwise)

Preceding gene: 203284537

Following gene: 203284533

Centisome position: 73.58

GC content: 26.63

Gene sequence:

>1476_bases
ATGAATAATTTATCACTCTTTACAGACTTTTATGAACTATCAATGATGAATGCTTACTTTACAAAAAATATCAATCCAAA
AGCAAAATTTGAAATGTTTTTCAGAAAAACACCATTTAATAATGGATATATAATTCTATCAGGAATCCACACACTAATTA
ATATTTTAAAAGAATTACACTTTAACAAAGAAGAGATTGAATACCTAGAAAGCCTTAACTATTTTGATAAAAAATTCTTA
GAATATCTAAAAACATTTAAATTAAATATAAAAATAAATTCAATTGCAGAAGGGAGAATTGTTTTTCCTCATGAACCCAT
ACTAATCATTGAAGGAAACTTAATTGAACTTTTACTAATAGAAGGACTAGTATTAAACACAATAAACTTTGAAAGCTTAA
TTGCAACAAAAACAGCAAGAATTAAAGAAGCTGGTGCTAAAAATCTAGCAGAACTTGGACTTAGAAGAGCACAAGGAATT
AATGGCGCACTCTCAGCAAGCAAAGCTGCTTATATAGGAGGTGCTAATTTTACAAGTAATGTGCTTGCAGGATATAAATA
TAATATTCCTATAATTGGCACAATGGCTCATAGTTGGGTAATGAGTTTCCCAAACGAAGAAGAAGCTTTTTGGGAATATG
CAAAAACATATCCAAATAATGTCAATTTATTAATTGATACCTATGACACTCTAAAAAGCGGACTTAAGAACGCAATAAAA
ATTTTTAAACAATTACAAAATCAAGGGAAAAAAAATTTTTCTGTTAGAATTGACAGTGGGGATCTTGAATATTTAAGCAA
AGAAGTTAGAAGAAAACTTAATGAAAATGAACTATTTGATGTAAAGATTATAATATCAAATGAACTTGACGAAGAAATTA
TTATGTATCTAAATTCAATTCATGCTCCCATTGACTGTTGGGGAGTTGGAACAAATTTGGTTACAGCAAAAGGAGAATCT
AATCTTTCGGGAGTATATAAAATGATATCTATTCAACAAAATGGCAAATTTATCCCCAAAATGAAAATATCAAATAACAT
TGATAAAGCAACACTACCTTCTCAAAAAGGAGTTGTTAGAATATATTCAAACAACCAAATGATTTTTGACCTAATTTTTT
TAAAAGAAGAAGAAGAAGAAATAAAAAAAATTTTAAATTTAAAAAAACAATTTACAATCTTTCATCCTACACAAGATAAT
ACTTTTAAAGAAATAAAAACTTACGATAGTTTCGAATTTTTAATACATACAATTTTTGAAAACGGCAATATCCTCCAACC
CGACGAATTAAAATTAGAAAATATAAGGGTAAATGTTCAAAATGATCTTAAAAAAATTGATCATACCTATAAAAGACTCA
TAAACCCACATATATACAAAGTAAGTATTACTGAAAAATTAAAAAATCTAAAAAACACACTTGCTAAAGCAAATAATATA
ATTCCATGTACAAGATATATAAAACAAACAAAATAA

Upstream 100 bases:

>100_bases
TACTAATAGTTTATTTACTTTTAATCCAACCAAAAAGTTGATTAAAATAGACAGTATAAAACACACAAATCAAATATCTC
TTGGTGTATAATGTAAAACA

Downstream 100 bases:

>100_bases
GCAATATTTACAATAAAGTTAACGAGCTAATTCGAAATGACAATTTATTTAAAAAAGAAACTATTATCCTTGTCAAAAAT
AACATTTTAAGTGATGAAAT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNNLSLFTDFYELSMMNAYFTKNINPKAKFEMFFRKTPFNNGYIILSGIHTLINILKELHFNKEEIEYLESLNYFDKKFL
EYLKTFKLNIKINSIAEGRIVFPHEPILIIEGNLIELLLIEGLVLNTINFESLIATKTARIKEAGAKNLAELGLRRAQGI
NGALSASKAAYIGGANFTSNVLAGYKYNIPIIGTMAHSWVMSFPNEEEAFWEYAKTYPNNVNLLIDTYDTLKSGLKNAIK
IFKQLQNQGKKNFSVRIDSGDLEYLSKEVRRKLNENELFDVKIIISNELDEEIIMYLNSIHAPIDCWGVGTNLVTAKGES
NLSGVYKMISIQQNGKFIPKMKISNNIDKATLPSQKGVVRIYSNNQMIFDLIFLKEEEEEIKKILNLKKQFTIFHPTQDN
TFKEIKTYDSFEFLIHTIFENGNILQPDELKLENIRVNVQNDLKKIDHTYKRLINPHIYKVSITEKLKNLKNTLAKANNI
IPCTRYIKQTK

Sequences:

>Translated_491_residues
MNNLSLFTDFYELSMMNAYFTKNINPKAKFEMFFRKTPFNNGYIILSGIHTLINILKELHFNKEEIEYLESLNYFDKKFL
EYLKTFKLNIKINSIAEGRIVFPHEPILIIEGNLIELLLIEGLVLNTINFESLIATKTARIKEAGAKNLAELGLRRAQGI
NGALSASKAAYIGGANFTSNVLAGYKYNIPIIGTMAHSWVMSFPNEEEAFWEYAKTYPNNVNLLIDTYDTLKSGLKNAIK
IFKQLQNQGKKNFSVRIDSGDLEYLSKEVRRKLNENELFDVKIIISNELDEEIIMYLNSIHAPIDCWGVGTNLVTAKGES
NLSGVYKMISIQQNGKFIPKMKISNNIDKATLPSQKGVVRIYSNNQMIFDLIFLKEEEEEIKKILNLKKQFTIFHPTQDN
TFKEIKTYDSFEFLIHTIFENGNILQPDELKLENIRVNVQNDLKKIDHTYKRLINPHIYKVSITEKLKNLKNTLAKANNI
IPCTRYIKQTK
>Mature_491_residues
MNNLSLFTDFYELSMMNAYFTKNINPKAKFEMFFRKTPFNNGYIILSGIHTLINILKELHFNKEEIEYLESLNYFDKKFL
EYLKTFKLNIKINSIAEGRIVFPHEPILIIEGNLIELLLIEGLVLNTINFESLIATKTARIKEAGAKNLAELGLRRAQGI
NGALSASKAAYIGGANFTSNVLAGYKYNIPIIGTMAHSWVMSFPNEEEAFWEYAKTYPNNVNLLIDTYDTLKSGLKNAIK
IFKQLQNQGKKNFSVRIDSGDLEYLSKEVRRKLNENELFDVKIIISNELDEEIIMYLNSIHAPIDCWGVGTNLVTAKGES
NLSGVYKMISIQQNGKFIPKMKISNNIDKATLPSQKGVVRIYSNNQMIFDLIFLKEEEEEIKKILNLKKQFTIFHPTQDN
TFKEIKTYDSFEFLIHTIFENGNILQPDELKLENIRVNVQNDLKKIDHTYKRLINPHIYKVSITEKLKNLKNTLAKANNI
IPCTRYIKQTK

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=536, Percent_Identity=28.544776119403, Blast_Score=257, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71997952, Length=542, Percent_Identity=34.3173431734317, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71997947, Length=542, Percent_Identity=34.3173431734317, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71997955, Length=209, Percent_Identity=42.5837320574163, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24581587, Length=535, Percent_Identity=33.0841121495327, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=40.6862745098039, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=40.6862745098039, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=40.6862745098039, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=40.6862745098039, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=40.6862745098039, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56590; Mature: 56590

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLSLFTDFYELSMMNAYFTKNINPKAKFEMFFRKTPFNNGYIILSGIHTLINILKELH
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCCCCEEEEECHHHHHHHHHHHC
FNKEEIEYLESLNYFDKKFLEYLKTFKLNIKINSIAEGRIVFPHEPILIIEGNLIELLLI
CCHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEECEECCEEECCCCCEEEEECCHHHHHHH
EGLVLNTINFESLIATKTARIKEAGAKNLAELGLRRAQGINGALSASKAAYIGGANFTSN
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCH
VLAGYKYNIPIIGTMAHSWVMSFPNEEEAFWEYAKTYPNNVNLLIDTYDTLKSGLKNAIK
HHCCEEECCCEEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHH
IFKQLQNQGKKNFSVRIDSGDLEYLSKEVRRKLNENELFDVKIIISNELDEEIIMYLNSI
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHC
HAPIDCWGVGTNLVTAKGESNLSGVYKMISIQQNGKFIPKMKISNNIDKATLPSQKGVVR
CCCEEEEECCCEEEEECCCCCHHHHEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCEEE
IYSNNQMIFDLIFLKEEEEEIKKILNLKKQFTIFHPTQDNTFKEIKTYDSFEFLIHTIFE
EEECCEEEEEEEEECCCHHHHHHHHCCHHHEEEEECCCCCCHHHHHHCCHHHHHHHHHHC
NGNILQPDELKLENIRVNVQNDLKKIDHTYKRLINPHIYKVSITEKLKNLKNTLAKANNI
CCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCC
IPCTRYIKQTK
CHHHHHHHCCC
>Mature Secondary Structure
MNNLSLFTDFYELSMMNAYFTKNINPKAKFEMFFRKTPFNNGYIILSGIHTLINILKELH
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCCCCEEEEECHHHHHHHHHHHC
FNKEEIEYLESLNYFDKKFLEYLKTFKLNIKINSIAEGRIVFPHEPILIIEGNLIELLLI
CCHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEECEECCEEECCCCCEEEEECCHHHHHHH
EGLVLNTINFESLIATKTARIKEAGAKNLAELGLRRAQGINGALSASKAAYIGGANFTSN
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCH
VLAGYKYNIPIIGTMAHSWVMSFPNEEEAFWEYAKTYPNNVNLLIDTYDTLKSGLKNAIK
HHCCEEECCCEEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHH
IFKQLQNQGKKNFSVRIDSGDLEYLSKEVRRKLNENELFDVKIIISNELDEEIIMYLNSI
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHC
HAPIDCWGVGTNLVTAKGESNLSGVYKMISIQQNGKFIPKMKISNNIDKATLPSQKGVVR
CCCEEEEECCCEEEEECCCCCHHHHEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCEEE
IYSNNQMIFDLIFLKEEEEEIKKILNLKKQFTIFHPTQDNTFKEIKTYDSFEFLIHTIFE
EEECCEEEEEEEEECCCHHHHHHHHCCHHHEEEEECCCCCCHHHHHHCCHHHHHHHHHHC
NGNILQPDELKLENIRVNVQNDLKKIDHTYKRLINPHIYKVSITEKLKNLKNTLAKANNI
CCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCC
IPCTRYIKQTK
CHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]