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The map label for this gene is obgE

Identifier: 197116564

GI number: 197116564

Start: 194169

End: 195185

Strand: Direct

Name: obgE

Synonym: Gbem_0164

Alternate gene names: 197116564

Gene position: 194169-195185 (Clockwise)

Preceding gene: 197116563

Following gene: 197116584

Centisome position: 4.21

GC content: 64.7

Gene sequence:

>1017_bases
ATGAGTTTTATAGATGAAGTTAAGATAAACGTGAAGTCCGGCGACGGCGGTGCCGGGTGCGTCTCCTTCCGCAGGGAGAA
GTTCATCCCGCTGGGAGGGCCCGACGGCGGCGACGGCGGCAAGGGTGGCGACGTGATCGTCAAGGTGTCTTCGCACCTCT
CCACGCTGCTCGACCTGCGCCAGCACCCGCACCAGAAGGCCGGCCGCGGCAAGAACGGCATGGGTAGCGACCGGCACGGC
GCGAACGGCCACACCCTGGAGATCCTGGTGCCGCAGGGGACCGTGATCAAGGATGCCGAGACCGGGGAGATCCTCGCCGA
CCTCGCCGAGCCCGACTCCTCCATGGTGCTCCTGAAGGGGGGGCGCGGCGGGCAGGGGAACGCCCGGTTCAAGACCGCCA
CCCACAAGGCTCCCAAGTTCGCGCAGCCCGGCGAGCCTGGCGAAGAGCGCTGGATCAGGATGGAGCTGAAGCTGATGGCG
GACGTGGGTCTGCTCGGCATGCCCAGCGTCGGGAAGTCCTCGCTGATCGCGAAGATCTCGGCCGCACGCCCCAAGATCGC
CGAATACCACTTCACCACGCTCAAGCCGAGCCTCGGCGTGGTCCAGTACAAGAACTACCGCTCCTTCGTCATGGCCGATA
TTCCCGGTCTGATCGAGGGGGCGAGCGAGGGGGCGGGGCTTGGGCACCGTTTCCTCAAACACCTGGAGCGTACCGGGCAG
CTGCTGCACCTGCTCGACCTCTCCTGGATGCCGGATCGGGATCCCATCGCAGAGTACGAGGCGATCAACCGTGAGCTCGC
GCTCTTCAACCCCGAGCTTGCCGACAAACGCCAAACTGTCGTCGTCAACAAGATCGACCTCCCCCATGTCAGGGAGAACC
TGAAAGAGATCCTCCCCTACTTCGAGGAGCGGGGAATAAAGGTCTTCCCCATCTCCGCCGCGACCGGGGAAGGGATACCG
GAGCTCCTGGACGACATCGCCTTCAACCTGTGGGGCGAGCCGGAAGAGACCTGGTAG

Upstream 100 bases:

>100_bases
AGGTCTCCGTTTACCCGGCCAACTAGCCAACGCAGCATAAAAGAGTGTGAAAGCCCGGAGCCGCAAGGTCCGGGCTTTTG
CTGTTTCCACAGGAAAGTTA

Downstream 100 bases:

>100_bases
GGATTAAAAATAGAAGAGGGGAGCAGCCGAAGCGGTTGCTCCCCTTTTTTTATGTTGGAAATAATGGCAAGGTTCAGTTC
TTCAAAAGTTTTTCAGTCTT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSFIDEVKINVKSGDGGAGCVSFRREKFIPLGGPDGGDGGKGGDVIVKVSSHLSTLLDLRQHPHQKAGRGKNGMGSDRHG
ANGHTLEILVPQGTVIKDAETGEILADLAEPDSSMVLLKGGRGGQGNARFKTATHKAPKFAQPGEPGEERWIRMELKLMA
DVGLLGMPSVGKSSLIAKISAARPKIAEYHFTTLKPSLGVVQYKNYRSFVMADIPGLIEGASEGAGLGHRFLKHLERTGQ
LLHLLDLSWMPDRDPIAEYEAINRELALFNPELADKRQTVVVNKIDLPHVRENLKEILPYFEERGIKVFPISAATGEGIP
ELLDDIAFNLWGEPEETW

Sequences:

