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The map label for this gene is metC-1 [H]

Identifier: 197118599

GI number: 197118599

Start: 2581247

End: 2582395

Strand: Direct

Name: metC-1 [H]

Synonym: Gbem_2218

Alternate gene names: 197118599

Gene position: 2581247-2582395 (Clockwise)

Preceding gene: 197118588

Following gene: 197118600

Centisome position: 55.93

GC content: 62.92

Gene sequence:

>1149_bases
ATGAAGATCGCAACCGAAGCAGCACAGATAGGCCTGCAGCGCGACACCCGCACCGGAGCGGTGACCGTCCCCATCTACCA
GACCGCCACCTTCCGCCATCCCGGTCTTGGTCAGAGCACCGGCTACGACTACAGCAGGTCGGGCAACCCCACGCGCCAGG
CGTTAGAGGAAGGGCTCGCCGTCCTGGAGGGAGGGTGCCGCGGCTTCGCCTACGCCTCGGGGATGGCCGCCATCACGAGC
CTCATGTTCCTCTTCAAGCAGGGGGACCACCTGATAGTAACCGAGGACCTCTACGGCGGGAGCTACCGGCTTTTCGAGAA
GCTGTTCCAGCAGTTCGGGCTCAGCTTCAGCTACGTCGACACGAGCGACATCGAACTGGTGCGCCAGGCCATCCGGCCCA
ACACCCGCGCGCTCTTCGTAGAGTCCCTCACCAACCCGCTTTTGAAGGTGGCCGACGTCGAGAAACTTGCGGCACTCTGC
AAAGAGCGCGACATGCTCTGCATCGTGGACAACACCTTCCTGACTCCGTATCTCTTGCGCTGTCTGGACCTTGGCGCCGA
CATCACCGTCTATTCCGGGAGCAAGTACCTGGCCGGCCACAACGACACCGTCTGCGGCCTGGTGGCAGTAAAGGACCCGG
CGCTTGCCGAGCAGGTCTACTTCCACCAGAACGGCGCCGGCGCCGTCCTAGGCCCGCAGGATTCCTGGCTAACCGTCAGG
GGGATCAAGACCCTCACCATCCGGATGGACCGGCAGCAGGAAAACGCCCTTGCCATAGCGCAGTGGTTGACCCTCCACCC
GCAAGTCGCGAAGGTGCATTACCCCGGTCTTCCCGATCATCCCGGCCACGAGCTGATGAAACAGCGCGGCAAAGGTTTCG
GCGCCATGATCGCCTTCGAAGTGACTGAGCCGCACCTGGTCAACACGCTGTTGATGAAGACCCGTCTGATCTCCTTCGCC
GAGAGCCTGGGGGGCGTCGAGAGCCTGATCACCTTCCCCGCGGTGCAGACCCACGCGGACATCGAGCCGGAGACGCTGAA
GCGGCTCGGCATAAACCATTTACTGCTCCGCCTTTCGGTGGGGATAGAAGACAAGGACGACCTGATCGCCGACCTGGCGC
AGGCGTTCGCAGGAGGAGAACCGGAATGA

Upstream 100 bases:

>100_bases
AGCGGCGACGCTTCGGAAGATAAGGAAGCGCGGACCTACTATAGAAAAGTCCCCTTCCGACCCCGGAAGGGGACTTTTTC
CTATTGGAGGCAAAGAAAAA

Downstream 100 bases:

>100_bases
AATTCGCGACCGAACTGATACACGGCGGAGCCCCGATTGACCCGGAGCACGGCTCCCTGAGCCACCCCATCTACCTGAGC
TCCACCTTTGCCCAGCGCTC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKIATEAAQIGLQRDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGLAVLEGGCRGFAYASGMAAITS
LMFLFKQGDHLIVTEDLYGGSYRLFEKLFQQFGLSFSYVDTSDIELVRQAIRPNTRALFVESLTNPLLKVADVEKLAALC
KERDMLCIVDNTFLTPYLLRCLDLGADITVYSGSKYLAGHNDTVCGLVAVKDPALAEQVYFHQNGAGAVLGPQDSWLTVR
GIKTLTIRMDRQQENALAIAQWLTLHPQVAKVHYPGLPDHPGHELMKQRGKGFGAMIAFEVTEPHLVNTLLMKTRLISFA
ESLGGVESLITFPAVQTHADIEPETLKRLGINHLLLRLSVGIEDKDDLIADLAQAFAGGEPE

Sequences:

