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The map label for this gene is fadD [C]

Identifier: 203284063

GI number: 203284063

Start: 147909

End: 149798

Strand: Reverse

Name: fadD [C]

Synonym: BDU_141

Alternate gene names: 203284063

Gene position: 149798-147909 (Counterclockwise)

Preceding gene: 203284064

Following gene: 203284061

Centisome position: 16.08

GC content: 28.41

Gene sequence:

>1890_bases
ATGTCAATAGTAAAGACTTTTTTTGAGATTGCTAGTAAGCATGGTTGTGGAATTGCACAAATATATAAAAATAATAAAGA
CTATTTTAAAGTTACTTATGCTGATTTGAAAGAGAATGTTTTAAAATTTGCTTCCTTTTTAAGGAAAATTAATTTAGGAT
ATCAAGATAAAGTATTTATTTGTTCTGAAAATAGAATTGAATGGAGTGTTATAGATTTTGCGATTTTATCTTTAGGTGCT
GTTGATGTTCCTAAGGGTATTGATATTACTCTTTTTGAGGCTGAAATAATTATTAATAATATTGTTCCGAATGTAATCAT
AGTTGAAAATGTAGATCTTCTTGATTTAATTATTAAGCTTAAGTTTCAAATAAAACCTACTGTAATTGTTATTGATGATT
TGTATGAAAAAGATAAATTACGTTTTAGTGAGTTTGAAGTTTATACTTATAAAGAGTGTATTTTAATTGGAGAAAATGCG
AGACAGGATGAAGAGATTATTGAGACTGTCAATAATATTAGTCTTAATGATATGGCAACAATAATATATACTTCTGGTAC
TACAGGAAATCCTAAAGGAGTGATGCTCTCTCATGCTAATTTTCTTTATCAGGTGTCTAGTTTTAGTCGGATGATTAGTG
TTACTGAGGGGCAGATATTTATGTGTATTTTGCCAATTTGGCATTCATTTCAAAGGTCATTTTCTTATAATATTTTTCTT
AAAGGTATGACTTGTTTATTTTCAAATATTGTTCCAAGAAATATGCTTGATGATATTAGAAATATTAATCCTCATTATAT
TGCTGCTGTTCCTAGACTTTGGATTGCAATAAAACAAAATATTGTTAAAGAGATTTCAAAAAAAAACTTTTTTGTAAGGT
TATTGTTTAGGATTTTTGTTAAATTTGCATGTATTAATGACATTTGTCGTAGAATAATTTTAGGTTTATATCCTGATAAT
GGACTGGATTTATTAATCCCTTTCAAAAAAATTTTAAGTATTTTGGGAGTAATAGTTTTATTTCCTTTGAATGTTTTGGG
AAATTTGATTGTATTTAAAAAAATAAAAAAAGTTTTAGGCAATAATTTTGTTGTTGGTATTTCTGGTGGGGGTAGCATAC
CTTTGTATGTTGTGAGGTTTTTTAATGCAATTGGTATTAATCTTGCTAATGCTTATGGCTTAACGGAGGCATCTCCAGGT
GTTGCATCTAATGAGTATGGGAAGATAATTGTTGGTACTAGTGGTAAAATATTACCCGGAACTATTGCTGAGATTAGAGA
TGAGAATGGCGTAAAACTTAAAAAACCTGGGAAAGGAGTTTTGTTTATTAAAGGTCCTCAAGTTATGATTGGATATTATC
AAGATATAGAGGCTACAAGGCAAGTTATTGGTGATGATGGATTTTTAGATACGGGTGATATTGTGAAATTGTCAAAAGAT
AATGTTGTTCAAATTATAGGGAGGGAGAAAGATACTATTGTTTTAAACAATGGAGAAAATATTGAACCTGCTCCCATTGA
AATTAAGCTTGAAGAATCTTTACTTATTGAGAAAGCTGTTGTTGTTGGGCAAGATCAAAAATTTTTAGGTGCATTAATTC
TTCCTAATTTTGAGGAGATAAATAAATATTTAGAGAGCATAGGGCATAAAATTCGTGATACTAATAAACAACAAATTATT
GCAAATAATATTGTTCTTAAAGCTATTGGTGATGAGATAAAAAAACTTATTAATAGGGCCAATGGATTTAAACCTTTTGA
GCAGATACTAAAGTTTGTTCTTTTAGAAAAGCCATTTGAAGTAGGGAAAGAGATGTCTATTAAAATGGATATTAAGCGTA
ATTATATTTCGAATTTTTATCGAAATGAGATAAAAAATTTATTCTCCTGA

Upstream 100 bases:

>100_bases
AATTGGTATATTCTCAGGCAAGATTAAGTTATGATTTTGTTATTTAAAATGTTATAATTATTAATAATAATTCTTTATAA
TAAGTTTGTAGTAGGATCAT

Downstream 100 bases:

>100_bases
TTTATTGTAATATTATCTCAAGTTCTTTTATATCTTTTAATTTTGTGTTAGGTGAATGAGACTGTTTGTATACAAAGCCA
TTTCCTTTAATATTTATTTT

Product: long-chain-fatty-acid CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MSIVKTFFEIASKHGCGIAQIYKNNKDYFKVTYADLKENVLKFASFLRKINLGYQDKVFICSENRIEWSVIDFAILSLGA
VDVPKGIDITLFEAEIIINNIVPNVIIVENVDLLDLIIKLKFQIKPTVIVIDDLYEKDKLRFSEFEVYTYKECILIGENA
RQDEEIIETVNNISLNDMATIIYTSGTTGNPKGVMLSHANFLYQVSSFSRMISVTEGQIFMCILPIWHSFQRSFSYNIFL
KGMTCLFSNIVPRNMLDDIRNINPHYIAAVPRLWIAIKQNIVKEISKKNFFVRLLFRIFVKFACINDICRRIILGLYPDN
GLDLLIPFKKILSILGVIVLFPLNVLGNLIVFKKIKKVLGNNFVVGISGGGSIPLYVVRFFNAIGINLANAYGLTEASPG
VASNEYGKIIVGTSGKILPGTIAEIRDENGVKLKKPGKGVLFIKGPQVMIGYYQDIEATRQVIGDDGFLDTGDIVKLSKD
NVVQIIGREKDTIVLNNGENIEPAPIEIKLEESLLIEKAVVVGQDQKFLGALILPNFEEINKYLESIGHKIRDTNKQQII
ANNIVLKAIGDEIKKLINRANGFKPFEQILKFVLLEKPFEVGKEMSIKMDIKRNYISNFYRNEIKNLFS

Sequences:

>Translated_629_residues
MSIVKTFFEIASKHGCGIAQIYKNNKDYFKVTYADLKENVLKFASFLRKINLGYQDKVFICSENRIEWSVIDFAILSLGA
VDVPKGIDITLFEAEIIINNIVPNVIIVENVDLLDLIIKLKFQIKPTVIVIDDLYEKDKLRFSEFEVYTYKECILIGENA
RQDEEIIETVNNISLNDMATIIYTSGTTGNPKGVMLSHANFLYQVSSFSRMISVTEGQIFMCILPIWHSFQRSFSYNIFL
KGMTCLFSNIVPRNMLDDIRNINPHYIAAVPRLWIAIKQNIVKEISKKNFFVRLLFRIFVKFACINDICRRIILGLYPDN
GLDLLIPFKKILSILGVIVLFPLNVLGNLIVFKKIKKVLGNNFVVGISGGGSIPLYVVRFFNAIGINLANAYGLTEASPG
VASNEYGKIIVGTSGKILPGTIAEIRDENGVKLKKPGKGVLFIKGPQVMIGYYQDIEATRQVIGDDGFLDTGDIVKLSKD
NVVQIIGREKDTIVLNNGENIEPAPIEIKLEESLLIEKAVVVGQDQKFLGALILPNFEEINKYLESIGHKIRDTNKQQII
ANNIVLKAIGDEIKKLINRANGFKPFEQILKFVLLEKPFEVGKEMSIKMDIKRNYISNFYRNEIKNLFS
>Mature_628_residues
SIVKTFFEIASKHGCGIAQIYKNNKDYFKVTYADLKENVLKFASFLRKINLGYQDKVFICSENRIEWSVIDFAILSLGAV
DVPKGIDITLFEAEIIINNIVPNVIIVENVDLLDLIIKLKFQIKPTVIVIDDLYEKDKLRFSEFEVYTYKECILIGENAR
QDEEIIETVNNISLNDMATIIYTSGTTGNPKGVMLSHANFLYQVSSFSRMISVTEGQIFMCILPIWHSFQRSFSYNIFLK
GMTCLFSNIVPRNMLDDIRNINPHYIAAVPRLWIAIKQNIVKEISKKNFFVRLLFRIFVKFACINDICRRIILGLYPDNG
LDLLIPFKKILSILGVIVLFPLNVLGNLIVFKKIKKVLGNNFVVGISGGGSIPLYVVRFFNAIGINLANAYGLTEASPGV
ASNEYGKIIVGTSGKILPGTIAEIRDENGVKLKKPGKGVLFIKGPQVMIGYYQDIEATRQVIGDDGFLDTGDIVKLSKDN
VVQIIGREKDTIVLNNGENIEPAPIEIKLEESLLIEKAVVVGQDQKFLGALILPNFEEINKYLESIGHKIRDTNKQQIIA
NNIVLKAIGDEIKKLINRANGFKPFEQILKFVLLEKPFEVGKEMSIKMDIKRNYISNFYRNEIKNLFS

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=587, Percent_Identity=26.0647359454855, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI27477105, Length=658, Percent_Identity=24.0121580547112, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI42794760, Length=625, Percent_Identity=24.48, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI42794758, Length=625, Percent_Identity=24.48, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI42794756, Length=625, Percent_Identity=24.48, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI83745141, Length=657, Percent_Identity=25.2663622526636, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI57165410, Length=631, Percent_Identity=24.405705229794, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI57165412, Length=631, Percent_Identity=24.5641838351823, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI12669909, Length=638, Percent_Identity=24.294670846395, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI4758332, Length=638, Percent_Identity=24.294670846395, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI42794754, Length=644, Percent_Identity=22.6708074534161, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI42794752, Length=644, Percent_Identity=22.6708074534161, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI156151445, Length=172, Percent_Identity=32.5581395348837, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788107, Length=515, Percent_Identity=25.0485436893204, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI145693145, Length=166, Percent_Identity=30.1204819277108, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541856, Length=640, Percent_Identity=24.375, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17510401, Length=601, Percent_Identity=24.9584026622296, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17556552, Length=608, Percent_Identity=25.1644736842105, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25147511, Length=657, Percent_Identity=23.7442922374429, Blast_Score=133, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI193204819, Length=663, Percent_Identity=23.5294117647059, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17553312, Length=548, Percent_Identity=25, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17564090, Length=463, Percent_Identity=24.622030237581, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI133901848, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531443, Length=152, Percent_Identity=30.9210526315789, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560308, Length=165, Percent_Identity=30.9090909090909, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=192, Percent_Identity=29.6875, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320852, Length=602, Percent_Identity=25.0830564784053, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323903, Length=426, Percent_Identity=23.4741784037559, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324893, Length=396, Percent_Identity=24.7474747474747, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322182, Length=448, Percent_Identity=22.3214285714286, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24666501, Length=648, Percent_Identity=22.8395061728395, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24666497, Length=648, Percent_Identity=22.8395061728395, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281366413, Length=648, Percent_Identity=22.8395061728395, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17933690, Length=647, Percent_Identity=23.6476043276662, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62471679, Length=640, Percent_Identity=22.96875, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62471683, Length=640, Percent_Identity=22.96875, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62471685, Length=640, Percent_Identity=22.96875, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24586636, Length=640, Percent_Identity=22.96875, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62471689, Length=640, Percent_Identity=22.96875, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62471681, Length=642, Percent_Identity=23.208722741433, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62471687, Length=642, Percent_Identity=23.208722741433, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24586634, Length=642, Percent_Identity=23.208722741433, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI22026970, Length=642, Percent_Identity=23.208722741433, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19921316, Length=650, Percent_Identity=22, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859661, Length=259, Percent_Identity=28.1853281853282, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 71070; Mature: 70938

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVKTFFEIASKHGCGIAQIYKNNKDYFKVTYADLKENVLKFASFLRKINLGYQDKVFI
CHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CSENRIEWSVIDFAILSLGAVDVPKGIDITLFEAEIIINNIVPNVIIVENVDLLDLIIKL
ECCCCEEEHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHCCCCEEEEECCHHHHHHHHH
KFQIKPTVIVIDDLYEKDKLRFSEFEVYTYKECILIGENARQDEEIIETVNNISLNDMAT
EEEECCEEEEEECCCCCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
IIYTSGTTGNPKGVMLSHANFLYQVSSFSRMISVTEGQIFMCILPIWHSFQRSFSYNIFL
EEEECCCCCCCCCEEEECCHHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHCCCEEEEE
KGMTCLFSNIVPRNMLDDIRNINPHYIAAVPRLWIAIKQNIVKEISKKNFFVRLLFRIFV
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
KFACINDICRRIILGLYPDNGLDLLIPFKKILSILGVIVLFPLNVLGNLIVFKKIKKVLG
HHHHHHHHHHHHHEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NNFVVGISGGGSIPLYVVRFFNAIGINLANAYGLTEASPGVASNEYGKIIVGTSGKILPG
CCEEEEECCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
TIAEIRDENGVKLKKPGKGVLFIKGPQVMIGYYQDIEATRQVIGDDGFLDTGDIVKLSKD
HHHHHCCCCCCEEECCCCEEEEEECCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEECCC
NVVQIIGREKDTIVLNNGENIEPAPIEIKLEESLLIEKAVVVGQDQKFLGALILPNFEEI
CEEEEECCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHEECCCHHHH
NKYLESIGHKIRDTNKQQIIANNIVLKAIGDEIKKLINRANGFKPFEQILKFVLLEKPFE
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
VGKEMSIKMDIKRNYISNFYRNEIKNLFS
CCCCEEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIVKTFFEIASKHGCGIAQIYKNNKDYFKVTYADLKENVLKFASFLRKINLGYQDKVFI
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CSENRIEWSVIDFAILSLGAVDVPKGIDITLFEAEIIINNIVPNVIIVENVDLLDLIIKL
ECCCCEEEHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHCCCCEEEEECCHHHHHHHHH
KFQIKPTVIVIDDLYEKDKLRFSEFEVYTYKECILIGENARQDEEIIETVNNISLNDMAT
EEEECCEEEEEECCCCCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
IIYTSGTTGNPKGVMLSHANFLYQVSSFSRMISVTEGQIFMCILPIWHSFQRSFSYNIFL
EEEECCCCCCCCCEEEECCHHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHCCCEEEEE
KGMTCLFSNIVPRNMLDDIRNINPHYIAAVPRLWIAIKQNIVKEISKKNFFVRLLFRIFV
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
KFACINDICRRIILGLYPDNGLDLLIPFKKILSILGVIVLFPLNVLGNLIVFKKIKKVLG
HHHHHHHHHHHHHEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NNFVVGISGGGSIPLYVVRFFNAIGINLANAYGLTEASPGVASNEYGKIIVGTSGKILPG
CCEEEEECCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
TIAEIRDENGVKLKKPGKGVLFIKGPQVMIGYYQDIEATRQVIGDDGFLDTGDIVKLSKD
HHHHHCCCCCCEEECCCCEEEEEECCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEECCC
NVVQIIGREKDTIVLNNGENIEPAPIEIKLEESLLIEKAVVVGQDQKFLGALILPNFEEI
CEEEEECCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHEECCCHHHH
NKYLESIGHKIRDTNKQQIIANNIVLKAIGDEIKKLINRANGFKPFEQILKFVLLEKPFE
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
VGKEMSIKMDIKRNYISNFYRNEIKNLFS
CCCCEEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]