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The map label for this gene is copA [H]

Identifier: 197117619

GI number: 197117619

Start: 1426941

End: 1429361

Strand: Reverse

Name: copA [H]

Synonym: Gbem_1231

Alternate gene names: 197117619

Gene position: 1429361-1426941 (Counterclockwise)

Preceding gene: 197117620

Following gene: 197117618

Centisome position: 30.97

GC content: 66.71

Gene sequence:

>2421_bases
TTGACGGCCGCCCAATTCCCATGCTTTCACTGCGGAGCCGAGATCCCCGCCGGGGCGCTGGTGGAGGAGCGCGCGGACGA
CGCTACCTTGAGCTTTTGCTGCCACGGCTGCCACGGCGCCTACCTCGTCATCAACGGGGCCGGGCTCGCGGACTTCTACC
GGCGCAGGGAGTGGCGGGAGAGTGGCCTTTCCCCGCAGGCCTTCCAGGGGAAGTACCAGGAGAGCTACCTCGCCCGCTTC
GTCTACCAAGCCGGCGCTGCGAGTGCCATCGACATCATCATCGACGGCATCCGCTGCGCCTCCTGCGTCTGGCTCAACGA
AAAAATCATCGGGAGGATCGCCGGAGTACAAGAAGTCCGCGTCAACTACGCCACCGGAAGGGCGCGCGTACTTTTCGACG
GCTCGCGCACCTCGCCGGCGCAGATCTTCTCCAGGATCGACGAGTTGGGCTACCTCCCCCGCCCCTACACCCGCAACGCA
GCTAAAGAAGTGGCGCTGAACGAGCACAAGGATCTCCTCTTTCGTTTCGGCACCGCGGCCTTTCTCTCCATGCAGCTCAT
GGCCTATGCCTTCGCCCTTTACGCCGGCTACTTCCTGGGCATCGACGAGCAGATGAAGAATTACCTGCAGCTCTTCTCGT
GGCTGGTGACGACGCCGGTGGTCTTTTACTGCGGCTGGCCCTTTCTTCGCGGCGCCTGGCGCGGCATCGTCAACGGCTCC
CCCAACATGGAACTCCTCATCGCCACAGGCGCCCTCTCCTCGTACGGCTACAGCGTCTATGCGACCTTCGCCGGCGAGGA
GGTGTACTTCGAGACCGCGGCGATGATCGTCACCCTGATCCTCATAGGGAGGCTCCTGGAAAATGCCGCCAAAAGGAGGG
CCTCCAGCGGGATCGAGAGGCTCATGGAACTTTGCTCCGGTGAAGCGCAACGCTTCAAGGGAGACGAGCTGGAGCCGGTC
GACCCCTCCCTTCTACGTCCGGGCGACCTGATCCTGGTTTCCCCGGGGGAACGCTTCCCCGTTGACGGCACCATAGCCGA
AGAGGCCACGGACGTCGACGAGTCCGCCGCGACCGGCGAGCCGCTCCCCCTTTACAAGCAGGCGGGAGACCAGGTGATTG
CGGGAAGCTGCAACCTGACCGGAGCCGTCCGGGTGCGCTGCGACAGGGAGGTGGAGGAAAGCTTCATCGCCCGCGTGGCG
CGCCTGGTGGAGCAGGCGCAGAGCCGCCGCGCGCCGATCCAGCGCCTGGCGGACCGGATCAGCGGTTATTTCGTACCCGC
TGTCCTCACCCTCGCCGTCGCCACCTTCTGCTGGCACTACTCGGTGGGTGGGGAGTTCGGCCCCAGCCTCATGACCGCCT
TGGCCGTCGTCGTCATCGCCTGCCCCTGCGCCCTTGGCCTCGCGACTCCCACGGCCATCCTCGCCGGGACCGGCGCCGCC
GCCTCCGCCGGGGTTATTTTCAAAGGGGGGGACATCCTGGAGCGGCTGAGCCGGGTCACCGTCGCCGTCTTCGACAAGAC
CGGCACCCTCACCTGCGGGACTCCCATGCTGGTTGACGTTCAGCCGGCGCAGGGACTTTCCCGCGGCGAGGTCCTGGCGC
TCGCCGCTGCGGTGGAGCGGGGCTCGCTGCACCCCATCGCGAAAGCGGTGCGCGAGTACGCCGAGGCAAACGGCATCGCC
TACCCGGTGGGAGAGGAGCTGGTGAGTCTCGCCGGCGGCGGGGTCACCGGCAGGGTCGCCGGGGAAGCGGTCGCCGTCGG
CAGCATCTGTTTCCTGAAGCGGACCGGCGCCAGCGGCGTCCCCGAACGGGTCGAGTCGCCGGAGGGGGGGATCGTGGTAG
GGGTTGCGCGCAGGGGGCGTTACTGCGGCGCGCTGGTGTTGAAGGACCGGATCCGGGAGGATGCGCCGGGGCTCGTTTCC
TACTTCAAGAGGGGGGGGATCGGGACGCTTCTATTCAGCGGCGACCGGCAGGAGTGCACCGAAAAAGCGGCGCTGGCCGC
CGGGATAGATAAGGCTTGGGGGGAGCTTTCCCCGGCGGAAAAGGCGGCGAAGATCGAGAGGTTGCGCGAGGAAGGGGGAA
CCGTCCTTATGGTGGGCGACGGCATCAACGACGCCCCGGCGCTTTCGGCTGCCGACGTCGGCTGCGCAGTCGCGGGGGGG
ACCGACATCGCCATGGAGACCTCCGACCTGGTGCTCGCCAAGCCCGACCTGGAGCGGCTGGCCGAGGCCCACCGGATGGC
GCGGCGCACCATGGCCGTAGTGCGGCAGAATCTGGCCTGGGCTTTTCTCTACAACGTGGTCGGCGTCCCGTTGGCCATGA
CCGGGCGGCTGACGCCGGTGTATGCTGCAGCTGCCATGGCGCTCAGTTCGATTTGCGTGGTCGGCAACTCGCTCAAACTT
ATGAGGACAAGAAATGGCTAG

