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The map label for this gene is acdA [H]

Identifier: 197117839

GI number: 197117839

Start: 1678569

End: 1679726

Strand: Direct

Name: acdA [H]

Synonym: Gbem_1452

Alternate gene names: 197117839

Gene position: 1678569-1679726 (Clockwise)

Preceding gene: 197117838

Following gene: 197117840

Centisome position: 36.37

GC content: 62.44

Gene sequence:

>1158_bases
ATGAGGTTCGGGCTGACGGATGAACAAAAGATGATGCAGGATATGGCGAGGGATTTCGCGCAGAAAGAGATCCTGCCTAC
GCTCAAGGAAGACGAGATCAACCACACCTTCCGCCCCGAACTGGTCAAGAAGATGGCCGGTCTGGGCTTTTTCGGCTGCG
CCCTTCCTGAGGAATACGGCGGCAACGGCTGCGGCTTTTTGGAGTCGGTCATCCTTGCCGAACAGCTCGCCACCGTGAGC
GGCTCCTCAAGGCTGCCGCTGAACATGCAGAACATAGGCCCCTCCCTCACGGTCAACAAGTTCGGCACCAAGGAGCAGAA
AGAGCGTTTCATCCCCGACTGGGTGAGCGCCGAATCCTTCGGCTTCTTCGCCATCACCGAGCCCAACTCCGGCTCCGACG
TAGTGAGCATGGGGACCACCGCCACCGACCGCGGCGACCACTGGGAGATCAACGGCCAGAAGATGTGGATCTCCAACGCC
CACGTAGGCGACTGGGGCCTTCTCTACGCCGTCACCGACCGCGCCGCCAAGCACAAGGGGATGACCTGCTTCGTCATCAA
CCTCAAGGGTAACGAGGGGATCATCACCGCCGCCATCGAGTCCAAAGTGGGCCTTCACTGCGCGCCTACCGGCGAGATCT
CATTCAACCAGGCGAAGATCCCCAAAGACTCGGTCCTGGGCGAGGTGGGGCAGGGCTTCCAGATCTGCATGTGGCAGCTG
AACAACACCCGTATCAGCTGTGCCGCGGGCGCGCTCGGCATCGGCGCCGGCGCCATCGAGGCCGCCATCGGCTACGCCAA
CGAGAGGACCCAGTTCGGCAAGAAGATCGGCTCGTACCAGATGATCCAGGCTTCCATCGCCGAGATGGTGGCCGAGCACG
AAGCGGCGCGCCTTCTGGTCTACCAGGCGGCCTGGCTCAAGGACCAGGGGCTTCCCAACCAGTACCAGACCTCCATGGCG
AAGCTGTTCGCCTCCGAGGCGGCGGTACACGCGGCCACCGAAACCATGAAGATCTTCGGGAGCTACGGCTTCTCCACAGA
GTACCCGGCCGAGCGCTGGCTGCGCGACTCGATGTCGCTTAGGACCGTGGAAGGGACCAGCAACATCCAGAAGACCATCA
TCGCCGGCTTCGCCCTGGGCGACGCGGTGAACCGCTAG

Upstream 100 bases:

>100_bases
TCGGTACTCCACTACCATTTAGTGCTTGACAGCAAATTGGTATTCTAGTACTAAATTACAAAACGGCATTTGCGAAACAC
AATAACTGAGGAGGTGGCCA

Downstream 100 bases:

>100_bases
GGGGAAACGCCCTCAGCATGAACCTTCCCTCACCCTGACCCTCTCCCAAAGGGAGAGGGGATTGTGAAGCGAGAGGGTGG
TTATGAAGCGAGAAGCTGCC

Product: glutaryl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MRFGLTDEQKMMQDMARDFAQKEILPTLKEDEINHTFRPELVKKMAGLGFFGCALPEEYGGNGCGFLESVILAEQLATVS
GSSRLPLNMQNIGPSLTVNKFGTKEQKERFIPDWVSAESFGFFAITEPNSGSDVVSMGTTATDRGDHWEINGQKMWISNA
HVGDWGLLYAVTDRAAKHKGMTCFVINLKGNEGIITAAIESKVGLHCAPTGEISFNQAKIPKDSVLGEVGQGFQICMWQL
NNTRISCAAGALGIGAGAIEAAIGYANERTQFGKKIGSYQMIQASIAEMVAEHEAARLLVYQAAWLKDQGLPNQYQTSMA
KLFASEAAVHAATETMKIFGSYGFSTEYPAERWLRDSMSLRTVEGTSNIQKTIIAGFALGDAVNR

Sequences:

>Translated_385_residues
MRFGLTDEQKMMQDMARDFAQKEILPTLKEDEINHTFRPELVKKMAGLGFFGCALPEEYGGNGCGFLESVILAEQLATVS
GSSRLPLNMQNIGPSLTVNKFGTKEQKERFIPDWVSAESFGFFAITEPNSGSDVVSMGTTATDRGDHWEINGQKMWISNA
HVGDWGLLYAVTDRAAKHKGMTCFVINLKGNEGIITAAIESKVGLHCAPTGEISFNQAKIPKDSVLGEVGQGFQICMWQL
NNTRISCAAGALGIGAGAIEAAIGYANERTQFGKKIGSYQMIQASIAEMVAEHEAARLLVYQAAWLKDQGLPNQYQTSMA
KLFASEAAVHAATETMKIFGSYGFSTEYPAERWLRDSMSLRTVEGTSNIQKTIIAGFALGDAVNR
>Mature_385_residues
MRFGLTDEQKMMQDMARDFAQKEILPTLKEDEINHTFRPELVKKMAGLGFFGCALPEEYGGNGCGFLESVILAEQLATVS
GSSRLPLNMQNIGPSLTVNKFGTKEQKERFIPDWVSAESFGFFAITEPNSGSDVVSMGTTATDRGDHWEINGQKMWISNA
HVGDWGLLYAVTDRAAKHKGMTCFVINLKGNEGIITAAIESKVGLHCAPTGEISFNQAKIPKDSVLGEVGQGFQICMWQL
NNTRISCAAGALGIGAGAIEAAIGYANERTQFGKKIGSYQMIQASIAEMVAEHEAARLLVYQAAWLKDQGLPNQYQTSMA
KLFASEAAVHAATETMKIFGSYGFSTEYPAERWLRDSMSLRTVEGTSNIQKTIIAGFALGDAVNR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=39.4179894179894, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=34.5013477088949, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=35.1063829787234, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=35.1063829787234, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=32.8042328042328, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=32.9787234042553, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI226958414, Length=359, Percent_Identity=33.7047353760446, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=35.4466858789625, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=35.4466858789625, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI21361497, Length=346, Percent_Identity=34.971098265896, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=28.5714285714286, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4501857, Length=386, Percent_Identity=27.4611398963731, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=28.3422459893048, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI48976061, Length=337, Percent_Identity=24.3323442136499, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI211971008, Length=337, Percent_Identity=24.3323442136499, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI38505218, Length=397, Percent_Identity=23.4256926952141, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786223, Length=371, Percent_Identity=26.9541778975741, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI87081958, Length=391, Percent_Identity=27.6214833759591, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87081702, Length=291, Percent_Identity=26.8041237113402, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=36.6576819407008, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=35.0404312668464, Blast_Score=250, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=33.419689119171, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=33.9473684210526, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=34.7368421052632, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=389, Percent_Identity=32.133676092545, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=37.9061371841155, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=30.2139037433155, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=29.6296296296296, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71985184, Length=389, Percent_Identity=31.3624678663239, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=30.5454545454545, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=350, Percent_Identity=30.2857142857143, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17505929, Length=351, Percent_Identity=29.3447293447293, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=333, Percent_Identity=31.5315315315315, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=32.3651452282158, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=30.8988764044944, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=25.6944444444444, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=267, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=267, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=38.0952380952381, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=36.1185983827493, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=35.7333333333333, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=33.5106382978723, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=32.8083989501312, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=32.258064516129, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI19920834, Length=376, Percent_Identity=29.7872340425532, Blast_Score=165, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41925; Mature: 41925

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFGLTDEQKMMQDMARDFAQKEILPTLKEDEINHTFRPELVKKMAGLGFFGCALPEEYG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCHHHC
GNGCGFLESVILAEQLATVSGSSRLPLNMQNIGPSLTVNKFGTKEQKERFIPDWVSAESF
CCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCEEEECCCCHHHHHHCCCCCCCCCCC
GFFAITEPNSGSDVVSMGTTATDRGDHWEINGQKMWISNAHVGDWGLLYAVTDRAAKHKG
CEEEEECCCCCCCEEEECCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEHHHHHHCCC
MTCFVINLKGNEGIITAAIESKVGLHCAPTGEISFNQAKIPKDSVLGEVGQGFQICMWQL
CEEEEEEEECCCCEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEEE
NNTRISCAAGALGIGAGAIEAAIGYANERTQFGKKIGSYQMIQASIAEMVAEHEAARLLV
CCCEEEEECCCHHCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YQAAWLKDQGLPNQYQTSMAKLFASEAAVHAATETMKIFGSYGFSTEYPAERWLRDSMSL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCE
RTVEGTSNIQKTIIAGFALGDAVNR
EEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFGLTDEQKMMQDMARDFAQKEILPTLKEDEINHTFRPELVKKMAGLGFFGCALPEEYG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCHHHC
GNGCGFLESVILAEQLATVSGSSRLPLNMQNIGPSLTVNKFGTKEQKERFIPDWVSAESF
CCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCEEEECCCCHHHHHHCCCCCCCCCCC
GFFAITEPNSGSDVVSMGTTATDRGDHWEINGQKMWISNAHVGDWGLLYAVTDRAAKHKG
CEEEEECCCCCCCEEEECCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEHHHHHHCCC
MTCFVINLKGNEGIITAAIESKVGLHCAPTGEISFNQAKIPKDSVLGEVGQGFQICMWQL
CEEEEEEEECCCCEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEEE
NNTRISCAAGALGIGAGAIEAAIGYANERTQFGKKIGSYQMIQASIAEMVAEHEAARLLV
CCCEEEEECCCHHCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YQAAWLKDQGLPNQYQTSMAKLFASEAAVHAATETMKIFGSYGFSTEYPAERWLRDSMSL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCE
RTVEGTSNIQKTIIAGFALGDAVNR
EEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]