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The map label for this gene is fdh [H]

Identifier: 197116539

GI number: 197116539

Start: 171528

End: 172733

Strand: Reverse

Name: fdh [H]

Synonym: Gbem_0139

Alternate gene names: 197116539

Gene position: 172733-171528 (Counterclockwise)

Preceding gene: 197116540

Following gene: 197116538

Centisome position: 3.74

GC content: 63.68

Gene sequence:

>1206_bases
ATGAGGGCAGTATGCTGGCATGGCAAACAGGACGTGCGGGTGGACACCGTGCCCGACCCGGAGATCGTACAGAAGGGGGA
CGTCATCGTTAAGGTCGCCCTCACCTGCATCTGCGGTTCCGACCTGCACCTTTACAACGGCTACGTCCCCACCATGAAAA
AGGGGGACATCCTGGGGCACGAGTTCGTCGGTGAGATCGTCGCGGCCTGCCCCGGCGTCACCCACTTCAGGGTCGGCGAC
CGCGTCATCGTGCCGTTTCCCATCAGTTGCGGCGCGTGCTGGTACTGCAAGCACGAGCTCTGGTCGCTTTGCGACAACAC
CAACCCGAACTCCTGGATGATGGAACACATCTACGGCGACACCGGCGGCGGGATCTTCGGTTACTCCCATCTCTACGGGG
GGTATGCGGGCGGCCAGGCTGAATACGTCCGCGTTCCCTTCGCCGACGTGGGGCTCGAGAAGATACCGGACGGGATACCG
TACGAGCAAGTGGTGCTCCTAACCGACATAATGCCGACCGGCTACCAGGCCGCCGTCTACTGCAATATCAACCCGGGGGA
TACCGTCGCCGTCTGGGGATGCGGACCGGTGGGGCTTCTGGCCATGAAATCGGCGAAGCTTCTCGGAGCCGAGCGGGTGA
TCGGCATCGACCGGTTCCCCGACCGCCTGCAGATGGCGCACAGCCAGTGCCAGGCCGAGGTGCTCAACTACGAGGAGGTG
GACGTAGCCGAGCAGTTGCAGAACATGACCGGCGGCCGCGGCCCCGACTCCTGCATCGACGCGGTCGGCCTCGAGGCCCG
CGGCACAGGCATAGAGGATGTCTACGACCTGGTGAAACAGACACTGCGTCTGGAGACCGACCGTGCCTCTGCGCTGCGCC
AGCTGGTTCGGGCGTGCCGCAAAGGAGGCACCCTTTCTATCTCCGGTGTCTACAGCGGATTCATCGACAAGTTCCCCATG
GGGGCCATCTTCGCCAAAGGGCTCACCGTGCGCGGAGGGCAGGCCCACGTGCACAAGTACCTCCCTCACCTGGTGAAGCT
GGTCGCGGAGCAGCAGATCGATCCCTCCTCCATCATCACCCACAGGATGTCGCTGGAGGACGCGCCCGCCGGCTACCGCA
CCTTCCTGAAGAAGCAGGATTCCTGCATCAAGATCGCGCTCACACCGGAGCACGCCGCCCCGAAGACAGAACCAGCCTCC
CCGTAA

Upstream 100 bases:

>100_bases
TGAAGCAGATCCTCGAAGTGGGCGAGGAGACGACCGCGAGGCGGACCGCCTAATAAAACCGAGCCGAGCGCCCGGAACCG
GGACGCGACAAGGAGGAGAT

Downstream 100 bases:

