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The map label for this gene is yciR [C]

Identifier: 197116513

GI number: 197116513

Start: 135769

End: 137934

Strand: Direct

Name: yciR [C]

Synonym: Gbem_0113

Alternate gene names: 197116513

Gene position: 135769-137934 (Clockwise)

Preceding gene: 197116512

Following gene: 197116526

Centisome position: 2.94

GC content: 63.39

Gene sequence:

>2166_bases
ATGAGCCCCTTGCGCCTGAGTTTCGTGAGGAACCTGCCGCTGAAGCGCAAGCTGATGCTGATCATCATGCTCTGCTGCTG
CGCCTCCCTTTTGGCGGCGTCCATATTCTTTCTCACCAGGGATGCCAAGGGGCTGTACCAGGTGCAGCGGGAAGACCTGG
TCTCGCTGGCGGAAATCATCGGAGCCAACTCCGCCTCGGCCCTGGTCTTCGACGACCCGGAATCCGCGCAGCGGACCATC
GCCCCGCTGGCGAGCAAGCGCTCCATCCTGGCCGTTTACGTATTGACCAGCGAAGGGCAGATCATGGCGCGCCACGTGGC
GCCGGAGGCGGGAAACGCGGAGCTCCCGCTGGAGCGGCTGGGGTCCTCCCCCTCGCCGGCTGCCGTGCTCGCGGCCGTGG
AGACCATCAGGAAAACGGCCGAAAAGAACAGCGCCGTCTCCGGTTTCGACTGCCTGGTGCAGCCGGTCTACTTCGACTAC
GAGCGGGTCGGCACCGTCGTCATCCATGCCGACACCGAGCTGTTCCGGAAAAACCTGCGCTGGACCGCGACGGTCACCCT
GCTTTTCATGCTGGTCACCGTCATCGCGGCCTATTTCTTCTCGGCCAAGCTGCAACAGATGATCTCCAGGCCGCTACTGG
ATCTTCTCTCCTCCATGAAGGACGTCTCCGCCAGCAAGAACTACGCGATAAGGGTGGCGAAGCCCTCGGACGACGAGATC
GGGCTTCTCTACGACGGCTTCAACGAGATGCTCTCCGAGATCGAGGAGCGCAACCAGATCCTCAGGCAGCGCCAGGCGCA
CCTGCAGCAGCTGGCGCACTACGATCCGCTGACCCGGCTCCCCAACCGCACCCTGTTCTACGACCGGCTGGCCCAGGCGC
TGTACCAGGCCGAGCGGAGCAGGCAGGCCCTGAGCGTGATCTTCATCGACCTGGACCATTTCAAGGACATCAACGACACC
CTCGGGCACCGCACCGGGGATCTGTTGCTGATCGAGGTGGCCAGCCGGCTCTCCACCGTGGTGCGCAGCTGCGACACCGT
GGCGCGGCTCGGGGGGGACGAGTTCACCATATTCACCCAGAACGTGGTGAACGCCGAGAACGCGGCCATCGTGGCGGCGA
AGCTGAACGGGCTCTTCGCCAAGCCCTTCCATCTGGGCGAAAGCGAGATCTACGTCACGGCCAGCATCGGGGTGACCCTG
TTCCCGCACGACGGCAAGACGGTGGACGAGCTGCTGATGAACGCGGACATCGCCATGTACCACGCGAAAGCCTGCGGCAA
GAACGTCTACAAGATGTTCGACAGGAAGATGAACGAGCACGCGACCGAGAGGGTGACGCTGCTGTCGGACTTAAGGCTTG
CGCTGGAGCGCGACGAATTCGTGCTGCACTACCAGCCCAAGGTGGACCTCCTCACCGGCAACGTGACCTCGGTGGAGGCC
CTGGTGCGCTGGATGCACCCGAGGCTGGGGATGCTGGCGCCGGACAAGTTCATCCGGCTGAGCGAGGAGAGCGGGTTCAT
CGTGGAATTGACCGACTGGGTGCTGCGCACCGCCTGCAGCCAGGCCAAGAAGTGGCAGGAGCAAAACCTGGGCTCGGTGC
GGGTGGCGGTGAACCTCTCGCCCTACCATTTCCAGCGCCAGGACGTGAAGGAGGCGATCTTGTCGGTGCTGGAAGCGACG
GGCCTTGAGCCGGCGCTCCTTGAGATAGAGATCACCGAGTCGGCGCTGATGCAAAACGACGAGTACACCTGTGCGCTGTT
CCGGGAGCTGAGGGAACTCGGCATGACCATCTCGGTGGACGATTTCGGCACCGGCTATTCCTCCCTGAGCTACCTGCACC
GGTTCCCCATCAACACGCTGAAGATCGACCGGACCTTCATCCTGAACATGATGAAGAGCACCGAGGACCAGGCCATCGTC
ACGGCCATCATCGCCATGGCCAAGAGCCTCAACATGCAGATCGTAGCGGAGGGGGTGGAGACGGTGGACCAGTTGGAGAA
GCTAAAGGATCAGGGTTGCCACGAGATCCAGGGCTTCCTGGTGTCGCGCCCGGTGGCCGCGGACGCGGTCACCGAGTTCT
TCACGCCGGAAAACCACCTGCACCAGCACACCGACCCTGCGCAGCCGGAGCCTCCTCAAGGGGCATCGCCGGCAACACGC
CCTTAG

Upstream 100 bases:

>100_bases
GGGTGCGTTTCGAGATCAACCTGAAAGCGGCCCAGCAGTCCAGGGTCAAGATCAGTTCGCAGCTGCTCAAGCTGGCCAAG
CTGATAAGAGAGGGTGACCA

Downstream 100 bases:

>100_bases
GCTGCGGCGACGCCGTCTCCCGGCTTCGTGCCGGGAGGGCGGAGGGGGCGGGAAAGGCGCCGATGCGCAGGGAGTTTCCC
AGCACGGTGAGGCTGGAGAC

Product: HAMP domain-containing protein diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 720

Protein sequence:

>721_residues
MSPLRLSFVRNLPLKRKLMLIIMLCCCASLLAASIFFLTRDAKGLYQVQREDLVSLAEIIGANSASALVFDDPESAQRTI
APLASKRSILAVYVLTSEGQIMARHVAPEAGNAELPLERLGSSPSPAAVLAAVETIRKTAEKNSAVSGFDCLVQPVYFDY
ERVGTVVIHADTELFRKNLRWTATVTLLFMLVTVIAAYFFSAKLQQMISRPLLDLLSSMKDVSASKNYAIRVAKPSDDEI
GLLYDGFNEMLSEIEERNQILRQRQAHLQQLAHYDPLTRLPNRTLFYDRLAQALYQAERSRQALSVIFIDLDHFKDINDT
LGHRTGDLLLIEVASRLSTVVRSCDTVARLGGDEFTIFTQNVVNAENAAIVAAKLNGLFAKPFHLGESEIYVTASIGVTL
FPHDGKTVDELLMNADIAMYHAKACGKNVYKMFDRKMNEHATERVTLLSDLRLALERDEFVLHYQPKVDLLTGNVTSVEA
LVRWMHPRLGMLAPDKFIRLSEESGFIVELTDWVLRTACSQAKKWQEQNLGSVRVAVNLSPYHFQRQDVKEAILSVLEAT
GLEPALLEIEITESALMQNDEYTCALFRELRELGMTISVDDFGTGYSSLSYLHRFPINTLKIDRTFILNMMKSTEDQAIV
TAIIAMAKSLNMQIVAEGVETVDQLEKLKDQGCHEIQGFLVSRPVAADAVTEFFTPENHLHQHTDPAQPEPPQGASPATR
P

Sequences:

