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The map label for this gene is rpoB

Identifier: 197117316

GI number: 197117316

Start: 1084862

End: 1088977

Strand: Direct

Name: rpoB

Synonym: Gbem_0926

Alternate gene names: 197117316

Gene position: 1084862-1088977 (Clockwise)

Preceding gene: 197117315

Following gene: 197117317

Centisome position: 23.51

GC content: 61.47

Gene sequence:

>4116_bases
ATGGCTTATTCAATCGCGAATAACCCCCTGTTGCGCAAGAACTTCGCCAAGATCCACAAGATCATCGACATACCGAACCT
CATCGACATCCAGAAAAATTCCTACAAGAGATTCCTCCAACTAGACACTCCCGTAGACGCACGCAAAAATTCCGGCCTCG
AAGCCGTTTTCCGCAGCGTCTTCCCGATCAGGGACTTCAGCGACACCGCCTCGCTTGAGTACGTTTCGTATTCGCTCGGC
GCGCCCAAGTACGACGTGGAGGAGTGCCACCAGCGCGGCATGACCTTCGCGGCCCCGATGAAGGTGAAGGTGAGGCTGGT
GGTGTGGGATGTGGCGAAGGACCCCGGTACCAGATCGATCCGCGATATCAAGGAGCAGGAGGTTTATTTCGGCGAAATCC
CGCTGATGACCGACAACGGGACCTTTATCATAAACGGCACCGAGCGCGTCATCGTGAGCCAGCTGCACCGCTCTCCGGGC
GTTTTCTACGACCACGACAAAGGGAAGACCCACTCCAGCGGCAAGGTGCTCTACTCCGCTCGCGTGATTCCGTACCGCGG
CTCGTGGCTTGACTTTGAATTTGACCATAAAGACATCCTTTATGTTCGCATAGACAGACGGCGCAAGATGCCGGCCACCG
TGCTCCTCAAGGCGCTCGGCTACTCCAATGACGCGCTGATCAACTACTTCTACAAGTCCGAAGAGGTAAAGCTCGGCGAC
AACGGCGCCATGACCAAGCTCGCCGACGCTGAGCTTCTCTCGAACCAGAAGGCTACCGCTGACATCGTCGACCCGGCTAC
CGGCGAGGTGATCCTCAAGGCGAACCGCAAGTTCACCAAGGCGGCGCTCAGGAAGATGGCCGAGCACGGGATCAAGGAGA
TCCCCATCTCCGAGGAGGAGGTGGTTGCAAAGGTCGCTTCGCACGACATCTACGACCCGGCTACCGGCGAGATCATCGTG
GAGTGCAACGAGGAGCTCACCCAGGCCAAACTCGAGGAGATCATCCAGAAGGGGATCACCACCTTCCAGGTGCTCTTCAT
CGACAACCTGCACGTCACCTCCAGCTTCCGCGACACCATCCTGATCGACAAGATCGGCTCCACCGACGAGGCGCTGATCG
AGATCTACCGCCGTCTGCGTCCGGGCGACCCGCCGACGCTTAAGAGCGCGCTGGTTCTCTTCGAGAACCTGTTCTTCAAC
GCGGAGCGCTACGACCTCTCCGCCGTCGGCCGCCTGAAGCTCAACTACAAGCTGGGCGTAGACGTGCCGCTTGACTGCAT
GACGCTCACCCGCGAGGACATCCTCGAGGTGGTGCGCTACCTGATCGAGCTGAAAAACGGCAAGGGGAACATCGATGACA
TCGACCACCTGGGCAACCGTCGTGTCCGCGCCGTGGGCGAGCTTTTGGAAAACCAGTACCGCATCGGCCTGGTCAGGATG
GAGCGCGCCATCAAGGAGCGCATGAGCCTGCAGGAAGTCGAGAACCTGATGCCGCACGACCTGATCAACTCCAAGCCGGT
CTCCGCAGTAGTGAAGGAGTTCTTCGGCTCCTCGCAGCTCTCCCAGTTCATGGACCAGACCAACCCGCTCTCCGAGGTCA
CGCACAAGCGCCGTCTCTCGGCTCTGGGACCGGGGGGCCTAACCCGCGAGCGCGCGGGCTTCGAAGTCCGCGACGTACAC
CCGACCCACTACGGCCGCGTCTGCCCGATCGAGACCCCTGAGGGTCCGAACATCGGTCTCATCGCGTCGCTCTCTACCTA
CGCAAGGATCAACGAGCACGGCTTCGTCGAGACGCCGTACCGCGTGGTCAGTGAAGGGAAGGTGACCGACGAGGTCCGCT
TCTTCTCGGCTCTCGAGGAGGAAGGGCACGCCATCGCCCAGGCCAACGCCGAGATCGATAAAGACGGGCGCTTCGCAGCT
GACTACATCTCGGCCAGGAAATCCGGCGAGTTCGTCCTCGTGGGACGCGACGAGCTGGAGCTTATGGACGTGGCCCCGAT
GCAGCTGGTTTCCGTCGCGGCATCGCTGATCCCGTTCCTCGAGAACGACGACGCGAACCGCGCACTGATGGGTTCCAACA
TGCAGCGCCAGGCCGTTCCGCTTCTGCGCGCCGACTCTCCGCTGGTAGGAACCGGGATGGAGCGCGTCGTCGCACGCGAC
TCCGGTGTTTCCTCGGTTGCCCGCCATAACGGGGTGGTGGAGAGCGTCGATGCCTCCCGCATCGTCGTCAAAATCGACGA
GGATCAGTACGACGCGACCGGCACCGGCGTCGACATCTACAACCTGATCAAGTTCGCCCGCTCCAACCAGAACACCTGCA
TCAACCAGAGGCCGGTGGTAAAGGTAGGCGACCACGTGAAGGCTGGCGACATCATCGCCGACGGCCCCTCCACCGACATG
GGCGAGCTGGCTCTGGGGCAGAACGTGCTGATCGCGTTCATGCCGTGGGGCGGCTACAACTACGAGGACTCCATCCTCAT
CTCGGAGCGCCTGGTAAAAGACGACCGCTACACCTCGATCCACATCGAGGAGTTCGAGGCCGTGGCCCGCGACACCAAGC
TCGGCAAGGAGGAGATCACCTCCGACATCCCGAACCTGGGCGAAGAGACCCTGAAGGACCTGGACGAGTCGGGCATCATC
AGGATCGGCGCTGAAGTCCGTCCGGGCGATATCCTGGTCGGCAAGATCACTCCGAAGGGCGAGACCCAGCTCTCCCCGGA
AGAGAAACTCCTGCGCGCCATCTTCGGCGAGAAGGCGGGCGACGTGCGCGACACCTCGCTGCGCGTACCGCCGGGGGTGG
AAGGTACCGTCATCGGTGCCAAGATCTTCTCCCGTAAGGGTGCCGACAAGGACGCCCGTACCGAGATCATCGAGAAGGCC
GAGGAGATGCGGCTTCGGAAAGACGAGCAGGACGAGATCCGGATCATCCGCGATTCGGCTATCGGGAAGCTGAAGAAACT
GCTGGTGGGCAAGGCCGCCGCAGTGAAGATAGAAGGGAGCGACGGCAAGGTGCTGATCCCGAAAGGGGCGGCCATCACCG
AGGAGATGCTGAAATCGTTCTCCATGGACCGCTGGGACGAGATCTCCATCGCCGACGACGACACCATCGACGAGAAAGTG
GCCCAGACGCTCTCCACGCTGAACCAGCAGATCGACATCATCAAGTACGTCTTCGACGACAAGGTGCAGAAGCTGCGCCG
CGGCGACGATCTGCCGCCGGGCGTCATCAAGATGGTCAAGGTCTACATCGCCATCAAGCGTAAGCTCCAGGTGGGCGACA
AGATGGCGGGCCGCCACGGTAACAAGGGTGTCGTTTCCAGGATCCTCCCGGAAGAGGACATGCCGTACATGGAAGACGGC
CGTCCGGTAGAGATCGTGCTGAACCCGCTGGGCGTACCTTCCCGTATGAACGTTGGGCAGATCCTCGAGATGCACCTCGG
CTGGGGCGCCAAGGGGCTCGGCTGGAAGATCGAGGAGTTCCTCGAGAAGAACGCCCCGCACGATGAGATCAAGAGGTTCC
TGAAGGGGGCGTACGACAACCCGGAAATGGACCGCTTCCTCGATACTCTGGAAGGTGAGGAGCTCCTCAACCTGGCACGA
CGCCTGAAGCGCGGCATCCCCATGTCGTCGCCGGTCTTCGAGGGTGCGAGCGAGGAGTCGATACAGTCGATGCTGACCCA
TGCAGGCTTCAGCACCACCGGTCAGGTCACCCTCTACGACGGCAAGAGCGGCGACAAGTTCATGCACCAGGTCACCGTCG
GGATCATGTACTTCTTGAAGCTGCACCACCTGGTCGACGACAAGATCCACGCGAGGAGCATCGGGCCCTACTCTCTGGTC
ACCCAGCAGCCGCTGGGGGGCAAGGCGCGGTTCGGCGGTCAGAGGCTCGGGGAGATGGAGGTCTGGGCGATGGAGGCCTA
CGGCGCCGCATACGCGCTGCAGGAATTCCTCACCGTCAAGTCCGACGACGTGGCCGGCCGCACCAGGATGTACGAGGCCA
TCGTCAAAGGGAAGCACACCCTGGAGCCGGGCCTGCCCGAGTCGTTCAACGTCCTCATCAAGGAACTCCAGTCCCTTGGC
CTCGACGTGGAACTCCTGGAAGGCGACGAGGACTAA

Upstream 100 bases:

>100_bases
AGTTTGAGGCCGCTTCACCCCGCTGTACCCGCCACAACTACCACAGCAGGAAATTCAAGGGGGTGGAGGTCTTCCAAGGC
GTTCACCACAAGGAGAAGAT

Downstream 100 bases:

>100_bases
AAACTGTTCAACGTTCAACGTTCGGCGTTTAAACCCACTGCCGGTTTTTCGCCGAACGTTGAACGCGGAACGTTGAACGG
CCTCTTAATCTGATTACGTA

Product: DNA-directed RNA polymerase subunit beta

Products: NA

Alternate protein names: RNAP subunit beta; RNA polymerase subunit beta; Transcriptase subunit beta

Number of amino acids: Translated: 1371; Mature: 1370

Protein sequence:

>1371_residues
MAYSIANNPLLRKNFAKIHKIIDIPNLIDIQKNSYKRFLQLDTPVDARKNSGLEAVFRSVFPIRDFSDTASLEYVSYSLG
APKYDVEECHQRGMTFAAPMKVKVRLVVWDVAKDPGTRSIRDIKEQEVYFGEIPLMTDNGTFIINGTERVIVSQLHRSPG
VFYDHDKGKTHSSGKVLYSARVIPYRGSWLDFEFDHKDILYVRIDRRRKMPATVLLKALGYSNDALINYFYKSEEVKLGD
NGAMTKLADAELLSNQKATADIVDPATGEVILKANRKFTKAALRKMAEHGIKEIPISEEEVVAKVASHDIYDPATGEIIV
ECNEELTQAKLEEIIQKGITTFQVLFIDNLHVTSSFRDTILIDKIGSTDEALIEIYRRLRPGDPPTLKSALVLFENLFFN
AERYDLSAVGRLKLNYKLGVDVPLDCMTLTREDILEVVRYLIELKNGKGNIDDIDHLGNRRVRAVGELLENQYRIGLVRM
ERAIKERMSLQEVENLMPHDLINSKPVSAVVKEFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVH
PTHYGRVCPIETPEGPNIGLIASLSTYARINEHGFVETPYRVVSEGKVTDEVRFFSALEEEGHAIAQANAEIDKDGRFAA
DYISARKSGEFVLVGRDELELMDVAPMQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADSPLVGTGMERVVARD
SGVSSVARHNGVVESVDASRIVVKIDEDQYDATGTGVDIYNLIKFARSNQNTCINQRPVVKVGDHVKAGDIIADGPSTDM
GELALGQNVLIAFMPWGGYNYEDSILISERLVKDDRYTSIHIEEFEAVARDTKLGKEEITSDIPNLGEETLKDLDESGII
RIGAEVRPGDILVGKITPKGETQLSPEEKLLRAIFGEKAGDVRDTSLRVPPGVEGTVIGAKIFSRKGADKDARTEIIEKA
EEMRLRKDEQDEIRIIRDSAIGKLKKLLVGKAAAVKIEGSDGKVLIPKGAAITEEMLKSFSMDRWDEISIADDDTIDEKV
AQTLSTLNQQIDIIKYVFDDKVQKLRRGDDLPPGVIKMVKVYIAIKRKLQVGDKMAGRHGNKGVVSRILPEEDMPYMEDG
RPVEIVLNPLGVPSRMNVGQILEMHLGWGAKGLGWKIEEFLEKNAPHDEIKRFLKGAYDNPEMDRFLDTLEGEELLNLAR
RLKRGIPMSSPVFEGASEESIQSMLTHAGFSTTGQVTLYDGKSGDKFMHQVTVGIMYFLKLHHLVDDKIHARSIGPYSLV
TQQPLGGKARFGGQRLGEMEVWAMEAYGAAYALQEFLTVKSDDVAGRTRMYEAIVKGKHTLEPGLPESFNVLIKELQSLG
LDVELLEGDED

Sequences:

