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The map label for this gene is gapA [H]

Identifier: 197118717

GI number: 197118717

Start: 2712073

End: 2713068

Strand: Direct

Name: gapA [H]

Synonym: Gbem_2336

Alternate gene names: 197118717

Gene position: 2712073-2713068 (Clockwise)

Preceding gene: 197118706

Following gene: 197118718

Centisome position: 58.76

GC content: 58.23

Gene sequence:

>996_bases
ATGGCTTTAAGAGTGGCTATTAACGGTTTCGGCAGAATCGGACGTTGCGTACTTAGGGCAGCTGCACTGGAGCAGGGTTT
TGAGTTCGTCGCCATCAATGACCTTACTGATGCGAAGACCTTGGCACACCTGTTAAAGTATGATTCGGTTCATGGAACTT
TCCCCGGTGAAGTATCGGTGGACGGCGACAAAATTATCGTCAACGGCAAGGCGATCAAGGTACTCGCGGTAAGAAACCCC
GCAGAACTCCCTTGGAAGGAGATGAAGGTCGACATCGTGCTCGAATCGACCGGCCTCTTCACCGCCCGGGACAAGGCGGC
GCAGCACCTGACCGCAGGCGCGAAAAAGGTTGTCATCTCGGCCCCCGCCACCGACCCGGACCTTACCATAGTCTTGGGTG
TCAACGACAAGGAATATGACAAGAACAAGCACCACATCGTCTCCAACGCATCCTGCACCACCAACTGCCTCGCCCCGGTC
GCCAAGGTTCTGCAGGAGAGCTTCGGCATCGAAAAAGGGCTTGTCACCACGGTCCATTCCTACACCAACGACCAGAACAT
CCTCGATCTTCCGCACAAGGACCTGCGCCGCGCCAGGGCAGCCGCCCTTTCCATGATCCCCACCACCACCGGCGCCGCCA
AGGCGGTAGCGCTGGTGCTTCCGGCCCTTAAGGGGAAACTGGACGGTATGGCCATCCGGGTGCCGACACCGAACGTCTCG
GTGGTCGACCTGGTGGCTACCCTCTCCAAGGAGACCGACGCGCAGCAGGTGAACGCGGCCCTGAAGGCTGCGGCCGACGG
TCCTCTCAAGGGAATCCTCGGTTTTTGCGAAGAGCAGCTGGTCTCCATCGATTTCAACGGCAACAAGCTCTCCTCGATCG
TCGACGCCCCCTCCACCAAGGTGATCGGCGGCAACATGGTGAAGGTGATCTCCTGGTACGACAACGAAATGGGCTTCTCC
ACCAGGGTAGTCGGACTGATGAAGATACTCCTTTAG

Upstream 100 bases:

>100_bases
CGATAGCGTGAATATCTTGAATTAAAATTGTTGACGCCCCTCTCTCACGTTGTTAATATCGCCAATTGTGAAGGATTACT
TAATTAACAGGAGGAGCGCA

Downstream 100 bases:

>100_bases
GAAAAGGTGGTACTTGGAAGGGTAGATGTGATAAGTAGACGGGGGGGAGGCTGCTCCTCCCCGTATTTATTTTTATTGAT
TCAGGAGGTGTCATGTCAAT

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MALRVAINGFGRIGRCVLRAAALEQGFEFVAINDLTDAKTLAHLLKYDSVHGTFPGEVSVDGDKIIVNGKAIKVLAVRNP
AELPWKEMKVDIVLESTGLFTARDKAAQHLTAGAKKVVISAPATDPDLTIVLGVNDKEYDKNKHHIVSNASCTTNCLAPV
AKVLQESFGIEKGLVTTVHSYTNDQNILDLPHKDLRRARAAALSMIPTTTGAAKAVALVLPALKGKLDGMAIRVPTPNVS
VVDLVATLSKETDAQQVNAALKAAADGPLKGILGFCEEQLVSIDFNGNKLSSIVDAPSTKVIGGNMVKVISWYDNEMGFS
TRVVGLMKILL

Sequences:

>Translated_331_residues
MALRVAINGFGRIGRCVLRAAALEQGFEFVAINDLTDAKTLAHLLKYDSVHGTFPGEVSVDGDKIIVNGKAIKVLAVRNP
AELPWKEMKVDIVLESTGLFTARDKAAQHLTAGAKKVVISAPATDPDLTIVLGVNDKEYDKNKHHIVSNASCTTNCLAPV
AKVLQESFGIEKGLVTTVHSYTNDQNILDLPHKDLRRARAAALSMIPTTTGAAKAVALVLPALKGKLDGMAIRVPTPNVS
VVDLVATLSKETDAQQVNAALKAAADGPLKGILGFCEEQLVSIDFNGNKLSSIVDAPSTKVIGGNMVKVISWYDNEMGFS
TRVVGLMKILL
>Mature_330_residues
ALRVAINGFGRIGRCVLRAAALEQGFEFVAINDLTDAKTLAHLLKYDSVHGTFPGEVSVDGDKIIVNGKAIKVLAVRNPA
ELPWKEMKVDIVLESTGLFTARDKAAQHLTAGAKKVVISAPATDPDLTIVLGVNDKEYDKNKHHIVSNASCTTNCLAPVA
KVLQESFGIEKGLVTTVHSYTNDQNILDLPHKDLRRARAAALSMIPTTTGAAKAVALVLPALKGKLDGMAIRVPTPNVSV
VDLVATLSKETDAQQVNAALKAAADGPLKGILGFCEEQLVSIDFNGNKLSSIVDAPSTKVIGGNMVKVISWYDNEMGFST
RVVGLMKILL

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=331, Percent_Identity=49.2447129909366, Blast_Score=324, Evalue=6e-89,
Organism=Homo sapiens, GI7669492, Length=327, Percent_Identity=49.5412844036697, Blast_Score=317, Evalue=1e-86,
Organism=Escherichia coli, GI1788079, Length=328, Percent_Identity=54.2682926829268, Blast_Score=351, Evalue=3e-98,
Organism=Escherichia coli, GI1789295, Length=329, Percent_Identity=47.112462006079, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17534677, Length=330, Percent_Identity=52.4242424242424, Blast_Score=330, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17534679, Length=330, Percent_Identity=51.8181818181818, Blast_Score=328, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI32566163, Length=333, Percent_Identity=51.3513513513513, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17568413, Length=333, Percent_Identity=51.3513513513513, Blast_Score=322, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6322468, Length=328, Percent_Identity=53.0487804878049, Blast_Score=336, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6321631, Length=328, Percent_Identity=53.6585365853659, Blast_Score=335, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6322409, Length=330, Percent_Identity=52.4242424242424, Blast_Score=335, Evalue=6e-93,
Organism=Drosophila melanogaster, GI17933600, Length=329, Percent_Identity=50.7598784194529, Blast_Score=320, Evalue=6e-88,
Organism=Drosophila melanogaster, GI18110149, Length=329, Percent_Identity=50.7598784194529, Blast_Score=320, Evalue=6e-88,
Organism=Drosophila melanogaster, GI85725000, Length=329, Percent_Identity=50.4559270516717, Blast_Score=317, Evalue=6e-87,
Organism=Drosophila melanogaster, GI22023983, Length=329, Percent_Identity=50.4559270516717, Blast_Score=317, Evalue=6e-87,
Organism=Drosophila melanogaster, GI19922412, Length=325, Percent_Identity=49.2307692307692, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 35228; Mature: 35097

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRVAINGFGRIGRCVLRAAALEQGFEFVAINDLTDAKTLAHLLKYDSVHGTFPGEVSV
CEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEE
DGDKIIVNGKAIKVLAVRNPAELPWKEMKVDIVLESTGLFTARDKAAQHLTAGAKKVVIS
CCCEEEECCCEEEEEEECCCCCCCHHHEEEEEEEECCCCEEEHHHHHHHHHCCCCEEEEE
APATDPDLTIVLGVNDKEYDKNKHHIVSNASCTTNCLAPVAKVLQESFGIEKGLVTTVHS
CCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHEEHH
YTNDQNILDLPHKDLRRARAAALSMIPTTTGAAKAVALVLPALKGKLDGMAIRVPTPNVS
CCCCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCH
VVDLVATLSKETDAQQVNAALKAAADGPLKGILGFCEEQLVSIDFNGNKLSSIVDAPSTK
HHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCE
VIGGNMVKVISWYDNEMGFSTRVVGLMKILL
EECCCEEEEEEEECCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
ALRVAINGFGRIGRCVLRAAALEQGFEFVAINDLTDAKTLAHLLKYDSVHGTFPGEVSV
EEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEE
DGDKIIVNGKAIKVLAVRNPAELPWKEMKVDIVLESTGLFTARDKAAQHLTAGAKKVVIS
CCCEEEECCCEEEEEEECCCCCCCHHHEEEEEEEECCCCEEEHHHHHHHHHCCCCEEEEE
APATDPDLTIVLGVNDKEYDKNKHHIVSNASCTTNCLAPVAKVLQESFGIEKGLVTTVHS
CCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHEEHH
YTNDQNILDLPHKDLRRARAAALSMIPTTTGAAKAVALVLPALKGKLDGMAIRVPTPNVS
CCCCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCH
VVDLVATLSKETDAQQVNAALKAAADGPLKGILGFCEEQLVSIDFNGNKLSSIVDAPSTK
HHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCE
VIGGNMVKVISWYDNEMGFSTRVVGLMKILL
EECCCEEEEEEEECCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2684782; 2227448; 2656407; 7408868; 193030; 3586018; 9175858 [H]