>Translated_721_residues
MSPLRLSFVRNLPLKRKLMLIIMLCCCASLLAASIFFLTRDAKGLYQVQREDLVSLAEIIGANSASALVFDDPESAQRTI
APLASKRSILAVYVLTSEGQIMARHVAPEAGNAELPLERLGSSPSPAAVLAAVETIRKTAEKNSAVSGFDCLVQPVYFDY
ERVGTVVIHADTELFRKNLRWTATVTLLFMLVTVIAAYFFSAKLQQMISRPLLDLLSSMKDVSASKNYAIRVAKPSDDEI
GLLYDGFNEMLSEIEERNQILRQRQAHLQQLAHYDPLTRLPNRTLFYDRLAQALYQAERSRQALSVIFIDLDHFKDINDT
LGHRTGDLLLIEVASRLSTVVRSCDTVARLGGDEFTIFTQNVVNAENAAIVAAKLNGLFAKPFHLGESEIYVTASIGVTL
FPHDGKTVDELLMNADIAMYHAKACGKNVYKMFDRKMNEHATERVTLLSDLRLALERDEFVLHYQPKVDLLTGNVTSVEA
LVRWMHPRLGMLAPDKFIRLSEESGFIVELTDWVLRTACSQAKKWQEQNLGSVRVAVNLSPYHFQRQDVKEAILSVLEAT
GLEPALLEIEITESALMQNDEYTCALFRELRELGMTISVDDFGTGYSSLSYLHRFPINTLKIDRTFILNMMKSTEDQAIV
TAIIAMAKSLNMQIVAEGVETVDQLEKLKDQGCHEIQGFLVSRPVAADAVTEFFTPENHLHQHTDPAQPEPPQGASPATR
P
>Mature_720_residues
SPLRLSFVRNLPLKRKLMLIIMLCCCASLLAASIFFLTRDAKGLYQVQREDLVSLAEIIGANSASALVFDDPESAQRTIA
PLASKRSILAVYVLTSEGQIMARHVAPEAGNAELPLERLGSSPSPAAVLAAVETIRKTAEKNSAVSGFDCLVQPVYFDYE
RVGTVVIHADTELFRKNLRWTATVTLLFMLVTVIAAYFFSAKLQQMISRPLLDLLSSMKDVSASKNYAIRVAKPSDDEIG
LLYDGFNEMLSEIEERNQILRQRQAHLQQLAHYDPLTRLPNRTLFYDRLAQALYQAERSRQALSVIFIDLDHFKDINDTL
GHRTGDLLLIEVASRLSTVVRSCDTVARLGGDEFTIFTQNVVNAENAAIVAAKLNGLFAKPFHLGESEIYVTASIGVTLF
PHDGKTVDELLMNADIAMYHAKACGKNVYKMFDRKMNEHATERVTLLSDLRLALERDEFVLHYQPKVDLLTGNVTSVEAL
VRWMHPRLGMLAPDKFIRLSEESGFIVELTDWVLRTACSQAKKWQEQNLGSVRVAVNLSPYHFQRQDVKEAILSVLEATG
LEPALLEIEITESALMQNDEYTCALFRELRELGMTISVDDFGTGYSSLSYLHRFPINTLKIDRTFILNMMKSTEDQAIVT
AIIAMAKSLNMQIVAEGVETVDQLEKLKDQGCHEIQGFLVSRPVAADAVTEFFTPENHLHQHTDPAQPEPPQGASPATRP

Specific function: Unknown

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MHYT domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=433, Percent_Identity=38.3371824480369, Blast_Score=313, Evalue=3e-86,
Organism=Escherichia coli, GI87081921, Length=436, Percent_Identity=34.4036697247706, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI226510982, Length=544, Percent_Identity=27.9411764705882, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1788502, Length=248, Percent_Identity=35.8870967741936, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI1786507, Length=267, Percent_Identity=32.2097378277154, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI87081845, Length=254, Percent_Identity=33.4645669291339, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI1787055, Length=260, Percent_Identity=31.1538461538462, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081980, Length=274, Percent_Identity=31.3868613138686, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI87081743, Length=233, Percent_Identity=33.0472103004292, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1790496, Length=233, Percent_Identity=30.9012875536481, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082096, Length=445, Percent_Identity=23.8202247191011, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788849, Length=437, Percent_Identity=25.629290617849, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1788381, Length=445, Percent_Identity=25.6179775280899, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1788956, Length=416, Percent_Identity=26.6826923076923, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87081977, Length=164, Percent_Identity=36.5853658536585, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI87082007, Length=171, Percent_Identity=35.0877192982456, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1787262, Length=165, Percent_Identity=31.5151515151515, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1787802, Length=162, Percent_Identity=32.0987654320988, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693134, Length=162, Percent_Identity=35.8024691358025, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1787410, Length=156, Percent_Identity=32.6923076923077, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1786584, Length=168, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081881, Length=186, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787816, Length=164, Percent_Identity=32.9268292682927, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081974, Length=83, Percent_Identity=42.1686746987952, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788085, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1789650, Length=446, Percent_Identity=21.0762331838565, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 80509; Mature: 80377

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLRLSFVRNLPLKRKLMLIIMLCCCASLLAASIFFLTRDAKGLYQVQREDLVSLAEII
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GANSASALVFDDPESAQRTIAPLASKRSILAVYVLTSEGQIMARHVAPEAGNAELPLERL
CCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCHHHC
GSSPSPAAVLAAVETIRKTAEKNSAVSGFDCLVQPVYFDYERVGTVVIHADTELFRKNLR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCEEEEECCHHHHHHCCC
WTATVTLLFMLVTVIAAYFFSAKLQQMISRPLLDLLSSMKDVSASKNYAIRVAKPSDDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCE
GLLYDGFNEMLSEIEERNQILRQRQAHLQQLAHYDPLTRLPNRTLFYDRLAQALYQAERS
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHH
RQALSVIFIDLDHFKDINDTLGHRTGDLLLIEVASRLSTVVRSCDTVARLGGDEFTIFTQ
CCEEEEEEEEHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEH
NVVNAENAAIVAAKLNGLFAKPFHLGESEIYVTASIGVTLFPHDGKTVDELLMNADIAMY
HHCCCCCCEEEEEECCCEEECCEECCCCCEEEEEECCEEEECCCCCHHHHHHHCCCHHHH
HAKACGKNVYKMFDRKMNEHATERVTLLSDLRLALERDEFVLHYQPKVDLLTGNVTSVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHH
LVRWMHPRLGMLAPDKFIRLSEESGFIVELTDWVLRTACSQAKKWQEQNLGSVRVAVNLS
HHHHHCCCCCCCCCCHHEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
PYHFQRQDVKEAILSVLEATGLEPALLEIEITESALMQNDEYTCALFRELRELGMTISVD
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHCCCCHHHHHHHHHHHCCCEEEEC
DFGTGYSSLSYLHRFPINTLKIDRTFILNMMKSTEDQAIVTAIIAMAKSLNMQIVAEGVE
CCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHH
TVDQLEKLKDQGCHEIQGFLVSRPVAADAVTEFFTPENHLHQHTDPAQPEPPQGASPATR
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCC
P
C
>Mature Secondary Structure 
SPLRLSFVRNLPLKRKLMLIIMLCCCASLLAASIFFLTRDAKGLYQVQREDLVSLAEII
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GANSASALVFDDPESAQRTIAPLASKRSILAVYVLTSEGQIMARHVAPEAGNAELPLERL
CCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCHHHC
GSSPSPAAVLAAVETIRKTAEKNSAVSGFDCLVQPVYFDYERVGTVVIHADTELFRKNLR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCEEEEECCHHHHHHCCC
WTATVTLLFMLVTVIAAYFFSAKLQQMISRPLLDLLSSMKDVSASKNYAIRVAKPSDDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCE
GLLYDGFNEMLSEIEERNQILRQRQAHLQQLAHYDPLTRLPNRTLFYDRLAQALYQAERS
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHH
RQALSVIFIDLDHFKDINDTLGHRTGDLLLIEVASRLSTVVRSCDTVARLGGDEFTIFTQ
CCEEEEEEEEHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEH
NVVNAENAAIVAAKLNGLFAKPFHLGESEIYVTASIGVTLFPHDGKTVDELLMNADIAMY
HHCCCCCCEEEEEECCCEEECCEECCCCCEEEEEECCEEEECCCCCHHHHHHHCCCHHHH
HAKACGKNVYKMFDRKMNEHATERVTLLSDLRLALERDEFVLHYQPKVDLLTGNVTSVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHH
LVRWMHPRLGMLAPDKFIRLSEESGFIVELTDWVLRTACSQAKKWQEQNLGSVRVAVNLS
HHHHHCCCCCCCCCCHHEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
PYHFQRQDVKEAILSVLEATGLEPALLEIEITESALMQNDEYTCALFRELRELGMTISVD
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHCCCCHHHHHHHHHHHCCCEEEEC
DFGTGYSSLSYLHRFPINTLKIDRTFILNMMKSTEDQAIVTAIIAMAKSLNMQIVAEGVE
CCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHH
TVDQLEKLKDQGCHEIQGFLVSRPVAADAVTEFFTPENHLHQHTDPAQPEPPQGASPATR
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]