>Translated_382_residues
MKIATEAAQIGLQRDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGLAVLEGGCRGFAYASGMAAITS
LMFLFKQGDHLIVTEDLYGGSYRLFEKLFQQFGLSFSYVDTSDIELVRQAIRPNTRALFVESLTNPLLKVADVEKLAALC
KERDMLCIVDNTFLTPYLLRCLDLGADITVYSGSKYLAGHNDTVCGLVAVKDPALAEQVYFHQNGAGAVLGPQDSWLTVR
GIKTLTIRMDRQQENALAIAQWLTLHPQVAKVHYPGLPDHPGHELMKQRGKGFGAMIAFEVTEPHLVNTLLMKTRLISFA
ESLGGVESLITFPAVQTHADIEPETLKRLGINHLLLRLSVGIEDKDDLIADLAQAFAGGEPE
>Mature_382_residues
MKIATEAAQIGLQRDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGLAVLEGGCRGFAYASGMAAITS
LMFLFKQGDHLIVTEDLYGGSYRLFEKLFQQFGLSFSYVDTSDIELVRQAIRPNTRALFVESLTNPLLKVADVEKLAALC
KERDMLCIVDNTFLTPYLLRCLDLGADITVYSGSKYLAGHNDTVCGLVAVKDPALAEQVYFHQNGAGAVLGPQDSWLTVR
GIKTLTIRMDRQQENALAIAQWLTLHPQVAKVHYPGLPDHPGHELMKQRGKGFGAMIAFEVTEPHLVNTLLMKTRLISFA
ESLGGVESLITFPAVQTHADIEPETLKRLGINHLLLRLSVGIEDKDDLIADLAQAFAGGEPE

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=383, Percent_Identity=44.6475195822454, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI299473759, Length=383, Percent_Identity=40.9921671018277, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI25453487, Length=382, Percent_Identity=40.0523560209424, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1790375, Length=377, Percent_Identity=42.7055702917772, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=30.8673469387755, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17538055, Length=366, Percent_Identity=40.9836065573771, Blast_Score=277, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17560056, Length=364, Percent_Identity=38.7362637362637, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=37.874659400545, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=40.2597402597403, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6321254, Length=407, Percent_Identity=34.3980343980344, Blast_Score=202, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323333, Length=418, Percent_Identity=32.0574162679426, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=303, Percent_Identity=31.6831683168317, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321904, Length=384, Percent_Identity=27.8645833333333, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19922554, Length=377, Percent_Identity=40.8488063660477, Blast_Score=305, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41837; Mature: 41837

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIATEAAQIGLQRDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGLA
CCCCHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VLEGGCRGFAYASGMAAITSLMFLFKQGDHLIVTEDLYGGSYRLFEKLFQQFGLSFSYVD
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECC
TSDIELVRQAIRPNTRALFVESLTNPLLKVADVEKLAALCKERDMLCIVDNTFLTPYLLR
CHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
CLDLGADITVYSGSKYLAGHNDTVCGLVAVKDPALAEQVYFHQNGAGAVLGPQDSWLTVR
HHHCCCCEEEECCCEEECCCCCCEEEEEEECCCHHHHHHEEEECCCCEEECCCCCEEEEE
GIKTLTIRMDRQQENALAIAQWLTLHPQVAKVHYPGLPDHPGHELMKQRGKGFGAMIAFE
CEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEE
VTEPHLVNTLLMKTRLISFAESLGGVESLITFPAVQTHADIEPETLKRLGINHLLLRLSV
ECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCHHHHHHHCHHHEEEEEEC
GIEDKDDLIADLAQAFAGGEPE
CCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKIATEAAQIGLQRDTRTGAVTVPIYQTATFRHPGLGQSTGYDYSRSGNPTRQALEEGLA
CCCCHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VLEGGCRGFAYASGMAAITSLMFLFKQGDHLIVTEDLYGGSYRLFEKLFQQFGLSFSYVD
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECC
TSDIELVRQAIRPNTRALFVESLTNPLLKVADVEKLAALCKERDMLCIVDNTFLTPYLLR
CHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
CLDLGADITVYSGSKYLAGHNDTVCGLVAVKDPALAEQVYFHQNGAGAVLGPQDSWLTVR
HHHCCCCEEEECCCEEECCCCCCEEEEEEECCCHHHHHHEEEECCCCEEECCCCCEEEEE
GIKTLTIRMDRQQENALAIAQWLTLHPQVAKVHYPGLPDHPGHELMKQRGKGFGAMIAFE
CEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEE
VTEPHLVNTLLMKTRLISFAESLGGVESLITFPAVQTHADIEPETLKRLGINHLLLRLSV
ECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCHHHHHHHCHHHEEEEEEC
GIEDKDDLIADLAQAFAGGEPE
CCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]