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The map label for this gene is parC [H]

Identifier: 203283964

GI number: 203283964

Start: 43235

End: 45118

Strand: Reverse

Name: parC [H]

Synonym: BDU_40

Alternate gene names: 203283964

Gene position: 45118-43235 (Counterclockwise)

Preceding gene: 203283965

Following gene: 203283963

Centisome position: 4.84

GC content: 26.8

Gene sequence:

>1884_bases
ATGAACATTAAAACATTACTTAGAGATAATTTTTTACAGTATTCATCTTATGTTATTAAAGATCGTGCAATTGCTAGTGT
TATTGATGGATTTAAACCGGTACAGAGACGAATAATACATTCTCTTTTTGAAATGAATGATGGTAATTTTCATAAAGTTG
CAAATGTTGTTGGAAATACAATGAAATATCATCCTCATGGAGATACTTCAATTTATGAAGCTCTTGTTAATATGGCAAAT
AAAGATTTATTTATTGAAAAGCAAGGAAATTTTGGTAATCTTTTAACGGGTGATCCTGCTTCTGCATCTCGTTATATTGA
ATGTCGATTAACTCCTTTAGCGTTTGAAGTGCTCTATAGTAAGGAAATAACGACTTATGAGCCTTCTTATGATGGTCGTA
ATGCTGAGCCTTTGATTTTTCCTGCTAAAATTCCTGTAATACTTATTCAGGGAAGTGAAGGAATTGCTGTTGGTATGGCT
GCTAAAATTCTTCCTCATAACTTTAATGAAATTTTAAGAGCTGTTAAGAGTGAGTTGCTTGGTGAAGCTTATAAGCTTTA
TCCTGATTTCCCAACAGGTGGAATAGTTGATGTTAATGAGTATGCTGATGGCAATGGAAAGGTTTTGGTTCGTGCAAAAA
TTGAACCTACAGATGATAATAAGGCTATTTTGATAAAAGAATTACCTTTTGGAGAAACTACAGAAAGTTTAATAGCTTCA
ATTGAGAGGGCTATTCGTAAAAACTATATTAAAGTTTCGAGTATTAATGATTTTACTACAGAAAATGTAGAGATTGAATT
GACCCTTCCAAGGGGGGTATATGCCAATGAAATTATTGAAAAACTGTATCATTATACAAATTGTCAAGTTTCTATTTCTG
TTAATTTGCTTTTATTGAGTGATAGATATCCTGTTATTTATACTGTTACAGATATTATCAAGTTTCATGCTGAGCATTTA
CAAAAAGTTTTAAAGATGGAGCTTGAACTTGAGAGAAGTAAGATACTTGAAAAAATTTTTTCTAAGACCTTAGAGCAAAT
ATTTATTGAACATAAGATTTATAAAATTCTTGAAACTATTTCTAAAGAATCTGATGTTGTTGATATTGTAATGAGTGAAA
TTGTTAAGTATGGAGATAGGTTTTCTAGAAAAATTGTTTTAGATGATATTGAGAACTTGCTTAAAATTCCTATTAGGAAA
ATAAGTATGTTTGATATTGATAAAAATAATAAAGATATTCAAATTTTAAGTAAAGAATTAAAAAGTGTAGAAAGTAATAT
TGAATCAATTAAAAATTATGCAATAAATTTTATTGATAAACTTCTTGCTAAATATTCAAAAATGTATCATAGAAAGACAG
AGATATCTCTTATTGAATCCAAAAATGCTAGAGAAATTGCTACTAAGAATATGAAAATTTATGTGAGTTTAAAAGCAGGG
TTTGTTGGAACCAGTCTTATTGATGGTGAATTTATTGGAAATGCTAGTTATTATGATAAGGTATTAATCTTTAAAAAGGA
TTCTTATATTTTAAAAAATATTGAAGATAAGACCTTTATTGAAAAGAATAATGTTAGTGTTTTAGTTTATGATATAAATA
ATTCTAAGGAGCAGGTATTTTCTATAATTTATCTTAATAAAGTCGATAATTTTTATTATGTTAAAAGATTTAGGATAGAT
AAGTTTTTAACTGATAAAGTTTATTATTTTTTAAATAAAGATGATGAATTTATAGATTTTACTTTTAATGCACAATTTGT
GGCGTTTTCTACTAGTAGAGATGTTGTTAAAATGATTGATATTAATAATTTTATGATTAAATCGCGAATTTCTGTAGGTA
AGAGAATTTCAAATAATATTATTAAAAAAGTTAAATTTAAATAA

Upstream 100 bases:

>100_bases
TAGATCTTGTCAATATTAAAGAAATAAAAGAGCAATTGGGATTTTATATGGGGCCAAATACTCCTGAGAGACGAAACTTT
ATTATGGAGAATTTAATTTA

Downstream 100 bases:

>100_bases
ATTGAAGATGAAATAAATTATTGAACAATTCTTTTAATATGTATATAATGCAAACACTAGGCTGTTTATTTTGGGGGTAT
TTTATGAAGAGAGTATTAAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MNIKTLLRDNFLQYSSYVIKDRAIASVIDGFKPVQRRIIHSLFEMNDGNFHKVANVVGNTMKYHPHGDTSIYEALVNMAN
KDLFIEKQGNFGNLLTGDPASASRYIECRLTPLAFEVLYSKEITTYEPSYDGRNAEPLIFPAKIPVILIQGSEGIAVGMA
AKILPHNFNEILRAVKSELLGEAYKLYPDFPTGGIVDVNEYADGNGKVLVRAKIEPTDDNKAILIKELPFGETTESLIAS
IERAIRKNYIKVSSINDFTTENVEIELTLPRGVYANEIIEKLYHYTNCQVSISVNLLLLSDRYPVIYTVTDIIKFHAEHL
QKVLKMELELERSKILEKIFSKTLEQIFIEHKIYKILETISKESDVVDIVMSEIVKYGDRFSRKIVLDDIENLLKIPIRK
ISMFDIDKNNKDIQILSKELKSVESNIESIKNYAINFIDKLLAKYSKMYHRKTEISLIESKNAREIATKNMKIYVSLKAG
FVGTSLIDGEFIGNASYYDKVLIFKKDSYILKNIEDKTFIEKNNVSVLVYDINNSKEQVFSIIYLNKVDNFYYVKRFRID
KFLTDKVYYFLNKDDEFIDFTFNAQFVAFSTSRDVVKMIDINNFMIKSRISVGKRISNNIIKKVKFK

Sequences:

>Translated_627_residues
MNIKTLLRDNFLQYSSYVIKDRAIASVIDGFKPVQRRIIHSLFEMNDGNFHKVANVVGNTMKYHPHGDTSIYEALVNMAN
KDLFIEKQGNFGNLLTGDPASASRYIECRLTPLAFEVLYSKEITTYEPSYDGRNAEPLIFPAKIPVILIQGSEGIAVGMA
AKILPHNFNEILRAVKSELLGEAYKLYPDFPTGGIVDVNEYADGNGKVLVRAKIEPTDDNKAILIKELPFGETTESLIAS
IERAIRKNYIKVSSINDFTTENVEIELTLPRGVYANEIIEKLYHYTNCQVSISVNLLLLSDRYPVIYTVTDIIKFHAEHL
QKVLKMELELERSKILEKIFSKTLEQIFIEHKIYKILETISKESDVVDIVMSEIVKYGDRFSRKIVLDDIENLLKIPIRK
ISMFDIDKNNKDIQILSKELKSVESNIESIKNYAINFIDKLLAKYSKMYHRKTEISLIESKNAREIATKNMKIYVSLKAG
FVGTSLIDGEFIGNASYYDKVLIFKKDSYILKNIEDKTFIEKNNVSVLVYDINNSKEQVFSIIYLNKVDNFYYVKRFRID
KFLTDKVYYFLNKDDEFIDFTFNAQFVAFSTSRDVVKMIDINNFMIKSRISVGKRISNNIIKKVKFK
>Mature_627_residues
MNIKTLLRDNFLQYSSYVIKDRAIASVIDGFKPVQRRIIHSLFEMNDGNFHKVANVVGNTMKYHPHGDTSIYEALVNMAN
KDLFIEKQGNFGNLLTGDPASASRYIECRLTPLAFEVLYSKEITTYEPSYDGRNAEPLIFPAKIPVILIQGSEGIAVGMA
AKILPHNFNEILRAVKSELLGEAYKLYPDFPTGGIVDVNEYADGNGKVLVRAKIEPTDDNKAILIKELPFGETTESLIAS
IERAIRKNYIKVSSINDFTTENVEIELTLPRGVYANEIIEKLYHYTNCQVSISVNLLLLSDRYPVIYTVTDIIKFHAEHL
QKVLKMELELERSKILEKIFSKTLEQIFIEHKIYKILETISKESDVVDIVMSEIVKYGDRFSRKIVLDDIENLLKIPIRK
ISMFDIDKNNKDIQILSKELKSVESNIESIKNYAINFIDKLLAKYSKMYHRKTEISLIESKNAREIATKNMKIYVSLKAG
FVGTSLIDGEFIGNASYYDKVLIFKKDSYILKNIEDKTFIEKNNVSVLVYDINNSKEQVFSIIYLNKVDNFYYVKRFRID
KFLTDKVYYFLNKDDEFIDFTFNAQFVAFSTSRDVVKMIDINNFMIKSRISVGKRISNNIIKKVKFK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=27.6729559748428, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI19913406, Length=173, Percent_Identity=34.1040462427746, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1788562, Length=374, Percent_Identity=32.8877005347594, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789396, Length=499, Percent_Identity=29.0581162324649, Blast_Score=159, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17535065, Length=312, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=229, Percent_Identity=27.0742358078603, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115534553, Length=168, Percent_Identity=26.1904761904762, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=193, Percent_Identity=26.4248704663212, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=230, Percent_Identity=29.1304347826087, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136538, Length=247, Percent_Identity=29.5546558704453, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72195; Mature: 72195

