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The map label for this gene is 197106021

Identifier: 197106021

GI number: 197106021

Start: 2940623

End: 2942182

Strand: Direct

Name: 197106021

Synonym: PHZ_c2560

Alternate gene names: NA

Gene position: 2940623-2942182 (Clockwise)

Preceding gene: 197106020

Following gene: 197106023

Centisome position: 73.58

GC content: 70.77

Gene sequence:

>1560_bases
ATGGATTGGTCCCCTGAAGTCGAGGCCCTGCGTCGTCGCCGCGCCGCCGCGGCCCGGATGGGCGGCGAGGCCGCCGTCGA
GAAGCACCACAACGCCGGCCGCCTTACGGTGCGCGAGCGGATCGCCCTGCTGCTGGACGCAGACAGCTTCGAGGAGCTCG
GAGGCCTGACGGGATCGGTGATCAGCGAACCGGACGGCGAAGGGGAAGCTTTCACCGCGGCCAACATCGTCCTCGGGCTC
GGGCGCGTCGACGGCCGTCGGGTCGTCGTGGTCGGAGACGATTTCACGATCCGCGGCGGATCCAGCGAGGCGAGCAGCCA
GCCCAAGCAGCGGCACGCCGAACAGTTGCCGCACGAGTTCCGGCTGCCGCTGATCCGCCTGGTCGACGGATCCGGCGGCG
GCGGCTCCGTCCGGGAGCTGGAGCGCCTGCAACGCACCTATGTGCCCCTGGGCCGCTACCGCCTGCCCACCGTCTACCTG
ATGGCCAAGAATCTGGCGGAGGTGCCGGTGGTCGGCCTCTGCCTCGGCTCCGTTGCGGGCCTGGGCGCCATGCGCGTGGC
GGCGAGCCACTACTCGATGATGATCCGGGACACGAGCCACCTCTTCGTGGCCGGTCCGCCGCTCGTCGGCGCCACGGGCG
AGAAGCGCACGAAGGAGGAGCTGGGCGGAGCCAGCGTGCACGGAACCAGCGGCGCGGTCGACGACGTGGTGGATAGCGAA
GCGGAGGCCTTTTCCCGCACCCGCCGGTTCCTCTCCTACCTGCCGAGCTCGATCTGGGAGCTTCCCGAGCGCGTCGAGCC
GACCGACGACCCGGAGCGGCGCGAGGAGAGCCTCCTGTCGATCGTCCCGCGGGAGCGGCGGCGGCCCTATCTGATGCGCA
AGATCATCGAGGCGGTGGTGGACCGCGGGTCGTTCTTCGAGATCTCGCGCGCATACGGCAAGTCCATCGTCACCGGTCTG
GCCCGCCTGGACGGCTGGCCTGTGGCCGTGATGGCCGGCGATCCGTACACCCTGGCCGGCGCCTGGACCGCTCAGGCGGC
GCAGAAGATCACCCGCTTCATCGACATGGCCAACACCTTCCACCTGCCGGTCGTGCACTTGGTCGATTGCCCCGGCTTCG
AGATCGGCCTGCGCGGCGAAACGGCCAACACCTTGCGGCACGGGGCGCGGGCCTTCTTCGCCATCAACCAGTTCACAGGC
CCCTGGTGCAGCGTGATCGTCCGCAACGCCTTCGGGCTCGGCGGAGCCGCGCACCAGCCCATCAACGCGCCCACGCAGCG
GTTCGCCTGGCCCTCCGGCCGGTGGGGCTCGCTTCCCACCGAAGGCGGCATCGAGGCCGCCTATCGGGCGGAGATCGAGG
CCGCCGAGGATCCGGAGGCCGCCCGCGCCGAGATCTACCGCCGGCTGGAGTCCCTCCAGTCCCCGATGAGGACGGCCGAG
GCCTACGACATCGAGGATGTCGTCGACCCGCGGGAGACGCGCCCGCTCCTTTGCCGCTTCGCCAACATGGCCGCGCCTCT
GCGCAAGCCGGGCCCGGTCAGCCTGACGATGCGGCCCTGA

Upstream 100 bases:

>100_bases
GCGGACGGTTGGTTGAACTGCTGGTCGCGGCCGGCGAGGCGGTGAGCGAGGACCAGGTCATCGCGCGCATGGAACTCGGC
TGAAGAACGGGAAGGACGGC

Downstream 100 bases:

>100_bases
AGGCCCCCTCCGCTCAGGCGCGCGGGGCGCTCAGCGCCTCGTCGGCCAGGCGGGCGGCCTCCGCCATGTCGGGGGTCTCG
CAGGCCGCGACGTATTCGCG

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MDWSPEVEALRRRRAAAARMGGEAAVEKHHNAGRLTVRERIALLLDADSFEELGGLTGSVISEPDGEGEAFTAANIVLGL
GRVDGRRVVVVGDDFTIRGGSSEASSQPKQRHAEQLPHEFRLPLIRLVDGSGGGGSVRELERLQRTYVPLGRYRLPTVYL
MAKNLAEVPVVGLCLGSVAGLGAMRVAASHYSMMIRDTSHLFVAGPPLVGATGEKRTKEELGGASVHGTSGAVDDVVDSE
AEAFSRTRRFLSYLPSSIWELPERVEPTDDPERREESLLSIVPRERRRPYLMRKIIEAVVDRGSFFEISRAYGKSIVTGL
ARLDGWPVAVMAGDPYTLAGAWTAQAAQKITRFIDMANTFHLPVVHLVDCPGFEIGLRGETANTLRHGARAFFAINQFTG
PWCSVIVRNAFGLGGAAHQPINAPTQRFAWPSGRWGSLPTEGGIEAAYRAEIEAAEDPEAARAEIYRRLESLQSPMRTAE
AYDIEDVVDPRETRPLLCRFANMAAPLRKPGPVSLTMRP

Sequences:

>Translated_519_residues
MDWSPEVEALRRRRAAAARMGGEAAVEKHHNAGRLTVRERIALLLDADSFEELGGLTGSVISEPDGEGEAFTAANIVLGL
GRVDGRRVVVVGDDFTIRGGSSEASSQPKQRHAEQLPHEFRLPLIRLVDGSGGGGSVRELERLQRTYVPLGRYRLPTVYL
MAKNLAEVPVVGLCLGSVAGLGAMRVAASHYSMMIRDTSHLFVAGPPLVGATGEKRTKEELGGASVHGTSGAVDDVVDSE
AEAFSRTRRFLSYLPSSIWELPERVEPTDDPERREESLLSIVPRERRRPYLMRKIIEAVVDRGSFFEISRAYGKSIVTGL
ARLDGWPVAVMAGDPYTLAGAWTAQAAQKITRFIDMANTFHLPVVHLVDCPGFEIGLRGETANTLRHGARAFFAINQFTG
PWCSVIVRNAFGLGGAAHQPINAPTQRFAWPSGRWGSLPTEGGIEAAYRAEIEAAEDPEAARAEIYRRLESLQSPMRTAE
AYDIEDVVDPRETRPLLCRFANMAAPLRKPGPVSLTMRP
>Mature_519_residues
MDWSPEVEALRRRRAAAARMGGEAAVEKHHNAGRLTVRERIALLLDADSFEELGGLTGSVISEPDGEGEAFTAANIVLGL
GRVDGRRVVVVGDDFTIRGGSSEASSQPKQRHAEQLPHEFRLPLIRLVDGSGGGGSVRELERLQRTYVPLGRYRLPTVYL
MAKNLAEVPVVGLCLGSVAGLGAMRVAASHYSMMIRDTSHLFVAGPPLVGATGEKRTKEELGGASVHGTSGAVDDVVDSE
AEAFSRTRRFLSYLPSSIWELPERVEPTDDPERREESLLSIVPRERRRPYLMRKIIEAVVDRGSFFEISRAYGKSIVTGL
ARLDGWPVAVMAGDPYTLAGAWTAQAAQKITRFIDMANTFHLPVVHLVDCPGFEIGLRGETANTLRHGARAFFAINQFTG
PWCSVIVRNAFGLGGAAHQPINAPTQRFAWPSGRWGSLPTEGGIEAAYRAEIEAAEDPEAARAEIYRRLESLQSPMRTAE
AYDIEDVVDPRETRPLLCRFANMAAPLRKPGPVSLTMRP

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=503, Percent_Identity=31.2127236580517, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI295821216, Length=523, Percent_Identity=30.019120458891, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI11545863, Length=523, Percent_Identity=28.6806883365201, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI134142062, Length=319, Percent_Identity=24.7648902821317, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147359, Length=516, Percent_Identity=31.2015503875969, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI25147362, Length=516, Percent_Identity=31.2015503875969, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17552936, Length=523, Percent_Identity=29.4455066921606, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=371, Percent_Identity=24.5283018867925, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24586065, Length=524, Percent_Identity=30.3435114503817, Blast_Score=185, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56653; Mature: 56653

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWSPEVEALRRRRAAAARMGGEAAVEKHHNAGRLTVRERIALLLDADSFEELGGLTGSV
CCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEHHHHHHHHCCCCCHHHHCCCCCCC
ISEPDGEGEAFTAANIVLGLGRVDGRRVVVVGDDFTIRGGSSEASSQPKQRHAEQLPHEF
CCCCCCCCCEEEHHHHHEEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHCCHHH
RLPLIRLVDGSGGGGSVRELERLQRTYVPLGRYRLPTVYLMAKNLAEVPVVGLCLGSVAG
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHH
LGAMRVAASHYSMMIRDTSHLFVAGPPLVGATGEKRTKEELGGASVHGTSGAVDDVVDSE
HHHHHHHHHHHHEEEECCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHH
AEAFSRTRRFLSYLPSSIWELPERVEPTDDPERREESLLSIVPRERRRPYLMRKIIEAVV
HHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHH
DRGSFFEISRAYGKSIVTGLARLDGWPVAVMAGDPYTLAGAWTAQAAQKITRFIDMANTF
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHCCC
HLPVVHLVDCPGFEIGLRGETANTLRHGARAFFAINQFTGPWCSVIVRNAFGLGGAAHQP
CCCEEEEECCCCCEEEECCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCCCCCC
INAPTQRFAWPSGRWGSLPTEGGIEAAYRAEIEAAEDPEAARAEIYRRLESLQSPMRTAE
CCCCHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AYDIEDVVDPRETRPLLCRFANMAAPLRKPGPVSLTMRP
CCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECC
>Mature Secondary Structure
MDWSPEVEALRRRRAAAARMGGEAAVEKHHNAGRLTVRERIALLLDADSFEELGGLTGSV
CCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEHHHHHHHHCCCCCHHHHCCCCCCC
ISEPDGEGEAFTAANIVLGLGRVDGRRVVVVGDDFTIRGGSSEASSQPKQRHAEQLPHEF
CCCCCCCCCEEEHHHHHEEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHCCHHH
RLPLIRLVDGSGGGGSVRELERLQRTYVPLGRYRLPTVYLMAKNLAEVPVVGLCLGSVAG
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHH
LGAMRVAASHYSMMIRDTSHLFVAGPPLVGATGEKRTKEELGGASVHGTSGAVDDVVDSE
HHHHHHHHHHHHEEEECCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHH
AEAFSRTRRFLSYLPSSIWELPERVEPTDDPERREESLLSIVPRERRRPYLMRKIIEAVV
HHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHH
DRGSFFEISRAYGKSIVTGLARLDGWPVAVMAGDPYTLAGAWTAQAAQKITRFIDMANTF
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHCCC
HLPVVHLVDCPGFEIGLRGETANTLRHGARAFFAINQFTGPWCSVIVRNAFGLGGAAHQP
CCCEEEEECCCCCEEEECCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCCCCCC
INAPTQRFAWPSGRWGSLPTEGGIEAAYRAEIEAAEDPEAARAEIYRRLESLQSPMRTAE
CCCCHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AYDIEDVVDPRETRPLLCRFANMAAPLRKPGPVSLTMRP
CCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]