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The map label for this gene is mutM-1 [H]

Identifier: 197118515

GI number: 197118515

Start: 2481465

End: 2482274

Strand: Direct

Name: mutM-1 [H]

Synonym: Gbem_2133

Alternate gene names: 197118515

Gene position: 2481465-2482274 (Clockwise)

Preceding gene: 197118514

Following gene: 197118516

Centisome position: 53.77

GC content: 64.44

Gene sequence:

>810_bases
ATGCCCGAATTACCTGAAGTCGAAGTGACGCGGCTTGGGATCGCCGCACAACTGGTCGGAGCCAGGATCGCCGCTGTCGC
CATTCGCAGCGCCAAACTGCGCACCATGGTGCCGCAGGAACTCCCGCGTCTTCTTGTCGGCCAGAGCATCCTTTCGCTGA
CCCGTCGCGGCAAGTACCTGATCATTACCTGCCGGCAAGGCTCCTTGCTGCTGCACCTGGGCATGACCGGGCACCTGCGC
CTGGTTCCCGCCGGAGCCGGCGCAGGCGTGCACGACCACTTCGACCTGGAGCTTGAGTCCAGCCTTATATTGCGGCTCAA
CGACGTGCGCCGCTTCGGCTCGATTCACTTCACCTCCGGCGACCCGCTAAAGCACAAGCTTTTGCAGGGAATCGGGCCGG
AACCTTTGACCGATGAGCTCACCGGGCCCTACCTCTACCGCAAAAGCCGCGGCAAGAAGGCGCCCCTGCAGCGCTTCCTG
ATGGATAGCTCCGTGGTCGCCGGGCTTGGCAACATCTACGCGGCCGAGACCCTGTTCCGCTGCGGCATGCTTCCGCCCAC
ACCCGCGGGCTCCCTCTCCGAGGCCGACTGCGACAGGCTTTGCGACTGCATCAAGAAAACCCTCGCCGCCTCCATCGAGG
CCGGCCGCGTCATGGATTTCAGCGTCCGCGAGGAGAAGCTCGTCTATTTCCCGCAACAGCTCTTCGTCTACGGCAGGGAA
GGGCTCGCCTGCCGGCAATGCGGCAGCGCCATAGAGCGGGGAAGGCTCGGCAACCGCTCCACCTTCTACTGCCCCCGCTG
CCAGAGCTAG

Upstream 100 bases:

>100_bases
ACCTGCTTCACCTGCGGGGCAGAGGCCAACTCCGCCGACAACGTCTGCAACCCGATGCCCATGGGGTAGCAAGCGGCACG
CCGGTCCACACGGAGCACCG

Downstream 100 bases:

>100_bases
CTTTAACTGCGCCTTTGCATTGACCTTCCCCTGCCGGTTGATAAGCTGCCGCAGGGGTTGGGGCTTGCCCCGCGATTCTT
TTATAGGGAGGGTAACCAAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPELPEVEVTRLGIAAQLVGARIAAVAIRSAKLRTMVPQELPRLLVGQSILSLTRRGKYLIITCRQGSLLLHLGMTGHLR
LVPAGAGAGVHDHFDLELESSLILRLNDVRRFGSIHFTSGDPLKHKLLQGIGPEPLTDELTGPYLYRKSRGKKAPLQRFL
MDSSVVAGLGNIYAAETLFRCGMLPPTPAGSLSEADCDRLCDCIKKTLAASIEAGRVMDFSVREEKLVYFPQQLFVYGRE
GLACRQCGSAIERGRLGNRSTFYCPRCQS

Sequences:

>Translated_269_residues
MPELPEVEVTRLGIAAQLVGARIAAVAIRSAKLRTMVPQELPRLLVGQSILSLTRRGKYLIITCRQGSLLLHLGMTGHLR
LVPAGAGAGVHDHFDLELESSLILRLNDVRRFGSIHFTSGDPLKHKLLQGIGPEPLTDELTGPYLYRKSRGKKAPLQRFL
MDSSVVAGLGNIYAAETLFRCGMLPPTPAGSLSEADCDRLCDCIKKTLAASIEAGRVMDFSVREEKLVYFPQQLFVYGRE
GLACRQCGSAIERGRLGNRSTFYCPRCQS
>Mature_268_residues
PELPEVEVTRLGIAAQLVGARIAAVAIRSAKLRTMVPQELPRLLVGQSILSLTRRGKYLIITCRQGSLLLHLGMTGHLRL
VPAGAGAGVHDHFDLELESSLILRLNDVRRFGSIHFTSGDPLKHKLLQGIGPEPLTDELTGPYLYRKSRGKKAPLQRFLM
DSSVVAGLGNIYAAETLFRCGMLPPTPAGSLSEADCDRLCDCIKKTLAASIEAGRVMDFSVREEKLVYFPQQLFVYGREG
LACRQCGSAIERGRLGNRSTFYCPRCQS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=271, Percent_Identity=44.280442804428, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1786932, Length=276, Percent_Identity=25.3623188405797, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 29506; Mature: 29375

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVTRLGIAAQLVGARIAAVAIRSAKLRTMVPQELPRLLVGQSILSLTRRGKYL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEE
IITCRQGSLLLHLGMTGHLRLVPAGAGAGVHDHFDLELESSLILRLNDVRRFGSIHFTSG
EEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCEEECCCEEEEEHHHHHHCCEEECCC
DPLKHKLLQGIGPEPLTDELTGPYLYRKSRGKKAPLQRFLMDSSVVAGLGNIYAAETLFR
CHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CGMLPPTPAGSLSEADCDRLCDCIKKTLAASIEAGRVMDFSVREEKLVYFPQQLFVYGRE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHEECCHHHHHCCCC
GLACRQCGSAIERGRLGNRSTFYCPRCQS
CCHHHHHHHHHHHCCCCCCCCEECCCCCC
>Mature Secondary Structure 
PELPEVEVTRLGIAAQLVGARIAAVAIRSAKLRTMVPQELPRLLVGQSILSLTRRGKYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEE
IITCRQGSLLLHLGMTGHLRLVPAGAGAGVHDHFDLELESSLILRLNDVRRFGSIHFTSG
EEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCEEECCCEEEEEHHHHHHCCEEECCC
DPLKHKLLQGIGPEPLTDELTGPYLYRKSRGKKAPLQRFLMDSSVVAGLGNIYAAETLFR
CHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CGMLPPTPAGSLSEADCDRLCDCIKKTLAASIEAGRVMDFSVREEKLVYFPQQLFVYGRE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHEECCHHHHHCCCC
GLACRQCGSAIERGRLGNRSTFYCPRCQS
CCHHHHHHHHHHHCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA