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The map label for this gene is ptrB [H]

Identifier: 197106183

GI number: 197106183

Start: 3117698

End: 3119878

Strand: Direct

Name: ptrB [H]

Synonym: PHZ_c2722

Alternate gene names: 197106183

Gene position: 3117698-3119878 (Clockwise)

Preceding gene: 197106181

Following gene: 197106184

Centisome position: 78.02

GC content: 70.52

Gene sequence:

>2181_bases
TTGGCCTTGAGCCCGCCGCGGGTCCGACGCATTTACCCCGGCATGACCCTTCCCAAGCCGCCCGTCGCGCCGAAGCGCCC
CGTCACGATCGAACAGCTCGGCCGCACGCGGACCGACGACTACGCCTGGATGAAGGACGAGAACTGGCAGCAGGTGCTGC
GCGACCCCGCCGCGCTGCGGGCCGACATCCGCGAGCACCTGACGGCCGAGAACGCCTACACGAAGACCGTGCTGGCCGGG
ACCGAGGACCTGCAGGCGACGCTGTTCGCCGAGATGAAGGCGCGCATCAAGGAGGACGACAGCTCGGTCCCCGCGCCCGA
CGGGCCGTTCGAATACTACATCCGCTACGAGACGGGGGCGGAGCACCCCATCCATGCGCGCCGGCCGCGGGGCGGCGGCG
AGGAACAGGTGCTGATCGACGAGACGGCTCTGGCGAAGGACAAAGCCTACTTCCACGTCGGCCACGCCGGCCACACGCCC
GACCACGCCCTCTTCGCCTGGGCCGCCGACGAGCAGGGCAGCGAGTACTACAGGGTCCGGGTGAAGGACCTTGCGTCGGG
TGAGGAGGTCGGCCCGCCCATCGAGAGCGCCTACGGCGACTTCGCCTTCTCCCCGTGCTCCGGGTGGCTGTTCTGGATCT
GGCGCGACGAGAACGCCCGGCCGGCCAAGGTCTTCCGTCGGCCCGCCCGTCCCGGCGCGGACTGGAGCGGCGAGGACGTG
CTGGTCTACGAGGAGCACGACGACGGCATGTTCCTGGGCGTCGGGACCGCGTCCGACGACAGCCACGTCCTGATCCACGT
CGGTAACCAGGAGACCACCGAGCTGTGGCTGATCCCGGCCGCCGATCCCACGGCGAGGCCCGTCGTGGCCGAGCCGCGGC
AGGTGGGCGTCAAGTACGGTCTCGACCACTGGGGCGACCGCTGGGTGATCCGCACGAACGCCGACGGGGCGGTGGACTTC
AAGCTGTGCGTCTCGGACGCCGCGGTCCCGGCCAAGGCGACGTGGCGCGAGTTCGTCCCGCACCAGCCCGGCCGCTACAT
CACCGGCTTCGCGGCGTACGCCGGGCATCTGGTCCGCGCCGAGCGGGTGAACGCCCTCGATCGCCTCGTGGTCATGGACC
GCGCCCCGATCGGCGAGACGGGCGGCGAGCACGTGGTGGCCTTCGACGAGGAGGCCTACGCCCTGAACCTCGAGACGGGC
TTCGAGTACGACACCACGCTCACCCGTTTCGTCTACCAGTCGCCGACGACGCCGCGGCAGTGGTTCGACTACGACATGGC
CAGCCGCGAGCGCACCCTGCGCAAGACCCAGGAGGTGCCGTCCGGCCACGACCCGAGCCGCTACGTGGCCCGCCGCCTGC
ACGCGCGGGCGTCGGACGGGGCCGAGGTGCCAATCACCCTGCTGATGCTGAAGGATGCGCCAAAGGACGGCTCGGCGCCG
GTGCTGCTCTACGGCTACGGCAGCTACGGCCACGCCATGGAGCCCGCGTTCTCGATCCGCAACCTGTCCCTCGTGGACCG
CGGCTGGATCTGGGCCACGGCGCACATCCGCGGCGGCTCGGACAAGGGCTGGGGCTGGTTCCTCGACGGTCGCAAGGAGA
AGAAGACCAACACCTTCACCGACTTCATCGCCTGCGCCGAGCACCTGATCGCCGAGGGCTATGCGTCCAAGGGCCGGATC
GCGGCCTACGGCGGCTCGGCCGGGGGCATGCTGATGGGCGCGGTGGCCAACCTGCGGCCCGACCTGTGGGGCGCGATCAT
CGCCGCCGTGCCGTTCGTGGACGTGCTGAACACCATGAGCGACACCTCCCTGCCGCTGACGCCGCCCGAGTGGCCCGAGT
GGGGCAACCCCATCGAGGATCCGGAGGCCTACGACCGGATCGCCGGCTACAGCCCCTACGACCAGGTGGGGCCCCGCGCC
TATCCGCCGGTCCTGGCCACCGGCGGCCTGTCGGACCCGCGCGTGACCTATTGGGAGCCCGCCAAATGGGTCGCCAGGCT
GCGCGATTTCACGACAGGCGAGGCCCCCATCCTGCTCAGGATCAACATGGAGGCCGGCCACGGCGGCGCCTCCGGCCGTT
TCGACTTCCTGAAGGAGATCGCCCTGGACTACGCTTTCGCGATCTGGGCCATCGAGGGGAGCTGGAAGGCCGATGCTGAT
CCGTCCCGCGCAGGCGGGTGA

Upstream 100 bases:

>100_bases
CCGCGTCTTCGCGCGGTCTCGATGTATTCGAAGTGAATCAGAGTCAGCGGTTCACAACAAGCGAACAACCGCGTGATGGC
CCGCGCCAGAACGACGCGAC

Downstream 100 bases:

>100_bases
CGCGGACGCCCTGGCGGCCATCTACGGCCATCACGTCCTCACCGGCTTCGGAACGTTCGAGGAGGTCCCGCCGACGCCCG
CAGAGATGGAGCGCCGCCGC

Product: prolyl oligopeptidase family protein

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 726; Mature: 725

Protein sequence:

>726_residues
MALSPPRVRRIYPGMTLPKPPVAPKRPVTIEQLGRTRTDDYAWMKDENWQQVLRDPAALRADIREHLTAENAYTKTVLAG
TEDLQATLFAEMKARIKEDDSSVPAPDGPFEYYIRYETGAEHPIHARRPRGGGEEQVLIDETALAKDKAYFHVGHAGHTP
DHALFAWAADEQGSEYYRVRVKDLASGEEVGPPIESAYGDFAFSPCSGWLFWIWRDENARPAKVFRRPARPGADWSGEDV
LVYEEHDDGMFLGVGTASDDSHVLIHVGNQETTELWLIPAADPTARPVVAEPRQVGVKYGLDHWGDRWVIRTNADGAVDF
KLCVSDAAVPAKATWREFVPHQPGRYITGFAAYAGHLVRAERVNALDRLVVMDRAPIGETGGEHVVAFDEEAYALNLETG
FEYDTTLTRFVYQSPTTPRQWFDYDMASRERTLRKTQEVPSGHDPSRYVARRLHARASDGAEVPITLLMLKDAPKDGSAP
VLLYGYGSYGHAMEPAFSIRNLSLVDRGWIWATAHIRGGSDKGWGWFLDGRKEKKTNTFTDFIACAEHLIAEGYASKGRI
AAYGGSAGGMLMGAVANLRPDLWGAIIAAVPFVDVLNTMSDTSLPLTPPEWPEWGNPIEDPEAYDRIAGYSPYDQVGPRA
YPPVLATGGLSDPRVTYWEPAKWVARLRDFTTGEAPILLRINMEAGHGGASGRFDFLKEIALDYAFAIWAIEGSWKADAD
PSRAGG

Sequences:

>Translated_726_residues
MALSPPRVRRIYPGMTLPKPPVAPKRPVTIEQLGRTRTDDYAWMKDENWQQVLRDPAALRADIREHLTAENAYTKTVLAG
TEDLQATLFAEMKARIKEDDSSVPAPDGPFEYYIRYETGAEHPIHARRPRGGGEEQVLIDETALAKDKAYFHVGHAGHTP
DHALFAWAADEQGSEYYRVRVKDLASGEEVGPPIESAYGDFAFSPCSGWLFWIWRDENARPAKVFRRPARPGADWSGEDV
LVYEEHDDGMFLGVGTASDDSHVLIHVGNQETTELWLIPAADPTARPVVAEPRQVGVKYGLDHWGDRWVIRTNADGAVDF
KLCVSDAAVPAKATWREFVPHQPGRYITGFAAYAGHLVRAERVNALDRLVVMDRAPIGETGGEHVVAFDEEAYALNLETG
FEYDTTLTRFVYQSPTTPRQWFDYDMASRERTLRKTQEVPSGHDPSRYVARRLHARASDGAEVPITLLMLKDAPKDGSAP
VLLYGYGSYGHAMEPAFSIRNLSLVDRGWIWATAHIRGGSDKGWGWFLDGRKEKKTNTFTDFIACAEHLIAEGYASKGRI
AAYGGSAGGMLMGAVANLRPDLWGAIIAAVPFVDVLNTMSDTSLPLTPPEWPEWGNPIEDPEAYDRIAGYSPYDQVGPRA
YPPVLATGGLSDPRVTYWEPAKWVARLRDFTTGEAPILLRINMEAGHGGASGRFDFLKEIALDYAFAIWAIEGSWKADAD
PSRAGG
>Mature_725_residues
ALSPPRVRRIYPGMTLPKPPVAPKRPVTIEQLGRTRTDDYAWMKDENWQQVLRDPAALRADIREHLTAENAYTKTVLAGT
EDLQATLFAEMKARIKEDDSSVPAPDGPFEYYIRYETGAEHPIHARRPRGGGEEQVLIDETALAKDKAYFHVGHAGHTPD
HALFAWAADEQGSEYYRVRVKDLASGEEVGPPIESAYGDFAFSPCSGWLFWIWRDENARPAKVFRRPARPGADWSGEDVL
VYEEHDDGMFLGVGTASDDSHVLIHVGNQETTELWLIPAADPTARPVVAEPRQVGVKYGLDHWGDRWVIRTNADGAVDFK
LCVSDAAVPAKATWREFVPHQPGRYITGFAAYAGHLVRAERVNALDRLVVMDRAPIGETGGEHVVAFDEEAYALNLETGF
EYDTTLTRFVYQSPTTPRQWFDYDMASRERTLRKTQEVPSGHDPSRYVARRLHARASDGAEVPITLLMLKDAPKDGSAPV
LLYGYGSYGHAMEPAFSIRNLSLVDRGWIWATAHIRGGSDKGWGWFLDGRKEKKTNTFTDFIACAEHLIAEGYASKGRIA
AYGGSAGGMLMGAVANLRPDLWGAIIAAVPFVDVLNTMSDTSLPLTPPEWPEWGNPIEDPEAYDRIAGYSPYDQVGPRAY
PPVLATGGLSDPRVTYWEPAKWVARLRDFTTGEAPILLRINMEAGHGGASGRFDFLKEIALDYAFAIWAIEGSWKADADP
SRAGG

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI284172420, Length=520, Percent_Identity=30.9615384615385, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI284172413, Length=520, Percent_Identity=30.9615384615385, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI70778815, Length=520, Percent_Identity=30.9615384615385, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI284172438, Length=520, Percent_Identity=30.9615384615385, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI284172431, Length=520, Percent_Identity=30.9615384615385, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI41349456, Length=747, Percent_Identity=24.0963855421687, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI108860686, Length=313, Percent_Identity=34.5047923322684, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI108860692, Length=263, Percent_Identity=35.7414448669202, Blast_Score=144, Evalue=3e-34,
Organism=Escherichia coli, GI1788150, Length=702, Percent_Identity=35.1851851851852, Blast_Score=418, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24583414, Length=741, Percent_Identity=23.6167341430499, Blast_Score=153, Evalue=5e-37,
Organism=Drosophila melanogaster, GI221510989, Length=680, Percent_Identity=22.9411764705882, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 80486; Mature: 80355

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSPPRVRRIYPGMTLPKPPVAPKRPVTIEQLGRTRTDDYAWMKDENWQQVLRDPAALR
CCCCCCCHHHCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCEEECCCCCHHHHHCCHHHHH
ADIREHLTAENAYTKTVLAGTEDLQATLFAEMKARIKEDDSSVPAPDGPFEYYIRYETGA
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCC
EHPIHARRPRGGGEEQVLIDETALAKDKAYFHVGHAGHTPDHALFAWAADEQGSEYYRVR
CCCCCCCCCCCCCCCEEEEECHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCCEEEEEE
VKDLASGEEVGPPIESAYGDFAFSPCSGWLFWIWRDENARPAKVFRRPARPGADWSGEDV
EEECCCCCCCCCCHHHHCCCCEECCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCEE
LVYEEHDDGMFLGVGTASDDSHVLIHVGNQETTELWLIPAADPTARPVVAEPRQVGVKYG
EEEEECCCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHC
LDHWGDRWVIRTNADGAVDFKLCVSDAAVPAKATWREFVPHQPGRYITGFAAYAGHLVRA
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHHHHH
ERVNALDRLVVMDRAPIGETGGEHVVAFDEEAYALNLETGFEYDTTLTRFVYQSPTTPRQ
HHHHHHHHEEEEECCCCCCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHEECCCCCCHH
WFDYDMASRERTLRKTQEVPSGHDPSRYVARRLHARASDGAEVPITLLMLKDAPKDGSAP
HHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCC
VLLYGYGSYGHAMEPAFSIRNLSLVDRGWIWATAHIRGGSDKGWGWFLDGRKEKKTNTFT
EEEEECCCCCCCCCCCHHCCCEEEEECCEEEEEEEEECCCCCCCEEEECCCCCCCCHHHH
DFIACAEHLIAEGYASKGRIAAYGGSAGGMLMGAVANLRPDLWGAIIAAVPFVDVLNTMS
HHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
DTSLPLTPPEWPEWGNPIEDPEAYDRIAGYSPYDQVGPRAYPPVLATGGLSDPRVTYWEP
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCCCEEEECCCCCCCEEEECH
AKWVARLRDFTTGEAPILLRINMEAGHGGASGRFDFLKEIALDYAFAIWAIEGSWKADAD
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCCCC
PSRAGG
CCCCCC
>Mature Secondary Structure 
ALSPPRVRRIYPGMTLPKPPVAPKRPVTIEQLGRTRTDDYAWMKDENWQQVLRDPAALR
CCCCCCHHHCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCEEECCCCCHHHHHCCHHHHH
ADIREHLTAENAYTKTVLAGTEDLQATLFAEMKARIKEDDSSVPAPDGPFEYYIRYETGA
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCC
EHPIHARRPRGGGEEQVLIDETALAKDKAYFHVGHAGHTPDHALFAWAADEQGSEYYRVR
CCCCCCCCCCCCCCCEEEEECHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCCEEEEEE
VKDLASGEEVGPPIESAYGDFAFSPCSGWLFWIWRDENARPAKVFRRPARPGADWSGEDV
EEECCCCCCCCCCHHHHCCCCEECCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCEE
LVYEEHDDGMFLGVGTASDDSHVLIHVGNQETTELWLIPAADPTARPVVAEPRQVGVKYG
EEEEECCCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHC
LDHWGDRWVIRTNADGAVDFKLCVSDAAVPAKATWREFVPHQPGRYITGFAAYAGHLVRA
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEHHHHHHHHHHHH
ERVNALDRLVVMDRAPIGETGGEHVVAFDEEAYALNLETGFEYDTTLTRFVYQSPTTPRQ
HHHHHHHHEEEEECCCCCCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHEECCCCCCHH
WFDYDMASRERTLRKTQEVPSGHDPSRYVARRLHARASDGAEVPITLLMLKDAPKDGSAP
HHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCC
VLLYGYGSYGHAMEPAFSIRNLSLVDRGWIWATAHIRGGSDKGWGWFLDGRKEKKTNTFT
EEEEECCCCCCCCCCCHHCCCEEEEECCEEEEEEEEECCCCCCCEEEECCCCCCCCHHHH
DFIACAEHLIAEGYASKGRIAAYGGSAGGMLMGAVANLRPDLWGAIIAAVPFVDVLNTMS
HHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
DTSLPLTPPEWPEWGNPIEDPEAYDRIAGYSPYDQVGPRAYPPVLATGGLSDPRVTYWEP
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCCCEEEECCCCCCCEEEECH
AKWVARLRDFTTGEAPILLRINMEAGHGGASGRFDFLKEIALDYAFAIWAIEGSWKADAD
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCCCC
PSRAGG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7629037 [H]