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The map label for this gene is cusB [H]

Identifier: 197118546

GI number: 197118546

Start: 2522132

End: 2523502

Strand: Reverse

Name: cusB [H]

Synonym: Gbem_2165

Alternate gene names: 197118546

Gene position: 2523502-2522132 (Counterclockwise)

Preceding gene: 197118547

Following gene: 197118545

Centisome position: 54.68

GC content: 62.29

Gene sequence:

>1371_bases
ATGAAACAAAGTGTCAAGGTTGCAATCCCGATTGTCGTTATCCTGGTGGCCGCCGTTGCCGGCGGCGGCTATTACCTGGC
ACAGAAGAAAAATCCCCCCGCAGCTAAAGACAAGGCGGCGCAGGGGCCGGTGCTCTACACCTGCGCGATGCACCCCTTCA
TCATCAAGGACAAGCCGGGAACCTGCCCCATCTGCGGCATGCAGTTGATCAAGAAGGTCGAGGGAGCCCAGGCGAGCGCC
CAGGAGCAGAAGATGCTGGGGCACGTCTCACTCTCTCCCACCCAGGCGGTCATGGCCAACGTGGCGACCGTTCCGGCCGA
TTTTGCACCTCTCTCCAAAGAGATTAACGCGGTCGGCATCGTGCAGTACGACCAGTCCAGACAGGCGAAGGTCACGGCCT
GGGTGGCGGGGCGCATCGACAAGCTCCTCGTCAACACAGTCGGCGCCTACGTTTCCAAGGGGCGACCGGTAGCAGAGATC
TACTCTCCCGATCTGGTAGCCGCGCAGCAGGAGTATCTCCTAGCCCTGAAGAGCCGCGAGCAGTTCCAGAAATCCTCCAT
ACAGGCGATCTCCCAAGGGGGAGACGGGCTCGTTTCTTCCGCCCGCCAGAGGCTGAAGCTCATGGGGGTGAGGGACGAGC
AGATTGCAGGGCTGGAGAAGGCCGGACATCCCAACATAAAGCTCCCCATTTACACCCCCCTCTCCGGTGTGGTGATCGAA
AAGATGGTCCAGGAAGGGCAGTACGTGAACATGGGGGAGCCCCTTTTCAGCATCGCCGACCTCTCCAGCGTCTGGGTCGA
GGTCGAGGTGTACGAGAATGAGTTCGCCTTCGTGAAGGTGGGACAGAGGGTCGAGATACTTTCCCAGTCGTATCCTGGCA
AGACCTTCTCCGGGCGGGTCAGCTTCATCTATCCCTTCCTCGATCCCAAGACCCGTACCGTCAAGGTCAGGGTGGACCTG
GCGAACCCCGGCTTGAAGCTCAAGACCGACATGTTCGTCAACGCCCAGATCAAGGCGCCGCTTGGCAACACGCTGGTGGT
GCCGGCGACGGCGCTGATGGACACCGGCAAGCGCCAGGTCGTCTGGGTGGAGTCGCAGCCCGGCATGTTCGAGCCGCGCG
ACGTGCAGGTTGGCGCGCGGGTGGGGGACAAGGTACAGATCCTCTCCGGCTTGAAGCGGGGGGACAAGGTCGCGGCTTCC
GGCGGTTATCTGATCGATTCCGAGTCGCAGCTCTCGGCAGGGAGCGGTGGCGGCGGCCACGAAGGGCACGCAGGAGGAGC
GAAAGCTCCCGGCGGCACAGCCCCCGGAGCCGTTGCTCCGGCCGCCCCCAAGAAGGGCGGCGGCATGAACATGGATGACA
TGAAAATGTAG

Upstream 100 bases:

>100_bases
AGTACTACGACTCGATGGCCGACTACCAGATGAAGCTGGCGCAGCTAGAGGCGCTGATCGGCAAAGAACTCTAAAAAAAT
CCCGACCACGAGGTATTGAT

Downstream 100 bases:

>100_bases
CAAGAGGTATTTTTCGCACTGAACATCAAGCAGCCTCCAGCTCTCCCCATCCCTTGATGGGAGCGGGCTGGGGGGGTGGG
TGAACCTGCCAGCACCGCAA

Product: RND family metal ion efflux pump membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKQSVKVAIPIVVILVAAVAGGGYYLAQKKNPPAAKDKAAQGPVLYTCAMHPFIIKDKPGTCPICGMQLIKKVEGAQASA
QEQKMLGHVSLSPTQAVMANVATVPADFAPLSKEINAVGIVQYDQSRQAKVTAWVAGRIDKLLVNTVGAYVSKGRPVAEI
YSPDLVAAQQEYLLALKSREQFQKSSIQAISQGGDGLVSSARQRLKLMGVRDEQIAGLEKAGHPNIKLPIYTPLSGVVIE
KMVQEGQYVNMGEPLFSIADLSSVWVEVEVYENEFAFVKVGQRVEILSQSYPGKTFSGRVSFIYPFLDPKTRTVKVRVDL
ANPGLKLKTDMFVNAQIKAPLGNTLVVPATALMDTGKRQVVWVESQPGMFEPRDVQVGARVGDKVQILSGLKRGDKVAAS
GGYLIDSESQLSAGSGGGGHEGHAGGAKAPGGTAPGAVAPAAPKKGGGMNMDDMKM

Sequences:

>Translated_456_residues
MKQSVKVAIPIVVILVAAVAGGGYYLAQKKNPPAAKDKAAQGPVLYTCAMHPFIIKDKPGTCPICGMQLIKKVEGAQASA
QEQKMLGHVSLSPTQAVMANVATVPADFAPLSKEINAVGIVQYDQSRQAKVTAWVAGRIDKLLVNTVGAYVSKGRPVAEI
YSPDLVAAQQEYLLALKSREQFQKSSIQAISQGGDGLVSSARQRLKLMGVRDEQIAGLEKAGHPNIKLPIYTPLSGVVIE
KMVQEGQYVNMGEPLFSIADLSSVWVEVEVYENEFAFVKVGQRVEILSQSYPGKTFSGRVSFIYPFLDPKTRTVKVRVDL
ANPGLKLKTDMFVNAQIKAPLGNTLVVPATALMDTGKRQVVWVESQPGMFEPRDVQVGARVGDKVQILSGLKRGDKVAAS
GGYLIDSESQLSAGSGGGGHEGHAGGAKAPGGTAPGAVAPAAPKKGGGMNMDDMKM
>Mature_456_residues
MKQSVKVAIPIVVILVAAVAGGGYYLAQKKNPPAAKDKAAQGPVLYTCAMHPFIIKDKPGTCPICGMQLIKKVEGAQASA
QEQKMLGHVSLSPTQAVMANVATVPADFAPLSKEINAVGIVQYDQSRQAKVTAWVAGRIDKLLVNTVGAYVSKGRPVAEI
YSPDLVAAQQEYLLALKSREQFQKSSIQAISQGGDGLVSSARQRLKLMGVRDEQIAGLEKAGHPNIKLPIYTPLSGVVIE
KMVQEGQYVNMGEPLFSIADLSSVWVEVEVYENEFAFVKVGQRVEILSQSYPGKTFSGRVSFIYPFLDPKTRTVKVRVDL
ANPGLKLKTDMFVNAQIKAPLGNTLVVPATALMDTGKRQVVWVESQPGMFEPRDVQVGARVGDKVQILSGLKRGDKVAAS
GGYLIDSESQLSAGSGGGGHEGHAGGAKAPGGTAPGAVAPAAPKKGGGMNMDDMKM

Specific function: Part of a cation efflux system that mediates resistance to copper and silver [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786787, Length=408, Percent_Identity=29.9019607843137, Blast_Score=149, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 48325; Mature: 48325

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSVKVAIPIVVILVAAVAGGGYYLAQKKNPPAAKDKAAQGPVLYTCAMHPFIIKDKPG
CCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECCCC
TCPICGMQLIKKVEGAQASAQEQKMLGHVSLSPTQAVMANVATVPADFAPLSKEINAVGI
CCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCEEEE
VQYDQSRQAKVTAWVAGRIDKLLVNTVGAYVSKGRPVAEIYSPDLVAAQQEYLLALKSRE
EEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHH
QFQKSSIQAISQGGDGLVSSARQRLKLMGVRDEQIAGLEKAGHPNIKLPIYTPLSGVVIE
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHCHHHCCCCCEEEEEECCCHHHHHH
KMVQEGQYVNMGEPLFSIADLSSVWVEVEVYENEFAFVKVGQRVEILSQSYPGKTFSGRV
HHHHCCCEECCCCCHHHHHCCCEEEEEEEEECCCEEEEEECCHHHHHHCCCCCCCCCCEE
SFIYPFLDPKTRTVKVRVDLANPGLKLKTDMFVNAQIKAPLGNTLVVPATALMDTGKRQV
EEEEECCCCCCEEEEEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEECHHHHCCCCEEE
VWVESQPGMFEPRDVQVGARVGDKVQILSGLKRGDKVAASGGYLIDSESQLSAGSGGGGH
EEEECCCCCCCCCCEEECCCCCCHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCCCCCC
EGHAGGAKAPGGTAPGAVAPAAPKKGGGMNMDDMKM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MKQSVKVAIPIVVILVAAVAGGGYYLAQKKNPPAAKDKAAQGPVLYTCAMHPFIIKDKPG
CCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECCCC
TCPICGMQLIKKVEGAQASAQEQKMLGHVSLSPTQAVMANVATVPADFAPLSKEINAVGI
CCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCEEEE
VQYDQSRQAKVTAWVAGRIDKLLVNTVGAYVSKGRPVAEIYSPDLVAAQQEYLLALKSRE
EEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHH
QFQKSSIQAISQGGDGLVSSARQRLKLMGVRDEQIAGLEKAGHPNIKLPIYTPLSGVVIE
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHCHHHCCCCCEEEEEECCCHHHHHH
KMVQEGQYVNMGEPLFSIADLSSVWVEVEVYENEFAFVKVGQRVEILSQSYPGKTFSGRV
HHHHCCCEECCCCCHHHHHCCCEEEEEEEEECCCEEEEEECCHHHHHHCCCCCCCCCCEE
SFIYPFLDPKTRTVKVRVDLANPGLKLKTDMFVNAQIKAPLGNTLVVPATALMDTGKRQV
EEEEECCCCCCEEEEEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEECHHHHCCCCEEE
VWVESQPGMFEPRDVQVGARVGDKVQILSGLKRGDKVAASGGYLIDSESQLSAGSGGGGH
EEEECCCCCCCCCCEEECCCCCCHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCCCCCC
EGHAGGAKAPGGTAPGAVAPAAPKKGGGMNMDDMKM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]