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The map label for this gene is sppA [H]

Identifier: 197106190

GI number: 197106190

Start: 3126743

End: 3128515

Strand: Direct

Name: sppA [H]

Synonym: PHZ_c2729

Alternate gene names: 197106190

Gene position: 3126743-3128515 (Clockwise)

Preceding gene: 197106186

Following gene: 197106191

Centisome position: 78.24

GC content: 72.19

Gene sequence:

>1773_bases
ATGAAGCAGTTCCTGATCACGGCGGCGGGCGTGTTCGCCGGTCTGATGATCTTCCTCGTCGGCGTGCCCCTGATCCTCGT
CTCGCTGGCGCTGGGGGCGACCACCACGCCCGTGCCCTCGCGCGCGGTGCTGGAGCTCGACCTCCGGAACAACCTGACGG
ACCAAGCGCCGCAGAGCCCCCTCGCCGGCTTCGGCCGCGGCTCGGTGGCGGTGATGACCATCGTCGAGACCCTGCGGCGC
GCCGAGACCGACAGCCATGTGAAGGGCCTGCTGGTGCGCCTTCCCGAAGGCGGGATGGAGCCGGGCATGGCCGACGAGAT
CCGTCAGGCGCTGAAGCGCTTCCGGGCTAGCGGCAAGCCGGTGATCGCCCACAGCCAGGGCCTCTACCCCGGCGGCGTGG
TGACCTCGACCTACATGGTGGGCGCCGCTTCGGGCGAGCTGTGGATGCAGCCGGGCGCCTCGCTGCAGGTGACCGGCCTG
GCCACCGAGGACCTGTTCCTGAAGCGCTTCTTCGACAAGTACGGGGTCACGCCCCAGTACGAGCAGCGGCAGGAGTACAA
GAACGCGGTCAACACCTTCCTCTACAGCGACTACACGCCCGAGCACCGCGAGGCGACGCTGTCGTGGATGACCTCGGTCT
ACGGCGCGGGCCTGGCCGCCGCGGCCGCCGATCGCAAGACCGACGCGGCCGCGCTGCAAAGGACTCTCGAGGCCGGCCCT
TACGTCGCCGAGGACGCCCTGCGGCTGAAGCTCATCGACCGCGTGGGCCAGGTGCGGGAGGCCGAACAGGCCCTGCTCGC
GAAGGCGGGCGACAACGCCGAGATGGTGGAGTTCCGCGACTATGCGGGCGGCCGCACCGAGCGCCGCGCGCGCGGTTCGG
ACTCCATCGCGCTGATCGAGGCCGAGGGCCCGATCCTGACCGGCCGCGACGAGGGCGCGAGCCCGTTCGTCAGCAACGCC
GCCATCTACTCCGACGACCTGGCCGACGCCATCCAGCGGGCTACGCGCGCCAAGAGCGTCAAGGCCATCGTGCTGCGGGT
GAATTCCCCGGGTGGCTCGGACACCGCCTCCGAACAGATCCTCGACGCGGTGCGGGCGGCCAAGGCCAAGGGCAAGCCGG
TGGTGGTTTCGATGAGCTCCTACGCCGCCTCGGGCGGCTACTGGATCGCCTCGGAAGCCTCGGCGATCGTCGCCCAGCCC
ACGACCCTGACCGGCTCGATCGGCGTGTTCGGCGGCAAGTTCGCCCTGGGCGACGCCCTGGCCCGCTTCGGCGTCGACGT
GCGACAGACCGACGTCGGCGGCCCCTACACGGGCGCCTTCAACCTGGCCGAGCCTTTCACGGCGCCCCAGCGCGCGGCCT
TCTCGCGCTGGATGGACCGGATCTACGCCAACTTCCTCGAGCGGGTCGCCCGCGGCCGCAACCTGCCGCCCGAACGGGTC
GCCGAGATCGCCCGGGGCCGGGTCTGGACCGGCGCCCAGGCGCGCGAGCTGGGGCTGGTGGACGAGCTGGGCGGCTTCTA
CCAGGCGGTCGAGCGGGCGAAGGCTCTGGCCGGCCTGGAGGGCGAGGTGCAGATCCGCCGCATGACCCCAATGGAGAGCC
CGCTGGAGGCCCTGGAGCGCGCCATGGGCGTCTCGGCCGCCTCGGTGCGGACCCTGGCCGCGGCCGCCTGGGTGTTCGGC
GATCCCCGCGCCGAGGGGCTCCTCGACCGGGCGGTCGAGGCCCGCCTGCGGTCCGAGGGCGCGACGGTGCTCGCGCCGAC
CCCGATCCGCTAG

Upstream 100 bases:

>100_bases
TCGTCAGCGACGGCGGTGCGCGCACCCCCGCTAGGCGAGCGCTCAAATGTGTGCGACAGCCCGGCTGGCGATCCAGATTT
CGCCGGAATTCGGTAGCGGC

Downstream 100 bases:

>100_bases
GACCGCGGCGATGGCGGGGGCCGGCGACCATCGGCAAGCCTACGACCTGCTCGCGCGGGGCGACGTCGAGGGGGCGCTGA
GGCTCACCGCCGCCCTCCTC

Product: signal peptide peptidase SppA

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MKQFLITAAGVFAGLMIFLVGVPLILVSLALGATTTPVPSRAVLELDLRNNLTDQAPQSPLAGFGRGSVAVMTIVETLRR
AETDSHVKGLLVRLPEGGMEPGMADEIRQALKRFRASGKPVIAHSQGLYPGGVVTSTYMVGAASGELWMQPGASLQVTGL
ATEDLFLKRFFDKYGVTPQYEQRQEYKNAVNTFLYSDYTPEHREATLSWMTSVYGAGLAAAAADRKTDAAALQRTLEAGP
YVAEDALRLKLIDRVGQVREAEQALLAKAGDNAEMVEFRDYAGGRTERRARGSDSIALIEAEGPILTGRDEGASPFVSNA
AIYSDDLADAIQRATRAKSVKAIVLRVNSPGGSDTASEQILDAVRAAKAKGKPVVVSMSSYAASGGYWIASEASAIVAQP
TTLTGSIGVFGGKFALGDALARFGVDVRQTDVGGPYTGAFNLAEPFTAPQRAAFSRWMDRIYANFLERVARGRNLPPERV
AEIARGRVWTGAQARELGLVDELGGFYQAVERAKALAGLEGEVQIRRMTPMESPLEALERAMGVSAASVRTLAAAAWVFG
DPRAEGLLDRAVEARLRSEGATVLAPTPIR

Sequences:

>Translated_590_residues
MKQFLITAAGVFAGLMIFLVGVPLILVSLALGATTTPVPSRAVLELDLRNNLTDQAPQSPLAGFGRGSVAVMTIVETLRR
AETDSHVKGLLVRLPEGGMEPGMADEIRQALKRFRASGKPVIAHSQGLYPGGVVTSTYMVGAASGELWMQPGASLQVTGL
ATEDLFLKRFFDKYGVTPQYEQRQEYKNAVNTFLYSDYTPEHREATLSWMTSVYGAGLAAAAADRKTDAAALQRTLEAGP
YVAEDALRLKLIDRVGQVREAEQALLAKAGDNAEMVEFRDYAGGRTERRARGSDSIALIEAEGPILTGRDEGASPFVSNA
AIYSDDLADAIQRATRAKSVKAIVLRVNSPGGSDTASEQILDAVRAAKAKGKPVVVSMSSYAASGGYWIASEASAIVAQP
TTLTGSIGVFGGKFALGDALARFGVDVRQTDVGGPYTGAFNLAEPFTAPQRAAFSRWMDRIYANFLERVARGRNLPPERV
AEIARGRVWTGAQARELGLVDELGGFYQAVERAKALAGLEGEVQIRRMTPMESPLEALERAMGVSAASVRTLAAAAWVFG
DPRAEGLLDRAVEARLRSEGATVLAPTPIR
>Mature_590_residues
MKQFLITAAGVFAGLMIFLVGVPLILVSLALGATTTPVPSRAVLELDLRNNLTDQAPQSPLAGFGRGSVAVMTIVETLRR
AETDSHVKGLLVRLPEGGMEPGMADEIRQALKRFRASGKPVIAHSQGLYPGGVVTSTYMVGAASGELWMQPGASLQVTGL
ATEDLFLKRFFDKYGVTPQYEQRQEYKNAVNTFLYSDYTPEHREATLSWMTSVYGAGLAAAAADRKTDAAALQRTLEAGP
YVAEDALRLKLIDRVGQVREAEQALLAKAGDNAEMVEFRDYAGGRTERRARGSDSIALIEAEGPILTGRDEGASPFVSNA
AIYSDDLADAIQRATRAKSVKAIVLRVNSPGGSDTASEQILDAVRAAKAKGKPVVVSMSSYAASGGYWIASEASAIVAQP
TTLTGSIGVFGGKFALGDALARFGVDVRQTDVGGPYTGAFNLAEPFTAPQRAAFSRWMDRIYANFLERVARGRNLPPERV
AEIARGRVWTGAQARELGLVDELGGFYQAVERAKALAGLEGEVQIRRMTPMESPLEALERAMGVSAASVRTLAAAAWVFG
DPRAEGLLDRAVEARLRSEGATVLAPTPIR

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=532, Percent_Identity=34.0225563909774, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1787527, Length=220, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 62955; Mature: 62955

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFLITAAGVFAGLMIFLVGVPLILVSLALGATTTPVPSRAVLELDLRNNLTDQAPQSP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHCCCCCCCCCCC
LAGFGRGSVAVMTIVETLRRAETDSHVKGLLVRLPEGGMEPGMADEIRQALKRFRASGKP
CCCCCCCHHHHHHHHHHHHHCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCE
VIAHSQGLYPGGVVTSTYMVGAASGELWMQPGASLQVTGLATEDLFLKRFFDKYGVTPQY
EEEECCCCCCCCHHHHHEEEECCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCH
EQRQEYKNAVNTFLYSDYTPEHREATLSWMTSVYGAGLAAAAADRKTDAAALQRTLEAGP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCC
YVAEDALRLKLIDRVGQVREAEQALLAKAGDNAEMVEFRDYAGGRTERRARGSDSIALIE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCHHHCCCCCCEEEEE
AEGPILTGRDEGASPFVSNAAIYSDDLADAIQRATRAKSVKAIVLRVNSPGGSDTASEQI
CCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHH
LDAVRAAKAKGKPVVVSMSSYAASGGYWIASEASAIVAQPTTLTGSIGVFGGKFALGDAL
HHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCEEEECCCEEECCCCCCCCHHHHHHHH
ARFGVDVRQTDVGGPYTGAFNLAEPFTAPQRAAFSRWMDRIYANFLERVARGRNLPPERV
HHHCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AEIARGRVWTGAQARELGLVDELGGFYQAVERAKALAGLEGEVQIRRMTPMESPLEALER
HHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
AMGVSAASVRTLAAAAWVFGDPRAEGLLDRAVEARLRSEGATVLAPTPIR
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCC
>Mature Secondary Structure
MKQFLITAAGVFAGLMIFLVGVPLILVSLALGATTTPVPSRAVLELDLRNNLTDQAPQSP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHCCCCCCCCCCC
LAGFGRGSVAVMTIVETLRRAETDSHVKGLLVRLPEGGMEPGMADEIRQALKRFRASGKP
CCCCCCCHHHHHHHHHHHHHCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCE
VIAHSQGLYPGGVVTSTYMVGAASGELWMQPGASLQVTGLATEDLFLKRFFDKYGVTPQY
EEEECCCCCCCCHHHHHEEEECCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCH
EQRQEYKNAVNTFLYSDYTPEHREATLSWMTSVYGAGLAAAAADRKTDAAALQRTLEAGP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCC
YVAEDALRLKLIDRVGQVREAEQALLAKAGDNAEMVEFRDYAGGRTERRARGSDSIALIE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCHHHCCCCCCEEEEE
AEGPILTGRDEGASPFVSNAAIYSDDLADAIQRATRAKSVKAIVLRVNSPGGSDTASEQI
CCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHH
LDAVRAAKAKGKPVVVSMSSYAASGGYWIASEASAIVAQPTTLTGSIGVFGGKFALGDAL
HHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCEEEECCCEEECCCCCCCCHHHHHHHH
ARFGVDVRQTDVGGPYTGAFNLAEPFTAPQRAAFSRWMDRIYANFLERVARGRNLPPERV
HHHCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AEIARGRVWTGAQARELGLVDELGGFYQAVERAKALAGLEGEVQIRRMTPMESPLEALER
HHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
AMGVSAASVRTLAAAAWVFGDPRAEGLLDRAVEARLRSEGATVLAPTPIR
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3522590; 9097039; 9278503; 7973728 [H]