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The map label for this gene is hbdA [H]

Identifier: 197119207

GI number: 197119207

Start: 3260602

End: 3261447

Strand: Reverse

Name: hbdA [H]

Synonym: Gbem_2834

Alternate gene names: 197119207

Gene position: 3261447-3260602 (Counterclockwise)

Preceding gene: 197119208

Following gene: 197119206

Centisome position: 70.67

GC content: 59.81

Gene sequence:

>846_bases
ATGTTCAAGACAGTCGGTGTTTTAGGGGCGGGGCAGATGGGAAGCGGGATCGCCCACGTTTTCGCGCAGCACGCTTACCA
GGTCCTGGTCTTCGATATCTCCGAGGCACAGCTTTCGAAAGCGCTCAAATCGATCGAGCAGAACCTGGAGCGGCAGGCTA
AGAAGGGGGTCATCTTCGACACCAGCATCCAGGGGATCATGGCCCGCATCACGGCCACCAAGGAGCTCAAGGACTTCGCC
GGCTGCGACCTCGTCATCGAGGCCGCCACCGAAAACGAGGCGCTCAAGTTCGATCTCTTCAGAAAGCTTGACGAGGTGGT
GAAAAAGGAAGCGATCCTCGCCTCCAATACCTCCTCCATCTCCATTACCCGCATCGCGGCAGTGACCAAAAGGCCGGATC
AGGTGATCGGGATGCACTTCATGAACCCGGTGCCGGTGATGCAGCTGGTCGAGGTAATCCGCGGCATCGCCACCAGCGAC
GAAACCTTCGAGGCCATAGGGCACCTGGTAGGCCTCCTGAACAAGCAGATGGCCGTCTCCCAGGACTACCCCGGCTTCAT
CGTGAACCGGGTGCTGATCCCGATGATCAACGAGGCGGTCTTCGCCCTCTACGAAGGGATAGCTACCGCCGAGGACATCG
ACAAGGGGATGAAGCTCGGCACCAACCAGCCGATGGGCCCCCTGCAGTTGGCCGATTTCATCGGGCTCGACACGGTGCTC
GCCATCTGCAACGTGCTGCACGACGGCTTCAAGGACCCGAAGTACCGCCCCTGCCCGCTCCTGGTGAAGATGGTGGACGC
AGGCTACCTCGGCAAGAAATCCGGGAAGGGCTTTTACAACTACTAG

Upstream 100 bases:

>100_bases
GCGCGCTATGGGCTCGCCACGCTCTGCATCGGGGGCGGCGAGGCGGTCGCGGTCATTTTCGAAAGGGTCTAGACACTTTT
CTCGCAGGGGGGAGGCTTAC

Downstream 100 bases:

>100_bases
CATCTCTTTGGGGGAGATCTCATGGACGCGAAGAATATCCTGTGTGAAATAAATGAAGGGGTGGCAGTGGTGACGGTGAA
CCGGCCGGAAAGCCTCAACG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MFKTVGVLGAGQMGSGIAHVFAQHAYQVLVFDISEAQLSKALKSIEQNLERQAKKGVIFDTSIQGIMARITATKELKDFA
GCDLVIEAATENEALKFDLFRKLDEVVKKEAILASNTSSISITRIAAVTKRPDQVIGMHFMNPVPVMQLVEVIRGIATSD
ETFEAIGHLVGLLNKQMAVSQDYPGFIVNRVLIPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLQLADFIGLDTVL
AICNVLHDGFKDPKYRPCPLLVKMVDAGYLGKKSGKGFYNY

Sequences:

>Translated_281_residues
MFKTVGVLGAGQMGSGIAHVFAQHAYQVLVFDISEAQLSKALKSIEQNLERQAKKGVIFDTSIQGIMARITATKELKDFA
GCDLVIEAATENEALKFDLFRKLDEVVKKEAILASNTSSISITRIAAVTKRPDQVIGMHFMNPVPVMQLVEVIRGIATSD
ETFEAIGHLVGLLNKQMAVSQDYPGFIVNRVLIPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLQLADFIGLDTVL
AICNVLHDGFKDPKYRPCPLLVKMVDAGYLGKKSGKGFYNY
>Mature_281_residues
MFKTVGVLGAGQMGSGIAHVFAQHAYQVLVFDISEAQLSKALKSIEQNLERQAKKGVIFDTSIQGIMARITATKELKDFA
GCDLVIEAATENEALKFDLFRKLDEVVKKEAILASNTSSISITRIAAVTKRPDQVIGMHFMNPVPVMQLVEVIRGIATSD
ETFEAIGHLVGLLNKQMAVSQDYPGFIVNRVLIPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLQLADFIGLDTVL
AICNVLHDGFKDPKYRPCPLLVKMVDAGYLGKKSGKGFYNY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=43.006993006993, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=41.4473684210526, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=36.3957597173145, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=35.2542372881356, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=35.3951890034364, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI115430219, Length=254, Percent_Identity=25.9842519685039, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787661, Length=280, Percent_Identity=42.1428571428571, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=35.2059925093633, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788682, Length=255, Percent_Identity=36.4705882352941, Blast_Score=141, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=40.8304498269896, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=39.9305555555556, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=37.5, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144276, Length=280, Percent_Identity=36.0714285714286, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17508951, Length=280, Percent_Identity=36.0714285714286, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=35.4838709677419, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=279, Percent_Identity=35.1254480286738, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=28.4697508896797, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=27.8571428571429, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115533614, Length=201, Percent_Identity=24.3781094527363, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203623, Length=201, Percent_Identity=24.3781094527363, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=37.8091872791519, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=37.8091872791519, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=37.8091872791519, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=30.9322033898305, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129993, Length=223, Percent_Identity=26.9058295964126, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30671; Mature: 30671

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTVGVLGAGQMGSGIAHVFAQHAYQVLVFDISEAQLSKALKSIEQNLERQAKKGVIFD
CCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEE
TSIQGIMARITATKELKDFAGCDLVIEAATENEALKFDLFRKLDEVVKKEAILASNTSSI
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
SITRIAAVTKRPDQVIGMHFMNPVPVMQLVEVIRGIATSDETFEAIGHLVGLLNKQMAVS
EEHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
QDYPGFIVNRVLIPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLQLADFIGLDTVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AICNVLHDGFKDPKYRPCPLLVKMVDAGYLGKKSGKGFYNY
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFKTVGVLGAGQMGSGIAHVFAQHAYQVLVFDISEAQLSKALKSIEQNLERQAKKGVIFD
CCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEE
TSIQGIMARITATKELKDFAGCDLVIEAATENEALKFDLFRKLDEVVKKEAILASNTSSI
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
SITRIAAVTKRPDQVIGMHFMNPVPVMQLVEVIRGIATSDETFEAIGHLVGLLNKQMAVS
EEHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
QDYPGFIVNRVLIPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLQLADFIGLDTVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AICNVLHDGFKDPKYRPCPLLVKMVDAGYLGKKSGKGFYNY
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]