Upstream 100 bases:

>100_bases
TCCGGACTTCGTTGCCGGTATCCGCCCAGAGTGAGCTTCAGGGGGTGCTCCTCTTCACCAGGGGCGAGGCCAGCGCGAGC
CAAAGGGTGGTGTTCTTCAA

Downstream 100 bases:

>100_bases
CTCACTTATCGCCTTGATGGGGCTGTCGCTTTTTCTCGGATGCGCATGCTGGCTCGTCTTTCTCTGGGCGGTGCGGCGCG
GGGAATTCCACGACATGGAG

Product: heavy metal-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MTAAQFPCFHCGAEIPAGALVEERADDATLSFCCHGCHGAYLVINGAGLADFYRRREWRESGLSPQAFQGKYQESYLARF
VYQAGAASAIDIIIDGIRCASCVWLNEKIIGRIAGVQEVRVNYATGRARVLFDGSRTSPAQIFSRIDELGYLPRPYTRNA
AKEVALNEHKDLLFRFGTAAFLSMQLMAYAFALYAGYFLGIDEQMKNYLQLFSWLVTTPVVFYCGWPFLRGAWRGIVNGS
PNMELLIATGALSSYGYSVYATFAGEEVYFETAAMIVTLILIGRLLENAAKRRASSGIERLMELCSGEAQRFKGDELEPV
DPSLLRPGDLILVSPGERFPVDGTIAEEATDVDESAATGEPLPLYKQAGDQVIAGSCNLTGAVRVRCDREVEESFIARVA
RLVEQAQSRRAPIQRLADRISGYFVPAVLTLAVATFCWHYSVGGEFGPSLMTALAVVVIACPCALGLATPTAILAGTGAA
ASAGVIFKGGDILERLSRVTVAVFDKTGTLTCGTPMLVDVQPAQGLSRGEVLALAAAVERGSLHPIAKAVREYAEANGIA
YPVGEELVSLAGGGVTGRVAGEAVAVGSICFLKRTGASGVPERVESPEGGIVVGVARRGRYCGALVLKDRIREDAPGLVS
YFKRGGIGTLLFSGDRQECTEKAALAAGIDKAWGELSPAEKAAKIERLREEGGTVLMVGDGINDAPALSAADVGCAVAGG
TDIAMETSDLVLAKPDLERLAEAHRMARRTMAVVRQNLAWAFLYNVVGVPLAMTGRLTPVYAAAAMALSSICVVGNSLKL
MRTRNG

Sequences:

>Translated_806_residues
MTAAQFPCFHCGAEIPAGALVEERADDATLSFCCHGCHGAYLVINGAGLADFYRRREWRESGLSPQAFQGKYQESYLARF
VYQAGAASAIDIIIDGIRCASCVWLNEKIIGRIAGVQEVRVNYATGRARVLFDGSRTSPAQIFSRIDELGYLPRPYTRNA
AKEVALNEHKDLLFRFGTAAFLSMQLMAYAFALYAGYFLGIDEQMKNYLQLFSWLVTTPVVFYCGWPFLRGAWRGIVNGS
PNMELLIATGALSSYGYSVYATFAGEEVYFETAAMIVTLILIGRLLENAAKRRASSGIERLMELCSGEAQRFKGDELEPV
DPSLLRPGDLILVSPGERFPVDGTIAEEATDVDESAATGEPLPLYKQAGDQVIAGSCNLTGAVRVRCDREVEESFIARVA
RLVEQAQSRRAPIQRLADRISGYFVPAVLTLAVATFCWHYSVGGEFGPSLMTALAVVVIACPCALGLATPTAILAGTGAA
ASAGVIFKGGDILERLSRVTVAVFDKTGTLTCGTPMLVDVQPAQGLSRGEVLALAAAVERGSLHPIAKAVREYAEANGIA
YPVGEELVSLAGGGVTGRVAGEAVAVGSICFLKRTGASGVPERVESPEGGIVVGVARRGRYCGALVLKDRIREDAPGLVS
YFKRGGIGTLLFSGDRQECTEKAALAAGIDKAWGELSPAEKAAKIERLREEGGTVLMVGDGINDAPALSAADVGCAVAGG
TDIAMETSDLVLAKPDLERLAEAHRMARRTMAVVRQNLAWAFLYNVVGVPLAMTGRLTPVYAAAAMALSSICVVGNSLKL
MRTRNG
>Mature_805_residues
TAAQFPCFHCGAEIPAGALVEERADDATLSFCCHGCHGAYLVINGAGLADFYRRREWRESGLSPQAFQGKYQESYLARFV
YQAGAASAIDIIIDGIRCASCVWLNEKIIGRIAGVQEVRVNYATGRARVLFDGSRTSPAQIFSRIDELGYLPRPYTRNAA
KEVALNEHKDLLFRFGTAAFLSMQLMAYAFALYAGYFLGIDEQMKNYLQLFSWLVTTPVVFYCGWPFLRGAWRGIVNGSP
NMELLIATGALSSYGYSVYATFAGEEVYFETAAMIVTLILIGRLLENAAKRRASSGIERLMELCSGEAQRFKGDELEPVD
PSLLRPGDLILVSPGERFPVDGTIAEEATDVDESAATGEPLPLYKQAGDQVIAGSCNLTGAVRVRCDREVEESFIARVAR
LVEQAQSRRAPIQRLADRISGYFVPAVLTLAVATFCWHYSVGGEFGPSLMTALAVVVIACPCALGLATPTAILAGTGAAA
SAGVIFKGGDILERLSRVTVAVFDKTGTLTCGTPMLVDVQPAQGLSRGEVLALAAAVERGSLHPIAKAVREYAEANGIAY
PVGEELVSLAGGGVTGRVAGEAVAVGSICFLKRTGASGVPERVESPEGGIVVGVARRGRYCGALVLKDRIREDAPGLVSY
FKRGGIGTLLFSGDRQECTEKAALAAGIDKAWGELSPAEKAAKIERLREEGGTVLMVGDGINDAPALSAADVGCAVAGGT
DIAMETSDLVLAKPDLERLAEAHRMARRTMAVVRQNLAWAFLYNVVGVPLAMTGRLTPVYAAAAMALSSICVVGNSLKLM
RTRNG

Specific function: Involved in copper export [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=806, Percent_Identity=31.1414392059553, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI55743073, Length=533, Percent_Identity=31.7073170731707, Blast_Score=259, Evalue=8e-69,
Organism=Homo sapiens, GI115529486, Length=534, Percent_Identity=30.3370786516854, Blast_Score=259, Evalue=8e-69,
Organism=Escherichia coli, GI1786691, Length=744, Percent_Identity=35.0806451612903, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1789879, Length=716, Percent_Identity=34.0782122905028, Blast_Score=323, Evalue=3e-89,
Organism=Escherichia coli, GI1786914, Length=454, Percent_Identity=28.8546255506608, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI2367363, Length=587, Percent_Identity=23.8500851788756, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17556548, Length=803, Percent_Identity=30.1369863013699, Blast_Score=311, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6320475, Length=632, Percent_Identity=32.753164556962, Blast_Score=308, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6319772, Length=591, Percent_Identity=29.2724196277496, Blast_Score=250, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6325221, Length=540, Percent_Identity=26.1111111111111, Blast_Score=118, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321430, Length=541, Percent_Identity=26.0628465804067, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI221329854, Length=521, Percent_Identity=33.0134357005758, Blast_Score=239, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 85889; Mature: 85757

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAQFPCFHCGAEIPAGALVEERADDATLSFCCHGCHGAYLVINGAGLADFYRRREWRE
CCCCCCCHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHH
SGLSPQAFQGKYQESYLARFVYQAGAASAIDIIIDGIRCASCVWLNEKIIGRIAGVQEVR
CCCCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHEEEECHHHHHHHCCHHHHE
VNYATGRARVLFDGSRTSPAQIFSRIDELGYLPRPYTRNAAKEVALNEHKDLLFRFGTAA
EEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLSMQLMAYAFALYAGYFLGIDEQMKNYLQLFSWLVTTPVVFYCGWPFLRGAWRGIVNGS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
PNMELLIATGALSSYGYSVYATFAGEEVYFETAAMIVTLILIGRLLENAAKRRASSGIER
CCEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMELCSGEAQRFKGDELEPVDPSLLRPGDLILVSPGERFPVDGTIAEEATDVDESAATGE
HHHHHCCCHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCC
PLPLYKQAGDQVIAGSCNLTGAVRVRCDREVEESFIARVARLVEQAQSRRAPIQRLADRI
CCCHHHHCCCEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SGYFVPAVLTLAVATFCWHYSVGGEFGPSLMTALAVVVIACPCALGLATPTAILAGTGAA
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCC
ASAGVIFKGGDILERLSRVTVAVFDKTGTLTCGTPMLVDVQPAQGLSRGEVLALAAAVER
CCCCEEEECHHHHHHHHHHEEEEEECCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHHC
GSLHPIAKAVREYAEANGIAYPVGEELVSLAGGGVTGRVAGEAVAVGSICFLKRTGASGV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHEEEEEECCCCCC
PERVESPEGGIVVGVARRGRYCGALVLKDRIREDAPGLVSYFKRGGIGTLLFSGDRQECT
CHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHH
EKAALAAGIDKAWGELSPAEKAAKIERLREEGGTVLMVGDGINDAPALSAADVGCAVAGG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEECC
TDIAMETSDLVLAKPDLERLAEAHRMARRTMAVVRQNLAWAFLYNVVGVPLAMTGRLTPV
CCEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHH
YAAAAMALSSICVVGNSLKLMRTRNG
HHHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
TAAQFPCFHCGAEIPAGALVEERADDATLSFCCHGCHGAYLVINGAGLADFYRRREWRE
CCCCCCHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHH
SGLSPQAFQGKYQESYLARFVYQAGAASAIDIIIDGIRCASCVWLNEKIIGRIAGVQEVR
CCCCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHEEEECHHHHHHHCCHHHHE
VNYATGRARVLFDGSRTSPAQIFSRIDELGYLPRPYTRNAAKEVALNEHKDLLFRFGTAA
EEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLSMQLMAYAFALYAGYFLGIDEQMKNYLQLFSWLVTTPVVFYCGWPFLRGAWRGIVNGS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
PNMELLIATGALSSYGYSVYATFAGEEVYFETAAMIVTLILIGRLLENAAKRRASSGIER
CCEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMELCSGEAQRFKGDELEPVDPSLLRPGDLILVSPGERFPVDGTIAEEATDVDESAATGE
HHHHHCCCHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCC
PLPLYKQAGDQVIAGSCNLTGAVRVRCDREVEESFIARVARLVEQAQSRRAPIQRLADRI
CCCHHHHCCCEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SGYFVPAVLTLAVATFCWHYSVGGEFGPSLMTALAVVVIACPCALGLATPTAILAGTGAA
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCC
ASAGVIFKGGDILERLSRVTVAVFDKTGTLTCGTPMLVDVQPAQGLSRGEVLALAAAVER
CCCCEEEECHHHHHHHHHHEEEEEECCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHHC
GSLHPIAKAVREYAEANGIAYPVGEELVSLAGGGVTGRVAGEAVAVGSICFLKRTGASGV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHEEEEEECCCCCC
PERVESPEGGIVVGVARRGRYCGALVLKDRIREDAPGLVSYFKRGGIGTLLFSGDRQECT
CHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHH
EKAALAAGIDKAWGELSPAEKAAKIERLREEGGTVLMVGDGINDAPALSAADVGCAVAGG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEECC
TDIAMETSDLVLAKPDLERLAEAHRMARRTMAVVRQNLAWAFLYNVVGVPLAMTGRLTPV
CCEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHH
YAAAAMALSSICVVGNSLKLMRTRNG
HHHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA