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The map label for this gene is uvrC

Identifier: 203284366

GI number: 203284366

Start: 488571

End: 490379

Strand: Reverse

Name: uvrC

Synonym: BDU_455

Alternate gene names: 203284366

Gene position: 490379-488571 (Counterclockwise)

Preceding gene: 203284369

Following gene: 203284364

Centisome position: 52.63

GC content: 24.93

Gene sequence:

>1809_bases
ATGAGAAAACACTTAAACGATTTATATAAACAAATAGAAAAATTTCCAAAAACAAGTGGTTGCTATAAAATGTACTCGAA
AGACAACAAAATATTATATATTGGAAAAGCTAAAAATTTAAGGTCAAGGGTAAAAAACTATTTTTCAAAACGAACTAGCC
ATAAAACCAAGATATTAATGAATAACGTAACAAATATAGAAATAATTACTACAAACAGCGAATATGAAGCGCTACTATTA
GAGTGTAACTTAATCAAAAAATACAAACCAACTTATAATATCAAATTAAAAGATGATAAAGGATATCCTATGATAAGAAT
AACTTGTGAAAAATATCCAAGAATTTTTAAAACTAGAAAGATAATAAATGATGGAAGTGAATATTTTGGACCATATGTTA
ATGTTAAAAATTTAGATTTAGTATTAGATCTTATTAACAAAACATTTAAAACAAAAAAATGCAAAAAAAAATCAAAAAAT
CCTTGTCTTTATTTCCATATGGGTCAGTGTCTAGGAGTATGTTATAGAGAAGATCTTGAAGACGAATATAGAAAAGAAAT
AGAGCAAATCAAACATATTTTAAATGGAAACATATCGAAACTTTTAAATGACATTGAAATCAAAATGAAAGAAGTCATTA
TGAAGGAAAATTTTGAAGCAGCAATAAAACTAAAAGAAACTAAAAAATCATTAATTGAAATAAGTCAAACTCAAATAATT
ACAAAGATAGATAAACTTAGTGAAGACTATCTATACATTCACAAAACTAATAGCTTAAATACAATAGTAATACTTAAATA
CAAAGACGGTAAATTAACAGAAAAAGACATTCATTTTGATGAAAGCATATATGAAGAGGATGAACTAATAGAAAAATTTA
TAACACAATATTATACATCTCCAAACATGATAGTACCAGATAAAATACACATTTTTAAAAAAATTGACACTTCAAACATT
ACAAAATTAATAAATGAACTTAAAAATATAAAAACTGAAATCATATATAAAGAAACTCAAGATAACATTAAAATAATTGA
AATGGCAACTTCTAATGCAAAACTTGCATTAATAACATATAATCATGAAAAAAATAAGGCTATTGAAAATCTAAAAACCA
TTCTTGAAATGAAAAAATTACCAAAAACAATTGAAGGCTTTGATATTGCTCATATAAATGGATATAAAACAGTAGCATCA
CTTGTTACGTTTAAAATGGGAAAACCTTTTAAAGACGGATATAGGGTTTATAAAATTAACTCACTAAGTAATGGAGAGAT
TGATGATTGTAAGGCAATAAAAGAAGTCATATCAAGAAGATATTCAAAATTAATCAATGAACAATTAAAATTGCCGGATT
TAATACTAATTGACGGTGGCAAAGGTCAGCTTAACGCTGCTTATTCCATTTTAAAAGGACTAAGGATTGAAGAGAAAATA
GCCATTTGTGCATTGGCAAAAAAGGAAGAAATAATATTTTTACCAAATAAAAATCAAGGCATAAAATTACAAAAAAGAAA
CTCTGCTCTTCAAGTATTACAAAATGTTCGAGATGAAGCTCACAGAAGGGCAAATAATTTTAACAACAAACTACACAACA
ATATCAAATTAAATTACACCAAAATAAAAGGCATTGGAGAACAAAAAGCAAAAAAGATCTTAAAAGTTCTTGGAACATAT
AAAGACATATTACTTCTAAATGAAGATGAAATAGCCACAAAAATGAAAATTAATATTACAATGGCAAATAAAATCAAAAA
ATTTGCAGAAGAACAAAATTTAAACAATAAACAAAACAATCATATCTAA

Upstream 100 bases:

>100_bases
TATCAATAAAAAAATCAAAAATACATAATGTTTAAATATGATATAATATTATATCACAAAAACAATAATGATTATTTAAA
AGCAATAATAGACAATAAAA

Downstream 100 bases:

>100_bases
CTATTAAAAATCACACTTAAATTTTAAAGAAAAATTCTCCAAAATAGTATCATCTTGATTTAACAAGATTACTACCATAA
AATATGACAAATTTAAATGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MRKHLNDLYKQIEKFPKTSGCYKMYSKDNKILYIGKAKNLRSRVKNYFSKRTSHKTKILMNNVTNIEIITTNSEYEALLL
ECNLIKKYKPTYNIKLKDDKGYPMIRITCEKYPRIFKTRKIINDGSEYFGPYVNVKNLDLVLDLINKTFKTKKCKKKSKN
PCLYFHMGQCLGVCYREDLEDEYRKEIEQIKHILNGNISKLLNDIEIKMKEVIMKENFEAAIKLKETKKSLIEISQTQII
TKIDKLSEDYLYIHKTNSLNTIVILKYKDGKLTEKDIHFDESIYEEDELIEKFITQYYTSPNMIVPDKIHIFKKIDTSNI
TKLINELKNIKTEIIYKETQDNIKIIEMATSNAKLALITYNHEKNKAIENLKTILEMKKLPKTIEGFDIAHINGYKTVAS
LVTFKMGKPFKDGYRVYKINSLSNGEIDDCKAIKEVISRRYSKLINEQLKLPDLILIDGGKGQLNAAYSILKGLRIEEKI
AICALAKKEEIIFLPNKNQGIKLQKRNSALQVLQNVRDEAHRRANNFNNKLHNNIKLNYTKIKGIGEQKAKKILKVLGTY
KDILLLNEDEIATKMKINITMANKIKKFAEEQNLNNKQNNHI

Sequences:

>Translated_602_residues
MRKHLNDLYKQIEKFPKTSGCYKMYSKDNKILYIGKAKNLRSRVKNYFSKRTSHKTKILMNNVTNIEIITTNSEYEALLL
ECNLIKKYKPTYNIKLKDDKGYPMIRITCEKYPRIFKTRKIINDGSEYFGPYVNVKNLDLVLDLINKTFKTKKCKKKSKN
PCLYFHMGQCLGVCYREDLEDEYRKEIEQIKHILNGNISKLLNDIEIKMKEVIMKENFEAAIKLKETKKSLIEISQTQII
TKIDKLSEDYLYIHKTNSLNTIVILKYKDGKLTEKDIHFDESIYEEDELIEKFITQYYTSPNMIVPDKIHIFKKIDTSNI
TKLINELKNIKTEIIYKETQDNIKIIEMATSNAKLALITYNHEKNKAIENLKTILEMKKLPKTIEGFDIAHINGYKTVAS
LVTFKMGKPFKDGYRVYKINSLSNGEIDDCKAIKEVISRRYSKLINEQLKLPDLILIDGGKGQLNAAYSILKGLRIEEKI
AICALAKKEEIIFLPNKNQGIKLQKRNSALQVLQNVRDEAHRRANNFNNKLHNNIKLNYTKIKGIGEQKAKKILKVLGTY
KDILLLNEDEIATKMKINITMANKIKKFAEEQNLNNKQNNHI
>Mature_602_residues
MRKHLNDLYKQIEKFPKTSGCYKMYSKDNKILYIGKAKNLRSRVKNYFSKRTSHKTKILMNNVTNIEIITTNSEYEALLL
ECNLIKKYKPTYNIKLKDDKGYPMIRITCEKYPRIFKTRKIINDGSEYFGPYVNVKNLDLVLDLINKTFKTKKCKKKSKN
PCLYFHMGQCLGVCYREDLEDEYRKEIEQIKHILNGNISKLLNDIEIKMKEVIMKENFEAAIKLKETKKSLIEISQTQII
TKIDKLSEDYLYIHKTNSLNTIVILKYKDGKLTEKDIHFDESIYEEDELIEKFITQYYTSPNMIVPDKIHIFKKIDTSNI
TKLINELKNIKTEIIYKETQDNIKIIEMATSNAKLALITYNHEKNKAIENLKTILEMKKLPKTIEGFDIAHINGYKTVAS
LVTFKMGKPFKDGYRVYKINSLSNGEIDDCKAIKEVISRRYSKLINEQLKLPDLILIDGGKGQLNAAYSILKGLRIEEKI
AICALAKKEEIIFLPNKNQGIKLQKRNSALQVLQNVRDEAHRRANNFNNKLHNNIKLNYTKIKGIGEQKAKKILKVLGTY
KDILLLNEDEIATKMKINITMANKIKKFAEEQNLNNKQNNHI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=592, Percent_Identity=30.4054054054054, Blast_Score=287, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_BORDL (B5RM14)