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKTLLRDNFLQYSSYVIKDRAIASVIDGFKPVQRRIIHSLFEMNDGNFHKVANVVGNT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
MKYHPHGDTSIYEALVNMANKDLFIEKQGNFGNLLTGDPASASRYIECRLTPLAFEVLYS
EEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECHHHEEHHHC
KEITTYEPSYDGRNAEPLIFPAKIPVILIQGSEGIAVGMAAKILPHNFNEILRAVKSELL
CCCCEECCCCCCCCCCCEEEECCCCEEEEECCCCEEEEHHHHHCCCCHHHHHHHHHHHHC
GEAYKLYPDFPTGGIVDVNEYADGNGKVLVRAKIEPTDDNKAILIKELPFGETTESLIAS
CCHHEECCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
IERAIRKNYIKVSSINDFTTENVEIELTLPRGVYANEIIEKLYHYTNCQVSISVNLLLLS
HHHHHHHCCEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEEEE
DRYPVIYTVTDIIKFHAEHLQKVLKMELELERSKILEKIFSKTLEQIFIEHKIYKILETI
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKESDVVDIVMSEIVKYGDRFSRKIVLDDIENLLKIPIRKISMFDIDKNNKDIQILSKEL
CCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHH
KSVESNIESIKNYAINFIDKLLAKYSKMYHRKTEISLIESKNAREIATKNMKIYVSLKAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCCEEEEEEEECC
FVGTSLIDGEFIGNASYYDKVLIFKKDSYILKNIEDKTFIEKNNVSVLVYDINNSKEQVF
CEECEEECCCEECCCCHHCEEEEEECCCHHHHCCCCCCEEECCCCEEEEEECCCCHHHEE
SIIYLNKVDNFYYVKRFRIDKFLTDKVYYFLNKDDEFIDFTFNAQFVAFSTSRDVVKMID
EEEEEECCCCEEEEEEEHHHHHHHCCEEEEECCCCCEEEEEECCEEEEEECCCCEEEEEE
INNFMIKSRISVGKRISNNIIKKVKFK
CCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIKTLLRDNFLQYSSYVIKDRAIASVIDGFKPVQRRIIHSLFEMNDGNFHKVANVVGNT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
MKYHPHGDTSIYEALVNMANKDLFIEKQGNFGNLLTGDPASASRYIECRLTPLAFEVLYS
EEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECHHHEEHHHC
KEITTYEPSYDGRNAEPLIFPAKIPVILIQGSEGIAVGMAAKILPHNFNEILRAVKSELL
CCCCEECCCCCCCCCCCEEEECCCCEEEEECCCCEEEEHHHHHCCCCHHHHHHHHHHHHC
GEAYKLYPDFPTGGIVDVNEYADGNGKVLVRAKIEPTDDNKAILIKELPFGETTESLIAS
CCHHEECCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
IERAIRKNYIKVSSINDFTTENVEIELTLPRGVYANEIIEKLYHYTNCQVSISVNLLLLS
HHHHHHHCCEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEEEE
DRYPVIYTVTDIIKFHAEHLQKVLKMELELERSKILEKIFSKTLEQIFIEHKIYKILETI
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKESDVVDIVMSEIVKYGDRFSRKIVLDDIENLLKIPIRKISMFDIDKNNKDIQILSKEL
CCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHH
KSVESNIESIKNYAINFIDKLLAKYSKMYHRKTEISLIESKNAREIATKNMKIYVSLKAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCCEEEEEEEECC
FVGTSLIDGEFIGNASYYDKVLIFKKDSYILKNIEDKTFIEKNNVSVLVYDINNSKEQVF
CEECEEECCCEECCCCHHCEEEEEECCCHHHHCCCCCCEEECCCCEEEEEECCCCHHHEE
SIIYLNKVDNFYYVKRFRIDKFLTDKVYYFLNKDDEFIDFTFNAQFVAFSTSRDVVKMID
EEEEEECCCCEEEEEEEHHHHHHHCCEEEEECCCCCEEEEEECCEEEEEECCCCEEEEEE
INNFMIKSRISVGKRISNNIIKKVKFK
CCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]