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The map label for this gene is dsbC [H]

Identifier: 197117715

GI number: 197117715

Start: 1530975

End: 1531703

Strand: Direct

Name: dsbC [H]

Synonym: Gbem_1327

Alternate gene names: 197117715

Gene position: 1530975-1531703 (Clockwise)

Preceding gene: 197117714

Following gene: 197117718

Centisome position: 33.17

GC content: 61.45

Gene sequence:

>729_bases
ATGTGGTTTACTCGGAGAATCCTGGCAGCTTGTTTGTCCGCAGCGGTGCTGCTTCTTCTGGCAGGTGTGTCGTTCGCCGC
CCCGATCTCCCCTGAAAACGCCTTTCGCAGCGCGTTCCCCCAGGTCCCCTTCGACAGTATGACCCCCACAGAGATCAAGG
GTGTGTACGAGGTCGTTTCCGGGCCCAACATCTTCTACTACTACCCGGAGAAGGATCTCATCCTCACCGGCGAGATCGTG
GGGAAGGACCTCAAGAGCCGTACGGCGGAGCGGAAGCAGGCGCTCAGCTCGCAGGTGGCGGCCAAGGCGATGGAAGCGGT
CAAGGAGCTGCCGCTCGACAAGGCGGTCAAGGTGGGGGACGGCAAGAAGACGGTCATCGAGTTCACCGACCCCGACTGCC
CGTACTGCAGGAAGGCTTCCGAGTACTTCACCAAGAGAAGCGACGTGACCAGGTACGTCTTCTTCGCGCCGCTGGCGCAC
CCGGCGGCCATCAAGAAGATCGAGTACATCCTTTCCGCCGAGAACAAGGCCGAGGCCTATGACGCCATGATGCTGGGCGA
GGAGATTCCGGCCTCCGCCAAGCCGGCGAGCGCCGAGGTGAAGAAGCTGGCCCAGGAGCACCTCGCACTGGCGAGAAAGG
TGGGTATCCAGGGGACCCCGACCTTCTTCGTCAAGGGGGAGCAGGTCATCGGCGCCGACACCAAGAAGCTGGATGAGCTT
TTGAAATAA

Upstream 100 bases:

>100_bases
ACGCCGAAAAAATTTCCTCGCGCTCCCACCTTTCCTGAAACATATGCTATAGTTGCCGCTGGCTCGGCCAGCAATTTTAA
TTAACTAGAATGGAGGCCTT

Downstream 100 bases:

>100_bases
CCTTCTTCACGCCAAAGGGGAGATGGAGACGATCCCGAACCTGCCGTCGTAACCGGGATCGATCTCCACCTCGCCCAGGC
GCATCTTGCCGATGCCGCGC

Product: protein disulfide bond isomerase

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MWFTRRILAACLSAAVLLLLAGVSFAAPISPENAFRSAFPQVPFDSMTPTEIKGVYEVVSGPNIFYYYPEKDLILTGEIV
GKDLKSRTAERKQALSSQVAAKAMEAVKELPLDKAVKVGDGKKTVIEFTDPDCPYCRKASEYFTKRSDVTRYVFFAPLAH
PAAIKKIEYILSAENKAEAYDAMMLGEEIPASAKPASAEVKKLAQEHLALARKVGIQGTPTFFVKGEQVIGADTKKLDEL
LK

Sequences:

>Translated_242_residues
MWFTRRILAACLSAAVLLLLAGVSFAAPISPENAFRSAFPQVPFDSMTPTEIKGVYEVVSGPNIFYYYPEKDLILTGEIV
GKDLKSRTAERKQALSSQVAAKAMEAVKELPLDKAVKVGDGKKTVIEFTDPDCPYCRKASEYFTKRSDVTRYVFFAPLAH
PAAIKKIEYILSAENKAEAYDAMMLGEEIPASAKPASAEVKKLAQEHLALARKVGIQGTPTFFVKGEQVIGADTKKLDEL
LK
>Mature_242_residues
MWFTRRILAACLSAAVLLLLAGVSFAAPISPENAFRSAFPQVPFDSMTPTEIKGVYEVVSGPNIFYYYPEKDLILTGEIV
GKDLKSRTAERKQALSSQVAAKAMEAVKELPLDKAVKVGDGKKTVIEFTDPDCPYCRKASEYFTKRSDVTRYVFFAPLAH
PAAIKKIEYILSAENKAEAYDAMMLGEEIPASAKPASAEVKKLAQEHLALARKVGIQGTPTFFVKGEQVIGADTKKLDEL
LK

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: NA

Molecular weight: Translated: 26542; Mature: 26542

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFTRRILAACLSAAVLLLLAGVSFAAPISPENAFRSAFPQVPFDSMTPTEIKGVYEVVS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
GPNIFYYYPEKDLILTGEIVGKDLKSRTAERKQALSSQVAAKAMEAVKELPLDKAVKVGD
CCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEECCC
GKKTVIEFTDPDCPYCRKASEYFTKRSDVTRYVFFAPLAHPAAIKKIEYILSAENKAEAY
CCEEEEEECCCCCHHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHCCCHHHHH
DAMMLGEEIPASAKPASAEVKKLAQEHLALARKVGIQGTPTFFVKGEQVIGADTKKLDEL
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCHHHHHHH
LK
HC
>Mature Secondary Structure
MWFTRRILAACLSAAVLLLLAGVSFAAPISPENAFRSAFPQVPFDSMTPTEIKGVYEVVS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
GPNIFYYYPEKDLILTGEIVGKDLKSRTAERKQALSSQVAAKAMEAVKELPLDKAVKVGD
CCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEECCC
GKKTVIEFTDPDCPYCRKASEYFTKRSDVTRYVFFAPLAHPAAIKKIEYILSAENKAEAY
CCEEEEEECCCCCHHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHCCCHHHHH
DAMMLGEEIPASAKPASAEVKKLAQEHLALARKVGIQGTPTFFVKGEQVIGADTKKLDEL
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCHHHHHHH
LK
HC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]