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The map label for this gene is purC

Identifier: 197118888

GI number: 197118888

Start: 2911843

End: 2912733

Strand: Direct

Name: purC

Synonym: Gbem_2511

Alternate gene names: 197118888

Gene position: 2911843-2912733 (Clockwise)

Preceding gene: 197118887

Following gene: 197118889

Centisome position: 63.09

GC content: 60.72

Gene sequence:

>891_bases
ATGACTACACCGGTACTCAACACTGATTTCCCCGGTCTGAAGCTCGCCGCCCGCGGCAAGGTGCGCGACATCTACGACCT
GGGAGAGACGCTGCTCATCGTCACCACCGACAGGATCTCTGCTTTCGACGTGATCATGAACGAGGGCATCCCGCACAAGG
GGTACGTGCTGACCCAGATCTCCGCCTACTGGTTCCGTCAAATGGAAGACATCATCAAGAACCACATCATCTCCACCGAT
GTCACCGACTTCCCGAAAGAGTGCCAGCCGTACGCCGACGTCCTGGCCGGGCGCTCCATGTGGGTGAAAAAGGCTAAGCC
TTTGGCGGCCGAGTGCATCGTGCGCGGCTACATCTCCGGCTCCGGCTGGAAGGACTACCAAAAGACCGGCGCCATCTGCG
GCATCAAGCTTCCGGAAGGGCTCAAGGAATCCGACCGCCTCCCCCAGCCGATCTTCACCCCTTCCACTAAGGCGGAGCTG
GGAACCCACGACGAGAACATCTCTTTCGAGGAGATGTGCCGGATCTGCGGCACCGAGATCTCCACCAAGGTGCGCGACGT
AACCCTCGCCATCTACGAGAAGGCCCGCGACTTGGCCGACCAGAAAGGGATCATCATCGCCGACACCAAGTTCGAGTACG
GCATCTACGACGGCGAGCTGATCATCATCGACGAGTGCATGACACCTGACTCCAGCCGTTTCTGGCCCAAGGAGAGCTAC
AAGCCGGGCGGCCCGCAGCCCTCCTTCGACAAGCAGTTCCTGCGTGACTACCTGGAGACGCTCGACTGGGGCAAGACGGC
GCCGGCGCCGCCGCTTCCCGAAGAGATCGTCAGGAAGACCGGCGAGAAGTACATGGAAGCGCTGGTGAAGCTGACCGGCA
AAGGGATCTAG

Upstream 100 bases:

>100_bases
AAATCGACAGCTATTCAAGTGCGAGGTGGAGGGTGCAGGTGCACGCTTCACCTTTCACTTTTAACGCTTGAAGCGCGAAC
CATAAAAGGAGAATGGACAA

Downstream 100 bases:

>100_bases
GGATCGAACCGATGCCCCGCCTCCTCACCGGGGGCGGGGCTTTTTTTGTGCCGGCAAAGGAAAAAGACGATGCTGAAGCA
GACCTTGACCCTGCTGTTTC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTTPVLNTDFPGLKLAARGKVRDIYDLGETLLIVTTDRISAFDVIMNEGIPHKGYVLTQISAYWFRQMEDIIKNHIISTD
VTDFPKECQPYADVLAGRSMWVKKAKPLAAECIVRGYISGSGWKDYQKTGAICGIKLPEGLKESDRLPQPIFTPSTKAEL
GTHDENISFEEMCRICGTEISTKVRDVTLAIYEKARDLADQKGIIIADTKFEYGIYDGELIIIDECMTPDSSRFWPKESY
KPGGPQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVKLTGKGI

Sequences:

>Translated_296_residues
MTTPVLNTDFPGLKLAARGKVRDIYDLGETLLIVTTDRISAFDVIMNEGIPHKGYVLTQISAYWFRQMEDIIKNHIISTD
VTDFPKECQPYADVLAGRSMWVKKAKPLAAECIVRGYISGSGWKDYQKTGAICGIKLPEGLKESDRLPQPIFTPSTKAEL
GTHDENISFEEMCRICGTEISTKVRDVTLAIYEKARDLADQKGIIIADTKFEYGIYDGELIIIDECMTPDSSRFWPKESY
KPGGPQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVKLTGKGI
>Mature_295_residues
TTPVLNTDFPGLKLAARGKVRDIYDLGETLLIVTTDRISAFDVIMNEGIPHKGYVLTQISAYWFRQMEDIIKNHIISTDV
TDFPKECQPYADVLAGRSMWVKKAKPLAAECIVRGYISGSGWKDYQKTGAICGIKLPEGLKESDRLPQPIFTPSTKAELG
THDENISFEEMCRICGTEISTKVRDVTLAIYEKARDLADQKGIIIADTKFEYGIYDGELIIIDECMTPDSSRFWPKESYK
PGGPQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVKLTGKGI

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=25.9911894273128, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319326, Length=300, Percent_Identity=49, Blast_Score=273, Evalue=3e-74,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_GEOBB (B5EGN6)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002139315.1
- GeneID:   6782508
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_2511
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33244; Mature: 33112

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPVLNTDFPGLKLAARGKVRDIYDLGETLLIVTTDRISAFDVIMNEGIPHKGYVLTQI
CCCCCCCCCCCCCEEECCCCHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCCCEEHHHH
SAYWFRQMEDIIKNHIISTDVTDFPKECQPYADVLAGRSMWVKKAKPLAAECIVRGYISG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCC
SGWKDYQKTGAICGIKLPEGLKESDRLPQPIFTPSTKAELGTHDENISFEEMCRICGTEI
CCCCHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHH
STKVRDVTLAIYEKARDLADQKGIIIADTKFEYGIYDGELIIIDECMTPDSSRFWPKESY
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCEECCEECCCEEEEECCCCCCCCCCCCCCCC
KPGGPQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVKLTGKGI
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTPVLNTDFPGLKLAARGKVRDIYDLGETLLIVTTDRISAFDVIMNEGIPHKGYVLTQI
CCCCCCCCCCCCEEECCCCHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCCCEEHHHH
SAYWFRQMEDIIKNHIISTDVTDFPKECQPYADVLAGRSMWVKKAKPLAAECIVRGYISG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCC
SGWKDYQKTGAICGIKLPEGLKESDRLPQPIFTPSTKAELGTHDENISFEEMCRICGTEI
CCCCHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHH
STKVRDVTLAIYEKARDLADQKGIIIADTKFEYGIYDGELIIIDECMTPDSSRFWPKESY
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCEECCEECCCEEEEECCCCCCCCCCCCCCCC
KPGGPQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVKLTGKGI
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA