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The map label for this gene is fadN [H]

Identifier: 197118508

GI number: 197118508

Start: 2470855

End: 2473224

Strand: Direct

Name: fadN [H]

Synonym: Gbem_2126

Alternate gene names: 197118508

Gene position: 2470855-2473224 (Clockwise)

Preceding gene: 197118507

Following gene: 197118509

Centisome position: 53.54

GC content: 64.09

Gene sequence:

>2370_bases
ATGAGACAGATAAACAAGGTCGCGGTACTGGGGGCAGGGGTCATGGGAGCGGCCATAGCTGCGCATCTGGCCAACGCCGG
CATCGAGGTACTGCTGCTGGACCTGGTTCCCCCCGACGCCCCGCCCCGGGGAGAGGGAGCGGACCGGGAGCGAAGCCGGA
TTGCCACGAACGCGCTTTCCGCCTTAGCCTCCGCGAAGCCCGCGCCGCTGTACGCGCCGGCCTATGCCGAATACATCCAC
CCCGGCAATTTCGAGGACGACGCGGCAAGGCTCAAGGAATGCGACTGGGTGATCGAGGTGGTGCTGGAGAACCTGGAGGT
GAAGCTGAAGCTCTTCGCAGAGCTGGTGGTTCCGAACCTGAAGCCCGACGCCGTTCTTTCCACCAACACCTCCGGGCTCT
CGGTGAACGAACTGGCCCGGGCGCTGCCGGAAGAGGTGAGGCGGCGCTTCATGGTCACCCATTTCTTCAATCCCCCCCGC
TACATGCGCCTGATGGAGATGGTCCCCTGTGCCGAAACCGACCCGAAAGTGCTGGCCGCGATGGCGCAATTCCTGGGGAA
GAGGCTCGGTAAGGGGGTGGTCTACGGGAAGGACACCCCGAACTTCATCGCCAACCGCATCGGCACCTATGCCGGCTCCG
CCGCCTGGCGCCATATGACGAGCATGGGGCTTACCGTCGAGGAGGTCGACGCCGTCACCGGCCCGGCGCTCGCCCGACCC
AAGACCGGCACCTTCGCCCTTTGGGACCTGGTGGGGATCGATACGGTGGTCCGGGTGCTCGACAACAGCTATGCCCTTCT
TTCCGGCGACGACGAGCGCGAACTGCTCCGGGTGCCGGAAGAGATCCGGCGCATGGTCGCCGACGGCCTTACCGGCAAGA
AAGGAAAGGGGGGCTTCTATCGTCGCGAGACCGTAGAAGGGGAAAGCGTGAAGGTTTGCTACGACTACCATAGCGGCAGC
TACAACCCCTGCGTCCGTCCCAAGTTCGCCTCGGTGGCCGCCGCCAAACAGATCGACGACCCGGCGCAGCGCGTGAGGAC
TCTTCTATCCGGTGGGGATCGCGCGGCTCAATTCGCCTGGCTCACCCTGCGGGACACCTTGATCTACGTAGTGAAGAGGC
TTGCCGAAATCGCCGACGACGTGGTCAACGTCGATAACGCCATGAAATGGGGTTACAACTGGGAGCTCGGCCCCTTCGAA
TTGCTGGACGCCCTCGGGGTCGCCGAGTTCGTCTCCCGCTGCGAGCGCGACGGCGTTGCCCTGCCGGACTGGCTCAAAGA
GGTGCAGAGCTTCTACCGGGTCGAGGGGGGCAAAAAGTTCCAGTACCTCCCGGAAAAGCACGATTTTGCGGAAATACCGA
GGCCCGAGGGAAGCGTCTCGCTCACCCTTTTGAATAGCGCCGGCGGCGAGGTGGAGCGAAACTCAGCCGCTTCGCTCATC
GACATAGGGGACGGCGTATTCTGCCTCGAATTCCATTCCAAGCTGAACACCATGGGGGGGGAGACGCTCGCCATGATCCA
GAAGGGGATCCGGCGCGCCGAGGCCGACGGGGTCGGGATGGTCATCGCCAACGAGGGGGGGGCGTTCTCCGCCGGCGCCA
ACCTGATGCTCGTCGCCATGGCGATAGCGGAAGGGGCCTGGGACGACTTAGCCCTCACCGTAAAGGCCTTCCAAAAGGCG
ATGATGTCCATCAAGTACTCGAAGGTTCCGGTGGTCGCCGCTCCCCACGGCCTAGCCATGGGAGGGGCGTGCGAGACCTG
CCTGCACGCCGACGCCATCAACGCCCATGCCGAGACCTACATGGGGCTGGTGGAGATCGGCGTAGGGCTGATCCCGGCCG
GCGGCGGCACCAAGGAGATGGCCATCAGGGCGGTCAGGCTTGCCGAGGAGAACGGGGCCGACGTCCAGCCCTTTTTGTTC
CGCAACTACCAGAACATCGCCATGGGCAAGGTGAGCAGTTCCGCTGCCGAACTGCTGACGCTGGGGCTTATGCGGCAGGG
GGACGGCATCACGCTCGACCTGGACCGGCGCATCCACGACGCCAAGCTGAAGGCGATAGCGCTCGCCGCGAACTACCGGC
CGGGGCGCCCGTCAACCGGCATCAAGGCGCCCGGTAAAAGTGTCGCCTCCAGCATCAAGGTGCAGCTTTGGAACCTTGAG
CGCGGCGGCTTCATTTCCAGCTACGACAGCTACCTCGCCTCAGGCATAGCCGACGTCATCACCGGCGGCGACGTCCCCGG
CGGCACCCTCATCACCGAAGAGTACCTGTTGGAGCTGGAGCGCGAGATGTTCCTCAAGTTCTGCGGCCAGAAGAAGACCC
TGGAGCGCATCCAGCACATGCTGAAAAAAGGGAGGCCTCTCAGGAACTAG

Upstream 100 bases:

>100_bases
GTGAAACGGCAGGTAATCTCGGAGAGGTACCGGGACCAGATAGACCATCTCTACAACGGCAGCGAATCGTAAGGGCCTGC
CTGCGCAATCGGAGGACGTG

Downstream 100 bases:

>100_bases
GGGGGCGCTACCATAGGAGAAACACCATGAGAACCGCATACATAGTTATCGCCCTGCGCACTCCGGCGACCAAGGCCTAC
AAAGGGAAACTGAGGCAGGT

Product: bifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MRQINKVAVLGAGVMGAAIAAHLANAGIEVLLLDLVPPDAPPRGEGADRERSRIATNALSALASAKPAPLYAPAYAEYIH
PGNFEDDAARLKECDWVIEVVLENLEVKLKLFAELVVPNLKPDAVLSTNTSGLSVNELARALPEEVRRRFMVTHFFNPPR
YMRLMEMVPCAETDPKVLAAMAQFLGKRLGKGVVYGKDTPNFIANRIGTYAGSAAWRHMTSMGLTVEEVDAVTGPALARP
KTGTFALWDLVGIDTVVRVLDNSYALLSGDDERELLRVPEEIRRMVADGLTGKKGKGGFYRRETVEGESVKVCYDYHSGS
YNPCVRPKFASVAAAKQIDDPAQRVRTLLSGGDRAAQFAWLTLRDTLIYVVKRLAEIADDVVNVDNAMKWGYNWELGPFE
LLDALGVAEFVSRCERDGVALPDWLKEVQSFYRVEGGKKFQYLPEKHDFAEIPRPEGSVSLTLLNSAGGEVERNSAASLI
DIGDGVFCLEFHSKLNTMGGETLAMIQKGIRRAEADGVGMVIANEGGAFSAGANLMLVAMAIAEGAWDDLALTVKAFQKA
MMSIKYSKVPVVAAPHGLAMGGACETCLHADAINAHAETYMGLVEIGVGLIPAGGGTKEMAIRAVRLAEENGADVQPFLF
RNYQNIAMGKVSSSAAELLTLGLMRQGDGITLDLDRRIHDAKLKAIALAANYRPGRPSTGIKAPGKSVASSIKVQLWNLE
RGGFISSYDSYLASGIADVITGGDVPGGTLITEEYLLELEREMFLKFCGQKKTLERIQHMLKKGRPLRN

Sequences:

>Translated_789_residues
MRQINKVAVLGAGVMGAAIAAHLANAGIEVLLLDLVPPDAPPRGEGADRERSRIATNALSALASAKPAPLYAPAYAEYIH
PGNFEDDAARLKECDWVIEVVLENLEVKLKLFAELVVPNLKPDAVLSTNTSGLSVNELARALPEEVRRRFMVTHFFNPPR
YMRLMEMVPCAETDPKVLAAMAQFLGKRLGKGVVYGKDTPNFIANRIGTYAGSAAWRHMTSMGLTVEEVDAVTGPALARP
KTGTFALWDLVGIDTVVRVLDNSYALLSGDDERELLRVPEEIRRMVADGLTGKKGKGGFYRRETVEGESVKVCYDYHSGS
YNPCVRPKFASVAAAKQIDDPAQRVRTLLSGGDRAAQFAWLTLRDTLIYVVKRLAEIADDVVNVDNAMKWGYNWELGPFE
LLDALGVAEFVSRCERDGVALPDWLKEVQSFYRVEGGKKFQYLPEKHDFAEIPRPEGSVSLTLLNSAGGEVERNSAASLI
DIGDGVFCLEFHSKLNTMGGETLAMIQKGIRRAEADGVGMVIANEGGAFSAGANLMLVAMAIAEGAWDDLALTVKAFQKA
MMSIKYSKVPVVAAPHGLAMGGACETCLHADAINAHAETYMGLVEIGVGLIPAGGGTKEMAIRAVRLAEENGADVQPFLF
RNYQNIAMGKVSSSAAELLTLGLMRQGDGITLDLDRRIHDAKLKAIALAANYRPGRPSTGIKAPGKSVASSIKVQLWNLE
RGGFISSYDSYLASGIADVITGGDVPGGTLITEEYLLELEREMFLKFCGQKKTLERIQHMLKKGRPLRN
>Mature_789_residues
MRQINKVAVLGAGVMGAAIAAHLANAGIEVLLLDLVPPDAPPRGEGADRERSRIATNALSALASAKPAPLYAPAYAEYIH
PGNFEDDAARLKECDWVIEVVLENLEVKLKLFAELVVPNLKPDAVLSTNTSGLSVNELARALPEEVRRRFMVTHFFNPPR
YMRLMEMVPCAETDPKVLAAMAQFLGKRLGKGVVYGKDTPNFIANRIGTYAGSAAWRHMTSMGLTVEEVDAVTGPALARP
KTGTFALWDLVGIDTVVRVLDNSYALLSGDDERELLRVPEEIRRMVADGLTGKKGKGGFYRRETVEGESVKVCYDYHSGS
YNPCVRPKFASVAAAKQIDDPAQRVRTLLSGGDRAAQFAWLTLRDTLIYVVKRLAEIADDVVNVDNAMKWGYNWELGPFE
LLDALGVAEFVSRCERDGVALPDWLKEVQSFYRVEGGKKFQYLPEKHDFAEIPRPEGSVSLTLLNSAGGEVERNSAASLI
DIGDGVFCLEFHSKLNTMGGETLAMIQKGIRRAEADGVGMVIANEGGAFSAGANLMLVAMAIAEGAWDDLALTVKAFQKA
MMSIKYSKVPVVAAPHGLAMGGACETCLHADAINAHAETYMGLVEIGVGLIPAGGGTKEMAIRAVRLAEENGADVQPFLF
RNYQNIAMGKVSSSAAELLTLGLMRQGDGITLDLDRRIHDAKLKAIALAANYRPGRPSTGIKAPGKSVASSIKVQLWNLE
RGGFISSYDSYLASGIADVITGGDVPGGTLITEEYLLELEREMFLKFCGQKKTLERIQHMLKKGRPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=298, Percent_Identity=29.5302013422819, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI296179427, Length=315, Percent_Identity=28.2539682539683, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI68989263, Length=257, Percent_Identity=29.9610894941634, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI261878539, Length=257, Percent_Identity=29.9610894941634, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI20127408, Length=309, Percent_Identity=27.831715210356, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1787661, Length=402, Percent_Identity=30.5970149253731, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1788682, Length=331, Percent_Identity=27.4924471299094, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1790281, Length=177, Percent_Identity=32.7683615819209, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17549919, Length=309, Percent_Identity=31.3915857605178, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17553560, Length=315, Percent_Identity=28.5714285714286, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144276, Length=347, Percent_Identity=29.6829971181556, Blast_Score=97, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17508953, Length=424, Percent_Identity=28.3018867924528, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17508951, Length=430, Percent_Identity=28.6046511627907, Blast_Score=94, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17558304, Length=417, Percent_Identity=27.3381294964029, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17563036, Length=301, Percent_Identity=29.2358803986711, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985923, Length=302, Percent_Identity=25.1655629139073, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921000, Length=259, Percent_Identity=29.3436293436293, Blast_Score=73, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583077, Length=259, Percent_Identity=29.3436293436293, Blast_Score=73, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583079, Length=259, Percent_Identity=29.3436293436293, Blast_Score=73, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 85488; Mature: 85488

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQINKVAVLGAGVMGAAIAAHLANAGIEVLLLDLVPPDAPPRGEGADRERSRIATNALS
CCCCCCCCEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
ALASAKPAPLYAPAYAEYIHPGNFEDDAARLKECDWVIEVVLENLEVKLKLFAELVVPNL
HHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KPDAVLSTNTSGLSVNELARALPEEVRRRFMVTHFFNPPRYMRLMEMVPCAETDPKVLAA
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
MAQFLGKRLGKGVVYGKDTPNFIANRIGTYAGSAAWRHMTSMGLTVEEVDAVTGPALARP
HHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
KTGTFALWDLVGIDTVVRVLDNSYALLSGDDERELLRVPEEIRRMVADGLTGKKGKGGFY
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
RRETVEGESVKVCYDYHSGSYNPCVRPKFASVAAAKQIDDPAQRVRTLLSGGDRAAQFAW
CCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHEEE
LTLRDTLIYVVKRLAEIADDVVNVDNAMKWGYNWELGPFELLDALGVAEFVSRCERDGVA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
LPDWLKEVQSFYRVEGGKKFQYLPEKHDFAEIPRPEGSVSLTLLNSAGGEVERNSAASLI
CHHHHHHHHHHHHCCCCCEECCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEE
DIGDGVFCLEFHSKLNTMGGETLAMIQKGIRRAEADGVGMVIANEGGAFSAGANLMLVAM
ECCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHH
AIAEGAWDDLALTVKAFQKAMMSIKYSKVPVVAAPHGLAMGGACETCLHADAINAHAETY
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
MGLVEIGVGLIPAGGGTKEMAIRAVRLAEENGADVQPFLFRNYQNIAMGKVSSSAAELLT
HHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHCCCCHHHHHHHH
LGLMRQGDGITLDLDRRIHDAKLKAIALAANYRPGRPSTGIKAPGKSVASSIKVQLWNLE
HHHHCCCCCEEEECCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCHHHHHCEEEEEEECC
RGGFISSYDSYLASGIADVITGGDVPGGTLITEEYLLELEREMFLKFCGQKKTLERIQHM
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LKKGRPLRN
HHCCCCCCC
>Mature Secondary Structure
MRQINKVAVLGAGVMGAAIAAHLANAGIEVLLLDLVPPDAPPRGEGADRERSRIATNALS
CCCCCCCCEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
ALASAKPAPLYAPAYAEYIHPGNFEDDAARLKECDWVIEVVLENLEVKLKLFAELVVPNL
HHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KPDAVLSTNTSGLSVNELARALPEEVRRRFMVTHFFNPPRYMRLMEMVPCAETDPKVLAA
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHH
MAQFLGKRLGKGVVYGKDTPNFIANRIGTYAGSAAWRHMTSMGLTVEEVDAVTGPALARP
HHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
KTGTFALWDLVGIDTVVRVLDNSYALLSGDDERELLRVPEEIRRMVADGLTGKKGKGGFY
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
RRETVEGESVKVCYDYHSGSYNPCVRPKFASVAAAKQIDDPAQRVRTLLSGGDRAAQFAW
CCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHEEE
LTLRDTLIYVVKRLAEIADDVVNVDNAMKWGYNWELGPFELLDALGVAEFVSRCERDGVA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
LPDWLKEVQSFYRVEGGKKFQYLPEKHDFAEIPRPEGSVSLTLLNSAGGEVERNSAASLI
CHHHHHHHHHHHHCCCCCEECCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEE
DIGDGVFCLEFHSKLNTMGGETLAMIQKGIRRAEADGVGMVIANEGGAFSAGANLMLVAM
ECCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHH
AIAEGAWDDLALTVKAFQKAMMSIKYSKVPVVAAPHGLAMGGACETCLHADAINAHAETY
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
MGLVEIGVGLIPAGGGTKEMAIRAVRLAEENGADVQPFLFRNYQNIAMGKVSSSAAELLT
HHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHCCCCHHHHHHHH
LGLMRQGDGITLDLDRRIHDAKLKAIALAANYRPGRPSTGIKAPGKSVASSIKVQLWNLE
HHHHCCCCCEEEECCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCHHHHHCEEEEEEECC
RGGFISSYDSYLASGIADVITGGDVPGGTLITEEYLLELEREMFLKFCGQKKTLERIQHM
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LKKGRPLRN
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]