Click here to switch to the map view.

The map label for this gene is ilvC [H]

Identifier: 197119131

GI number: 197119131

Start: 3187535

End: 3189007

Strand: Direct

Name: ilvC [H]

Synonym: Gbem_2758

Alternate gene names: 197119131

Gene position: 3187535-3189007 (Clockwise)

Preceding gene: 197119112

Following gene: 197119142

Centisome position: 69.07

GC content: 61.64

Gene sequence:

>1473_bases
ATGGGAGTGAACTATTTCAACACCCTGCCGCTGCGCCGCCAGCTCCAGGAACTGGGCACCTGCCGCTTCATGGACGCATC
CGAGTTCGCCAACGGCTGCGAGTACGTCAAAGGTAAGAAGATCGTCATCGTCGGCTGCGGCGCACAGGGGCTCAACCAGG
GTCTCAACATGCGCGACAGCGGGCTGGACGTCTCCTACACCCTGAGGAAAGAAGCGATAGAGCAGAAGCGTCAGTCCTAC
CTGAACGCCTCCGAGAACGGCTTCAAGGTAGGCTCCTACGAGGAACTGCTCCCCGGCGCCGACATCGTCATGAACCTCGC
CCCGGACAAGCAGCACAGCAACGTCGTCGATACCGTCATTCCCTTCATGAAGCAGGGCGCCGTGTTCAGCTACGCCCACG
GCTTCAACATCGTCGAAGAAGGGACTCAGATCCGCAAGGACTTAACCGTCGTCATGGTCGCCCCTAAATGCCCCGGCTCC
GAGGTGCGCGCCGAGTACAAGCGCGGCTTCGGCGTCCCGACCCTTATCGCCGTGCATGGCGAGAACGACCCCAACGGCGA
CGGCCTTGAGATCGCCAAAGCGCTTGCTTCCGCTCAGGGTGGCGACCGCGCCGGCGTGCTGGAGTCCTCTTTCGTGGCCG
AAGTCAAATCGGACCTGATGGGCGAGCAGACCATCCTCTGCGGTATGCTGCAGGCGGGCGCCCTTCTTTGCTTCGACAAG
ATGACGCAAAACGGCATCGCCGCACCCTACGCCGTCAAGCTGATCCAGTACGGCTGGGAGACCATCACCGAGGCGCTCAA
GCACGGCGGCATCACCAACATGATGGATCGCCTCTCCAACCCGGCGAAGCTCATCGCCTTCAAGCTGGCCGACGAGCTGA
AGGACATCATGCGCCCGCTGTTCCAGAAACACATGGACGACATCATGAGCGGCGAGTTCTCCCGCACCATGATGGAGGAC
TGGGCCAACGACGACGTGAAACTCCTCACCTGGCGCGAGCAGACCGGCCAGACCGCGTTCGAGAAGACCGAGGCAGCCGG
CGAGATCTCCGAGCAGGAGTACTTCGACAAGGCGATCCTGATGGTCGCCATGGTCAAGGCAGGCGTGGAACTCGCCTTCG
AGACCATGGTGCAGACCGGCATCGAGCCGGAGAGCGCCTACTACGAGTCTCTGCACGAGACCCCGCTCATCGCCAACACC
ATCGCCAGAAAGAAACTGTACGAGATGAACCGCGTCATTTCCGACACCGCCGAGTACGGCTGCTACCTGTTCTCCCACGC
CTGCGTACCCCTGCTCAAGGACTTCATGTCCAAGGTCGGCACCGACGTGATCGGCAAAGGGCTTGCGGCTAAGGACAACA
GCGTGGACAACCAGCTCTTGGTTGCGGTCAACGCCGAGATCCGCAGCCATCTGGTCGAGGAAGTCGGCGCCGAGCTGCGC
GCCGCCATGAAGGGCATGCAGAAGATCGTCTAG

Upstream 100 bases:

>100_bases
TGCACAATAATTCAATTTACGCAATGTGAAATATGGTATACAGTCGGCACACTTTCAGACTTGTAACCACACCACAACAT
AGATTCAGGAGGGAATACCG

Downstream 100 bases:

>100_bases
CCTGAAGCTGTAGTTCCAAAGAGGTAACAAAAAAGGCGCTTCCGTATAACCACGGAAGCGCCTTTTTCATTTGAGATGGC
GGGAGAGTCAGTCGGGGAAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MGVNYFNTLPLRRQLQELGTCRFMDASEFANGCEYVKGKKIVIVGCGAQGLNQGLNMRDSGLDVSYTLRKEAIEQKRQSY
LNASENGFKVGSYEELLPGADIVMNLAPDKQHSNVVDTVIPFMKQGAVFSYAHGFNIVEEGTQIRKDLTVVMVAPKCPGS
EVRAEYKRGFGVPTLIAVHGENDPNGDGLEIAKALASAQGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGALLCFDK
MTQNGIAAPYAVKLIQYGWETITEALKHGGITNMMDRLSNPAKLIAFKLADELKDIMRPLFQKHMDDIMSGEFSRTMMED
WANDDVKLLTWREQTGQTAFEKTEAAGEISEQEYFDKAILMVAMVKAGVELAFETMVQTGIEPESAYYESLHETPLIANT
IARKKLYEMNRVISDTAEYGCYLFSHACVPLLKDFMSKVGTDVIGKGLAAKDNSVDNQLLVAVNAEIRSHLVEEVGAELR
AAMKGMQKIV

Sequences:

>Translated_490_residues
MGVNYFNTLPLRRQLQELGTCRFMDASEFANGCEYVKGKKIVIVGCGAQGLNQGLNMRDSGLDVSYTLRKEAIEQKRQSY
LNASENGFKVGSYEELLPGADIVMNLAPDKQHSNVVDTVIPFMKQGAVFSYAHGFNIVEEGTQIRKDLTVVMVAPKCPGS
EVRAEYKRGFGVPTLIAVHGENDPNGDGLEIAKALASAQGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGALLCFDK
MTQNGIAAPYAVKLIQYGWETITEALKHGGITNMMDRLSNPAKLIAFKLADELKDIMRPLFQKHMDDIMSGEFSRTMMED
WANDDVKLLTWREQTGQTAFEKTEAAGEISEQEYFDKAILMVAMVKAGVELAFETMVQTGIEPESAYYESLHETPLIANT
IARKKLYEMNRVISDTAEYGCYLFSHACVPLLKDFMSKVGTDVIGKGLAAKDNSVDNQLLVAVNAEIRSHLVEEVGAELR
AAMKGMQKIV
>Mature_489_residues
GVNYFNTLPLRRQLQELGTCRFMDASEFANGCEYVKGKKIVIVGCGAQGLNQGLNMRDSGLDVSYTLRKEAIEQKRQSYL
NASENGFKVGSYEELLPGADIVMNLAPDKQHSNVVDTVIPFMKQGAVFSYAHGFNIVEEGTQIRKDLTVVMVAPKCPGSE
VRAEYKRGFGVPTLIAVHGENDPNGDGLEIAKALASAQGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGALLCFDKM
TQNGIAAPYAVKLIQYGWETITEALKHGGITNMMDRLSNPAKLIAFKLADELKDIMRPLFQKHMDDIMSGEFSRTMMEDW
ANDDVKLLTWREQTGQTAFEKTEAAGEISEQEYFDKAILMVAMVKAGVELAFETMVQTGIEPESAYYESLHETPLIANTI
ARKKLYEMNRVISDTAEYGCYLFSHACVPLLKDFMSKVGTDVIGKGLAAKDNSVDNQLLVAVNAEIRSHLVEEVGAELRA
AMKGMQKIV

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=487, Percent_Identity=72.6899383983573, Blast_Score=717, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=294, Percent_Identity=30.2721088435374, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 53872; Mature: 53740

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVNYFNTLPLRRQLQELGTCRFMDASEFANGCEYVKGKKIVIVGCGAQGLNQGLNMRDS
CCCCCCCCCHHHHHHHHHCCEECCCHHHHHCHHHHHCCCEEEEEECCCHHHHCCCCCCCC
GLDVSYTLRKEAIEQKRQSYLNASENGFKVGSYEELLPGADIVMNLAPDKQHSNVVDTVI
CCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEECCCCCCCCHHHHHHH
PFMKQGAVFSYAHGFNIVEEGTQIRKDLTVVMVAPKCPGSEVRAEYKRGFGVPTLIAVHG
HHHHCCCEEEHHCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEC
ENDPNGDGLEIAKALASAQGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGALLCFDK
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
MTQNGIAAPYAVKLIQYGWETITEALKHGGITNMMDRLSNPAKLIAFKLADELKDIMRPL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FQKHMDDIMSGEFSRTMMEDWANDDVKLLTWREQTGQTAFEKTEAAGEISEQEYFDKAIL
HHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHCCHHHHHHHHHCCHHHHHHHHHHHH
MVAMVKAGVELAFETMVQTGIEPESAYYESLHETPLIANTIARKKLYEMNRVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
CYLFSHACVPLLKDFMSKVGTDVIGKGLAAKDNSVDNQLLVAVNAEIRSHLVEEVGAELR
HHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
AAMKGMQKIV
HHHHHHHHCC
>Mature Secondary Structure 
GVNYFNTLPLRRQLQELGTCRFMDASEFANGCEYVKGKKIVIVGCGAQGLNQGLNMRDS
CCCCCCCCHHHHHHHHHCCEECCCHHHHHCHHHHHCCCEEEEEECCCHHHHCCCCCCCC
GLDVSYTLRKEAIEQKRQSYLNASENGFKVGSYEELLPGADIVMNLAPDKQHSNVVDTVI
CCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEECCCCCCCCHHHHHHH
PFMKQGAVFSYAHGFNIVEEGTQIRKDLTVVMVAPKCPGSEVRAEYKRGFGVPTLIAVHG
HHHHCCCEEEHHCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEC
ENDPNGDGLEIAKALASAQGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGALLCFDK
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
MTQNGIAAPYAVKLIQYGWETITEALKHGGITNMMDRLSNPAKLIAFKLADELKDIMRPL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FQKHMDDIMSGEFSRTMMEDWANDDVKLLTWREQTGQTAFEKTEAAGEISEQEYFDKAIL
HHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHCCHHHHHHHHHCCHHHHHHHHHHHH
MVAMVKAGVELAFETMVQTGIEPESAYYESLHETPLIANTIARKKLYEMNRVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
CYLFSHACVPLLKDFMSKVGTDVIGKGLAAKDNSVDNQLLVAVNAEIRSHLVEEVGAELR
HHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
AAMKGMQKIV
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA