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The map label for this gene is envZ [H]

Identifier: 197106314

GI number: 197106314

Start: 3267199

End: 3268563

Strand: Direct

Name: envZ [H]

Synonym: PHZ_c2853

Alternate gene names: 197106314

Gene position: 3267199-3268563 (Clockwise)

Preceding gene: 197106313

Following gene: 197106315

Centisome position: 81.76

GC content: 74.07

Gene sequence:

>1365_bases
ATGCGCCCGCAGACCCCGCTGCGCGCCTTCGGCCGCTGGCTGAAGAAGCGGCTGCCGACCACGCTGTTCGGCCGCAGCCT
GCTGATCATCGTCCTGCCGGTGGCCCTGATGCAGATCGCGGTCACCTACGTCTTCTTCGACGCCCACTGGCAGACCGTCA
CCAGCCGCCTCTCCGAGGGCCTGGCCGGCGACATCGCCTGGGCGGTCGAGAGCTACAAGGAGGACCCGCGGCCCGAGAGC
TTCGCCCGCCTGTCCAAGCGGGCCGAGGACTCCATGGGCCTGTCCGTCGCCCTCCAGCCCGGGCGCGAGCTGCCCGCCAG
CCGCCGCGACGCGCCGGCCCCGTTCCGGCCGTTCTTCGCCCCCATCGACCGCTCGCTCGAGCGGGCGCTGTCCGAGCGGC
TGGACGATCCCTACTGGTTCGACACCACCCGCTACCCCGCCTACGTGGACATCCGCGTGGACGTGCCGGGCGGGGTGATG
CGCATCCTCGCGCCCCGCGACCGGGCCTTCGCCACCCAGGGCCACATCTTCGTCCTGTGGATGACCGTGGCCACCGTGCT
GCTGACGGCGCTGGCCATCCTGTTCATCCGCAACCAGGTGCGGGCCATCGAGCGGCTGGCGAACGCCGCCGAGGCCTTCG
GGCGCGGCGTCGACCAGCCCAGCTTCAAGCCCCAGGGCGCCAAGGAGGTCCGCCGCGCCGCCCGCGCCTTCCTCGACATG
CGGGCCCGCATCCAGCGTCACATCGACCAGCGCACCACCCTGCTGGCCTCCGTCAGCCACGACCTGCGCACGCCGCTCAC
CCGCCTCAAGCTCGCCCTGGCCCTGGCCGAGCCCACCCGCGCCACGGCCGACATGAAGCGCGACCTGGCCGAGATGGAGC
ACATGATCGACGAGTACCTGGCCTTCGCCCGCGGCGAGGGCGGCGAGGCGCTGGAGCCCACGCCGCTGCGCGACTTGATC
GCCGAGGTCAGCGAGGGCGCCGTCCGCGCCGGGGCCGAGGTCGCGGTGCGGGTCGACCCCGGGCTCACCGCCGCCGTGCG
GCCGAACGGGCTGAAGCGGGCCCTGTCGAACCTGATCATGAACGCCGCCGCCCACGGCCAGCGGGTCGAGGTGGCCGCCC
GCCGGCGGGTGCAGGGGGGCATCGAGATCACCGTGGACGACGACGGCCCGGGCATCCCGGCCGAGCGCTACGAGGAGGCC
TTCCGCGCGTTCGCGCGCCTGGACGAGTCCCGCAACCAGAACACCAAGGGCGTGGGCCTGGGCCTGGCCATCGCCCGCGA
CGTCGCCCGCGGCCACGGCGGCGAGATCACCCTCGACCGTTCGCCCCTCGGCGGCCTGCGCGCCGTCGTGCGCCTGCCGG
GCTAG

Upstream 100 bases:

>100_bases
TGCAGGTGACCCGCCTGCGCCGCAAGATCGAGGACGACCCCAAGGCCCCGCGCTACCTCCAGACCGTCCGCGGCGTGGGC
TACCGCCTGGCCCCCGACTG

Downstream 100 bases:

>100_bases
AAAACGCCCCGAAGACGGGTCAGGCTCTCGCGCCGAACGGAGGATATCCCCATGCGCGCCGCCCTCGCCGTCTCCGCGCT
CGCCTCAGCCCTCGCCCTCG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MRPQTPLRAFGRWLKKRLPTTLFGRSLLIIVLPVALMQIAVTYVFFDAHWQTVTSRLSEGLAGDIAWAVESYKEDPRPES
FARLSKRAEDSMGLSVALQPGRELPASRRDAPAPFRPFFAPIDRSLERALSERLDDPYWFDTTRYPAYVDIRVDVPGGVM
RILAPRDRAFATQGHIFVLWMTVATVLLTALAILFIRNQVRAIERLANAAEAFGRGVDQPSFKPQGAKEVRRAARAFLDM
RARIQRHIDQRTTLLASVSHDLRTPLTRLKLALALAEPTRATADMKRDLAEMEHMIDEYLAFARGEGGEALEPTPLRDLI
AEVSEGAVRAGAEVAVRVDPGLTAAVRPNGLKRALSNLIMNAAAHGQRVEVAARRRVQGGIEITVDDDGPGIPAERYEEA
FRAFARLDESRNQNTKGVGLGLAIARDVARGHGGEITLDRSPLGGLRAVVRLPG

Sequences:

>Translated_454_residues
MRPQTPLRAFGRWLKKRLPTTLFGRSLLIIVLPVALMQIAVTYVFFDAHWQTVTSRLSEGLAGDIAWAVESYKEDPRPES
FARLSKRAEDSMGLSVALQPGRELPASRRDAPAPFRPFFAPIDRSLERALSERLDDPYWFDTTRYPAYVDIRVDVPGGVM
RILAPRDRAFATQGHIFVLWMTVATVLLTALAILFIRNQVRAIERLANAAEAFGRGVDQPSFKPQGAKEVRRAARAFLDM
RARIQRHIDQRTTLLASVSHDLRTPLTRLKLALALAEPTRATADMKRDLAEMEHMIDEYLAFARGEGGEALEPTPLRDLI
AEVSEGAVRAGAEVAVRVDPGLTAAVRPNGLKRALSNLIMNAAAHGQRVEVAARRRVQGGIEITVDDDGPGIPAERYEEA
FRAFARLDESRNQNTKGVGLGLAIARDVARGHGGEITLDRSPLGGLRAVVRLPG
>Mature_454_residues
MRPQTPLRAFGRWLKKRLPTTLFGRSLLIIVLPVALMQIAVTYVFFDAHWQTVTSRLSEGLAGDIAWAVESYKEDPRPES
FARLSKRAEDSMGLSVALQPGRELPASRRDAPAPFRPFFAPIDRSLERALSERLDDPYWFDTTRYPAYVDIRVDVPGGVM
RILAPRDRAFATQGHIFVLWMTVATVLLTALAILFIRNQVRAIERLANAAEAFGRGVDQPSFKPQGAKEVRRAARAFLDM
RARIQRHIDQRTTLLASVSHDLRTPLTRLKLALALAEPTRATADMKRDLAEMEHMIDEYLAFARGEGGEALEPTPLRDLI
AEVSEGAVRAGAEVAVRVDPGLTAAVRPNGLKRALSNLIMNAAAHGQRVEVAARRRVQGGIEITVDDDGPGIPAERYEEA
FRAFARLDESRNQNTKGVGLGLAIARDVARGHGGEITLDRSPLGGLRAVVRLPG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=33.6769759450172, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790346, Length=263, Percent_Identity=34.6007604562738, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787894, Length=291, Percent_Identity=29.8969072164948, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788393, Length=268, Percent_Identity=26.1194029850746, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787374, Length=271, Percent_Identity=29.1512915129151, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=32.4561403508772, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=27.1812080536913, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789149, Length=272, Percent_Identity=27.2058823529412, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786783, Length=243, Percent_Identity=27.5720164609054, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=275, Percent_Identity=24.3636363636364, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=289, Percent_Identity=26.643598615917, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=27.9461279461279, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=207, Percent_Identity=25.1207729468599, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50138; Mature: 50138

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPQTPLRAFGRWLKKRLPTTLFGRSLLIIVLPVALMQIAVTYVFFDAHWQTVTSRLSEG
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LAGDIAWAVESYKEDPRPESFARLSKRAEDSMGLSVALQPGRELPASRRDAPAPFRPFFA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHH
PIDRSLERALSERLDDPYWFDTTRYPAYVDIRVDVPGGVMRILAPRDRAFATQGHIFVLW
HHHHHHHHHHHHHCCCCCEECCCCCCEEEEEEEECCCCCEEHCCCCCHHHCCCCCEEHHH
MTVATVLLTALAILFIRNQVRAIERLANAAEAFGRGVDQPSFKPQGAKEVRRAARAFLDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RARIQRHIDQRTTLLASVSHDLRTPLTRLKLALALAEPTRATADMKRDLAEMEHMIDEYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AFARGEGGEALEPTPLRDLIAEVSEGAVRAGAEVAVRVDPGLTAAVRPNGLKRALSNLIM
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHHH
NAAAHGQRVEVAARRRVQGGIEITVDDDGPGIPAERYEEAFRAFARLDESRNQNTKGVGL
HHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
GLAIARDVARGHGGEITLDRSPLGGLRAVVRLPG
HHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCC
>Mature Secondary Structure
MRPQTPLRAFGRWLKKRLPTTLFGRSLLIIVLPVALMQIAVTYVFFDAHWQTVTSRLSEG
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LAGDIAWAVESYKEDPRPESFARLSKRAEDSMGLSVALQPGRELPASRRDAPAPFRPFFA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHH
PIDRSLERALSERLDDPYWFDTTRYPAYVDIRVDVPGGVMRILAPRDRAFATQGHIFVLW
HHHHHHHHHHHHHCCCCCEECCCCCCEEEEEEEECCCCCEEHCCCCCHHHCCCCCEEHHH
MTVATVLLTALAILFIRNQVRAIERLANAAEAFGRGVDQPSFKPQGAKEVRRAARAFLDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RARIQRHIDQRTTLLASVSHDLRTPLTRLKLALALAEPTRATADMKRDLAEMEHMIDEYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AFARGEGGEALEPTPLRDLIAEVSEGAVRAGAEVAVRVDPGLTAAVRPNGLKRALSNLIM
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHHH
NAAAHGQRVEVAARRRVQGGIEITVDDDGPGIPAERYEEAFRAFARLDESRNQNTKGVGL
HHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
GLAIARDVARGHGGEITLDRSPLGGLRAVVRLPG
HHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]