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The map label for this gene is dnaX [H]

Identifier: 197116612

GI number: 197116612

Start: 249166

End: 250914

Strand: Reverse

Name: dnaX [H]

Synonym: Gbem_0212

Alternate gene names: 197116612

Gene position: 250914-249166 (Counterclockwise)

Preceding gene: 197116613

Following gene: 197116611

Centisome position: 5.44

GC content: 66.38

Gene sequence:

>1749_bases
TTGTCCTATCTCGTACTCGCTAGAAAATGGCGCCCCCAGACCTTCAGCGATCTGGTCGGCCAGGAGCATGTCAGTCAGAC
CCTGAAAAACGCCATCGACGGCGGGCGGGTCGCGCACGCCTTCCTCTTCACCGGGGCCCGCGGGGTGGGAAAGACCAGCT
CGGCGCGCATCCTCGCCAAGGCGCTCAACTGCGAGAGCGGGCTGACCGTGGAGCCGTGCAATACCTGCTCCACCTGCCTG
GAGATCACCGAGGGGAACTCTGTCGACGTCTTCGAGATCGACGGCGCCTCCAACACCGGCGTGGACGACATCAGGGAGTT
GCGCGACAACATCAAGTACCTCCCGTCGCGCTCGCGCTACAAGATCTTCATCATCGACGAAGTCCACATGCTCACCACCA
ACGCCTTCAACGCGCTGTTGAAGACGCTGGAGGAGCCCCCCCCGCACGTCAAGTTCATCTTCGCCACCACTGAACCCCAC
AAGGTCCCCATCACCATCCTTTCGCGCTGCCAGCGTTTCGACTTCAAGAGGATCGCGCTGCCGCGCATCGTCTCCAGGCT
GCGCTACATAGTGGACCAGGAGGGGGTGCAGGTCTCGGACGAGGCGCTTGCCGTTGTGGCCAGAAAAGGGGACGGGAGCA
TGCGCGACTCGCTCTCCACGCTGGACCAGGTGCTCGCCTTCTGCGGCAACCAGGTCGCAGACGCCGACGTCGCGGCACTT
TTGGGCGTGGTGGACCGCCGCCTGATCATGGACGGCTGCCGCGCCGTGCTCTCGAAGGAGGTGCGCGAGGCGCTGCAGAT
CGTGGCGCAGGTGGATTCCTTCGGTTACAGCATGAGGCAGTTCTGCCGCGAGCTGATCGACCAGTTCCGCAACGTGGCCA
TCCTGAAGGCGGTCGGCGAACCGGGGGACCTCTTGGAACTCTCCGAGGCGGAGCTTGGCGAGTTGCGCACCCTGGCGGAT
GCCGCTACGGGGACCGACCTCCAGCGGCACCTGACGCTGCTCCTTAAGGCCGAGGCGGAGATGGCGCATGCGAGCTTCCC
GCGCCTGGTGCTGGAAATGACCATGATGAAGATGGCGACACTGGCGCCTGCGGTCGCGGTGCAGGAACTCCTCTCCCGGC
TGGACTCGCTGGAATCCGGAGCGCCCGCAGGTCCGCGCCCGGCCCGCCAGGAGGGCGCCCCTCGCGCCGCCGCGCCGCCG
GTCCAGGCGCCCCCCGCCGCCCGGGACCAGCACGCCGCACGCCCGGCCGCGCCCCCTTCCGCTCCGGCTCCCCAGCCCCC
CCCTGCCCCGCCGGCAGCTTCAGCTGCGCCGGCAGCCGCCGACGCAGGGAGCGGCGAGCTTTGGGGGAGCTTCGTGCAGT
TCGTCAAAGGGAAGCGTCCCATGCTCGGCACCGAGCTGGAGCAGGTCTACCCGGTCCAGGTCTCCCGCCAACTGCTGGAG
ATCGGCTGCCTGAACGGGACCTTCGAGCTGAAGAGGATGCAGGACCCGGAGCGGGTGACGGAACTGAAGGAACTCGCCAA
GACCCATTTCGGCGGAACCCCGGCGGTGAGGATAACGGTGTTGAGCGAACCCCCGAAGGACGCGCCGCCGAGCCTGTCGG
AAAAAAAAAACCTTGAAAATGCCGAGCGACAGGCAACCCTGAGGCGCGAGGCGGAGGAGCACCCGCTGGTGGCCGCGGCG
GTGGCGCTGTTCGACGGGGAAATCGCCGAAGTGAAGGAAATCCCCGGCAAGGATGTCATACAATCATAA

Upstream 100 bases:

>100_bases
CCAGCTATCAGCTCTTTCCGCAATCCCCCAGCCTCCCCCCGCCCCACGCGAACCATTGAACCAAACACCATGAACCACGA
CGCCATAGAGGTATGCCCCC

Downstream 100 bases:

>100_bases
CGATGTTCCGCGGTACGCTTAGATCAATAAAAGGAAATCGGAGGATAAGATGTCGAAAGGTTTAGCGCAGATCATGAAAC
AGGCTCAGATGATGCAGCAG

Product: DNA polymerase III subunits gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MSYLVLARKWRPQTFSDLVGQEHVSQTLKNAIDGGRVAHAFLFTGARGVGKTSSARILAKALNCESGLTVEPCNTCSTCL
EITEGNSVDVFEIDGASNTGVDDIRELRDNIKYLPSRSRYKIFIIDEVHMLTTNAFNALLKTLEEPPPHVKFIFATTEPH
KVPITILSRCQRFDFKRIALPRIVSRLRYIVDQEGVQVSDEALAVVARKGDGSMRDSLSTLDQVLAFCGNQVADADVAAL
LGVVDRRLIMDGCRAVLSKEVREALQIVAQVDSFGYSMRQFCRELIDQFRNVAILKAVGEPGDLLELSEAELGELRTLAD
AATGTDLQRHLTLLLKAEAEMAHASFPRLVLEMTMMKMATLAPAVAVQELLSRLDSLESGAPAGPRPARQEGAPRAAAPP
VQAPPAARDQHAARPAAPPSAPAPQPPPAPPAASAAPAAADAGSGELWGSFVQFVKGKRPMLGTELEQVYPVQVSRQLLE
IGCLNGTFELKRMQDPERVTELKELAKTHFGGTPAVRITVLSEPPKDAPPSLSEKKNLENAERQATLRREAEEHPLVAAA
VALFDGEIAEVKEIPGKDVIQS

Sequences:

>Translated_582_residues
MSYLVLARKWRPQTFSDLVGQEHVSQTLKNAIDGGRVAHAFLFTGARGVGKTSSARILAKALNCESGLTVEPCNTCSTCL
EITEGNSVDVFEIDGASNTGVDDIRELRDNIKYLPSRSRYKIFIIDEVHMLTTNAFNALLKTLEEPPPHVKFIFATTEPH
KVPITILSRCQRFDFKRIALPRIVSRLRYIVDQEGVQVSDEALAVVARKGDGSMRDSLSTLDQVLAFCGNQVADADVAAL
LGVVDRRLIMDGCRAVLSKEVREALQIVAQVDSFGYSMRQFCRELIDQFRNVAILKAVGEPGDLLELSEAELGELRTLAD
AATGTDLQRHLTLLLKAEAEMAHASFPRLVLEMTMMKMATLAPAVAVQELLSRLDSLESGAPAGPRPARQEGAPRAAAPP
VQAPPAARDQHAARPAAPPSAPAPQPPPAPPAASAAPAAADAGSGELWGSFVQFVKGKRPMLGTELEQVYPVQVSRQLLE
IGCLNGTFELKRMQDPERVTELKELAKTHFGGTPAVRITVLSEPPKDAPPSLSEKKNLENAERQATLRREAEEHPLVAAA
VALFDGEIAEVKEIPGKDVIQS
>Mature_581_residues
SYLVLARKWRPQTFSDLVGQEHVSQTLKNAIDGGRVAHAFLFTGARGVGKTSSARILAKALNCESGLTVEPCNTCSTCLE
ITEGNSVDVFEIDGASNTGVDDIRELRDNIKYLPSRSRYKIFIIDEVHMLTTNAFNALLKTLEEPPPHVKFIFATTEPHK
VPITILSRCQRFDFKRIALPRIVSRLRYIVDQEGVQVSDEALAVVARKGDGSMRDSLSTLDQVLAFCGNQVADADVAALL
GVVDRRLIMDGCRAVLSKEVREALQIVAQVDSFGYSMRQFCRELIDQFRNVAILKAVGEPGDLLELSEAELGELRTLADA
ATGTDLQRHLTLLLKAEAEMAHASFPRLVLEMTMMKMATLAPAVAVQELLSRLDSLESGAPAGPRPARQEGAPRAAAPPV
QAPPAARDQHAARPAAPPSAPAPQPPPAPPAASAAPAAADAGSGELWGSFVQFVKGKRPMLGTELEQVYPVQVSRQLLEI
GCLNGTFELKRMQDPERVTELKELAKTHFGGTPAVRITVLSEPPKDAPPSLSEKKNLENAERQATLRREAEEHPLVAAAV
ALFDGEIAEVKEIPGKDVIQS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=248, Percent_Identity=26.6129032258064, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194306571, Length=251, Percent_Identity=26.2948207171315, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI194306567, Length=251, Percent_Identity=26.2948207171315, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4506491, Length=297, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31881687, Length=297, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31563534, Length=278, Percent_Identity=24.4604316546763, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1786676, Length=367, Percent_Identity=43.0517711171662, Blast_Score=318, Evalue=7e-88,
Organism=Escherichia coli, GI1787341, Length=166, Percent_Identity=29.5180722891566, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=344, Percent_Identity=25.8720930232558, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71986063, Length=298, Percent_Identity=27.8523489932886, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=338, Percent_Identity=23.0769230769231, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=328, Percent_Identity=25.609756097561, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324039, Length=228, Percent_Identity=28.0701754385965, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322528, Length=299, Percent_Identity=24.4147157190635, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18859927, Length=290, Percent_Identity=24.1379310344828, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17647857, Length=315, Percent_Identity=22.8571428571429, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921076, Length=255, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63069; Mature: 62938

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVLARKWRPQTFSDLVGQEHVSQTLKNAIDGGRVAHAFLFTGARGVGKTSSARILAK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHH
ALNCESGLTVEPCNTCSTCLEITEGNSVDVFEIDGASNTGVDDIRELRDNIKYLPSRSRY
HHCCCCCCEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KIFIIDEVHMLTTNAFNALLKTLEEPPPHVKFIFATTEPHKVPITILSRCQRFDFKRIAL
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHH
PRIVSRLRYIVDQEGVQVSDEALAVVARKGDGSMRDSLSTLDQVLAFCGNQVADADVAAL
HHHHHHHHHHHHCCCCEECCHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGVVDRRLIMDGCRAVLSKEVREALQIVAQVDSFGYSMRQFCRELIDQFRNVAILKAVGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEHCCCC
PGDLLELSEAELGELRTLADAATGTDLQRHLTLLLKAEAEMAHASFPRLVLEMTMMKMAT
CCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPAVAVQELLSRLDSLESGAPAGPRPARQEGAPRAAAPPVQAPPAARDQHAARPAAPPS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APAPQPPPAPPAASAAPAAADAGSGELWGSFVQFVKGKRPMLGTELEQVYPVQVSRQLLE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IGCLNGTFELKRMQDPERVTELKELAKTHFGGTPAVRITVLSEPPKDAPPSLSEKKNLEN
HHCCCCCEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHCHHH
AERQATLRREAEEHPLVAAAVALFDGEIAEVKEIPGKDVIQS
HHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHCCCHHHCCC
>Mature Secondary Structure 
SYLVLARKWRPQTFSDLVGQEHVSQTLKNAIDGGRVAHAFLFTGARGVGKTSSARILAK
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHH
ALNCESGLTVEPCNTCSTCLEITEGNSVDVFEIDGASNTGVDDIRELRDNIKYLPSRSRY
HHCCCCCCEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KIFIIDEVHMLTTNAFNALLKTLEEPPPHVKFIFATTEPHKVPITILSRCQRFDFKRIAL
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHH
PRIVSRLRYIVDQEGVQVSDEALAVVARKGDGSMRDSLSTLDQVLAFCGNQVADADVAAL
HHHHHHHHHHHHCCCCEECCHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGVVDRRLIMDGCRAVLSKEVREALQIVAQVDSFGYSMRQFCRELIDQFRNVAILKAVGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEHCCCC
PGDLLELSEAELGELRTLADAATGTDLQRHLTLLLKAEAEMAHASFPRLVLEMTMMKMAT
CCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPAVAVQELLSRLDSLESGAPAGPRPARQEGAPRAAAPPVQAPPAARDQHAARPAAPPS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APAPQPPPAPPAASAAPAAADAGSGELWGSFVQFVKGKRPMLGTELEQVYPVQVSRQLLE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IGCLNGTFELKRMQDPERVTELKELAKTHFGGTPAVRITVLSEPPKDAPPSLSEKKNLEN
HHCCCCCEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHCHHH
AERQATLRREAEEHPLVAAAVALFDGEIAEVKEIPGKDVIQS
HHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]