>100_bases
CCCGGCCGCGCAGCACGCCGTCAAAGGAGATACCAGATGCCGACCGAAGAAGGGAAACAGTTCCCGCCGCAGCGCCAGGC
GCAGCCGGGAAAAGAAGCCG

Product: glutathione-dependent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MRAVCWHGKQDVRVDTVPDPEIVQKGDVIVKVALTCICGSDLHLYNGYVPTMKKGDILGHEFVGEIVAACPGVTHFRVGD
RVIVPFPISCGACWYCKHELWSLCDNTNPNSWMMEHIYGDTGGGIFGYSHLYGGYAGGQAEYVRVPFADVGLEKIPDGIP
YEQVVLLTDIMPTGYQAAVYCNINPGDTVAVWGCGPVGLLAMKSAKLLGAERVIGIDRFPDRLQMAHSQCQAEVLNYEEV
DVAEQLQNMTGGRGPDSCIDAVGLEARGTGIEDVYDLVKQTLRLETDRASALRQLVRACRKGGTLSISGVYSGFIDKFPM
GAIFAKGLTVRGGQAHVHKYLPHLVKLVAEQQIDPSSIITHRMSLEDAPAGYRTFLKKQDSCIKIALTPEHAAPKTEPAS
P

Sequences:

>Translated_401_residues
MRAVCWHGKQDVRVDTVPDPEIVQKGDVIVKVALTCICGSDLHLYNGYVPTMKKGDILGHEFVGEIVAACPGVTHFRVGD
RVIVPFPISCGACWYCKHELWSLCDNTNPNSWMMEHIYGDTGGGIFGYSHLYGGYAGGQAEYVRVPFADVGLEKIPDGIP
YEQVVLLTDIMPTGYQAAVYCNINPGDTVAVWGCGPVGLLAMKSAKLLGAERVIGIDRFPDRLQMAHSQCQAEVLNYEEV
DVAEQLQNMTGGRGPDSCIDAVGLEARGTGIEDVYDLVKQTLRLETDRASALRQLVRACRKGGTLSISGVYSGFIDKFPM
GAIFAKGLTVRGGQAHVHKYLPHLVKLVAEQQIDPSSIITHRMSLEDAPAGYRTFLKKQDSCIKIALTPEHAAPKTEPAS
P
>Mature_401_residues
MRAVCWHGKQDVRVDTVPDPEIVQKGDVIVKVALTCICGSDLHLYNGYVPTMKKGDILGHEFVGEIVAACPGVTHFRVGD
RVIVPFPISCGACWYCKHELWSLCDNTNPNSWMMEHIYGDTGGGIFGYSHLYGGYAGGQAEYVRVPFADVGLEKIPDGIP
YEQVVLLTDIMPTGYQAAVYCNINPGDTVAVWGCGPVGLLAMKSAKLLGAERVIGIDRFPDRLQMAHSQCQAEVLNYEEV
DVAEQLQNMTGGRGPDSCIDAVGLEARGTGIEDVYDLVKQTLRLETDRASALRQLVRACRKGGTLSISGVYSGFIDKFPM
GAIFAKGLTVRGGQAHVHKYLPHLVKLVAEQQIDPSSIITHRMSLEDAPAGYRTFLKKQDSCIKIALTPEHAAPKTEPAS
P

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=25.7452574525745, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501939, Length=348, Percent_Identity=25.8620689655172, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71565154, Length=380, Percent_Identity=25.2631578947368, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI34577061, Length=384, Percent_Identity=28.6458333333333, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501929, Length=386, Percent_Identity=28.4974093264249, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4501933, Length=400, Percent_Identity=28.25, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI71565152, Length=360, Percent_Identity=26.3888888888889, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073058, Length=256, Percent_Identity=30.46875, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71743840, Length=256, Percent_Identity=30.46875, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=44.1326530612245, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI87082125, Length=268, Percent_Identity=32.8358208955224, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787863, Length=375, Percent_Identity=27.4666666666667, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790045, Length=374, Percent_Identity=26.2032085561497, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788073, Length=365, Percent_Identity=22.1917808219178, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788075, Length=401, Percent_Identity=25.4364089775561, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI226510992, Length=363, Percent_Identity=23.9669421487603, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081918, Length=231, Percent_Identity=30.7359307359307, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=374, Percent_Identity=25.9358288770053, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788407, Length=382, Percent_Identity=26.9633507853403, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=391, Percent_Identity=27.3657289002558, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71997431, Length=390, Percent_Identity=26.6666666666667, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=364, Percent_Identity=27.7472527472527, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=409, Percent_Identity=24.6943765281174, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=409, Percent_Identity=24.6943765281174, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=411, Percent_Identity=24.8175182481752, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=385, Percent_Identity=23.6363636363636, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=285, Percent_Identity=29.1228070175439, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=428, Percent_Identity=23.8317757009346, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137530, Length=397, Percent_Identity=25.6926952141058, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737895, Length=249, Percent_Identity=30.5220883534137, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737897, Length=401, Percent_Identity=23.9401496259352, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 43608; Mature: 43608

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS01034 GLYCOSYL_HYDROL_F16

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVCWHGKQDVRVDTVPDPEIVQKGDVIVKVALTCICGSDLHLYNGYVPTMKKGDILGH
CCCEEECCCCCCEECCCCCHHHHHCCCEEEEEEHHHHCCCCCEEECCCCCCCCCCCCCHH
EFVGEIVAACPGVTHFRVGDRVIVPFPISCGACWYCKHELWSLCDNTNPNSWMMEHIYGD
HHHHHHHHHCCCCEEEECCCEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCEEHHHHCCC
TGGGIFGYSHLYGGYAGGQAEYVRVPFADVGLEKIPDGIPYEQVVLLTDIMPTGYQAAVY
CCCCCEEHHHHHCCCCCCCCCEEECCHHHCCHHHCCCCCCHHHEEEEECCCCCCCEEEEE
CNINPGDTVAVWGCGPVGLLAMKSAKLLGAERVIGIDRFPDRLQMAHSQCQAEVLNYEEV
EECCCCCEEEEECCCCHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHHHHHHCCCHHH
DVAEQLQNMTGGRGPDSCIDAVGLEARGTGIEDVYDLVKQTLRLETDRASALRQLVRACR
HHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KGGTLSISGVYSGFIDKFPMGAIFAKGLTVRGGQAHVHKYLPHLVKLVAEQQIDPSSIIT
CCCCEEEHHHHHHHHHHCCCHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
HRMSLEDAPAGYRTFLKKQDSCIKIALTPEHAAPKTEPASP
HHHCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRAVCWHGKQDVRVDTVPDPEIVQKGDVIVKVALTCICGSDLHLYNGYVPTMKKGDILGH
CCCEEECCCCCCEECCCCCHHHHHCCCEEEEEEHHHHCCCCCEEECCCCCCCCCCCCCHH
EFVGEIVAACPGVTHFRVGDRVIVPFPISCGACWYCKHELWSLCDNTNPNSWMMEHIYGD
HHHHHHHHHCCCCEEEECCCEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCEEHHHHCCC
TGGGIFGYSHLYGGYAGGQAEYVRVPFADVGLEKIPDGIPYEQVVLLTDIMPTGYQAAVY
CCCCCEEHHHHHCCCCCCCCCEEECCHHHCCHHHCCCCCCHHHEEEEECCCCCCCEEEEE
CNINPGDTVAVWGCGPVGLLAMKSAKLLGAERVIGIDRFPDRLQMAHSQCQAEVLNYEEV
EECCCCCEEEEECCCCHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHHHHHHCCCHHH
DVAEQLQNMTGGRGPDSCIDAVGLEARGTGIEDVYDLVKQTLRLETDRASALRQLVRACR
HHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KGGTLSISGVYSGFIDKFPMGAIFAKGLTVRGGQAHVHKYLPHLVKLVAEQQIDPSSIIT
CCCCEEEHHHHHHHHHHCCCHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
HRMSLEDAPAGYRTFLKKQDSCIKIALTPEHAAPKTEPASP
HHHCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]