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The map label for this gene is glcK [H]

Identifier: 197117714

GI number: 197117714

Start: 1529992

End: 1530912

Strand: Direct

Name: glcK [H]

Synonym: Gbem_1326

Alternate gene names: 197117714

Gene position: 1529992-1530912 (Clockwise)

Preceding gene: 197117713

Following gene: 197117715

Centisome position: 33.15

GC content: 70.03

Gene sequence:

>921_bases
ATGGAAAGTGTCTGTATCGGGGTGGACGTCGGGGGGACTAACCTTCGCTTCGCCCTGGTGGACCAAGGCGGCGCGGTGCT
TAGCAGGGTGAGCGAACCGACGGAGACGGTGACGGCTCCCGCGCCGTTTGTAGCCCGGCTGCAGGGGAGGGTGCAACAGC
TGCAAAGGGAGGCGCTGGCCCGGGGAGTCAGGGTCGCCGGCGTCGGCATCGGTGTCGCCGGTCTCGTCTCGGGTGAAGGT
GCGGTCCTTTCCAGCGTCAACCTCCCGGCGCTGCAGGGGGTAAACCTCGGCGCGGAGCTTTCGCGCGCCCTGGGGGTGCC
GGTGCTGGTGCTAAACGACGCCAACGCCTGCGCCGTCGGCGAGCAGCGCTTCGGCGCGGGAAAAGGGTACCGCTCCTGGC
TCATGCTCACCATCGGCACGGGGGTGGGGGCGGGGCTGATACTTGACGGCCGGCTCTGGACCGGGGCGAACGGGCTGGCC
GGCGAATTGGGGCACCTGACGGTGGAACCGGAGGGGCGCCCGTGCGGCTGCGGCAACCGGGGGTGCCTGGAGCAGTACAC
CTTTGCCACCGCCATTTCCGCGGGAAACGACAGCGCCGCTGCCGTCGCCCGGCGCGCGGTGAGCGGGGACGCCGCGGCTG
TCGCCCGTTTTGAGGGGGCTGGCCGCTACTTGGGCATCGCCGTGGCCGGGGTGCTCAACCTGCTGAACCTGGAAGCGGTA
GTGCTGGGAGGAGGGGTGTCAGAGAGTTTCGAGCTACTGGCCCCGGCGATGCGCCGGGAGATATGCTCCCGCACCCTTGC
GCTTCCCGGGGCGGCCGCCTGCGTCGTCAAGGGCGCCCTCGGCCCGGACGCCGGTGTCCTGGGTGCTGCCCAAGCCGCCT
TCGACGCCGAAAAAATTTCCTCGCGCTCCCACCTTTCCTGA

Upstream 100 bases:

>100_bases
ACTTCATGACTGTGGTAGCGGACGTCAGGGTGATCCCGGAGGCGCTTTTGGCGACTTACGACCGGCTGCTACCGTTTTTC
CAGGCGGCAGTGGAGGGGTG

Downstream 100 bases:

>100_bases
AACATATGCTATAGTTGCCGCTGGCTCGGCCAGCAATTTTAATTAACTAGAATGGAGGCCTTATGTGGTTTACTCGGAGA
ATCCTGGCAGCTTGTTTGTC

Product: ROK domain transcriptional regulator/sugar kinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MESVCIGVDVGGTNLRFALVDQGGAVLSRVSEPTETVTAPAPFVARLQGRVQQLQREALARGVRVAGVGIGVAGLVSGEG
AVLSSVNLPALQGVNLGAELSRALGVPVLVLNDANACAVGEQRFGAGKGYRSWLMLTIGTGVGAGLILDGRLWTGANGLA
GELGHLTVEPEGRPCGCGNRGCLEQYTFATAISAGNDSAAAVARRAVSGDAAAVARFEGAGRYLGIAVAGVLNLLNLEAV
VLGGGVSESFELLAPAMRREICSRTLALPGAAACVVKGALGPDAGVLGAAQAAFDAEKISSRSHLS

Sequences:

>Translated_306_residues
MESVCIGVDVGGTNLRFALVDQGGAVLSRVSEPTETVTAPAPFVARLQGRVQQLQREALARGVRVAGVGIGVAGLVSGEG
AVLSSVNLPALQGVNLGAELSRALGVPVLVLNDANACAVGEQRFGAGKGYRSWLMLTIGTGVGAGLILDGRLWTGANGLA
GELGHLTVEPEGRPCGCGNRGCLEQYTFATAISAGNDSAAAVARRAVSGDAAAVARFEGAGRYLGIAVAGVLNLLNLEAV
VLGGGVSESFELLAPAMRREICSRTLALPGAAACVVKGALGPDAGVLGAAQAAFDAEKISSRSHLS
>Mature_306_residues
MESVCIGVDVGGTNLRFALVDQGGAVLSRVSEPTETVTAPAPFVARLQGRVQQLQREALARGVRVAGVGIGVAGLVSGEG
AVLSSVNLPALQGVNLGAELSRALGVPVLVLNDANACAVGEQRFGAGKGYRSWLMLTIGTGVGAGLILDGRLWTGANGLA
GELGHLTVEPEGRPCGCGNRGCLEQYTFATAISAGNDSAAAVARRAVSGDAAAVARFEGAGRYLGIAVAGVLNLLNLEAV
VLGGGVSESFELLAPAMRREICSRTLALPGAAACVVKGALGPDAGVLGAAQAAFDAEKISSRSHLS

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=282, Percent_Identity=32.2695035460993, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4885285, Length=282, Percent_Identity=32.2695035460993, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI190014632, Length=282, Percent_Identity=32.2695035460993, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI298566325, Length=282, Percent_Identity=32.2695035460993, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1786891, Length=282, Percent_Identity=28.7234042553192, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787878, Length=275, Percent_Identity=26.1818181818182, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787363, Length=309, Percent_Identity=30.7443365695793, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790522, Length=271, Percent_Identity=31.7343173431734, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081733, Length=306, Percent_Identity=30.3921568627451, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082230, Length=248, Percent_Identity=31.8548387096774, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 30652; Mature: 30652

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVCIGVDVGGTNLRFALVDQGGAVLSRVSEPTETVTAPAPFVARLQGRVQQLQREALA
CCCEEEEEEECCCCEEEEEEECCCHHHHHCCCCCHHEECCCHHHHHHHHHHHHHHHHHHH
RGVRVAGVGIGVAGLVSGEGAVLSSVNLPALQGVNLGAELSRALGVPVLVLNDANACAVG
CCEEEEEECCCEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCEEEC
EQRFGAGKGYRSWLMLTIGTGVGAGLILDGRLWTGANGLAGELGHLTVEPEGRPCGCGNR
HHHCCCCCCCCEEEEEEECCCCCCCEEECCEEEECCCCCCCCCCEEEECCCCCCCCCCCC
GCLEQYTFATAISAGNDSAAAVARRAVSGDAAAVARFEGAGRYLGIAVAGVLNLLNLEAV
CHHHHHHHHHEEECCCCHHHHHHHHHHCCCHHHHEEECCCCCCHHHHHHHHHHHHHHEEE
VLGGGVSESFELLAPAMRREICSRTLALPGAAACVVKGALGPDAGVLGAAQAAFDAEKIS
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHC
SRSHLS
CCCCCC
>Mature Secondary Structure
MESVCIGVDVGGTNLRFALVDQGGAVLSRVSEPTETVTAPAPFVARLQGRVQQLQREALA
CCCEEEEEEECCCCEEEEEEECCCHHHHHCCCCCHHEECCCHHHHHHHHHHHHHHHHHHH
RGVRVAGVGIGVAGLVSGEGAVLSSVNLPALQGVNLGAELSRALGVPVLVLNDANACAVG
CCEEEEEECCCEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCEEEC
EQRFGAGKGYRSWLMLTIGTGVGAGLILDGRLWTGANGLAGELGHLTVEPEGRPCGCGNR
HHHCCCCCCCCEEEEEEECCCCCCCEEECCEEEECCCCCCCCCCEEEECCCCCCCCCCCC
GCLEQYTFATAISAGNDSAAAVARRAVSGDAAAVARFEGAGRYLGIAVAGVLNLLNLEAV
CHHHHHHHHHEEECCCCHHHHHHHHHHCCCHHHHEEECCCCCCHHHHHHHHHHHHHHEEE
VLGGGVSESFELLAPAMRREICSRTLALPGAAACVVKGALGPDAGVLGAAQAAFDAEKIS
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHC
SRSHLS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]