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The map label for this gene is garR [H]

Identifier: 197118689

GI number: 197118689

Start: 2682029

End: 2682886

Strand: Reverse

Name: garR [H]

Synonym: Gbem_2308

Alternate gene names: 197118689

Gene position: 2682886-2682029 (Counterclockwise)

Preceding gene: 197118690

Following gene: 197118688

Centisome position: 58.13

GC content: 60.26

Gene sequence:

>858_bases
ATGCTGAAGAAAATCGGTTTTGTAGGTCTGGGTACCGTGGGTGTCCACATGGCCGCCAACCTGGCCAAGTCGGACTACCA
GTTAACGGTGTTTGATCAGGATGCCAAGGCGGTTGCGGAACTGGCGACCTTGGGCGTCAAGGTCGGCGAGTCGCCCATGG
CGACCGCAAAAGGGCAGGACCTCGTCATCGTCATCGTGCCTGATAGCGACTTCCTAGTCTTCGGCCAAGATGGCGTTTTT
GAAGGTATAGACCCCGGTACTATCCTCGTCGACATGGGAACGCACTGCATCGAGACCATCCAGCGCATGGCCCAGGAGGC
CGTGAAGCACCGCGTCATGTTCCTTGAGGCTCCGGTATGGGGAAGCAAGGAGCACGCGGCCAACGGTCTGCTGACCATTC
TCGCCGGCGGGGACGAGGCGCTTCTGGGCCGCTGCCGCGAGCCGTTCTCCTATTTCGGTCTCAACATCATCCACATCGGC
AAAGTCGGCGACGCCACCAGGATGAAGCTGATCGTCAACCTGCTGCAGGCCGAGATGATGCAGTCCCTTTCCGAAGGTCT
CGTGTTCGGCGAGAAGATGGGATTCAAACCGGACAAGATCCTCGAGGTGCTGGACTCCGGCGGTGTCGCCTCTCCGCTGT
TCCACTCCAAGGGGCGCTCCATCGCCCGCGGCGATTTCAGCCGTAACCTGGCGCTCAAGTACGTTCACCTCCAGATGCTG
AGGGTGCTCGAGACGGCCGAGAAACTTGGCCTGGAGCTTCCTGCCGCCAAGACCGTCTCCGGCATTTTCGCCCAGGCGGT
GGCCGACGGCAGGGGAGAAGAGGATTTCTCCGCCATCGTGAAACTGCTGAGGAAATAG

Upstream 100 bases:

>100_bases
ATGAGTCCTTGAGTTTTTTAAGCCACATTCTCACCGCCAGTTAGACGCGGTGGAAAATGTTATCCGCTGATGACACGCAT
CAGCTACTTTCGGGGGTATT

Downstream 100 bases:

>100_bases
CAGGCGGCTCTTCAATCAGAATATCAAAAAGGGGCATCCCATCACGGGGTGCCCTTTTTTTTTAGACTCTATTGGCGATG
CGTGTTGGTTTCACACCTAT

Product: 3-hydroxyisobutyrate dehydrogenase family protein

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLKKIGFVGLGTVGVHMAANLAKSDYQLTVFDQDAKAVAELATLGVKVGESPMATAKGQDLVIVIVPDSDFLVFGQDGVF
EGIDPGTILVDMGTHCIETIQRMAQEAVKHRVMFLEAPVWGSKEHAANGLLTILAGGDEALLGRCREPFSYFGLNIIHIG
KVGDATRMKLIVNLLQAEMMQSLSEGLVFGEKMGFKPDKILEVLDSGGVASPLFHSKGRSIARGDFSRNLALKYVHLQML
RVLETAEKLGLELPAAKTVSGIFAQAVADGRGEEDFSAIVKLLRK

Sequences:

>Translated_285_residues
MLKKIGFVGLGTVGVHMAANLAKSDYQLTVFDQDAKAVAELATLGVKVGESPMATAKGQDLVIVIVPDSDFLVFGQDGVF
EGIDPGTILVDMGTHCIETIQRMAQEAVKHRVMFLEAPVWGSKEHAANGLLTILAGGDEALLGRCREPFSYFGLNIIHIG
KVGDATRMKLIVNLLQAEMMQSLSEGLVFGEKMGFKPDKILEVLDSGGVASPLFHSKGRSIARGDFSRNLALKYVHLQML
RVLETAEKLGLELPAAKTVSGIFAQAVADGRGEEDFSAIVKLLRK
>Mature_285_residues
MLKKIGFVGLGTVGVHMAANLAKSDYQLTVFDQDAKAVAELATLGVKVGESPMATAKGQDLVIVIVPDSDFLVFGQDGVF
EGIDPGTILVDMGTHCIETIQRMAQEAVKHRVMFLEAPVWGSKEHAANGLLTILAGGDEALLGRCREPFSYFGLNIIHIG
KVGDATRMKLIVNLLQAEMMQSLSEGLVFGEKMGFKPDKILEVLDSGGVASPLFHSKGRSIARGDFSRNLALKYVHLQML
RVLETAEKLGLELPAAKTVSGIFAQAVADGRGEEDFSAIVKLLRK

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=31.9148936170213, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=27.3648648648649, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI145693186, Length=286, Percent_Identity=28.3216783216783, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=30.0353356890459, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=29.5138888888889, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=25.9649122807018, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557316, Length=228, Percent_Identity=31.140350877193, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=27.0462633451957, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=25.4295532646048, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=25.4295532646048, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30637; Mature: 30637

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKIGFVGLGTVGVHMAANLAKSDYQLTVFDQDAKAVAELATLGVKVGESPMATAKGQD
CCCCCCEEEECHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCC
LVIVIVPDSDFLVFGQDGVFEGIDPGTILVDMGTHCIETIQRMAQEAVKHRVMFLEAPVW
EEEEEECCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEECCCC
GSKEHAANGLLTILAGGDEALLGRCREPFSYFGLNIIHIGKVGDATRMKLIVNLLQAEMM
CCHHHHCCCEEEEEECCCHHHHHHHCCCHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHH
QSLSEGLVFGEKMGFKPDKILEVLDSGGVASPLFHSKGRSIARGDFSRNLALKYVHLQML
HHHHHHCEEHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RVLETAEKLGLELPAAKTVSGIFAQAVADGRGEEDFSAIVKLLRK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLKKIGFVGLGTVGVHMAANLAKSDYQLTVFDQDAKAVAELATLGVKVGESPMATAKGQD
CCCCCCEEEECHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCC
LVIVIVPDSDFLVFGQDGVFEGIDPGTILVDMGTHCIETIQRMAQEAVKHRVMFLEAPVW
EEEEEECCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEECCCC
GSKEHAANGLLTILAGGDEALLGRCREPFSYFGLNIIHIGKVGDATRMKLIVNLLQAEMM
CCHHHHCCCEEEEEECCCHHHHHHHCCCHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHH
QSLSEGLVFGEKMGFKPDKILEVLDSGGVASPLFHSKGRSIARGDFSRNLALKYVHLQML
HHHHHHCEEHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RVLETAEKLGLELPAAKTVSGIFAQAVADGRGEEDFSAIVKLLRK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]