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The map label for this gene is aroE

Identifier: 197118973

GI number: 197118973

Start: 3007180

End: 3008052

Strand: Reverse

Name: aroE

Synonym: Gbem_2596

Alternate gene names: 197118973

Gene position: 3008052-3007180 (Counterclockwise)

Preceding gene: 197118974

Following gene: 197118972

Centisome position: 65.18

GC content: 67.35

Gene sequence:

>873_bases
ATGACTATTACAGGAAAGACCAAGGTCGCCGGGATCATCGGCTGGCCGGTCTCCCATTCCCTTTCGCCGCCGATGCATAA
TGCCGCCTTCGAGGCTCTCGGGCTCGACTTTACTTACGTCCCGTTCCCCGTTGCGCCGGAGCGCCTTGCCGCAGGGATAG
CCGGCCTCGCCGCCCTGGGTGTGGTCGGCTTCAGCGTCACCATCCCGCACAAGGTGGCGATCTTGCCCCTTTTGGACCGG
GTCACGCCGGAGGCCGAATTGATCGGCGCGGTGAACACGGTCGCAGTAGAGGAAGGAGCCCTCACCGGCTACAACACGGA
CGGGATCGGGCTTTTGTCCGCGCTCCGCTCGAAGCTAGGCTTCCACCCCGAGGGGCGCTCGGTGCTGGTGCTAGGAGCCG
GCGGTGCTGCCAGAAGCGCCGTTGCCTCGCTGGGACTTGCCGGCGCCGGCAGGGTCGAGGTGGCGAACCGCTCCCCGGAC
GCAGGGCGCTGCCTGGCAGAGGCGATGCGGGAGCGCCTCGCCGGGACCGATTTCGGGTTTCAGCCGCTGGGCCAAATATC
CGATAAGGGATACATGTCCAGCTTCGACCTCGTGGTCAACACCACCTCGGTGGGGATGGCGGGGGATGCCTTCGCCGGGC
TCGATCTGGCCGCGCTGAAGCCCGGCGCCTGCGTCTACGACATGGTGTATGCGCCTCCGGTAACCCCGTTGCTGGCTCAG
GCGGAGGCTGCCGGTGTGCCGTGGGCGAACGGGCTGGGGATGCTGGCCGCGCAGGGGGAGGCGGCATTCCGGATCTGGAC
CGGGGCCATCCCTCCGGAGGGGTGCATGGAAAAGGCGCTAGCCGCCCGGCTCACAACCCCAGGTAACCCTTGA

Upstream 100 bases:

>100_bases
GCAAAGACGAGGGGGTGCGGGCGCTGGATCTGGCTGGGCGGATCACGCCCCAGGCGGGGCAGCAGGCGCTGCAGATTCTC
AGAACCTACGGGGTGCGCTG

Downstream 100 bases:

>100_bases
CATTACTGTCATTACAAAATACCATTCACAGGTTCTTTAACCCCCTGAGGTACCTATGCACGTAAGCAGACTGGGTGAGC
TGCTGGTCAGCAACAGCCTC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTITGKTKVAGIIGWPVSHSLSPPMHNAAFEALGLDFTYVPFPVAPERLAAGIAGLAALGVVGFSVTIPHKVAILPLLDR
VTPEAELIGAVNTVAVEEGALTGYNTDGIGLLSALRSKLGFHPEGRSVLVLGAGGAARSAVASLGLAGAGRVEVANRSPD
AGRCLAEAMRERLAGTDFGFQPLGQISDKGYMSSFDLVVNTTSVGMAGDAFAGLDLAALKPGACVYDMVYAPPVTPLLAQ
AEAAGVPWANGLGMLAAQGEAAFRIWTGAIPPEGCMEKALAARLTTPGNP

Sequences:

>Translated_290_residues
MTITGKTKVAGIIGWPVSHSLSPPMHNAAFEALGLDFTYVPFPVAPERLAAGIAGLAALGVVGFSVTIPHKVAILPLLDR
VTPEAELIGAVNTVAVEEGALTGYNTDGIGLLSALRSKLGFHPEGRSVLVLGAGGAARSAVASLGLAGAGRVEVANRSPD
AGRCLAEAMRERLAGTDFGFQPLGQISDKGYMSSFDLVVNTTSVGMAGDAFAGLDLAALKPGACVYDMVYAPPVTPLLAQ
AEAAGVPWANGLGMLAAQGEAAFRIWTGAIPPEGCMEKALAARLTTPGNP
>Mature_289_residues
TITGKTKVAGIIGWPVSHSLSPPMHNAAFEALGLDFTYVPFPVAPERLAAGIAGLAALGVVGFSVTIPHKVAILPLLDRV
TPEAELIGAVNTVAVEEGALTGYNTDGIGLLSALRSKLGFHPEGRSVLVLGAGGAARSAVASLGLAGAGRVEVANRSPDA
GRCLAEAMRERLAGTDFGFQPLGQISDKGYMSSFDLVVNTTSVGMAGDAFAGLDLAALKPGACVYDMVYAPPVTPLLAQA
EAAGVPWANGLGMLAAQGEAAFRIWTGAIPPEGCMEKALAARLTTPGNP

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=278, Percent_Identity=36.6906474820144, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789675, Length=276, Percent_Identity=34.4202898550725, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320332, Length=272, Percent_Identity=27.9411764705882, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_GEOBB (B5EH68)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002139400.1
- ProteinModelPortal:   B5EH68
- GeneID:   6782593
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_2596
- HOGENOM:   HBG553408
- OMA:   RVEVANR
- ProtClustDB:   CLSK828389
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29457; Mature: 29326

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITGKTKVAGIIGWPVSHSLSPPMHNAAFEALGLDFTYVPFPVAPERLAAGIAGLAALG
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
VVGFSVTIPHKVAILPLLDRVTPEAELIGAVNTVAVEEGALTGYNTDGIGLLSALRSKLG
HHHEEEECCCCEEEHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHC
FHPEGRSVLVLGAGGAARSAVASLGLAGAGRVEVANRSPDAGRCLAEAMRERLAGTDFGF
CCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
QPLGQISDKGYMSSFDLVVNTTSVGMAGDAFAGLDLAALKPGACVYDMVYAPPVTPLLAQ
CCCHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCCHHHHH
AEAAGVPWANGLGMLAAQGEAAFRIWTGAIPPEGCMEKALAARLTTPGNP
HHHCCCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TITGKTKVAGIIGWPVSHSLSPPMHNAAFEALGLDFTYVPFPVAPERLAAGIAGLAALG
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
VVGFSVTIPHKVAILPLLDRVTPEAELIGAVNTVAVEEGALTGYNTDGIGLLSALRSKLG
HHHEEEECCCCEEEHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHC
FHPEGRSVLVLGAGGAARSAVASLGLAGAGRVEVANRSPDAGRCLAEAMRERLAGTDFGF
CCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
QPLGQISDKGYMSSFDLVVNTTSVGMAGDAFAGLDLAALKPGACVYDMVYAPPVTPLLAQ
CCCHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCCHHHHH
AEAAGVPWANGLGMLAAQGEAAFRIWTGAIPPEGCMEKALAARLTTPGNP
HHHCCCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA