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The map label for this gene is wecB-2 [H]

Identifier: 197118010

GI number: 197118010

Start: 1883291

End: 1884427

Strand: Direct

Name: wecB-2 [H]

Synonym: Gbem_1623

Alternate gene names: 197118010

Gene position: 1883291-1884427 (Clockwise)

Preceding gene: 197118009

Following gene: 197118011

Centisome position: 40.81

GC content: 58.14

Gene sequence:

>1137_bases
ATGAAAAAGATCAGAGTAATGACGGTCGTCGGCACGAGGCCTGAGATCATACGCCTTTCCCGCGTTATGGCGAAGCTGGA
CCAGCATGCCGATCACATATTGGTGCACACCGGGCAAAACTATGACTATGAGCTGAACGAGATCTTCTTTCACGACTTGG
GTGTCAGAAAGCCTGACCATTTCCTGGATGCGGCCGGTGCCAACGCCGCGGAGACTATCGGTCAGCTGATCATAAAGGTG
GACCAGGTACTAGAGAAGGAGAAGCCTGAAGCGCTCCTGGTCCTCGGGGACACGAACAGCTGCCTCGCCGCGCTGCCGGC
CAAGCGGCGCAAGATCCCGATCTTTCACATGGAGGCGGGCAACCGCTGCTTTGATCAGAGGGTGCCGGAGGAGACCAACC
GCAAGATAGTTGACCACATCTCCGACATCAATATGACTTACAGCTCTATAGCGCGCGAGTACCTTTTGCGCGAGGGACTG
CCGCCGGACCGGATCATCAAAACCGGGAGCCCGATGTTCGAGGTGCTGAATTCCTACATGCAAAAGATTGATGCCTCCGA
CGTTCTCACCCGGCTGGGACTTGCTCGCGGCGACTACTTCGTGGTCAGCGCCCACCGCGAAGAGAACGTTGATTCTGAGG
TGAACCTCGTCAAATTGGCTGCCATCCTGAACGGCATTGCCGAGCGCTACGGGAAAAGGGTTATAGTCTCTACCCATCCC
AGGACCCGCAAACGTTTCGAGGAGAAGGGGCTTTCCTTCCACGAGAAGGTGGAGCTCCTGAAGCCGCTCGGCTTCTCGGA
CTACGTCCACCTGCAAAAGCACGCCTTCGCCGTCCTCTCTGACAGCGGCACCATCACTGAGGAGTCATCCATCCTCAATT
TCCCGGCTCTGAATATTCGCGAGGCGCACGAGCGCCCCGAGGGGATGGAGGAGGCATCGGTGATGATGACCGGGCTGGAA
CCGGACCGGGTGCTGCAGGGGCTGGAGATCCTGCAGAGCCAGGAGCGGGGTGAGGTCAGAAGCCTGCGCCCGGTGTTCGA
CTACTCCATGCCCAACGTGTCCGACAAGGTGTTGCGCATCATCATCAGCTACACCGACTACGTGAACCGGGTGGTGTGGC
GCAAGGAGCTGAAGTAA

Upstream 100 bases:

>100_bases
GCAACATCGGCGCCAACGAAATGGTGACCGTGATGTGGTGCAACGAGCTGTTCGACCCGGAGCGGCCCGATACTTATTTC
GAAACTGTGGAGTGTGGTGC

Downstream 100 bases:

>100_bases
CGAACGGGTGAGATGCGCATGCATGTATTGGTAGTGACACAGTATTTTTGGCCTGAAAACTTCAAAATCAACGATGTTGT
AAAAGGGCTTGTCGAACGTG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKKIRVMTVVGTRPEIIRLSRVMAKLDQHADHILVHTGQNYDYELNEIFFHDLGVRKPDHFLDAAGANAAETIGQLIIKV
DQVLEKEKPEALLVLGDTNSCLAALPAKRRKIPIFHMEAGNRCFDQRVPEETNRKIVDHISDINMTYSSIAREYLLREGL
PPDRIIKTGSPMFEVLNSYMQKIDASDVLTRLGLARGDYFVVSAHREENVDSEVNLVKLAAILNGIAERYGKRVIVSTHP
RTRKRFEEKGLSFHEKVELLKPLGFSDYVHLQKHAFAVLSDSGTITEESSILNFPALNIREAHERPEGMEEASVMMTGLE
PDRVLQGLEILQSQERGEVRSLRPVFDYSMPNVSDKVLRIIISYTDYVNRVVWRKELK

Sequences:

>Translated_378_residues
MKKIRVMTVVGTRPEIIRLSRVMAKLDQHADHILVHTGQNYDYELNEIFFHDLGVRKPDHFLDAAGANAAETIGQLIIKV
DQVLEKEKPEALLVLGDTNSCLAALPAKRRKIPIFHMEAGNRCFDQRVPEETNRKIVDHISDINMTYSSIAREYLLREGL
PPDRIIKTGSPMFEVLNSYMQKIDASDVLTRLGLARGDYFVVSAHREENVDSEVNLVKLAAILNGIAERYGKRVIVSTHP
RTRKRFEEKGLSFHEKVELLKPLGFSDYVHLQKHAFAVLSDSGTITEESSILNFPALNIREAHERPEGMEEASVMMTGLE
PDRVLQGLEILQSQERGEVRSLRPVFDYSMPNVSDKVLRIIISYTDYVNRVVWRKELK
>Mature_378_residues
MKKIRVMTVVGTRPEIIRLSRVMAKLDQHADHILVHTGQNYDYELNEIFFHDLGVRKPDHFLDAAGANAAETIGQLIIKV
DQVLEKEKPEALLVLGDTNSCLAALPAKRRKIPIFHMEAGNRCFDQRVPEETNRKIVDHISDINMTYSSIAREYLLREGL
PPDRIIKTGSPMFEVLNSYMQKIDASDVLTRLGLARGDYFVVSAHREENVDSEVNLVKLAAILNGIAERYGKRVIVSTHP
RTRKRFEEKGLSFHEKVELLKPLGFSDYVHLQKHAFAVLSDSGTITEESSILNFPALNIREAHERPEGMEEASVMMTGLE
PDRVLQGLEILQSQERGEVRSLRPVFDYSMPNVSDKVLRIIISYTDYVNRVVWRKELK

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=345, Percent_Identity=28.1159420289855, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 43084; Mature: 43084

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIRVMTVVGTRPEIIRLSRVMAKLDQHADHILVHTGQNYDYELNEIFFHDLGVRKPDH
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCHH
FLDAAGANAAETIGQLIIKVDQVLEKEKPEALLVLGDTNSCLAALPAKRRKIPIFHMEAG
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCCCCCCEEEECCC
NRCFDQRVPEETNRKIVDHISDINMTYSSIAREYLLREGLPPDRIIKTGSPMFEVLNSYM
CHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHH
QKIDASDVLTRLGLARGDYFVVSAHREENVDSEVNLVKLAAILNGIAERYGKRVIVSTHP
HHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCC
RTRKRFEEKGLSFHEKVELLKPLGFSDYVHLQKHAFAVLSDSGTITEESSILNFPALNIR
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCHH
EAHERPEGMEEASVMMTGLEPDRVLQGLEILQSQERGEVRSLRPVFDYSMPNVSDKVLRI
HHHCCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHCCHHHHCCHHHCCCCCCHHHHHHHH
IISYTDYVNRVVWRKELK
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKIRVMTVVGTRPEIIRLSRVMAKLDQHADHILVHTGQNYDYELNEIFFHDLGVRKPDH
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCHH
FLDAAGANAAETIGQLIIKVDQVLEKEKPEALLVLGDTNSCLAALPAKRRKIPIFHMEAG
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCCCCCCEEEECCC
NRCFDQRVPEETNRKIVDHISDINMTYSSIAREYLLREGLPPDRIIKTGSPMFEVLNSYM
CHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHH
QKIDASDVLTRLGLARGDYFVVSAHREENVDSEVNLVKLAAILNGIAERYGKRVIVSTHP
HHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCC
RTRKRFEEKGLSFHEKVELLKPLGFSDYVHLQKHAFAVLSDSGTITEESSILNFPALNIR
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCHH
EAHERPEGMEEASVMMTGLEPDRVLQGLEILQSQERGEVRSLRPVFDYSMPNVSDKVLRI
HHHCCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHCCHHHHCCHHHCCCCCCHHHHHHHH
IISYTDYVNRVVWRKELK
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]