>Translated_1371_residues
MAYSIANNPLLRKNFAKIHKIIDIPNLIDIQKNSYKRFLQLDTPVDARKNSGLEAVFRSVFPIRDFSDTASLEYVSYSLG
APKYDVEECHQRGMTFAAPMKVKVRLVVWDVAKDPGTRSIRDIKEQEVYFGEIPLMTDNGTFIINGTERVIVSQLHRSPG
VFYDHDKGKTHSSGKVLYSARVIPYRGSWLDFEFDHKDILYVRIDRRRKMPATVLLKALGYSNDALINYFYKSEEVKLGD
NGAMTKLADAELLSNQKATADIVDPATGEVILKANRKFTKAALRKMAEHGIKEIPISEEEVVAKVASHDIYDPATGEIIV
ECNEELTQAKLEEIIQKGITTFQVLFIDNLHVTSSFRDTILIDKIGSTDEALIEIYRRLRPGDPPTLKSALVLFENLFFN
AERYDLSAVGRLKLNYKLGVDVPLDCMTLTREDILEVVRYLIELKNGKGNIDDIDHLGNRRVRAVGELLENQYRIGLVRM
ERAIKERMSLQEVENLMPHDLINSKPVSAVVKEFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVH
PTHYGRVCPIETPEGPNIGLIASLSTYARINEHGFVETPYRVVSEGKVTDEVRFFSALEEEGHAIAQANAEIDKDGRFAA
DYISARKSGEFVLVGRDELELMDVAPMQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADSPLVGTGMERVVARD
SGVSSVARHNGVVESVDASRIVVKIDEDQYDATGTGVDIYNLIKFARSNQNTCINQRPVVKVGDHVKAGDIIADGPSTDM
GELALGQNVLIAFMPWGGYNYEDSILISERLVKDDRYTSIHIEEFEAVARDTKLGKEEITSDIPNLGEETLKDLDESGII
RIGAEVRPGDILVGKITPKGETQLSPEEKLLRAIFGEKAGDVRDTSLRVPPGVEGTVIGAKIFSRKGADKDARTEIIEKA
EEMRLRKDEQDEIRIIRDSAIGKLKKLLVGKAAAVKIEGSDGKVLIPKGAAITEEMLKSFSMDRWDEISIADDDTIDEKV
AQTLSTLNQQIDIIKYVFDDKVQKLRRGDDLPPGVIKMVKVYIAIKRKLQVGDKMAGRHGNKGVVSRILPEEDMPYMEDG
RPVEIVLNPLGVPSRMNVGQILEMHLGWGAKGLGWKIEEFLEKNAPHDEIKRFLKGAYDNPEMDRFLDTLEGEELLNLAR
RLKRGIPMSSPVFEGASEESIQSMLTHAGFSTTGQVTLYDGKSGDKFMHQVTVGIMYFLKLHHLVDDKIHARSIGPYSLV
TQQPLGGKARFGGQRLGEMEVWAMEAYGAAYALQEFLTVKSDDVAGRTRMYEAIVKGKHTLEPGLPESFNVLIKELQSLG
LDVELLEGDED
>Mature_1370_residues
AYSIANNPLLRKNFAKIHKIIDIPNLIDIQKNSYKRFLQLDTPVDARKNSGLEAVFRSVFPIRDFSDTASLEYVSYSLGA
PKYDVEECHQRGMTFAAPMKVKVRLVVWDVAKDPGTRSIRDIKEQEVYFGEIPLMTDNGTFIINGTERVIVSQLHRSPGV
FYDHDKGKTHSSGKVLYSARVIPYRGSWLDFEFDHKDILYVRIDRRRKMPATVLLKALGYSNDALINYFYKSEEVKLGDN
GAMTKLADAELLSNQKATADIVDPATGEVILKANRKFTKAALRKMAEHGIKEIPISEEEVVAKVASHDIYDPATGEIIVE
CNEELTQAKLEEIIQKGITTFQVLFIDNLHVTSSFRDTILIDKIGSTDEALIEIYRRLRPGDPPTLKSALVLFENLFFNA
ERYDLSAVGRLKLNYKLGVDVPLDCMTLTREDILEVVRYLIELKNGKGNIDDIDHLGNRRVRAVGELLENQYRIGLVRME
RAIKERMSLQEVENLMPHDLINSKPVSAVVKEFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHP
THYGRVCPIETPEGPNIGLIASLSTYARINEHGFVETPYRVVSEGKVTDEVRFFSALEEEGHAIAQANAEIDKDGRFAAD
YISARKSGEFVLVGRDELELMDVAPMQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADSPLVGTGMERVVARDS
GVSSVARHNGVVESVDASRIVVKIDEDQYDATGTGVDIYNLIKFARSNQNTCINQRPVVKVGDHVKAGDIIADGPSTDMG
ELALGQNVLIAFMPWGGYNYEDSILISERLVKDDRYTSIHIEEFEAVARDTKLGKEEITSDIPNLGEETLKDLDESGIIR
IGAEVRPGDILVGKITPKGETQLSPEEKLLRAIFGEKAGDVRDTSLRVPPGVEGTVIGAKIFSRKGADKDARTEIIEKAE
EMRLRKDEQDEIRIIRDSAIGKLKKLLVGKAAAVKIEGSDGKVLIPKGAAITEEMLKSFSMDRWDEISIADDDTIDEKVA
QTLSTLNQQIDIIKYVFDDKVQKLRRGDDLPPGVIKMVKVYIAIKRKLQVGDKMAGRHGNKGVVSRILPEEDMPYMEDGR
PVEIVLNPLGVPSRMNVGQILEMHLGWGAKGLGWKIEEFLEKNAPHDEIKRFLKGAYDNPEMDRFLDTLEGEELLNLARR
LKRGIPMSSPVFEGASEESIQSMLTHAGFSTTGQVTLYDGKSGDKFMHQVTVGIMYFLKLHHLVDDKIHARSIGPYSLVT
QQPLGGKARFGGQRLGEMEVWAMEAYGAAYALQEFLTVKSDDVAGRTRMYEAIVKGKHTLEPGLPESFNVLIKELQSLGL
DVELLEGDED

Specific function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

COG id: COG0085

COG function: function code K; DNA-directed RNA polymerase, beta subunit/140 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA polymerase beta chain family

Homologues:

Organism=Homo sapiens, GI238908503, Length=294, Percent_Identity=29.9319727891156, Blast_Score=127, Evalue=6e-29,
Organism=Homo sapiens, GI238908505, Length=294, Percent_Identity=29.9319727891156, Blast_Score=127, Evalue=6e-29,
Organism=Homo sapiens, GI4505941, Length=301, Percent_Identity=28.9036544850498, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI33469941, Length=258, Percent_Identity=31.3953488372093, Blast_Score=113, Evalue=1e-24,
Organism=Homo sapiens, GI212286172, Length=258, Percent_Identity=31.3953488372093, Blast_Score=113, Evalue=1e-24,
Organism=Escherichia coli, GI1790419, Length=1374, Percent_Identity=56.9141193595342, Blast_Score=1603, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552304, Length=246, Percent_Identity=30.8943089430894, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144348, Length=294, Percent_Identity=29.2517006802721, Blast_Score=120, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17506623, Length=246, Percent_Identity=32.520325203252, Blast_Score=119, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324725, Length=268, Percent_Identity=32.089552238806, Blast_Score=131, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324781, Length=294, Percent_Identity=30.952380952381, Blast_Score=131, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6325267, Length=351, Percent_Identity=27.6353276353276, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17647877, Length=295, Percent_Identity=31.5254237288136, Blast_Score=129, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136444, Length=246, Percent_Identity=30.8943089430894, Blast_Score=119, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136446, Length=258, Percent_Identity=30.2325581395349, Blast_Score=105, Evalue=2e-22,

Paralogues:

None

Copy number: 4233 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): RPOB_GEOBB (B5EFP3)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137743.1
- ProteinModelPortal:   B5EFP3
- GeneID:   6783768
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0926
- HOGENOM:   HBG285547
- OMA:   FMTWEGY
- ProtClustDB:   PRK00405
- HAMAP:   MF_01321
- InterPro:   IPR010243
- InterPro:   IPR019462
- InterPro:   IPR015712
- InterPro:   IPR007120
- InterPro:   IPR007121
- InterPro:   IPR007644
- InterPro:   IPR007642
- InterPro:   IPR007645
- InterPro:   IPR007641
- InterPro:   IPR014724
- Gene3D:   G3DSA:2.40.50.150
- PANTHER:   PTHR20856
- TIGRFAMs:   TIGR02013

Pfam domain/function: PF04563 RNA_pol_Rpb2_1; PF04561 RNA_pol_Rpb2_2; PF04565 RNA_pol_Rpb2_3; PF10385 RNA_pol_Rpb2_45; PF00562 RNA_pol_Rpb2_6; PF04560 RNA_pol_Rpb2_7

EC number: =2.7.7.6

Molecular weight: Translated: 152915; Mature: 152784

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS01166 RNA_POL_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSIANNPLLRKNFAKIHKIIDIPNLIDIQKNSYKRFLQLDTPVDARKNSGLEAVFRSV
CCEECCCCCHHHHHHHHHHHHHCCCCCEECCCCCCHHHEEECCCCCCCCCCCHHHHHHHH
FPIRDFSDTASLEYVSYSLGAPKYDVEECHQRGMTFAAPMKVKVRLVVWDVAKDPGTRSI
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCEEECCCEEEEEEEEEEECCCCCCCHH
RDIKEQEVYFGEIPLMTDNGTFIINGTERVIVSQLHRSPGVFYDHDKGKTHSSGKVLYSA
HHHHHHCEEECCCEEEECCCEEEECCCHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEE
RVIPYRGSWLDFEFDHKDILYVRIDRRRKMPATVLLKALGYSNDALINYFYKSEEVKLGD
EEEEECCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEECC
NGAMTKLADAELLSNQKATADIVDPATGEVILKANRKFTKAALRKMAEHGIKEIPISEEE
CCCCHHHHHHHHHCCCCCCEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHH
VVAKVASHDIYDPATGEIIVECNEELTQAKLEEIIQKGITTFQVLFIDNLHVTSSFRDTI
HHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECEEEECCCCCEE
LIDKIGSTDEALIEIYRRLRPGDPPTLKSALVLFENLFFNAERYDLSAVGRLKLNYKLGV
EEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECC
DVPLDCMTLTREDILEVVRYLIELKNGKGNIDDIDHLGNRRVRAVGELLENQYRIGLVRM
CCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHH
ERAIKERMSLQEVENLMPHDLINSKPVSAVVKEFFGSSQLSQFMDQTNPLSEVTHKRRLS
HHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHH
ALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLIASLSTYARINEHGFVETPY
HCCCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCH
RVVSEGKVTDEVRFFSALEEEGHAIAQANAEIDKDGRFAADYISARKSGEFVLVGRDELE
HHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEECCCEE
LMDVAPMQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADSPLVGTGMERVVARD
EHHCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHCCHHCCCCCCCCCCHHHHHHCC
SGVSSVARHNGVVESVDASRIVVKIDEDQYDATGTGVDIYNLIKFARSNQNTCINQRPVV
CCHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCE
KVGDHVKAGDIIADGPSTDMGELALGQNVLIAFMPWGGYNYEDSILISERLVKDDRYTSI
EECCCCCCCCEEECCCCCCCHHHHCCCCEEEEEECCCCCCCCCCEEHHHHHHCCCCCEEE
HIEEFEAVARDTKLGKEEITSDIPNLGEETLKDLDESGIIRIGAEVRPGDILVGKITPKG
EHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCC
ETQLSPEEKLLRAIFGEKAGDVRDTSLRVPPGVEGTVIGAKIFSRKGADKDARTEIIEKA
CCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEHHHHHHCCCCCHHHHHHHHHHH
EEMRLRKDEQDEIRIIRDSAIGKLKKLLVGKAAAVKIEGSDGKVLIPKGAAITEEMLKSF
HHHHHCCCCCCHHEEEHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCHHHHHHHHHC
SMDRWDEISIADDDTIDEKVAQTLSTLNQQIDIIKYVFDDKVQKLRRGDDLPPGVIKMVK
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VYIAIKRKLQVGDKMAGRHGNKGVVSRILPEEDMPYMEDGRPVEIVLNPLGVPSRMNVGQ
HHHHHHHHHHHCHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHH
ILEMHLGWGAKGLGWKIEEFLEKNAPHDEIKRFLKGAYDNPEMDRFLDTLEGEELLNLAR
HHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHH
RLKRGIPMSSPVFEGASEESIQSMLTHAGFSTTGQVTLYDGKSGDKFMHQVTVGIMYFLK
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
LHHLVDDKIHARSIGPYSLVTQQPLGGKARFGGQRLGEMEVWAMEAYGAAYALQEFLTVK
HHHHHCCCHHHCCCCCHHHEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCC
SDDVAGRTRMYEAIVKGKHTLEPGLPESFNVLIKELQSLGLDVELLEGDED
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure 
AYSIANNPLLRKNFAKIHKIIDIPNLIDIQKNSYKRFLQLDTPVDARKNSGLEAVFRSV
CEECCCCCHHHHHHHHHHHHHCCCCCEECCCCCCHHHEEECCCCCCCCCCCHHHHHHHH
FPIRDFSDTASLEYVSYSLGAPKYDVEECHQRGMTFAAPMKVKVRLVVWDVAKDPGTRSI
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCEEECCCEEEEEEEEEEECCCCCCCHH
RDIKEQEVYFGEIPLMTDNGTFIINGTERVIVSQLHRSPGVFYDHDKGKTHSSGKVLYSA
HHHHHHCEEECCCEEEECCCEEEECCCHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEE
RVIPYRGSWLDFEFDHKDILYVRIDRRRKMPATVLLKALGYSNDALINYFYKSEEVKLGD
EEEEECCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEECC
NGAMTKLADAELLSNQKATADIVDPATGEVILKANRKFTKAALRKMAEHGIKEIPISEEE
CCCCHHHHHHHHHCCCCCCEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHH
VVAKVASHDIYDPATGEIIVECNEELTQAKLEEIIQKGITTFQVLFIDNLHVTSSFRDTI
HHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECEEEECCCCCEE
LIDKIGSTDEALIEIYRRLRPGDPPTLKSALVLFENLFFNAERYDLSAVGRLKLNYKLGV
EEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECC
DVPLDCMTLTREDILEVVRYLIELKNGKGNIDDIDHLGNRRVRAVGELLENQYRIGLVRM
CCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHH
ERAIKERMSLQEVENLMPHDLINSKPVSAVVKEFFGSSQLSQFMDQTNPLSEVTHKRRLS
HHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHH
ALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLIASLSTYARINEHGFVETPY
HCCCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCH
RVVSEGKVTDEVRFFSALEEEGHAIAQANAEIDKDGRFAADYISARKSGEFVLVGRDELE
HHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEECCCEE
LMDVAPMQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLRADSPLVGTGMERVVARD
EHHCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHCCHHCCCCCCCCCCHHHHHHCC
SGVSSVARHNGVVESVDASRIVVKIDEDQYDATGTGVDIYNLIKFARSNQNTCINQRPVV
CCHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCE
KVGDHVKAGDIIADGPSTDMGELALGQNVLIAFMPWGGYNYEDSILISERLVKDDRYTSI
EECCCCCCCCEEECCCCCCCHHHHCCCCEEEEEECCCCCCCCCCEEHHHHHHCCCCCEEE
HIEEFEAVARDTKLGKEEITSDIPNLGEETLKDLDESGIIRIGAEVRPGDILVGKITPKG
EHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCC
ETQLSPEEKLLRAIFGEKAGDVRDTSLRVPPGVEGTVIGAKIFSRKGADKDARTEIIEKA
CCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEHHHHHHCCCCCHHHHHHHHHHH
EEMRLRKDEQDEIRIIRDSAIGKLKKLLVGKAAAVKIEGSDGKVLIPKGAAITEEMLKSF
HHHHHCCCCCCHHEEEHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCHHHHHHHHHC
SMDRWDEISIADDDTIDEKVAQTLSTLNQQIDIIKYVFDDKVQKLRRGDDLPPGVIKMVK
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VYIAIKRKLQVGDKMAGRHGNKGVVSRILPEEDMPYMEDGRPVEIVLNPLGVPSRMNVGQ
HHHHHHHHHHHCHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHH
ILEMHLGWGAKGLGWKIEEFLEKNAPHDEIKRFLKGAYDNPEMDRFLDTLEGEELLNLAR
HHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHH
RLKRGIPMSSPVFEGASEESIQSMLTHAGFSTTGQVTLYDGKSGDKFMHQVTVGIMYFLK
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
LHHLVDDKIHARSIGPYSLVTQQPLGGKARFGGQRLGEMEVWAMEAYGAAYALQEFLTVK
HHHHHCCCHHHCCCCCHHHEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCC
SDDVAGRTRMYEAIVKGKHTLEPGLPESFNVLIKELQSLGLDVELLEGDED
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA