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The map label for this gene is nadC [H]

Identifier: 197106070

GI number: 197106070

Start: 2999863

End: 3000711

Strand: Direct

Name: nadC [H]

Synonym: PHZ_c2609

Alternate gene names: 197106070

Gene position: 2999863-3000711 (Clockwise)

Preceding gene: 197106069

Following gene: 197106071

Centisome position: 75.07

GC content: 73.03

Gene sequence:

>849_bases
ATGATCGAGCCGCTTCCCGACCTGCTGGTCCAGCCCATCGTCCGCGCCGCGCTCGCCGAAGACCTCGGCCGCGCCGGCGA
CGTCACCGCCCAGGCGTGCGTGCCCGAGGCCGCCGAGCTTTCGGTGGTCTTCGCCGCCCGCCGCGGCGGCGTCGTCGCGG
GCCTGTCCTGCGCGCGGCTGGCCATGGCCGAGCTCGACCCCGCCCTCGCCTTCGAGCCCCATGTGCGGGACGGCGACGTT
GTCCCGGCGGGGGCCGTCCTCGCGGCCGTCCAGGGCAAGGCGCGCGCGATCCTGTCGGCCGAGCGCACCGCGCTCAATCT
CCTCGGCCGCCTGTGCGGGATCGCCACCCTGACGCAGGACTACGTCGACGCGGTCGCAGGCACGGGCGCCAGGATCACCG
ACACCCGCAAGACGACGCCGGGCCTGCGGGCTCTGGAGAAGTACGCCGTCCGCTGCGGCGGCGGCGTGAACCACCGCTTC
GGCCTCGACGACGCCATCCTCATCAAGGACAACCACGTGGCCGCCTGCGGCTCGGTGGGCGAGGCGGTTCGCCGCGCGAA
GGCCTACGCCGGCCACCTGATGAAGGTCGAGGTGGAGGTGGACAACCTCGTGCAGTTCCACGAGGCGCTGGCCGCCGATC
CCGACGTTGTCATGCTCGACAACTTCAGCCTAGCGGACATGGCCGAGGCGGTGCGCCTCGGAAAGGGCCGCGTGGTCCTG
GAGGCCTCGGGCGGGGTCACCCTCGAGACCGTGCGCGCCATCGCCGAGACGGGGGTGGACGTGATCAGCGTCGGCGCCCT
CACCCACTCGGCCAAGGTCCTCGACATCGGCCTGGACGCGGTCGGCTAG

Upstream 100 bases:

>100_bases
GCGGCCACTTCCGCGAGGACTTCCCCCTGTCCGGCGAGGCCCGCCGCACCCTGGCGACCCTGGCCGACGTGGAGGGCGCG
GCCTTGAGGTTCGCCGCCGA

Downstream 100 bases:

>100_bases
GCGCAACCTCCGCCGCCCTGTCCTGTTCCCCCTCCAGCGGAGCTGAGGAGGACCGGGCATGGAGGGGATCGAGGCGCTGC
ACCCGTTCGTGGCGCGGCTG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MIEPLPDLLVQPIVRAALAEDLGRAGDVTAQACVPEAAELSVVFAARRGGVVAGLSCARLAMAELDPALAFEPHVRDGDV
VPAGAVLAAVQGKARAILSAERTALNLLGRLCGIATLTQDYVDAVAGTGARITDTRKTTPGLRALEKYAVRCGGGVNHRF
GLDDAILIKDNHVAACGSVGEAVRRAKAYAGHLMKVEVEVDNLVQFHEALAADPDVVMLDNFSLADMAEAVRLGKGRVVL
EASGGVTLETVRAIAETGVDVISVGALTHSAKVLDIGLDAVG

Sequences:

>Translated_282_residues
MIEPLPDLLVQPIVRAALAEDLGRAGDVTAQACVPEAAELSVVFAARRGGVVAGLSCARLAMAELDPALAFEPHVRDGDV
VPAGAVLAAVQGKARAILSAERTALNLLGRLCGIATLTQDYVDAVAGTGARITDTRKTTPGLRALEKYAVRCGGGVNHRF
GLDDAILIKDNHVAACGSVGEAVRRAKAYAGHLMKVEVEVDNLVQFHEALAADPDVVMLDNFSLADMAEAVRLGKGRVVL
EASGGVTLETVRAIAETGVDVISVGALTHSAKVLDIGLDAVG
>Mature_282_residues
MIEPLPDLLVQPIVRAALAEDLGRAGDVTAQACVPEAAELSVVFAARRGGVVAGLSCARLAMAELDPALAFEPHVRDGDV
VPAGAVLAAVQGKARAILSAERTALNLLGRLCGIATLTQDYVDAVAGTGARITDTRKTTPGLRALEKYAVRCGGGVNHRF
GLDDAILIKDNHVAACGSVGEAVRRAKAYAGHLMKVEVEVDNLVQFHEALAADPDVVMLDNFSLADMAEAVRLGKGRVVL
EASGGVTLETVRAIAETGVDVISVGALTHSAKVLDIGLDAVG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=35.6115107913669, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1786299, Length=272, Percent_Identity=45.2205882352941, Blast_Score=194, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6321162, Length=249, Percent_Identity=36.144578313253, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29097; Mature: 29097

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEPLPDLLVQPIVRAALAEDLGRAGDVTAQACVPEAAELSVVFAARRGGVVAGLSCARL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHEEEEEECCCCEEECHHHHHH
AMAELDPALAFEPHVRDGDVVPAGAVLAAVQGKARAILSAERTALNLLGRLCGIATLTQD
HHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVDAVAGTGARITDTRKTTPGLRALEKYAVRCGGGVNHRFGLDDAILIKDNHVAACGSVG
HHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEHHHHH
EAVRRAKAYAGHLMKVEVEVDNLVQFHEALAADPDVVMLDNFSLADMAEAVRLGKGRVVL
HHHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEE
EASGGVTLETVRAIAETGVDVISVGALTHSAKVLDIGLDAVG
EECCCCHHHHHHHHHHCCCCEEEECHHHCCCEEEEECCCCCC
>Mature Secondary Structure
MIEPLPDLLVQPIVRAALAEDLGRAGDVTAQACVPEAAELSVVFAARRGGVVAGLSCARL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHEEEEEECCCCEEECHHHHHH
AMAELDPALAFEPHVRDGDVVPAGAVLAAVQGKARAILSAERTALNLLGRLCGIATLTQD
HHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVDAVAGTGARITDTRKTTPGLRALEKYAVRCGGGVNHRFGLDDAILIKDNHVAACGSVG
HHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEHHHHH
EAVRRAKAYAGHLMKVEVEVDNLVQFHEALAADPDVVMLDNFSLADMAEAVRLGKGRVVL
HHHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEE
EASGGVTLETVRAIAETGVDVISVGALTHSAKVLDIGLDAVG
EECCCCHHHHHHHHHHCCCCEEEECHHHCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]