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The map label for this gene is virB3 [H]

Identifier: 197105811

GI number: 197105811

Start: 2660809

End: 2661147

Strand: Direct

Name: virB3 [H]

Synonym: PHZ_c2349

Alternate gene names: 197105811

Gene position: 2660809-2661147 (Clockwise)

Preceding gene: 197105810

Following gene: 197105812

Centisome position: 66.58

GC content: 69.32

Gene sequence:

>339_bases
GTGCGTAACGCCGAGCGCCTGACCGAAGACCCCCTGTTCCTGGCCTGCACCCGGCCTGCCCTGTTCCTCGGGGTTCCGAT
GGAAGCGGTCGGCGCCAATCTGATCGTCTCGGCGACCGCCTTCCTCGCGGGGGGCTCCCTCGCCTGGCTTCTGGTCGCGC
CCGCGCTGCATCTGGTGTTCCAGGCCATCTGCAAGTCCGACCCCAACGCGTTCCGGGTCCTCTACCTGTTCATTGAAACC
AAGGGCCGGGCGCGCAATGGCCGGCTCTGGGGCGGCAGCTCGCCGACTCCTCTGCCGCTGCGCCGCCGCTTTGCGACCGC
GGAGGTTACCCGTGGCTAG

Upstream 100 bases:

>100_bases
TTCGGCCATCTCGATCTGCGCCGCGCGGGGACCGTCGTGGTCGGGATCATCGTGATCTTCGGAGCCACAACCATCGTCGA
TCTGATCACGGGAGGGGCCG

Downstream 100 bases:

>100_bases
CCTCTCCGCCCGCCGGCGCGAACCAGAACCGGCTCGCTTCCTGCCCTATGCCCTCCATGTCTCCGACAGCGTGCTGGCGC
TGGATAGCGGGGCCTTGATG

Product: type IV secretory pathway, VirB3 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MRNAERLTEDPLFLACTRPALFLGVPMEAVGANLIVSATAFLAGGSLAWLLVAPALHLVFQAICKSDPNAFRVLYLFIET
KGRARNGRLWGGSSPTPLPLRRRFATAEVTRG

Sequences:

>Translated_112_residues
MRNAERLTEDPLFLACTRPALFLGVPMEAVGANLIVSATAFLAGGSLAWLLVAPALHLVFQAICKSDPNAFRVLYLFIET
KGRARNGRLWGGSSPTPLPLRRRFATAEVTRG
>Mature_112_residues
MRNAERLTEDPLFLACTRPALFLGVPMEAVGANLIVSATAFLAGGSLAWLLVAPALHLVFQAICKSDPNAFRVLYLFIET
KGRARNGRLWGGSSPTPLPLRRRFATAEVTRG

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG3702

COG function: function code U; Type IV secretory pathway, VirB3 components

Gene ontology:

Cell location: Cell outer membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the virB3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007792 [H]

Pfam domain/function: PF05101 VirB3 [H]

EC number: NA

Molecular weight: Translated: 12152; Mature: 12152

Theoretical pI: Translated: 11.25; Mature: 11.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNAERLTEDPLFLACTRPALFLGVPMEAVGANLIVSATAFLAGGSLAWLLVAPALHLVF
CCCCCCCCCCCEEEEECCCEEEECCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QAICKSDPNAFRVLYLFIETKGRARNGRLWGGSSPTPLPLRRRFATAEVTRG
HHHHCCCCCCEEEEEEEEECCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MRNAERLTEDPLFLACTRPALFLGVPMEAVGANLIVSATAFLAGGSLAWLLVAPALHLVF
CCCCCCCCCCCEEEEECCCEEEECCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QAICKSDPNAFRVLYLFIETKGRARNGRLWGGSSPTPLPLRRRFATAEVTRG
HHHHCCCCCCEEEEEEEEECCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10749166; 10882236 [H]