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The map label for this gene is mtaP [H]

Identifier: 197118043

GI number: 197118043

Start: 1923412

End: 1924275

Strand: Direct

Name: mtaP [H]

Synonym: Gbem_1656

Alternate gene names: 197118043

Gene position: 1923412-1924275 (Clockwise)

Preceding gene: 197118042

Following gene: 197118044

Centisome position: 41.68

GC content: 64.0

Gene sequence:

>864_bases
ATGGCAAACGAGGTAATCGGCGTTATCGGCGGCAGCGGGCTCTACGAGATGGAAGGGATGACCGGCGTCGCCCAGGTGAC
GGTCGACACCCCCTTCGGCAGGCCTAGCGACGAGTATGTGACCGGGACGCTGGACGGGGTCAGCATGGTATTCCTGCCGC
GGCACGGCAAGGGTCACCGCTTCACCCCCAGCGAGGTGAACTACCGCGCCAACATCTACGGCATGAAGAAGTTGGGCGTC
ACCCGCATCATCTCGGTGTCGGCCGTGGGTAGCCTCAGGGAGGAGATCGTTCCGGGGCACATCGTGATACCGGACCAGTT
CATCGACCGCACCCGCGGCTTCAGAAAGGACACCTTCTTCGGAAACGGCGTGGTGGGGCACGTCCAGTTCGCCGACCCGG
TCTGCGCAGAGCTTTCCGATCTTTTGCACGCGGCAGCCGTCGAGGTCGACGCGGTGGTGCACCGGGGAGGTTGCTACGTC
TGCATGGAAGGGCCCGCCTTCTCCACCCGCGCCGAGAGCCACCTGTACCGCTCCTTCGGGGCCTCCATCATCGGCATGAC
CAACCTCACCGAGGCGAAGCTCGCGCGCGAGGCGGAGATCTGCTACGGCGTCATCGCACTCTCCACCGACTACGACTGCT
GGCACGACGCCCACGCGGACGTCTCGGTGGAGGCTATCATCGCCATCATCAAAAATAACGTAGCCACCGCCAAGAAGATC
ATCCGCCAGGCCGTGGCGAAGGTCGCGGCAGGGCGCGGCTGCGGCTGCGGCGAGGCCCTCAAATACGCCATCATCAGCGA
CACCTCCGTGATCCCGGTAGAGACCCGCGAGAACCTGGAGCTGATCATGGGGAAATACCTCTAA

Upstream 100 bases:

>100_bases
GCGGCCAGCTCAAGGGACGGCTGGATCAGGAGGACGGCGAACGCCGCAACTGCGGCTGCGAAGGCTAGAGAGAACTGAAA
TAAAATCCCTGGAGGTAGAG

Downstream 100 bases:

>100_bases
GGAACCGGCAGCCTTTGCCGATAGATGCAGAATTAAGAATAGATTTGCCGTACCTCATCCCGCAACACTTCCAGGAGGTT
TCATGAGCATACTTGTCGTT

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MANEVIGVIGGSGLYEMEGMTGVAQVTVDTPFGRPSDEYVTGTLDGVSMVFLPRHGKGHRFTPSEVNYRANIYGMKKLGV
TRIISVSAVGSLREEIVPGHIVIPDQFIDRTRGFRKDTFFGNGVVGHVQFADPVCAELSDLLHAAAVEVDAVVHRGGCYV
CMEGPAFSTRAESHLYRSFGASIIGMTNLTEAKLAREAEICYGVIALSTDYDCWHDAHADVSVEAIIAIIKNNVATAKKI
IRQAVAKVAAGRGCGCGEALKYAIISDTSVIPVETRENLELIMGKYL

Sequences:

>Translated_287_residues
MANEVIGVIGGSGLYEMEGMTGVAQVTVDTPFGRPSDEYVTGTLDGVSMVFLPRHGKGHRFTPSEVNYRANIYGMKKLGV
TRIISVSAVGSLREEIVPGHIVIPDQFIDRTRGFRKDTFFGNGVVGHVQFADPVCAELSDLLHAAAVEVDAVVHRGGCYV
CMEGPAFSTRAESHLYRSFGASIIGMTNLTEAKLAREAEICYGVIALSTDYDCWHDAHADVSVEAIIAIIKNNVATAKKI
IRQAVAKVAAGRGCGCGEALKYAIISDTSVIPVETRENLELIMGKYL
>Mature_286_residues
ANEVIGVIGGSGLYEMEGMTGVAQVTVDTPFGRPSDEYVTGTLDGVSMVFLPRHGKGHRFTPSEVNYRANIYGMKKLGVT
RIISVSAVGSLREEIVPGHIVIPDQFIDRTRGFRKDTFFGNGVVGHVQFADPVCAELSDLLHAAAVEVDAVVHRGGCYVC
MEGPAFSTRAESHLYRSFGASIIGMTNLTEAKLAREAEICYGVIALSTDYDCWHDAHADVSVEAIIAIIKNNVATAKKII
RQAVAKVAAGRGCGCGEALKYAIISDTSVIPVETRENLELIMGKYL

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=250, Percent_Identity=43.2, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71980569, Length=285, Percent_Identity=40, Blast_Score=200, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6323045, Length=302, Percent_Identity=35.4304635761589, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI20130079, Length=249, Percent_Identity=40.9638554216867, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI221459247, Length=250, Percent_Identity=35.2, Blast_Score=165, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 30857; Mature: 30726

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEVIGVIGGSGLYEMEGMTGVAQVTVDTPFGRPSDEYVTGTLDGVSMVFLPRHGKGHR
CCCCEEEEECCCCEEEECCCCEEEEEEEECCCCCCCCCEEEEEECCEEEEEEECCCCCCC
FTPSEVNYRANIYGMKKLGVTRIISVSAVGSLREEIVPGHIVIPDQFIDRTRGFRKDTFF
CCCCCCCEEEEEEEEHHCCHHHEEHHHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCC
GNGVVGHVQFADPVCAELSDLLHAAAVEVDAVVHRGGCYVCMEGPAFSTRAESHLYRSFG
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHC
ASIIGMTNLTEAKLAREAEICYGVIALSTDYDCWHDAHADVSVEAIIAIIKNNVATAKKI
CCEEECCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
IRQAVAKVAAGRGCGCGEALKYAIISDTSVIPVETRENLELIMGKYL
HHHHHHHHHCCCCCCCHHHHEEEEECCCEEEEECCCCCHHHHHHCCC
>Mature Secondary Structure 
ANEVIGVIGGSGLYEMEGMTGVAQVTVDTPFGRPSDEYVTGTLDGVSMVFLPRHGKGHR
CCCEEEEECCCCEEEECCCCEEEEEEEECCCCCCCCCEEEEEECCEEEEEEECCCCCCC
FTPSEVNYRANIYGMKKLGVTRIISVSAVGSLREEIVPGHIVIPDQFIDRTRGFRKDTFF
CCCCCCCEEEEEEEEHHCCHHHEEHHHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCC
GNGVVGHVQFADPVCAELSDLLHAAAVEVDAVVHRGGCYVCMEGPAFSTRAESHLYRSFG
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHC
ASIIGMTNLTEAKLAREAEICYGVIALSTDYDCWHDAHADVSVEAIIAIIKNNVATAKKI
CCEEECCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
IRQAVAKVAAGRGCGCGEALKYAIISDTSVIPVETRENLELIMGKYL
HHHHHHHHHCCCCCCCHHHHEEEEECCCEEEEECCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA