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The map label for this gene is fkpA [H]

Identifier: 197118386

GI number: 197118386

Start: 2308798

End: 2309457

Strand: Direct

Name: fkpA [H]

Synonym: Gbem_2004

Alternate gene names: 197118386

Gene position: 2308798-2309457 (Clockwise)

Preceding gene: 197118385

Following gene: 197118387

Centisome position: 50.03

GC content: 56.97

Gene sequence:

>660_bases
ATGCGGAAACTGTTGATTGTTGCTCTTGTTGCATTAACCGCTGTACCGTCCTTTGCTGCAGATGAAAAGAAAGCGGAAGA
ACTGAAGACCTTTTATGCCATAGGGCAGGTCATGGCTCGCCAGCTAGGCGTCTTCAGCCTGGCACCTGACGAATTGACCC
AGGTGAAGAAGGGGCTCGATGACGGCATCGAAGGGAAGTCGCAAGTGGACATGGAGGCTTACAAGACGAAGATCCAGCAG
CTCGCCGTCGAGCGTCGCAACGCGCAGGGCGAGAAGCTTGCCGCACAGTCCAAGGAGTTTGTTGAAAAAGCTGCCAAAGA
GAAGGGTGCTGTGAAGACTCCCTCCGGTCTCATTTACAAGTCGCTCAAGGAAGGGACGGGGGCCGGCCCGGCTGCCACCG
ACAAGGTGAAGGTCAACTACCGCGGGACGCTGATCGACGGCAAGGAGTTCGACAGTTCCGCTGCAGCAGGCAAGCCTGCC
GAATTCAGGCTGGACCAGGTCATCAAGTGCTGGACCGAAGGCGTACAGAAGATGAAGGTCGGCGGCAAGGCACAGCTTGT
ATGTCCTCCTGATCTGGCCTACGGCGAGCGCGGTTCCGGGATCATCCCTGCCAACGCCACCCTGATCTTCGAAGTGGAAC
TTCTCGACGTAGTCAAGTAG

Upstream 100 bases:

>100_bases
GCAGGGGGGATTTACATCAGTGTTAAGCTGTAATGACATAGTAAAAAATGTTGGTATAGTATTGCCTGCTTTTAAAATCC
ATTTTCTGGAGGCCTATCCT

Downstream 100 bases:

>100_bases
CGCTTCTCGGGTAAAGCTTTCTTTCAATATTAAAAATTTCTATCAGAATTTTTCGTTGACAAAAGAGGGCGGCTGCACTA
TAAAGGAAAACCCTTGAGGC

Product: FKBP-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MRKLLIVALVALTAVPSFAADEKKAEELKTFYAIGQVMARQLGVFSLAPDELTQVKKGLDDGIEGKSQVDMEAYKTKIQQ
LAVERRNAQGEKLAAQSKEFVEKAAKEKGAVKTPSGLIYKSLKEGTGAGPAATDKVKVNYRGTLIDGKEFDSSAAAGKPA
EFRLDQVIKCWTEGVQKMKVGGKAQLVCPPDLAYGERGSGIIPANATLIFEVELLDVVK

Sequences:

>Translated_219_residues
MRKLLIVALVALTAVPSFAADEKKAEELKTFYAIGQVMARQLGVFSLAPDELTQVKKGLDDGIEGKSQVDMEAYKTKIQQ
LAVERRNAQGEKLAAQSKEFVEKAAKEKGAVKTPSGLIYKSLKEGTGAGPAATDKVKVNYRGTLIDGKEFDSSAAAGKPA
EFRLDQVIKCWTEGVQKMKVGGKAQLVCPPDLAYGERGSGIIPANATLIFEVELLDVVK
>Mature_219_residues
MRKLLIVALVALTAVPSFAADEKKAEELKTFYAIGQVMARQLGVFSLAPDELTQVKKGLDDGIEGKSQVDMEAYKTKIQQ
LAVERRNAQGEKLAAQSKEFVEKAAKEKGAVKTPSGLIYKSLKEGTGAGPAATDKVKVNYRGTLIDGKEFDSSAAAGKPA
EFRLDQVIKCWTEGVQKMKVGGKAQLVCPPDLAYGERGSGIIPANATLIFEVELLDVVK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=91, Percent_Identity=51.6483516483517, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI224809327, Length=91, Percent_Identity=51.6483516483517, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4758384, Length=91, Percent_Identity=51.6483516483517, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4758380, Length=83, Percent_Identity=51.8072289156626, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI224809331, Length=90, Percent_Identity=52.2222222222222, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI17149836, Length=81, Percent_Identity=54.320987654321, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503725, Length=81, Percent_Identity=54.320987654321, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503729, Length=99, Percent_Identity=45.4545454545455, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=49.4252873563218, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=49.4252873563218, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=49.4252873563218, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI33469985, Length=85, Percent_Identity=38.8235294117647, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789745, Length=211, Percent_Identity=40.7582938388626, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI87082390, Length=213, Percent_Identity=40.3755868544601, Blast_Score=136, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=45.9770114942529, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=48.3516483516484, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=98, Percent_Identity=45.9183673469388, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=53.4090909090909, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=100, Percent_Identity=47, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323482, Length=96, Percent_Identity=43.75, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=95, Percent_Identity=41.0526315789474, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24655568, Length=91, Percent_Identity=51.6483516483517, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=47.1153846153846, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=47.7272727272727, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=47.7272727272727, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24647110, Length=84, Percent_Identity=51.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356629, Length=88, Percent_Identity=47.7272727272727, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 23530; Mature: 23530

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLLIVALVALTAVPSFAADEKKAEELKTFYAIGQVMARQLGVFSLAPDELTQVKKGLD
CHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
DGIEGKSQVDMEAYKTKIQQLAVERRNAQGEKLAAQSKEFVEKAAKEKGAVKTPSGLIYK
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SLKEGTGAGPAATDKVKVNYRGTLIDGKEFDSSAAAGKPAEFRLDQVIKCWTEGVQKMKV
HHHHCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GGKAQLVCPPDLAYGERGSGIIPANATLIFEVELLDVVK
CCCEEEEECCCCCCCCCCCEECCCCCEEEEEEHHHHHCC
>Mature Secondary Structure
MRKLLIVALVALTAVPSFAADEKKAEELKTFYAIGQVMARQLGVFSLAPDELTQVKKGLD
CHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
DGIEGKSQVDMEAYKTKIQQLAVERRNAQGEKLAAQSKEFVEKAAKEKGAVKTPSGLIYK
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SLKEGTGAGPAATDKVKVNYRGTLIDGKEFDSSAAAGKPAEFRLDQVIKCWTEGVQKMKV
HHHHCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GGKAQLVCPPDLAYGERGSGIIPANATLIFEVELLDVVK
CCCEEEEECCCCCCCCCCCEECCCCCEEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]