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The map label for this gene is maeB-1 [H]

Identifier: 197117712

GI number: 197117712

Start: 1526938

End: 1529187

Strand: Reverse

Name: maeB-1 [H]

Synonym: Gbem_1324

Alternate gene names: 197117712

Gene position: 1529187-1526938 (Counterclockwise)

Preceding gene: 197117716

Following gene: 197117711

Centisome position: 33.13

GC content: 62.04

Gene sequence:

>2250_bases
ATGACAAAGAAAATGGACGCTCTCGAATACCATGCAACCGGGCGCAAGGGGAAGATCGAGGTCATCTCCTCCAAGCCGTG
TCTTACCTCCCGCGACCTCTCGCTTGCTTACACCCCGGGTGTCGCCGAACCGTGCCTTGCCATCGAGCAGGATCCCGAGC
TCGCCTACCAGTACACGGCGAAGGGGAACCTGGTCGCAGTAGTCTCCAACGGCACGGCGGTCCTGGGGCTGGGGAACATC
GGGGCCATCGCCGGCAAGCCGGTCATGGAGGGGAAAGGGGTCCTCTTCAAGCGCTTCGCCGACCTGGACGTCTTCGATCT
GGAGGTGAAGTCGGAGAACCCGGACGACGTGATCAAGGTGGTGCAGCTGCTGGAGCCCACCTTCGGCGGCATCAACCTCG
AGGACATCAAGGCGCCGGAGTGTTTCTACATCGAGGAGGAACTGAAGAAGACCATGAACATCCCGGTCTTCCACGACGAC
CAGCACGGAACGGCCATCATCTGTTCGGCGGCGCTCATCAACGCGTTGTCACTGGTCGGCAAGAAGATCGAGCAGGCAAG
AATCGTGATCAACGGCGCCGGCGCCGCCGGGGTCGCCTGCGCGAACCTCATCCTCTCCCTGGGAGCAAGAGCGAAAAACC
TTTTCATGTGCGACACCAAGGGGGTGATCTACAAGGGGAGAGCCGAGGGGATGAACCCTTACAAGGAGCGCCTGGCAAAC
GACACGCCGCTGCGCACGCTCGAAGAGGCGATGCGCGGGGCCGACGTCTTCATCGGGGTCTCCGCCAAAGGCGCCGTCAC
CCAGCAGATGGTGCGCGAGATGGCCAAGGACCCGGTGATCATGGCCATGGCCAATCCCCACCCGGAGATCACTCCGGAGG
AGGTGCTCTCGGTCCGCTCCGACGTCATCATGGCGACAGGCAGGTCGGACTACCCGAACCAGGTGAACAACGTGCTCGGC
TTCCCCTTCATCTTCCGGGGCGCGCTCGACGTCAGGGCCAGCACCATCAACGAGGAGATGAAGAAAGCCGCGGTTTTAGC
CCTGGCGGAACTGGCGCGGGAGGATTGCCCCGACTCGGTCTGCCGCGCCTACGGCAACGAGAGCTTCACCTTCGGGAGAA
ACTACATCATCCCCAAACCGTTCGACCCGCGCGCGCTTTTGCGGGTGGCCCCGGCGGTGGCCCAGGCGGCCATGGATTCG
GGGGTCGCCCGCATGCCGATCGAGGAGATGGCCAAGTACACCGAGTGGCTCGAAGCGCTGCAGGGGCGCGCCAAGGAGAC
CATGCGCCAGATCATCAACAAGGCGAAGTGCGACCCCAAGAAGATCGTCTTCCCGGAAGGGGACAACGAGAAGATCCTGA
GGGCGGCCTACGCGCTGATAGAGGAGGGGATCGCCCATCCCATCCTGATCGGGAACAAGGCCAAGGTGCAGGAGAAGATA
GCCGAGCTGGGGATGGAGCTTAACGCCACCGTAGTCGATCCCGAGACCTCGGAACTGACTGAAGGGTACGCCGCGGAGCT
TTACAGGAAACGCCAGCGCAAGGGGGTGACCCTCTCGGAGGCGCGCCGCATCATGCGCCGCAAGTCCAGGAACCATTTCG
GATCCATGATGGTGCACATGGGGGACGCGGATACCCTCCTCTCCGGCATCGACTCGCACTACCCCGACACCATCAGGCCG
GCGCTGGAGATCATCGGCAGGCAACCGCAGCTCTCCGGCGTGCACGGCATGTACATGATGGTCTTTAAAAAGGGGATCTA
TTTCCTCGCCGACACCACGGTGGAGATCGACCCGACAGCCGAGGAGCTGGCCGAAACCGCCCTCCTTGCGGCGGAAAAGG
TGAAGCTTCTCGACATCGTTCCCCGTATCGCCATGCTCTCCTTTGCCAACTTCGGGTCGGTGAACCACGACCTCACGGTA
AAGGTGAAAAGGGCGGTGGAGATCGTCAAGCAGAAGGCGCCGGAGCTTGAGATCGACGGGGAGATGCAGGCGGACACGGC
GGTGACCCCGGAGCTTCTGGAAAACTACACCTTCTCCACCCTCACCGGTCCCGCGAACATACTGATCTTCCCGGACCTCA
ACTCCGGTAACATCAGCTATAAGCTTTTGCACCGGCTGGGCGGGGCCGAAGCGATCGGGCCGCTTTTGATGGGAATGAAA
AAGCCGGTCCATGTGCTGCAAAGAGGGGACGATGTCTCCACCATCGTGAACATGGCGGCGATAGCCGTGGTCGACGCCCA
GAACCTGTAG

Upstream 100 bases:

>100_bases
ACCTCGTCTTAACAACCCGGACCGGAACAATGACAGATAGTACTTGTTTGGTCAATGAGCTGATAGCTCCAGGAGGGTAA
TTTATCTTGAGGAGGTAGCA

Downstream 100 bases:

>100_bases
CGGGACGGGGTACCCTGCGCCGCCCATCCCTCGCTGGACATCCCATCACCATAAAGGAAAGGGGCACCGTGAATACGGAG
CCCCTTTCTTAGTCGCGCAA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MTKKMDALEYHATGRKGKIEVISSKPCLTSRDLSLAYTPGVAEPCLAIEQDPELAYQYTAKGNLVAVVSNGTAVLGLGNI
GAIAGKPVMEGKGVLFKRFADLDVFDLEVKSENPDDVIKVVQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDD
QHGTAIICSAALINALSLVGKKIEQARIVINGAGAAGVACANLILSLGARAKNLFMCDTKGVIYKGRAEGMNPYKERLAN
DTPLRTLEEAMRGADVFIGVSAKGAVTQQMVREMAKDPVIMAMANPHPEITPEEVLSVRSDVIMATGRSDYPNQVNNVLG
FPFIFRGALDVRASTINEEMKKAAVLALAELAREDCPDSVCRAYGNESFTFGRNYIIPKPFDPRALLRVAPAVAQAAMDS
GVARMPIEEMAKYTEWLEALQGRAKETMRQIINKAKCDPKKIVFPEGDNEKILRAAYALIEEGIAHPILIGNKAKVQEKI
AELGMELNATVVDPETSELTEGYAAELYRKRQRKGVTLSEARRIMRRKSRNHFGSMMVHMGDADTLLSGIDSHYPDTIRP
ALEIIGRQPQLSGVHGMYMMVFKKGIYFLADTTVEIDPTAEELAETALLAAEKVKLLDIVPRIAMLSFANFGSVNHDLTV
KVKRAVEIVKQKAPELEIDGEMQADTAVTPELLENYTFSTLTGPANILIFPDLNSGNISYKLLHRLGGAEAIGPLLMGMK
KPVHVLQRGDDVSTIVNMAAIAVVDAQNL

Sequences:

>Translated_749_residues
MTKKMDALEYHATGRKGKIEVISSKPCLTSRDLSLAYTPGVAEPCLAIEQDPELAYQYTAKGNLVAVVSNGTAVLGLGNI
GAIAGKPVMEGKGVLFKRFADLDVFDLEVKSENPDDVIKVVQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDD
QHGTAIICSAALINALSLVGKKIEQARIVINGAGAAGVACANLILSLGARAKNLFMCDTKGVIYKGRAEGMNPYKERLAN
DTPLRTLEEAMRGADVFIGVSAKGAVTQQMVREMAKDPVIMAMANPHPEITPEEVLSVRSDVIMATGRSDYPNQVNNVLG
FPFIFRGALDVRASTINEEMKKAAVLALAELAREDCPDSVCRAYGNESFTFGRNYIIPKPFDPRALLRVAPAVAQAAMDS
GVARMPIEEMAKYTEWLEALQGRAKETMRQIINKAKCDPKKIVFPEGDNEKILRAAYALIEEGIAHPILIGNKAKVQEKI
AELGMELNATVVDPETSELTEGYAAELYRKRQRKGVTLSEARRIMRRKSRNHFGSMMVHMGDADTLLSGIDSHYPDTIRP
ALEIIGRQPQLSGVHGMYMMVFKKGIYFLADTTVEIDPTAEELAETALLAAEKVKLLDIVPRIAMLSFANFGSVNHDLTV
KVKRAVEIVKQKAPELEIDGEMQADTAVTPELLENYTFSTLTGPANILIFPDLNSGNISYKLLHRLGGAEAIGPLLMGMK
KPVHVLQRGDDVSTIVNMAAIAVVDAQNL
>Mature_748_residues
TKKMDALEYHATGRKGKIEVISSKPCLTSRDLSLAYTPGVAEPCLAIEQDPELAYQYTAKGNLVAVVSNGTAVLGLGNIG
AIAGKPVMEGKGVLFKRFADLDVFDLEVKSENPDDVIKVVQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDDQ
HGTAIICSAALINALSLVGKKIEQARIVINGAGAAGVACANLILSLGARAKNLFMCDTKGVIYKGRAEGMNPYKERLAND
TPLRTLEEAMRGADVFIGVSAKGAVTQQMVREMAKDPVIMAMANPHPEITPEEVLSVRSDVIMATGRSDYPNQVNNVLGF
PFIFRGALDVRASTINEEMKKAAVLALAELAREDCPDSVCRAYGNESFTFGRNYIIPKPFDPRALLRVAPAVAQAAMDSG
VARMPIEEMAKYTEWLEALQGRAKETMRQIINKAKCDPKKIVFPEGDNEKILRAAYALIEEGIAHPILIGNKAKVQEKIA
ELGMELNATVVDPETSELTEGYAAELYRKRQRKGVTLSEARRIMRRKSRNHFGSMMVHMGDADTLLSGIDSHYPDTIRPA
LEIIGRQPQLSGVHGMYMMVFKKGIYFLADTTVEIDPTAEELAETALLAAEKVKLLDIVPRIAMLSFANFGSVNHDLTVK
VKRAVEIVKQKAPELEIDGEMQADTAVTPELLENYTFSTLTGPANILIFPDLNSGNISYKLLHRLGGAEAIGPLLMGMKK
PVHVLQRGDDVSTIVNMAAIAVVDAQNL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=399, Percent_Identity=26.8170426065163, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI62420880, Length=399, Percent_Identity=26.8170426065163, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI239049447, Length=399, Percent_Identity=26.8170426065163, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4505143, Length=344, Percent_Identity=27.6162790697674, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4505145, Length=318, Percent_Identity=27.6729559748428, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI270265879, Length=318, Percent_Identity=27.6729559748428, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1788806, Length=754, Percent_Identity=50.3978779840849, Blast_Score=727, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=356, Percent_Identity=34.8314606741573, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1788800, Length=316, Percent_Identity=34.8101265822785, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87081919, Length=233, Percent_Identity=28.755364806867, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17537199, Length=415, Percent_Identity=22.6506024096386, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=269, Percent_Identity=28.6245353159851, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646388, Length=406, Percent_Identity=27.8325123152709, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646386, Length=406, Percent_Identity=27.8325123152709, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI78707242, Length=399, Percent_Identity=25.31328320802, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI78707238, Length=399, Percent_Identity=25.31328320802, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356279, Length=463, Percent_Identity=25.0539956803456, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362672, Length=463, Percent_Identity=25.0539956803456, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362674, Length=463, Percent_Identity=25.0539956803456, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78707240, Length=409, Percent_Identity=24.6943765281174, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281363503, Length=352, Percent_Identity=23.8636363636364, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281363505, Length=352, Percent_Identity=23.8636363636364, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78707236, Length=352, Percent_Identity=23.8636363636364, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78707232, Length=352, Percent_Identity=23.8636363636364, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81697; Mature: 81566

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKMDALEYHATGRKGKIEVISSKPCLTSRDLSLAYTPGVAEPCLAIEQDPELAYQYTA
CCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEC
KGNLVAVVSNGTAVLGLGNIGAIAGKPVMEGKGVLFKRFADLDVFDLEVKSENPDDVIKV
CCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHH
VQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDDQHGTAIICSAALINALSLVG
HHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHH
KKIEQARIVINGAGAAGVACANLILSLGARAKNLFMCDTKGVIYKGRAEGMNPYKERLAN
HHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCHHHHHHCC
DTPLRTLEEAMRGADVFIGVSAKGAVTQQMVREMAKDPVIMAMANPHPEITPEEVLSVRS
CCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHH
DVIMATGRSDYPNQVNNVLGFPFIFRGALDVRASTINEEMKKAAVLALAELAREDCPDSV
CEEEECCCCCCCHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
CRAYGNESFTFGRNYIIPKPFDPRALLRVAPAVAQAAMDSGVARMPIEEMAKYTEWLEAL
HHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QGRAKETMRQIINKAKCDPKKIVFPEGDNEKILRAAYALIEEGIAHPILIGNKAKVQEKI
HHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
AELGMELNATVVDPETSELTEGYAAELYRKRQRKGVTLSEARRIMRRKSRNHFGSMMVHM
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEE
GDADTLLSGIDSHYPDTIRPALEIIGRQPQLSGVHGMYMMVFKKGIYFLADTTVEIDPTA
CCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEECEEEECCCH
EELAETALLAAEKVKLLDIVPRIAMLSFANFGSVNHDLTVKVKRAVEIVKQKAPELEIDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCEECC
EMQADTAVTPELLENYTFSTLTGPANILIFPDLNSGNISYKLLHRLGGAEAIGPLLMGMK
CCCCCCCCCHHHHHCCCCEEECCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCC
KPVHVLQRGDDVSTIVNMAAIAVVDAQNL
CHHHHHHCCCHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure 
TKKMDALEYHATGRKGKIEVISSKPCLTSRDLSLAYTPGVAEPCLAIEQDPELAYQYTA
CCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEC
KGNLVAVVSNGTAVLGLGNIGAIAGKPVMEGKGVLFKRFADLDVFDLEVKSENPDDVIKV
CCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHH
VQLLEPTFGGINLEDIKAPECFYIEEELKKTMNIPVFHDDQHGTAIICSAALINALSLVG
HHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHH
KKIEQARIVINGAGAAGVACANLILSLGARAKNLFMCDTKGVIYKGRAEGMNPYKERLAN
HHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCHHHHHHCC
DTPLRTLEEAMRGADVFIGVSAKGAVTQQMVREMAKDPVIMAMANPHPEITPEEVLSVRS
CCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHH
DVIMATGRSDYPNQVNNVLGFPFIFRGALDVRASTINEEMKKAAVLALAELAREDCPDSV
CEEEECCCCCCCHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
CRAYGNESFTFGRNYIIPKPFDPRALLRVAPAVAQAAMDSGVARMPIEEMAKYTEWLEAL
HHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QGRAKETMRQIINKAKCDPKKIVFPEGDNEKILRAAYALIEEGIAHPILIGNKAKVQEKI
HHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
AELGMELNATVVDPETSELTEGYAAELYRKRQRKGVTLSEARRIMRRKSRNHFGSMMVHM
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEE
GDADTLLSGIDSHYPDTIRPALEIIGRQPQLSGVHGMYMMVFKKGIYFLADTTVEIDPTA
CCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEECEEEECCCH
EELAETALLAAEKVKLLDIVPRIAMLSFANFGSVNHDLTVKVKRAVEIVKQKAPELEIDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCEECC
EMQADTAVTPELLENYTFSTLTGPANILIFPDLNSGNISYKLLHRLGGAEAIGPLLMGMK
CCCCCCCCCHHHHHCCCCEEECCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCC
KPVHVLQRGDDVSTIVNMAAIAVVDAQNL
CHHHHHHCCCHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]