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The map label for this gene is metC-2 [H]

Identifier: 197118600

GI number: 197118600

Start: 2582392

End: 2583525

Strand: Direct

Name: metC-2 [H]

Synonym: Gbem_2219

Alternate gene names: 197118600

Gene position: 2582392-2583525 (Clockwise)

Preceding gene: 197118599

Following gene: 197118603

Centisome position: 55.95

GC content: 63.49

Gene sequence:

>1134_bases
ATGAAATTCGCGACCGAACTGATACACGGCGGAGCCCCGATTGACCCGGAGCACGGCTCCCTGAGCCACCCCATCTACCT
GAGCTCCACCTTTGCCCAGCGCTCCATGGAGCACTTCGGCAGGTACGACTACTCCCGCTCGGGGAACCCCACCCGCGAGG
CGCTCGAAGAGGCGGTGGCCGGGCTTGAGAAAGGCGCCGTCGGCCTTGCCTTCGCCTCCGGCATGGCAGCCATCTCCTCC
ACCCTGCTCATCTTCGCGCCGGGCGACCATCTGGTTGTCTGCGAAGACGTCTACGGCGGGACCTTCCGCGCCCTCACCAC
CGTATTGAAGGGTTGGGGGTTGAACGCCACCTTCGTCGACGCGACCGATACGGCCGCTATCGCCGCCGCCATCAGGCCCG
AGACCAAGGCGCTCTACCTGGAGACCCCCTCCAACCCGCTCATCAAGATCACCGACCTAAAGGGAGCCGCGGCGCTCGCC
AAGGAGAAGGGGATCCTCACCATCGTCGACAACACCTTCATGACCCCGTACTTGCAGCGCCCGCTGGAACTTGGGTGCGA
CATCGTGCTCCACAGCGGCACCAAGTTCCTGAACGGCCACTCCGACGTCCTCTGCGGCTTCGCCGTCGCCAAGGACCCGG
CAGTAGGCCAAAGGATCCGCTTCATCCAGAACGCCTTCGGCGCCGTCCTCGGGCCGCAGGACTGCTGGCTGGTTTTGCGC
GGACTGAAAACCTTGAAGGTGCGCATGGAAGAGCACCAGGCAAGCGCCAAGGTGATCGTCTCCTGGCTCAAAGAGCAGAA
GGAAGTGGCGAAGATTTACTACCCCGGGCTTCCCGAGCATCCCGGCTACGAGATCCACAACGCCCAGTCCGCCGGCCCGG
GCGCCGTACTTTCCTTCGAGTTGTCCAGTTATGAAGTGACCAGGAAGCTACTGGAAGGGGTGAAATTGTCCGCATTCGCC
GTGAGCCTGGGAGGGGTGGAAAGCATCCTCTCCTACCCCGCCAAGATGTCGCACGCCGCCATGCCCCCCGCCGAGCGCGA
GGCCAGGGGAATCAAGGACACGCTGGTGCGTCTGTCGGTAGGGTTAGAGGACCCCGAGGACCTGATCGCCGACATGGAGA
GTTCCCTTAGATAA

Upstream 100 bases:

>100_bases
TCGGCATAAACCATTTACTGCTCCGCCTTTCGGTGGGGATAGAAGACAAGGACGACCTGATCGCCGACCTGGCGCAGGCG
TTCGCAGGAGGAGAACCGGA

Downstream 100 bases:

>100_bases
GCTGCAGGCGGAAAACCGAAAGGCGGAACGCAGAGGTCACGGAGGTCCACGGAGGTCCACGGAGGTCCACGGAGGTCACC
GAGGTTTTTGTGGTAAACCC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKFATELIHGGAPIDPEHGSLSHPIYLSSTFAQRSMEHFGRYDYSRSGNPTREALEEAVAGLEKGAVGLAFASGMAAISS
TLLIFAPGDHLVVCEDVYGGTFRALTTVLKGWGLNATFVDATDTAAIAAAIRPETKALYLETPSNPLIKITDLKGAAALA
KEKGILTIVDNTFMTPYLQRPLELGCDIVLHSGTKFLNGHSDVLCGFAVAKDPAVGQRIRFIQNAFGAVLGPQDCWLVLR
GLKTLKVRMEEHQASAKVIVSWLKEQKEVAKIYYPGLPEHPGYEIHNAQSAGPGAVLSFELSSYEVTRKLLEGVKLSAFA
VSLGGVESILSYPAKMSHAAMPPAEREARGIKDTLVRLSVGLEDPEDLIADMESSLR

Sequences:

