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The map label for this gene is fur-1 [H]

Identifier: 197117974

GI number: 197117974

Start: 1840756

End: 1841187

Strand: Direct

Name: fur-1 [H]

Synonym: Gbem_1587

Alternate gene names: 197117974

Gene position: 1840756-1841187 (Clockwise)

Preceding gene: 197117973

Following gene: 197117975

Centisome position: 39.89

GC content: 60.42

Gene sequence:

>432_bases
ATGAAACGAGCCAAGAAAAAAATCTTCGCGGACTTCATCGCTCAGCGCGGACTCAAGACGACCAAGCAGCGGGACATCAT
CCTCGACAGCTTCCTGTCCAGCGACAGGCACCTGAGCATCGAGGACTTGTATCTGAAGCTCAGAGCCAAGCACCCGAACA
TCGGCTACGCCACGGTGTACCGGACTCTGAAGCTCTTCGCCGAGGCAGGTCTCGCCCGCGAGATGCAGTTCGGCGACGGC
CAGACCCGCTACGAGCACGTGGGGGAGGGCGAGCACCACGATCACTTGGTCTGCACCCGGTGCGGCCACATCGAGGAGTT
CGAGAACGAGACCATCGAGAAACTGCAGGACGAGGTGGCCAACAGCCGGGGCTTCCTGATCGAGCGCCACCGCCTCGAAC
TCTACGGCCTTTGCTCCGGCTGTAGAAAGTAA

Upstream 100 bases:

>100_bases
TCTGTCCATTCTGTCCATTCTGTCCGCAGTGCTTCAAAATAATCATTGACAGTGACGGGCGCCGCCGTTACTATGACATC
CACTTTCAATTGGGGTTCAC

Downstream 100 bases:

>100_bases
AGGGCTGGCGGGTTCCTCATTGGTTTAGGCTGCCCACCGGTTCTCTGCGGTCCCGCACCAAAAGCTATAAAAAATTTTTC
CCGCCATCATGAAAGTGATA

Product: ferric uptake regulation protein Fur

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MKRAKKKIFADFIAQRGLKTTKQRDIILDSFLSSDRHLSIEDLYLKLRAKHPNIGYATVYRTLKLFAEAGLAREMQFGDG
QTRYEHVGEGEHHDHLVCTRCGHIEEFENETIEKLQDEVANSRGFLIERHRLELYGLCSGCRK

Sequences:

>Translated_143_residues
MKRAKKKIFADFIAQRGLKTTKQRDIILDSFLSSDRHLSIEDLYLKLRAKHPNIGYATVYRTLKLFAEAGLAREMQFGDG
QTRYEHVGEGEHHDHLVCTRCGHIEEFENETIEKLQDEVANSRGFLIERHRLELYGLCSGCRK
>Mature_143_residues
MKRAKKKIFADFIAQRGLKTTKQRDIILDSFLSSDRHLSIEDLYLKLRAKHPNIGYATVYRTLKLFAEAGLAREMQFGDG
QTRYEHVGEGEHHDHLVCTRCGHIEEFENETIEKLQDEVANSRGFLIERHRLELYGLCSGCRK

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=134, Percent_Identity=39.5522388059701, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI87082363, Length=131, Percent_Identity=28.2442748091603, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 16608; Mature: 16608

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAKKKIFADFIAQRGLKTTKQRDIILDSFLSSDRHLSIEDLYLKLRAKHPNIGYATVY
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHH
RTLKLFAEAGLAREMQFGDGQTRYEHVGEGEHHDHLVCTRCGHIEEFENETIEKLQDEVA
HHHHHHHHHCHHHHHCCCCCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
NSRGFLIERHRLELYGLCSGCRK
CCCCCEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRAKKKIFADFIAQRGLKTTKQRDIILDSFLSSDRHLSIEDLYLKLRAKHPNIGYATVY
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHH
RTLKLFAEAGLAREMQFGDGQTRYEHVGEGEHHDHLVCTRCGHIEEFENETIEKLQDEVA
HHHHHHHHHCHHHHHCCCCCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
NSRGFLIERHRLELYGLCSGCRK
CCCCCEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]