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The map label for this gene is dsbC [H]

Identifier: 197117922

GI number: 197117922

Start: 1780755

End: 1781549

Strand: Direct

Name: dsbC [H]

Synonym: Gbem_1535

Alternate gene names: 197117922

Gene position: 1780755-1781549 (Clockwise)

Preceding gene: 197117921

Following gene: 197117923

Centisome position: 38.58

GC content: 61.26

Gene sequence:

>795_bases
ATGTCTTGGTTCAAAGGTCTCAAATATCTGGTCGCCGCAGCTTCTGCCCTCGCGCCCCTGGCGCTCGTCGTCCCCGTCTT
CGCCATGTCCGGCGGGTGCGGCGGAGAGTGCGCCTCGTGCCACAGCATCACCTTGCAGGAGGCCGGCTCGCTCCTGAAGG
GGATCGGAGTGGTCAAGGATGTGAAGCCAGCGGAAGTGCGCGGGTTATACGAGGTGACCTTCGAGCAGCAGGGAAACTCC
GGAGTCGCCTATGTCGATTACAGCAAGAAGTACATCATCGCCGGCCAGGCGTTCGACATCGCATCCAGACAGCCGGTGGG
GGCGAATGCGCCAGCAGCCAAGCAGCAGGAACGCCTCGACCCCAAGACCCTTTCCAGCAACGACGCGCTGGTGATGGGAA
ACCCAAAGGGGAAGAAGAAGCTCTTTGTCTTCACCGACCCCGAGTGCCCCTACTGCGCCAAGGCGCATGGCGAGTTGAAG
AAGCTCGCGGCCCTGGAACCGGATCTTGCCATCTACATCAAACTCTTTCCACTGAAGATGCACCCGAACGCCTACGACAA
GTCAAGGGTGATCCTGGCTGCGAAGTCGCTCGAACTGCTTGAGAACTCCTTCGCAGGCAAGGCGCTTCCTGCCGCCACCG
AGGCGACGCCGAAGAAACCAGTGGACGAGACCATCCGTTTCGCCGCCGCGGCGGGGATCAACTCCACCCCGACCTTGGTA
CTGCCGGACGGCCGGGTGCTTCCCGGCTTCAAGGATGCAGCCACAATGCAAAAGTTGCTGACGGGGACAAACTGA

Upstream 100 bases:

>100_bases
CTGAGAATTGCAGCCAATGGCGGGGCCTCTTCACTCCGTTGGTTGGCGGCATGATAGTTGCTGCACTCTGAAAGCCCAAA
ACGTCAAACGAGGTAGATAC

Downstream 100 bases:

>100_bases
GGCATCCGCCGCGACCGGCTCGGGTGGAACCTAGGCAGGCGCGTTTTTCAAAAGGACGAGGTATGCACATGGGAAACCGA
ATCGAGAAGCTCTTGATAAA

Product: protein disulfide bond isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSWFKGLKYLVAAASALAPLALVVPVFAMSGGCGGECASCHSITLQEAGSLLKGIGVVKDVKPAEVRGLYEVTFEQQGNS
GVAYVDYSKKYIIAGQAFDIASRQPVGANAPAAKQQERLDPKTLSSNDALVMGNPKGKKKLFVFTDPECPYCAKAHGELK
KLAALEPDLAIYIKLFPLKMHPNAYDKSRVILAAKSLELLENSFAGKALPAATEATPKKPVDETIRFAAAAGINSTPTLV
LPDGRVLPGFKDAATMQKLLTGTN

Sequences:

>Translated_264_residues
MSWFKGLKYLVAAASALAPLALVVPVFAMSGGCGGECASCHSITLQEAGSLLKGIGVVKDVKPAEVRGLYEVTFEQQGNS
GVAYVDYSKKYIIAGQAFDIASRQPVGANAPAAKQQERLDPKTLSSNDALVMGNPKGKKKLFVFTDPECPYCAKAHGELK
KLAALEPDLAIYIKLFPLKMHPNAYDKSRVILAAKSLELLENSFAGKALPAATEATPKKPVDETIRFAAAAGINSTPTLV
LPDGRVLPGFKDAATMQKLLTGTN
>Mature_263_residues
SWFKGLKYLVAAASALAPLALVVPVFAMSGGCGGECASCHSITLQEAGSLLKGIGVVKDVKPAEVRGLYEVTFEQQGNSG
VAYVDYSKKYIIAGQAFDIASRQPVGANAPAAKQQERLDPKTLSSNDALVMGNPKGKKKLFVFTDPECPYCAKAHGELKK
LAALEPDLAIYIKLFPLKMHPNAYDKSRVILAAKSLELLENSFAGKALPAATEATPKKPVDETIRFAAAAGINSTPTLVL
PDGRVLPGFKDAATMQKLLTGTN

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 27953; Mature: 27822

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWFKGLKYLVAAASALAPLALVVPVFAMSGGCGGECASCHSITLQEAGSLLKGIGVVKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHHHHHHHHHCCHHCC
VKPAEVRGLYEVTFEQQGNSGVAYVDYSKKYIIAGQAFDIASRQPVGANAPAAKQQERLD
CCCHHHCEEEEEEEEECCCCCEEEEECCCEEEEECCEECCCCCCCCCCCCCCHHHHHHCC
PKTLSSNDALVMGNPKGKKKLFVFTDPECPYCAKAHGELKKLAALEPDLAIYIKLFPLKM
CCCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEE
HPNAYDKSRVILAAKSLELLENSFAGKALPAATEATPKKPVDETIRFAAAAGINSTPTLV
CCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEE
LPDGRVLPGFKDAATMQKLLTGTN
CCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SWFKGLKYLVAAASALAPLALVVPVFAMSGGCGGECASCHSITLQEAGSLLKGIGVVKD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHHHHHHHHHCCHHCC
VKPAEVRGLYEVTFEQQGNSGVAYVDYSKKYIIAGQAFDIASRQPVGANAPAAKQQERLD
CCCHHHCEEEEEEEEECCCCCEEEEECCCEEEEECCEECCCCCCCCCCCCCCHHHHHHCC
PKTLSSNDALVMGNPKGKKKLFVFTDPECPYCAKAHGELKKLAALEPDLAIYIKLFPLKM
CCCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEE
HPNAYDKSRVILAAKSLELLENSFAGKALPAATEATPKKPVDETIRFAAAAGINSTPTLV
CCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEE
LPDGRVLPGFKDAATMQKLLTGTN
CCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]