>Translated_377_residues
MKFATELIHGGAPIDPEHGSLSHPIYLSSTFAQRSMEHFGRYDYSRSGNPTREALEEAVAGLEKGAVGLAFASGMAAISS
TLLIFAPGDHLVVCEDVYGGTFRALTTVLKGWGLNATFVDATDTAAIAAAIRPETKALYLETPSNPLIKITDLKGAAALA
KEKGILTIVDNTFMTPYLQRPLELGCDIVLHSGTKFLNGHSDVLCGFAVAKDPAVGQRIRFIQNAFGAVLGPQDCWLVLR
GLKTLKVRMEEHQASAKVIVSWLKEQKEVAKIYYPGLPEHPGYEIHNAQSAGPGAVLSFELSSYEVTRKLLEGVKLSAFA
VSLGGVESILSYPAKMSHAAMPPAEREARGIKDTLVRLSVGLEDPEDLIADMESSLR
>Mature_377_residues
MKFATELIHGGAPIDPEHGSLSHPIYLSSTFAQRSMEHFGRYDYSRSGNPTREALEEAVAGLEKGAVGLAFASGMAAISS
TLLIFAPGDHLVVCEDVYGGTFRALTTVLKGWGLNATFVDATDTAAIAAAIRPETKALYLETPSNPLIKITDLKGAAALA
KEKGILTIVDNTFMTPYLQRPLELGCDIVLHSGTKFLNGHSDVLCGFAVAKDPAVGQRIRFIQNAFGAVLGPQDCWLVLR
GLKTLKVRMEEHQASAKVIVSWLKEQKEVAKIYYPGLPEHPGYEIHNAQSAGPGAVLSFELSSYEVTRKLLEGVKLSAFA
VSLGGVESILSYPAKMSHAAMPPAEREARGIKDTLVRLSVGLEDPEDLIADMESSLR

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=364, Percent_Identity=44.2307692307692, Blast_Score=308, Evalue=4e-84,
Organism=Homo sapiens, GI299473759, Length=364, Percent_Identity=40.6593406593407, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI25453487, Length=363, Percent_Identity=38.5674931129477, Blast_Score=241, Evalue=9e-64,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=45.7671957671958, Blast_Score=319, Evalue=1e-88,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=29.4117647058824, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=368, Percent_Identity=42.1195652173913, Blast_Score=304, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI17538055, Length=368, Percent_Identity=41.8478260869565, Blast_Score=297, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI71980708, Length=364, Percent_Identity=35.4395604395604, Blast_Score=233, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=42.8571428571429, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6321254, Length=397, Percent_Identity=36.0201511335013, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6323333, Length=434, Percent_Identity=30.8755760368664, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6321170, Length=332, Percent_Identity=31.6265060240964, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321904, Length=395, Percent_Identity=28.6075949367089, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322970, Length=347, Percent_Identity=25.3602305475504, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922554, Length=379, Percent_Identity=43.7994722955145, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 40550; Mature: 40550

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFATELIHGGAPIDPEHGSLSHPIYLSSTFAQRSMEHFGRYDYSRSGNPTREALEEAVA
CCHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GLEKGAVGLAFASGMAAISSTLLIFAPGDHLVVCEDVYGGTFRALTTVLKGWGLNATFVD
HHHCCCHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEC
ATDTAAIAAAIRPETKALYLETPSNPLIKITDLKGAAALAKEKGILTIVDNTFMTPYLQR
CCCHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCHHHHHHCCCEEEEECCCCCCHHHHC
PLELGCDIVLHSGTKFLNGHSDVLCGFAVAKDPAVGQRIRFIQNAFGAVLGPQDCWLVLR
HHHCCCEEEEECCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
GLKTLKVRMEEHQASAKVIVSWLKEQKEVAKIYYPGLPEHPGYEIHNAQSAGPGAVLSFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEE
LSSYEVTRKLLEGVKLSAFAVSLGGVESILSYPAKMSHAAMPPAEREARGIKDTLVRLSV
CHHHHHHHHHHCCCCHHHEEEECCCHHHHHHCCHHHHHCCCCCHHHHHCCHHHHHHHHCC
GLEDPEDLIADMESSLR
CCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKFATELIHGGAPIDPEHGSLSHPIYLSSTFAQRSMEHFGRYDYSRSGNPTREALEEAVA
CCHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GLEKGAVGLAFASGMAAISSTLLIFAPGDHLVVCEDVYGGTFRALTTVLKGWGLNATFVD
HHHCCCHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEC
ATDTAAIAAAIRPETKALYLETPSNPLIKITDLKGAAALAKEKGILTIVDNTFMTPYLQR
CCCHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCHHHHHHCCCEEEEECCCCCCHHHHC
PLELGCDIVLHSGTKFLNGHSDVLCGFAVAKDPAVGQRIRFIQNAFGAVLGPQDCWLVLR
HHHCCCEEEEECCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
GLKTLKVRMEEHQASAKVIVSWLKEQKEVAKIYYPGLPEHPGYEIHNAQSAGPGAVLSFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEE
LSSYEVTRKLLEGVKLSAFAVSLGGVESILSYPAKMSHAAMPPAEREARGIKDTLVRLSV
CHHHHHHHHHHCCCCHHHEEEECCCHHHHHHCCHHHHHCCCCCHHHHHCCHHHHHHHHCC
GLEDPEDLIADMESSLR
CCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]