Other databases:

- EMBL:   CP000976
- RefSeq:   YP_002222106.1
- EnsemblBacteria:   EBBORT00000001235
- GeneID:   6918539
- GenomeReviews:   CP000976_GR
- KEGG:   bdu:BDU_455
- GeneTree:   EBGT00050000007493
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK14670
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70226; Mature: 70226

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKHLNDLYKQIEKFPKTSGCYKMYSKDNKILYIGKAKNLRSRVKNYFSKRTSHKTKILM
CCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEE
NNVTNIEIITTNSEYEALLLECNLIKKYKPTYNIKLKDDKGYPMIRITCEKYPRIFKTRK
ECCCEEEEEEECCCCEEEEEEEHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHH
IINDGSEYFGPYVNVKNLDLVLDLINKTFKTKKCKKKSKNPCLYFHMGQCLGVCYREDLE
HHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHH
DEYRKEIEQIKHILNGNISKLLNDIEIKMKEVIMKENFEAAIKLKETKKSLIEISQTQII
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHH
TKIDKLSEDYLYIHKTNSLNTIVILKYKDGKLTEKDIHFDESIYEEDELIEKFITQYYTS
HHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCC
PNMIVPDKIHIFKKIDTSNITKLINELKNIKTEIIYKETQDNIKIIEMATSNAKLALITY
CCEECCCCEEEEEECCHHHHHHHHHHHHCCHHHEEEEECCCCEEEEEEECCCCEEEEEEE
NHEKNKAIENLKTILEMKKLPKTIEGFDIAHINGYKTVASLVTFKMGKPFKDGYRVYKIN
CCCHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEE
SLSNGEIDDCKAIKEVISRRYSKLINEQLKLPDLILIDGGKGQLNAAYSILKGLRIEEKI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHH
AICALAKKEEIIFLPNKNQGIKLQKRNSALQVLQNVRDEAHRRANNFNNKLHNNIKLNYT
HEEEEECCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEE
KIKGIGEQKAKKILKVLGTYKDILLLNEDEIATKMKINITMANKIKKFAEEQNLNNKQNN
EECCCCHHHHHHHHHHHCCHHHEEEECCCCCEEEEEEEEEEHHHHHHHHHHCCCCCCCCC
HI
CC
>Mature Secondary Structure
MRKHLNDLYKQIEKFPKTSGCYKMYSKDNKILYIGKAKNLRSRVKNYFSKRTSHKTKILM
CCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEE
NNVTNIEIITTNSEYEALLLECNLIKKYKPTYNIKLKDDKGYPMIRITCEKYPRIFKTRK
ECCCEEEEEEECCCCEEEEEEEHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHH
IINDGSEYFGPYVNVKNLDLVLDLINKTFKTKKCKKKSKNPCLYFHMGQCLGVCYREDLE
HHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHH
DEYRKEIEQIKHILNGNISKLLNDIEIKMKEVIMKENFEAAIKLKETKKSLIEISQTQII
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHH
TKIDKLSEDYLYIHKTNSLNTIVILKYKDGKLTEKDIHFDESIYEEDELIEKFITQYYTS
HHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCC
PNMIVPDKIHIFKKIDTSNITKLINELKNIKTEIIYKETQDNIKIIEMATSNAKLALITY
CCEECCCCEEEEEECCHHHHHHHHHHHHCCHHHEEEEECCCCEEEEEEECCCCEEEEEEE
NHEKNKAIENLKTILEMKKLPKTIEGFDIAHINGYKTVASLVTFKMGKPFKDGYRVYKIN
CCCHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEE
SLSNGEIDDCKAIKEVISRRYSKLINEQLKLPDLILIDGGKGQLNAAYSILKGLRIEEKI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHH
AICALAKKEEIIFLPNKNQGIKLQKRNSALQVLQNVRDEAHRRANNFNNKLHNNIKLNYT
HEEEEECCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEE
KIKGIGEQKAKKILKVLGTYKDILLLNEDEIATKMKINITMANKIKKFAEEQNLNNKQNN
EECCCCHHHHHHHHHHHCCHHHEEEECCCCCEEEEEEEEEEHHHHHHHHHHCCCCCCCCC
HI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA