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The map label for this gene is hemF [H]

Identifier: 197106335

GI number: 197106335

Start: 3286648

End: 3287538

Strand: Direct

Name: hemF [H]

Synonym: PHZ_c2874

Alternate gene names: 197106335

Gene position: 3286648-3287538 (Clockwise)

Preceding gene: 197106334

Following gene: 197106341

Centisome position: 82.24

GC content: 71.27

Gene sequence:

>891_bases
ATGTCCGAGCCCGCCCCCACCCTGCCGCCCGAGATCCTCGCCCGCCGCGACCGCGCCAAGGCCTGGTTCGAGGATCTGCA
GGCCCGCATCTGCGCCGAGCTGGAGCGGCTCGAGGACGAGGCCCCGCCCGAGCTCTACCCGGACGCCCCGGGCCGCTTCG
AGATGCGCCCCTGGACGCGGGAGACCGGCGTCGGCGGCGGGACCGGCGGCCACCTCAAGGGCCGGCTGTTCGAGAAGGCC
GGCGTCCACACCTCGGCCGCCACCGCGCGCTTCTCGCCCGAGATGGCCGCCCAGATGCCGGGCGCGGACAAGGACCCGTC
CTACGTCTCGGCCTCGATCAGCCTGATCGTCCATCCGGTAAGCCCGCGGGTGCCCACCGTGCACATGAACACCCGCTTCC
TCTCCACGGCCGAGAGCTGGTTCGGCGGCGGCGCCGACCTCACCCCCATGCTGGACGAGCAGCGCAGCCAGGACGCCGAC
GACGCGAAGCTCTTCCACGCCGCCATGAAGGCCGCCTGCGATCCCTTCGATCCCGAGTGGCACCCCCGCTACAAGGCCTG
GTGCGACGAGTACTTCTTCCTGCCGCACCGGGGCGAGCCGCGCGGCATCGGCGGCATCTTCTACGACCGCCACAACACTG
GCGACTTCGAGACCGACTTCGCCTTCACCCGCGCCGTCGGCGAGGCGTTCCTGGACGTCTATCCGAAGATCGTCCGCCAC
CGGATGAGCGAGCCTTGGACCGACGCCGACCGCGCCGAGCAGCTCGTCCGCCGCGGCCGCTACGTCGAGTTCAACCTGCT
CTACGACCGCGGCACCATGTTCGGCCTCAAGGCGGGCGGCAACATCGAGACCATCCTCTCGTCCATGCCCCCCCTGGTCG
CCTGGCCGTAG

Upstream 100 bases:

>100_bases
TCGCTGAACGTCGTCACCGCCGCGGCCATGGCCCTTTCCGAAGCGCTCCGGCAGACCGGCGGCTTCCCAACCCCCGCCGC
GGCGGAGTAGCAGAGCGGCC

Downstream 100 bases:

>100_bases
GCGCCGCCGCCCTCCTCCCTCCATCGGGGGAGGGGGACCGCGAAGCGGTGGAGGGGGCCCGCCCCATCCGCCGCGCTCCC
GGCAAGCCCGCACCACCATG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSEPAPTLPPEILARRDRAKAWFEDLQARICAELERLEDEAPPELYPDAPGRFEMRPWTRETGVGGGTGGHLKGRLFEKA
GVHTSAATARFSPEMAAQMPGADKDPSYVSASISLIVHPVSPRVPTVHMNTRFLSTAESWFGGGADLTPMLDEQRSQDAD
DAKLFHAAMKAACDPFDPEWHPRYKAWCDEYFFLPHRGEPRGIGGIFYDRHNTGDFETDFAFTRAVGEAFLDVYPKIVRH
RMSEPWTDADRAEQLVRRGRYVEFNLLYDRGTMFGLKAGGNIETILSSMPPLVAWP

Sequences:

>Translated_296_residues
MSEPAPTLPPEILARRDRAKAWFEDLQARICAELERLEDEAPPELYPDAPGRFEMRPWTRETGVGGGTGGHLKGRLFEKA
GVHTSAATARFSPEMAAQMPGADKDPSYVSASISLIVHPVSPRVPTVHMNTRFLSTAESWFGGGADLTPMLDEQRSQDAD
DAKLFHAAMKAACDPFDPEWHPRYKAWCDEYFFLPHRGEPRGIGGIFYDRHNTGDFETDFAFTRAVGEAFLDVYPKIVRH
RMSEPWTDADRAEQLVRRGRYVEFNLLYDRGTMFGLKAGGNIETILSSMPPLVAWP
>Mature_295_residues
SEPAPTLPPEILARRDRAKAWFEDLQARICAELERLEDEAPPELYPDAPGRFEMRPWTRETGVGGGTGGHLKGRLFEKAG
VHTSAATARFSPEMAAQMPGADKDPSYVSASISLIVHPVSPRVPTVHMNTRFLSTAESWFGGGADLTPMLDEQRSQDADD
AKLFHAAMKAACDPFDPEWHPRYKAWCDEYFFLPHRGEPRGIGGIFYDRHNTGDFETDFAFTRAVGEAFLDVYPKIVRHR
MSEPWTDADRAEQLVRRGRYVEFNLLYDRGTMFGLKAGGNIETILSSMPPLVAWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=285, Percent_Identity=38.2456140350877, Blast_Score=195, Evalue=4e-50,
Organism=Escherichia coli, GI1788777, Length=284, Percent_Identity=42.2535211267606, Blast_Score=212, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=37.2239747634069, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17864388, Length=293, Percent_Identity=37.8839590443686, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33216; Mature: 33084

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPAPTLPPEILARRDRAKAWFEDLQARICAELERLEDEAPPELYPDAPGRFEMRPWTR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
ETGVGGGTGGHLKGRLFEKAGVHTSAATARFSPEMAAQMPGADKDPSYVSASISLIVHPV
HCCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCHHHHHHCCCCCCCCCCEEEEEEEEEECC
SPRVPTVHMNTRFLSTAESWFGGGADLTPMLDEQRSQDADDAKLFHAAMKAACDPFDPEW
CCCCCEEEECHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
HPRYKAWCDEYFFLPHRGEPRGIGGIFYDRHNTGDFETDFAFTRAVGEAFLDVYPKIVRH
CCCHHHHHHHEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RMSEPWTDADRAEQLVRRGRYVEFNLLYDRGTMFGLKAGGNIETILSSMPPLVAWP
HCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCEEEEECCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SEPAPTLPPEILARRDRAKAWFEDLQARICAELERLEDEAPPELYPDAPGRFEMRPWTR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
ETGVGGGTGGHLKGRLFEKAGVHTSAATARFSPEMAAQMPGADKDPSYVSASISLIVHPV
HCCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCHHHHHHCCCCCCCCCCEEEEEEEEEECC
SPRVPTVHMNTRFLSTAESWFGGGADLTPMLDEQRSQDADDAKLFHAAMKAACDPFDPEW
CCCCCEEEECHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
HPRYKAWCDEYFFLPHRGEPRGIGGIFYDRHNTGDFETDFAFTRAVGEAFLDVYPKIVRH
CCCHHHHHHHEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RMSEPWTDADRAEQLVRRGRYVEFNLLYDRGTMFGLKAGGNIETILSSMPPLVAWP
HCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCEEEEECCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA