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The map label for this gene is lctP [H]

Identifier: 203284508

GI number: 203284508

Start: 643939

End: 645474

Strand: Reverse

Name: lctP [H]

Synonym: BDU_605

Alternate gene names: 203284508

Gene position: 645474-643939 (Counterclockwise)

Preceding gene: 203284516

Following gene: 203284507

Centisome position: 69.28

GC content: 31.25

Gene sequence:

>1536_bases
ATGGTAAATAGAAAAAGGAGCTCACATTCAATTATGAATTTATATAATTTCATTAAAGCAGTAATTCCAATTATAATAAT
TATTATTGGGCTTGGAATAATAAAAAAACCAGCTTATTATGTCATACCAATATGTTTAATAGTTACTATTGCAATAGTTT
TATTTGACAAAAACCTAGGAATAAGCAATACAAGTCTTGCAATTCTTGAAGGAACAATAATGGGAATATGGCCAATAATT
ATTGTAATAGTAGCTGCTATTTTTACATATAAAATGGCTGAAAGCCAAAATGACATGCAAATCATAAAAGCAATGTTATC
AAATGTATCTTCTGACAGGCGAATAATCATTTTGTTGGTAGCATGGGGATTTGGTAACTTCTTGGAAGGAGTTGCAGGAT
ATGGAACTGCTGTTGCAATTCCTGTATCAATACTAATAGCAATGGGATTTGAACCATTTTTTGCATGTCTTTTATGTCTA
ATCATGGATACATCTTCAACTGCTTATGGTTCGGTAGGAATTCCTATAATATCTCTAGCACAAGCAACAGAGTTAGACGT
TAAAATGTTATCTTATGACATCTCTTTACAACTAATAATTCCAACACTTTTGATACCATTTATATTGGTTATTCTTGTAG
GAGGAGGAATTAAAAGCCTTAAAGGAGGAATGTTTATACTAACACTACTATCAGGTGCATCTATTGCAATATCGCAAGTT
TATGTTTCAAAAATCCTAGGACCAGAACTTCCTGCAATAATTGGAAGCATACCGGTAATGGCAATAATAATAATCTATGC
AAAATTTTTTGACAAAGAAAATAAAACTTGCAATAAAATAAAAGTATCAAAAATGCAAGGATTCCTTGCCTGCATGCCAT
ATATTTTAATAGTTTCACTTATAATAATTGTTTCCCCACTGTTTCACTCAATAAATAAATACTTATCAAACTTTAAAACA
ATTCTCGAAATTTATCCAGGAGCAAAGCCACTACAATTTAAATGGCTAACTTCACCAGGACTTCTAATTATTCTTGCAAC
CATAATATCTTATTCAATAAGAGGTGTCCCTATACTTGATCAACTAAAAACATTCCTCCTCACAATAAAAAAACTAGCAT
TGTCTTCATTTGTAATTATATGCATAGTATCAATATCAAGATTAATGACACATAGTGGAATGATCAAAGATCTTGCAGAT
GGCATCTCAACATTAACAGGCACATTATATCCACTATTTAGCCCATTAATTGGCGCTTTGGGGACTTTCTTAACAGGAAG
CGATACTGTTTCAAATGTTTTATTTGGACCTTTACAAACACAAATTGCAACCAATATTGATATTAATCCATATTGGCTAT
CAGCTGCAAATACAACAGGAGCAACAGGAGGAAAAATGATTTCTCCTCAAAACATAACAATCGCAACAACAACTGCAGGA
CTTATTGGACAAGAAGGAAAATTATTATCTAAAACCATTATATATGCTATTGGATACATTTTAATATCGGGAATTCTGGT
TTACTTCTTATTATAA

Upstream 100 bases:

>100_bases
TTATAAGCATTAAATAAAAGAAACATGCTCATAATGATAAAAATAATTTTCATACAATAAATATTGTATATTATTGCATA
AAAATTTGTTATAGAATTAA

Downstream 100 bases:

>100_bases
TAAATAATAAATTTAGATATATCATAATATTAACAAATAAGACTAACAAATAGTTGGTCTTATTTGAATAATCTATACAT
ACCTTAAAATTACTTGAATT

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MVNRKRSSHSIMNLYNFIKAVIPIIIIIIGLGIIKKPAYYVIPICLIVTIAIVLFDKNLGISNTSLAILEGTIMGIWPII
IVIVAAIFTYKMAESQNDMQIIKAMLSNVSSDRRIIILLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLLCL
IMDTSSTAYGSVGIPIISLAQATELDVKMLSYDISLQLIIPTLLIPFILVILVGGGIKSLKGGMFILTLLSGASIAISQV
YVSKILGPELPAIIGSIPVMAIIIIYAKFFDKENKTCNKIKVSKMQGFLACMPYILIVSLIIIVSPLFHSINKYLSNFKT
ILEIYPGAKPLQFKWLTSPGLLIILATIISYSIRGVPILDQLKTFLLTIKKLALSSFVIICIVSISRLMTHSGMIKDLAD
GISTLTGTLYPLFSPLIGALGTFLTGSDTVSNVLFGPLQTQIATNIDINPYWLSAANTTGATGGKMISPQNITIATTTAG
LIGQEGKLLSKTIIYAIGYILISGILVYFLL

Sequences:

>Translated_511_residues
MVNRKRSSHSIMNLYNFIKAVIPIIIIIIGLGIIKKPAYYVIPICLIVTIAIVLFDKNLGISNTSLAILEGTIMGIWPII
IVIVAAIFTYKMAESQNDMQIIKAMLSNVSSDRRIIILLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLLCL
IMDTSSTAYGSVGIPIISLAQATELDVKMLSYDISLQLIIPTLLIPFILVILVGGGIKSLKGGMFILTLLSGASIAISQV
YVSKILGPELPAIIGSIPVMAIIIIYAKFFDKENKTCNKIKVSKMQGFLACMPYILIVSLIIIVSPLFHSINKYLSNFKT
ILEIYPGAKPLQFKWLTSPGLLIILATIISYSIRGVPILDQLKTFLLTIKKLALSSFVIICIVSISRLMTHSGMIKDLAD
GISTLTGTLYPLFSPLIGALGTFLTGSDTVSNVLFGPLQTQIATNIDINPYWLSAANTTGATGGKMISPQNITIATTTAG
LIGQEGKLLSKTIIYAIGYILISGILVYFLL
>Mature_511_residues
MVNRKRSSHSIMNLYNFIKAVIPIIIIIIGLGIIKKPAYYVIPICLIVTIAIVLFDKNLGISNTSLAILEGTIMGIWPII
IVIVAAIFTYKMAESQNDMQIIKAMLSNVSSDRRIIILLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLLCL
IMDTSSTAYGSVGIPIISLAQATELDVKMLSYDISLQLIIPTLLIPFILVILVGGGIKSLKGGMFILTLLSGASIAISQV
YVSKILGPELPAIIGSIPVMAIIIIYAKFFDKENKTCNKIKVSKMQGFLACMPYILIVSLIIIVSPLFHSINKYLSNFKT
ILEIYPGAKPLQFKWLTSPGLLIILATIISYSIRGVPILDQLKTFLLTIKKLALSSFVIICIVSISRLMTHSGMIKDLAD
GISTLTGTLYPLFSPLIGALGTFLTGSDTVSNVLFGPLQTQIATNIDINPYWLSAANTTGATGGKMISPQNITIATTTAG
LIGQEGKLLSKTIIYAIGYILISGILVYFLL

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=532, Percent_Identity=31.9548872180451, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1790031, Length=523, Percent_Identity=30.019120458891, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 55128; Mature: 55128

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNRKRSSHSIMNLYNFIKAVIPIIIIIIGLGIIKKPAYYVIPICLIVTIAIVLFDKNLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ISNTSLAILEGTIMGIWPIIIVIVAAIFTYKMAESQNDMQIIKAMLSNVSSDRRIIILLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEE
AWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLLCLIMDTSSTAYGSVGIPIISLA
ECCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
QATELDVKMLSYDISLQLIIPTLLIPFILVILVGGGIKSLKGGMFILTLLSGASIAISQV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHH
YVSKILGPELPAIIGSIPVMAIIIIYAKFFDKENKTCNKIKVSKMQGFLACMPYILIVSL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIIVSPLFHSINKYLSNFKTILEIYPGAKPLQFKWLTSPGLLIILATIISYSIRGVPILD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHH
QLKTFLLTIKKLALSSFVIICIVSISRLMTHSGMIKDLADGISTLTGTLYPLFSPLIGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTFLTGSDTVSNVLFGPLQTQIATNIDINPYWLSAANTTGATGGKMISPQNITIATTTAG
HHHCCCCHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECHH
LIGQEGKLLSKTIIYAIGYILISGILVYFLL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MVNRKRSSHSIMNLYNFIKAVIPIIIIIIGLGIIKKPAYYVIPICLIVTIAIVLFDKNLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ISNTSLAILEGTIMGIWPIIIVIVAAIFTYKMAESQNDMQIIKAMLSNVSSDRRIIILLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEE
AWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLLCLIMDTSSTAYGSVGIPIISLA
ECCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
QATELDVKMLSYDISLQLIIPTLLIPFILVILVGGGIKSLKGGMFILTLLSGASIAISQV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHH
YVSKILGPELPAIIGSIPVMAIIIIYAKFFDKENKTCNKIKVSKMQGFLACMPYILIVSL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIIVSPLFHSINKYLSNFKTILEIYPGAKPLQFKWLTSPGLLIILATIISYSIRGVPILD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHH
QLKTFLLTIKKLALSSFVIICIVSISRLMTHSGMIKDLADGISTLTGTLYPLFSPLIGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTFLTGSDTVSNVLFGPLQTQIATNIDINPYWLSAANTTGATGGKMISPQNITIATTTAG
HHHCCCCHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECHH
LIGQEGKLLSKTIIYAIGYILISGILVYFLL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]