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The map label for this gene is dnaK [H]

Identifier: 197118980

GI number: 197118980

Start: 3017534

End: 3018811

Strand: Direct

Name: dnaK [H]

Synonym: Gbem_2603

Alternate gene names: 197118980

Gene position: 3017534-3018811 (Clockwise)

Preceding gene: 197118979

Following gene: 308535307

Centisome position: 65.38

GC content: 57.12

Gene sequence:

>1278_bases
ATGCAGATAGTTTTTGGTATCGATTTTGGCACCACCAATTCCGCCCTCTCCATCTACCGCAATAACAAAGTCGAAGTCGT
GAACGTGGACGAACTGAACGCAGGCAGCGCACTGATGCGCTCGGTACTGTACTTCACCGAGGATCAGGAGATCTTCGCCG
GACAAGAGGCGATCAACACCTACATCAACGAAGGCGCGGCAGGCAGATTCATGCAGTCGATAAAGACCTTCCTTCCCAAC
AGCAGCTTTGAAAGCACCGAGGTCTTTGGCAGGAAGTACGGCATCGACGATCTGGTAGCGATCATCCTGAGGAAGATCAA
GAAAAGGGGCGAAGAGTACGTCGGCTGCAGCGTCGACACGGTAGTGCTGGGGCGGCCCGTGCTCTTTTCCGAGGACCCGG
CGAAAGACGCACTGGCCCAAAAGCGCCTGGAGCAGGCGGGCCGCAAGGCAGGCTTCAAGCAGATCTACTTCCAGTGGGAG
CCGGTGGCGGCCGCACTGGCTTACGAGGAATCGCTGGCCGCGGGCGAGGAAAAGCTCGTCTTCATCGGGGACTTCGGCGG
AGGCACCTCCGACTTCACCGTCATCAAGGTGCGCGGCGGCGACTTTGCCCGCTCCGACCGCCGCAGCGACGTCCTTTCGC
TGGGAGGCGTCTATACGGCCGGGGACAAGTTCGATTCTCAGATAATGTGGGAGCGGATAGCCAAGTACTTCGGCCGGGGT
GTCAGATACAAAGGAATGGGAAAGGACGAACTGTTCGACATACCACTCAGCATCATCTACACCCTGTGCCAGTGGCACAG
AATTCCGCTTTTGAGAGCAAGGAAAACCAGGGAACAGATCAGGCTGATCAAGCATGCAGCGACAGACAAGCAAGCCATAG
AGAACCTTGAGCACCTGATCGGCGACAACTACGGCTTCTTCCTGTTCCAGTCCATAGAGAAGGCAAAATGCGAGCTCTCA
GATCAAGAGCTGAGTCACGTCCGCTTCAGCGAGCGCGATCTCTGCATAGAGGAACCGGTAACCAGGCAGGCTTTCGAGGA
GATGAATGGCGAGAATCTCGCTAAAATCGCGGGCTGCGTAGACGAGGTAGTGAGAGAATCCGGCGTCCCGCACAGCCAAA
TCGACACCGTCTTTCTTACCGGCGGCACGTCGCGCATTCCGATGATACGCAGGCTGTTCGAGGAGCGTTTCGGCGCGGAG
AAGTTGGAGAACAAGAATGCCTTTACCAGTGTCGCCCACGGATTGGGGACCAGCGTCCCGCTCTTCGTGGCATCGTGA

Upstream 100 bases:

>100_bases
TCGGGACATTAGGAGAGGCCGCTTTCTGGTTCCCAAGCTGCAATTCGGGAGTCTCTGCTGCGCAGCCGCTACTTTCCACC
CATCAGGAGCAGTCACACCC

Downstream 100 bases:

>100_bases
CCGGGATGCCGCACTAAGCGCTATCGGATGCTGCGCGGCAGTACGCACCCGCCAGGTTCGCTCATCAACAGACCTCTCCC
CCGCCAACAACTTCAAGCCA

Product: chaperone

Products: NA

Alternate protein names: HSP70; Heat shock 70 kDa protein; Heat shock protein 70 [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MQIVFGIDFGTTNSALSIYRNNKVEVVNVDELNAGSALMRSVLYFTEDQEIFAGQEAINTYINEGAAGRFMQSIKTFLPN
SSFESTEVFGRKYGIDDLVAIILRKIKKRGEEYVGCSVDTVVLGRPVLFSEDPAKDALAQKRLEQAGRKAGFKQIYFQWE
PVAAALAYEESLAAGEEKLVFIGDFGGGTSDFTVIKVRGGDFARSDRRSDVLSLGGVYTAGDKFDSQIMWERIAKYFGRG
VRYKGMGKDELFDIPLSIIYTLCQWHRIPLLRARKTREQIRLIKHAATDKQAIENLEHLIGDNYGFFLFQSIEKAKCELS
DQELSHVRFSERDLCIEEPVTRQAFEEMNGENLAKIAGCVDEVVRESGVPHSQIDTVFLTGGTSRIPMIRRLFEERFGAE
KLENKNAFTSVAHGLGTSVPLFVAS

Sequences:

>Translated_425_residues
MQIVFGIDFGTTNSALSIYRNNKVEVVNVDELNAGSALMRSVLYFTEDQEIFAGQEAINTYINEGAAGRFMQSIKTFLPN
SSFESTEVFGRKYGIDDLVAIILRKIKKRGEEYVGCSVDTVVLGRPVLFSEDPAKDALAQKRLEQAGRKAGFKQIYFQWE
PVAAALAYEESLAAGEEKLVFIGDFGGGTSDFTVIKVRGGDFARSDRRSDVLSLGGVYTAGDKFDSQIMWERIAKYFGRG
VRYKGMGKDELFDIPLSIIYTLCQWHRIPLLRARKTREQIRLIKHAATDKQAIENLEHLIGDNYGFFLFQSIEKAKCELS
DQELSHVRFSERDLCIEEPVTRQAFEEMNGENLAKIAGCVDEVVRESGVPHSQIDTVFLTGGTSRIPMIRRLFEERFGAE
KLENKNAFTSVAHGLGTSVPLFVAS
>Mature_425_residues
MQIVFGIDFGTTNSALSIYRNNKVEVVNVDELNAGSALMRSVLYFTEDQEIFAGQEAINTYINEGAAGRFMQSIKTFLPN
SSFESTEVFGRKYGIDDLVAIILRKIKKRGEEYVGCSVDTVVLGRPVLFSEDPAKDALAQKRLEQAGRKAGFKQIYFQWE
PVAAALAYEESLAAGEEKLVFIGDFGGGTSDFTVIKVRGGDFARSDRRSDVLSLGGVYTAGDKFDSQIMWERIAKYFGRG
VRYKGMGKDELFDIPLSIIYTLCQWHRIPLLRARKTREQIRLIKHAATDKQAIENLEHLIGDNYGFFLFQSIEKAKCELS
DQELSHVRFSERDLCIEEPVTRQAFEEMNGENLAKIAGCVDEVVRESGVPHSQIDTVFLTGGTSRIPMIRRLFEERFGAE
KLENKNAFTSVAHGLGTSVPLFVAS

Specific function: Acts as a chaperone [H]

COG id: COG0443

COG function: function code O; Molecular chaperone

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 70 family [H]

Homologues:

Organism=Homo sapiens, GI16507237, Length=442, Percent_Identity=26.4705882352941, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI24234688, Length=438, Percent_Identity=24.4292237442922, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI48928056, Length=469, Percent_Identity=23.8805970149254, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87082035, Length=460, Percent_Identity=23.4782608695652, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786196, Length=437, Percent_Identity=25.1716247139588, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786870, Length=197, Percent_Identity=26.3959390862944, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788875, Length=275, Percent_Identity=26.9090909090909, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534771, Length=445, Percent_Identity=26.2921348314607, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562024, Length=438, Percent_Identity=24.2009132420091, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17568549, Length=442, Percent_Identity=26.0180995475113, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17541098, Length=435, Percent_Identity=22.0689655172414, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322426, Length=437, Percent_Identity=23.3409610983982, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320805, Length=433, Percent_Identity=25.4041570438799, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323004, Length=439, Percent_Identity=22.5512528473804, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319314, Length=439, Percent_Identity=22.5512528473804, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322505, Length=438, Percent_Identity=23.5159817351598, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319972, Length=440, Percent_Identity=23.6363636363636, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324120, Length=440, Percent_Identity=23.6363636363636, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321855, Length=431, Percent_Identity=25.5220417633411, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24653595, Length=438, Percent_Identity=25.1141552511416, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24647034, Length=437, Percent_Identity=23.1121281464531, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24647038, Length=437, Percent_Identity=23.1121281464531, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24647036, Length=437, Percent_Identity=23.1121281464531, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737967, Length=437, Percent_Identity=23.1121281464531, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28571721, Length=437, Percent_Identity=23.1121281464531, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28571719, Length=437, Percent_Identity=23.1121281464531, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641406, Length=251, Percent_Identity=27.8884462151394, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641408, Length=251, Percent_Identity=27.8884462151394, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641402, Length=251, Percent_Identity=27.8884462151394, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641404, Length=251, Percent_Identity=27.8884462151394, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012725
- InterPro:   IPR018181
- InterPro:   IPR001023
- InterPro:   IPR013126 [H]

Pfam domain/function: PF00012 HSP70 [H]

EC number: NA

Molecular weight: Translated: 47578; Mature: 47578

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01036 HSP70_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIVFGIDFGTTNSALSIYRNNKVEVVNVDELNAGSALMRSVLYFTEDQEIFAGQEAINT
CEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
YINEGAAGRFMQSIKTFLPNSSFESTEVFGRKYGIDDLVAIILRKIKKRGEEYVGCSVDT
HHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCCCCCE
VVLGRPVLFSEDPAKDALAQKRLEQAGRKAGFKQIYFQWEPVAAALAYEESLAAGEEKLV
EEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCEEE
FIGDFGGGTSDFTVIKVRGGDFARSDRRSDVLSLGGVYTAGDKFDSQIMWERIAKYFGRG
EEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCC
VRYKGMGKDELFDIPLSIIYTLCQWHRIPLLRARKTREQIRLIKHAATDKQAIENLEHLI
CEECCCCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GDNYGFFLFQSIEKAKCELSDQELSHVRFSERDLCIEEPVTRQAFEEMNGENLAKIAGCV
CCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
DEVVRESGVPHSQIDTVFLTGGTSRIPMIRRLFEERFGAEKLENKNAFTSVAHGLGTSVP
HHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCCCCC
LFVAS
EEEEC
>Mature Secondary Structure
MQIVFGIDFGTTNSALSIYRNNKVEVVNVDELNAGSALMRSVLYFTEDQEIFAGQEAINT
CEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
YINEGAAGRFMQSIKTFLPNSSFESTEVFGRKYGIDDLVAIILRKIKKRGEEYVGCSVDT
HHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCCCCCE
VVLGRPVLFSEDPAKDALAQKRLEQAGRKAGFKQIYFQWEPVAAALAYEESLAAGEEKLV
EEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCEEE
FIGDFGGGTSDFTVIKVRGGDFARSDRRSDVLSLGGVYTAGDKFDSQIMWERIAKYFGRG
EEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCC
VRYKGMGKDELFDIPLSIIYTLCQWHRIPLLRARKTREQIRLIKHAATDKQAIENLEHLI
CEECCCCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GDNYGFFLFQSIEKAKCELSDQELSHVRFSERDLCIEEPVTRQAFEEMNGENLAKIAGCV
CCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
DEVVRESGVPHSQIDTVFLTGGTSRIPMIRRLFEERFGAEKLENKNAFTSVAHGLGTSVP
HHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCCCCC
LFVAS
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA