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The map label for this gene is acdA [H]

Identifier: 197119205

GI number: 197119205

Start: 3258607

End: 3259746

Strand: Reverse

Name: acdA [H]

Synonym: Gbem_2832

Alternate gene names: 197119205

Gene position: 3259746-3258607 (Counterclockwise)

Preceding gene: 197119206

Following gene: 197119204

Centisome position: 70.63

GC content: 60.96

Gene sequence:

>1140_bases
ATGAACTTTGAACTGAGCCAGGACCACAAGGTGTTGAAGGATAGCGTTCGGGATTTCGTGGTGAACGAGATCAAGCCGCT
CGCCATGCAGATCGACGAGGAGCATATGATCCCCGACGACCTGGTGCGCAAGATGGGGGAGATGGGTTTCCTCGGCTCCT
ACCTGCCGGAAGAGTACGGCGGCGCGGGGCTCGACATGCTCTCCTACGCCATCGTGGTCGAGGAGGTCTCCAAGGCCTGC
GGTTCCAGCGGCGTCCTCATCTCGGCCCACACCTCCCTTGCCTGCGGCCCGATCTACACCTTCGGCACCGAGGAGCAGAA
GAAAAAATGGCTCCCGGACCTGAACACCGGCAAGGTGATCGGCTGCTTCCTCCTGACCGAACCGGACGCCGGCAGCGACG
CCGGGGCCATCGCCACCACCTACAAGCGCGACGGCGATCATTTCGTGATCAACGGTTCGAAGATCTTCATCACCAACGGC
GGCTACAAGGGAACCGGCGTGCTCTTCGCCACCTCCGACAAAAACCTCAAGCACAAAGGGGTCTCCGCCTTCATCATCGA
CCTGCAGTCCCCGGGGGTCGAGATCCTCAAGAACGAGAAGAAGCTCGGCATCCGCGGCAGCTACACCACCGCCTTCGCCC
TCGACAGCGTCCGCATTCCGGTGGAGAACCTCCTAGGGCAGGAAGGGCAGGGGTTCAAGATCGCCATGGACACCCTGAAC
GGCGGCCGCATCGGCATCGCCTCCCAGGCTCTCGGCATCGCCGAAGGCGCCTTCGACCTGGCGCTTGCCTACTCCAAGGA
GAGAAAGCAGTTCGGCCATCCCATCTGCGAGCTGCAGGCGATCCAGTTCAAGCTGGCCGACATGTACGCGAAGATCGAGA
CCAGCAAGCTCATGACCTACAAGGCTGCCTGCCTGAAGGACAGCAAGAAGAACTACACCATGGAGTCCGCCATGTGTAAG
ATGCTCGCCTCGGAGGCGGCAACCTTCGTCACCAAGGAGGCGATCCAGATCCACGGCGGGTACGGCTTCATCGTCGACTA
CGAGGTGGAGCGGATGTACCGCGACGCGAAGATCACCGAGATCTACGAGGGGACCAACGAGGTTCAGCGCGTTGTGGTCT
CGAAGCTGCTCTTGTCTTAA

Upstream 100 bases:

>100_bases
AATGGGGGCGTTCGTGGAGAAGCGAAAGGCGAAGTTCCAGGGGAAATAACCGGAGCGGCGCCGGGAACCGACAACGATTT
TCTTACCAAGGGGGGATGAT

Downstream 100 bases:

>100_bases
TTCAGAAATGATGGCACCTACCCCCCACCCCCTAACCCCCTCCCGCTAGGGGAGGGGGGACTTTGGGACAACGCTGGGCG
TCGTCGGGTTGCTGCCCGGG

Product: short-chain acyl-CoA dehydrogenase

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNFELSQDHKVLKDSVRDFVVNEIKPLAMQIDEEHMIPDDLVRKMGEMGFLGSYLPEEYGGAGLDMLSYAIVVEEVSKAC
GSSGVLISAHTSLACGPIYTFGTEEQKKKWLPDLNTGKVIGCFLLTEPDAGSDAGAIATTYKRDGDHFVINGSKIFITNG
GYKGTGVLFATSDKNLKHKGVSAFIIDLQSPGVEILKNEKKLGIRGSYTTAFALDSVRIPVENLLGQEGQGFKIAMDTLN
GGRIGIASQALGIAEGAFDLALAYSKERKQFGHPICELQAIQFKLADMYAKIETSKLMTYKAACLKDSKKNYTMESAMCK
MLASEAATFVTKEAIQIHGGYGFIVDYEVERMYRDAKITEIYEGTNEVQRVVVSKLLLS

Sequences:

>Translated_379_residues
MNFELSQDHKVLKDSVRDFVVNEIKPLAMQIDEEHMIPDDLVRKMGEMGFLGSYLPEEYGGAGLDMLSYAIVVEEVSKAC
GSSGVLISAHTSLACGPIYTFGTEEQKKKWLPDLNTGKVIGCFLLTEPDAGSDAGAIATTYKRDGDHFVINGSKIFITNG
GYKGTGVLFATSDKNLKHKGVSAFIIDLQSPGVEILKNEKKLGIRGSYTTAFALDSVRIPVENLLGQEGQGFKIAMDTLN
GGRIGIASQALGIAEGAFDLALAYSKERKQFGHPICELQAIQFKLADMYAKIETSKLMTYKAACLKDSKKNYTMESAMCK
MLASEAATFVTKEAIQIHGGYGFIVDYEVERMYRDAKITEIYEGTNEVQRVVVSKLLLS
>Mature_379_residues
MNFELSQDHKVLKDSVRDFVVNEIKPLAMQIDEEHMIPDDLVRKMGEMGFLGSYLPEEYGGAGLDMLSYAIVVEEVSKAC
GSSGVLISAHTSLACGPIYTFGTEEQKKKWLPDLNTGKVIGCFLLTEPDAGSDAGAIATTYKRDGDHFVINGSKIFITNG
GYKGTGVLFATSDKNLKHKGVSAFIIDLQSPGVEILKNEKKLGIRGSYTTAFALDSVRIPVENLLGQEGQGFKIAMDTLN
GGRIGIASQALGIAEGAFDLALAYSKERKQFGHPICELQAIQFKLADMYAKIETSKLMTYKAACLKDSKKNYTMESAMCK
MLASEAATFVTKEAIQIHGGYGFIVDYEVERMYRDAKITEIYEGTNEVQRVVVSKLLLS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=50.9283819628647, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=38.8140161725067, Blast_Score=281, Evalue=9e-76,
Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=36.8, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=36.2433862433862, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=36.2433862433862, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI21361497, Length=380, Percent_Identity=39.7368421052632, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=33.3333333333333, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=36.3874345549738, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=36.3874345549738, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=34.6153846153846, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=31.9034852546917, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=28.8, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=29.2011019283747, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI38505218, Length=391, Percent_Identity=29.923273657289, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI48976061, Length=354, Percent_Identity=30.7909604519774, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI211971008, Length=354, Percent_Identity=30.7909604519774, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI218563752, Length=238, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI156104864, Length=345, Percent_Identity=25.7971014492754, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI156104866, Length=337, Percent_Identity=26.1127596439169, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=29.8429319371728, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=31.6753926701571, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87081702, Length=368, Percent_Identity=27.7173913043478, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082384, Length=263, Percent_Identity=24.7148288973384, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=39.572192513369, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=38.6058981233244, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=39.7905759162304, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=39.2670157068063, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=35.6020942408377, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=37.4005305039788, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=39.8860398860399, Blast_Score=240, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=34.5646437994723, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=41.726618705036, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=32.9787234042553, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=41.991341991342, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71985192, Length=298, Percent_Identity=38.5906040268456, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=34.6715328467153, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=29.3010752688172, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=30.0268096514745, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17562446, Length=390, Percent_Identity=27.9487179487179, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=31.5352697095436, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=30.6818181818182, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=26.7924528301887, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=26.7924528301887, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=50, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=44.3850267379679, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=40.2144772117962, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=37.3015873015873, Blast_Score=260, Evalue=8e-70,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=34.8284960422164, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI281363737, Length=355, Percent_Identity=37.7464788732394, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=30.4232804232804, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281365206, Length=361, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585193, Length=361, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585195, Length=361, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585191, Length=361, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 41447; Mature: 41447

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFELSQDHKVLKDSVRDFVVNEIKPLAMQIDEEHMIPDDLVRKMGEMGFLGSYLPEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHCCCCHHHHCCHHHC
GAGLDMLSYAIVVEEVSKACGSSGVLISAHTSLACGPIYTFGTEEQKKKWLPDLNTGKVI
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCEEECCCCHHHHHCCCCCCCCCEE
GCFLLTEPDAGSDAGAIATTYKRDGDHFVINGSKIFITNGGYKGTGVLFATSDKNLKHKG
EEEEEECCCCCCCCCCEEEEEECCCCEEEEECCEEEEECCCCCCCEEEEEECCCCCCCCC
VSAFIIDLQSPGVEILKNEKKLGIRGSYTTAFALDSVRIPVENLLGQEGQGFKIAMDTLN
CEEEEEEECCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEECCC
GGRIGIASQALGIAEGAFDLALAYSKERKQFGHPICELQAIQFKLADMYAKIETSKLMTY
CCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KAACLKDSKKNYTMESAMCKMLASEAATFVTKEAIQIHGGYGFIVDYEVERMYRDAKITE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEEHHHHHCCCHHHH
IYEGTNEVQRVVVSKLLLS
HHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFELSQDHKVLKDSVRDFVVNEIKPLAMQIDEEHMIPDDLVRKMGEMGFLGSYLPEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHCCCCHHHHCCHHHC
GAGLDMLSYAIVVEEVSKACGSSGVLISAHTSLACGPIYTFGTEEQKKKWLPDLNTGKVI
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCEEECCCCHHHHHCCCCCCCCCEE
GCFLLTEPDAGSDAGAIATTYKRDGDHFVINGSKIFITNGGYKGTGVLFATSDKNLKHKG
EEEEEECCCCCCCCCCEEEEEECCCCEEEEECCEEEEECCCCCCCEEEEEECCCCCCCCC
VSAFIIDLQSPGVEILKNEKKLGIRGSYTTAFALDSVRIPVENLLGQEGQGFKIAMDTLN
CEEEEEEECCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEECCC
GGRIGIASQALGIAEGAFDLALAYSKERKQFGHPICELQAIQFKLADMYAKIETSKLMTY
CCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KAACLKDSKKNYTMESAMCKMLASEAATFVTKEAIQIHGGYGFIVDYEVERMYRDAKITE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEEHHHHHCCCHHHH
IYEGTNEVQRVVVSKLLLS
HHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]