>Translated_338_residues
MSFIDEVKINVKSGDGGAGCVSFRREKFIPLGGPDGGDGGKGGDVIVKVSSHLSTLLDLRQHPHQKAGRGKNGMGSDRHG
ANGHTLEILVPQGTVIKDAETGEILADLAEPDSSMVLLKGGRGGQGNARFKTATHKAPKFAQPGEPGEERWIRMELKLMA
DVGLLGMPSVGKSSLIAKISAARPKIAEYHFTTLKPSLGVVQYKNYRSFVMADIPGLIEGASEGAGLGHRFLKHLERTGQ
LLHLLDLSWMPDRDPIAEYEAINRELALFNPELADKRQTVVVNKIDLPHVRENLKEILPYFEERGIKVFPISAATGEGIP
ELLDDIAFNLWGEPEETW
>Mature_337_residues
SFIDEVKINVKSGDGGAGCVSFRREKFIPLGGPDGGDGGKGGDVIVKVSSHLSTLLDLRQHPHQKAGRGKNGMGSDRHGA
NGHTLEILVPQGTVIKDAETGEILADLAEPDSSMVLLKGGRGGQGNARFKTATHKAPKFAQPGEPGEERWIRMELKLMAD
VGLLGMPSVGKSSLIAKISAARPKIAEYHFTTLKPSLGVVQYKNYRSFVMADIPGLIEGASEGAGLGHRFLKHLERTGQL
LHLLDLSWMPDRDPIAEYEAINRELALFNPELADKRQTVVVNKIDLPHVRENLKEILPYFEERGIKVFPISAATGEGIPE
LLDDIAFNLWGEPEETW

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=335, Percent_Identity=38.2089552238806, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI111955139, Length=352, Percent_Identity=36.6477272727273, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI111955063, Length=254, Percent_Identity=37.007874015748, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4758796, Length=117, Percent_Identity=34.1880341880342, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=328, Percent_Identity=49.390243902439, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI1787454, Length=139, Percent_Identity=29.4964028776978, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=330, Percent_Identity=38.1818181818182, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=305, Percent_Identity=30.4918032786885, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17555344, Length=101, Percent_Identity=35.6435643564356, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71981008, Length=141, Percent_Identity=32.6241134751773, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=183, Percent_Identity=40.4371584699454, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319281, Length=108, Percent_Identity=37.037037037037, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321612, Length=89, Percent_Identity=41.5730337078652, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129375, Length=328, Percent_Identity=41.1585365853659, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=34.0836012861736, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21356473, Length=107, Percent_Identity=34.5794392523364, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_GEOBB (B5E958)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002136991.1
- ProteinModelPortal:   B5E958
- SMR:   B5E958
- GeneID:   6782986
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0164
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- ProtClustDB:   PRK12299
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36778; Mature: 36646

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIDEVKINVKSGDGGAGCVSFRREKFIPLGGPDGGDGGKGGDVIVKVSSHLSTLLDLR
CCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
QHPHQKAGRGKNGMGSDRHGANGHTLEILVPQGTVIKDAETGEILADLAEPDSSMVLLKG
HCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHHHCCCCCCEEEEEC
GRGGQGNARFKTATHKAPKFAQPGEPGEERWIRMELKLMADVGLLGMPSVGKSSLIAKIS
CCCCCCCCEEEECCCCCCCCCCCCCCCHHHEEEEEEEHHHCCCCCCCCCCCCHHHHHHHH
AARPKIAEYHFTTLKPSLGVVQYKNYRSFVMADIPGLIEGASEGAGLGHRFLKHLERTGQ
HCCCCHHHEEEEECCCCCCEEEECCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHLLDLSWMPDRDPIAEYEAINRELALFNPELADKRQTVVVNKIDLPHVRENLKEILPY
EEEEHHCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
FEERGIKVFPISAATGEGIPELLDDIAFNLWGEPEETW
HHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SFIDEVKINVKSGDGGAGCVSFRREKFIPLGGPDGGDGGKGGDVIVKVSSHLSTLLDLR
CCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
QHPHQKAGRGKNGMGSDRHGANGHTLEILVPQGTVIKDAETGEILADLAEPDSSMVLLKG
HCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHHHCCCCCCEEEEEC
GRGGQGNARFKTATHKAPKFAQPGEPGEERWIRMELKLMADVGLLGMPSVGKSSLIAKIS
CCCCCCCCEEEECCCCCCCCCCCCCCCHHHEEEEEEEHHHCCCCCCCCCCCCHHHHHHHH
AARPKIAEYHFTTLKPSLGVVQYKNYRSFVMADIPGLIEGASEGAGLGHRFLKHLERTGQ
HCCCCHHHEEEEECCCCCCEEEECCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHLLDLSWMPDRDPIAEYEAINRELALFNPELADKRQTVVVNKIDLPHVRENLKEILPY
EEEEHHCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
FEERGIKVFPISAATGEGIPELLDDIAFNLWGEPEETW
HHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA