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The map label for this gene is phr [H]

Identifier: 197105770

GI number: 197105770

Start: 2614868

End: 2616235

Strand: Reverse

Name: phr [H]

Synonym: PHZ_c2308

Alternate gene names: 197105770

Gene position: 2616235-2614868 (Counterclockwise)

Preceding gene: 197105771

Following gene: 197105768

Centisome position: 65.47

GC content: 72.22

Gene sequence:

>1368_bases
GTGATCCCCTCGTCCCGCTTGAAGGTCCTCGTGGACGCGCCGCCGCGTCCCGGGGCCCGCTACGTGCTCTACTGGATGCA
GCAGTCCCAGCGCGCCGGCGGCAATCCCGCCCTGGAATACGCTGTCGAGCAGGCCAATGCGCTGAAGCTGCCGCTGCTGG
TCTGCTTCGGGCTTGCGGCCTTTCCGGAGGCCAACGCCCGGCACTACGACTTCATGCTGCGGGGGCTCGCCGAGGTGGAG
CGCGCGCTGGCGGCGCGGGGGATCGGCTTCGTCATCCGCAAACGGCCGCCGCACGAGCTGGTGCGAGAGCTGGCGGCCGA
CGCCGCCCTGGTCGTGGCCGACCGCGGCTACCTGCGCATCCAGCGGGCCTGGCGCGAGAGGCTGGCCGAGGGCCTGGCCC
GCCGGCTGGTGCAGGTGGAAGGCGACGTGGTCGTCCCCGTCGAGGCCGCCTCGAACAAGCACGAGTACGCCGCCCGCACC
ATCCGGCCGAAGCTGCACCGGCTGTGGGACGACTACCTGCACCCGCTGGCCGAGCGGCCGGTGAACCATCCCGCCCTCGG
CCTGCGCGTCGCCGGCGACGTGGACCTGTCCAAGGTGGACGCCGTCCTGGCGGGCCTGAAGATCGACCGGTCCGTGCCGC
CGGTCCGGCGCTTCGCGGCGGGCGAGGGGGCGGCCCGCGCGGCCCTGGCCGCCTTCCTGGATCGGGGCCTCGCCCGCTAC
GAGGCGGACCGCAGCCGTCCGGAGGCGGGCGCGGTCTCGCACCTCAGCCCCTACCTGCACTTCGGGCAGATCTCGCCGGT
GGAGATCGCGCTCGCGGTGCGGGAGGCCGGCGTCGTCAGCGGCGTGGCGACCTATCTGGAGGAGCTGATCGTCCGGCGCG
AGCTGGCCATGAACCACGCCTTCCAAGCGCCGGCCTACGACCGCTACGAGGTCCTGCCCGAGTGGGCCCGCCAGACGCTG
GCGGACCACGCCTCGGACCCGCGGCCGCACCTCTACACCCGCGATCAGTTCGAGGCGGCCGAGACGCACGATTCCTACTG
GAACGCGGCCATGCTCGAGATGCGGGCCACAGGCTACATGCACAACCGGCTGCGCATGTACTGGGGCAAGAAGATCCTGC
ACTGGTCGGCCAGCCCCGAGGAGGCGTGGGAGACGGCGCTGGCCCTCAACAACCGCTGGTTCCTCGACGGGCGCGACCCC
AACTCTTTCACCAACGTCGGCTGGCTGTTCGGCCTGCACGACCGCCCCTGGGGGCCGCAGCCGGTGTTCGGCACGGTCAG
GTCGATGGGCCCGAACACCTTCAAGAAGTTCGACGCCGAGGCCTACGTCCGCCAGGTCCGGGCCCTGGCGGACGCCGAAG
CCGTCTAG

Upstream 100 bases:

>100_bases
GCAGGCTCGAAGCTGAAGACGGCCGCCGAGCTCGGCATCCAGGTGCTCACCGAAGACGAATGGTTGGAGATGGTCGGCAG
CTAGGAGCCCGAACTCTCCC

Downstream 100 bases:

>100_bases
AGCGGGGCGGTGACCTCGGCGAGCCAGGCCTTGGCCTCGCCGTCCAGCAGCGGGCCGATCTCGCGCGCCACGCGGGCGTG
GTAGGCGTCGAACTGGGCCA

Product: deoxyribodipyrimidine photolyase - classI

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MIPSSRLKVLVDAPPRPGARYVLYWMQQSQRAGGNPALEYAVEQANALKLPLLVCFGLAAFPEANARHYDFMLRGLAEVE
RALAARGIGFVIRKRPPHELVRELAADAALVVADRGYLRIQRAWRERLAEGLARRLVQVEGDVVVPVEAASNKHEYAART
IRPKLHRLWDDYLHPLAERPVNHPALGLRVAGDVDLSKVDAVLAGLKIDRSVPPVRRFAAGEGAARAALAAFLDRGLARY
EADRSRPEAGAVSHLSPYLHFGQISPVEIALAVREAGVVSGVATYLEELIVRRELAMNHAFQAPAYDRYEVLPEWARQTL
ADHASDPRPHLYTRDQFEAAETHDSYWNAAMLEMRATGYMHNRLRMYWGKKILHWSASPEEAWETALALNNRWFLDGRDP
NSFTNVGWLFGLHDRPWGPQPVFGTVRSMGPNTFKKFDAEAYVRQVRALADAEAV

Sequences:

>Translated_455_residues
MIPSSRLKVLVDAPPRPGARYVLYWMQQSQRAGGNPALEYAVEQANALKLPLLVCFGLAAFPEANARHYDFMLRGLAEVE
RALAARGIGFVIRKRPPHELVRELAADAALVVADRGYLRIQRAWRERLAEGLARRLVQVEGDVVVPVEAASNKHEYAART
IRPKLHRLWDDYLHPLAERPVNHPALGLRVAGDVDLSKVDAVLAGLKIDRSVPPVRRFAAGEGAARAALAAFLDRGLARY
EADRSRPEAGAVSHLSPYLHFGQISPVEIALAVREAGVVSGVATYLEELIVRRELAMNHAFQAPAYDRYEVLPEWARQTL
ADHASDPRPHLYTRDQFEAAETHDSYWNAAMLEMRATGYMHNRLRMYWGKKILHWSASPEEAWETALALNNRWFLDGRDP
NSFTNVGWLFGLHDRPWGPQPVFGTVRSMGPNTFKKFDAEAYVRQVRALADAEAV
>Mature_455_residues
MIPSSRLKVLVDAPPRPGARYVLYWMQQSQRAGGNPALEYAVEQANALKLPLLVCFGLAAFPEANARHYDFMLRGLAEVE
RALAARGIGFVIRKRPPHELVRELAADAALVVADRGYLRIQRAWRERLAEGLARRLVQVEGDVVVPVEAASNKHEYAART
IRPKLHRLWDDYLHPLAERPVNHPALGLRVAGDVDLSKVDAVLAGLKIDRSVPPVRRFAAGEGAARAALAAFLDRGLARY
EADRSRPEAGAVSHLSPYLHFGQISPVEIALAVREAGVVSGVATYLEELIVRRELAMNHAFQAPAYDRYEVLPEWARQTL
ADHASDPRPHLYTRDQFEAAETHDSYWNAAMLEMRATGYMHNRLRMYWGKKILHWSASPEEAWETALALNNRWFLDGRDP
NSFTNVGWLFGLHDRPWGPQPVFGTVRSMGPNTFKKFDAEAYVRQVRALADAEAV

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586398, Length=436, Percent_Identity=40.3669724770642, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24586396, Length=436, Percent_Identity=40.3669724770642, Blast_Score=267, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24586404, Length=150, Percent_Identity=43.3333333333333, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 51036; Mature: 51036

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSSRLKVLVDAPPRPGARYVLYWMQQSQRAGGNPALEYAVEQANALKLPLLVCFGLAA
CCCCCCEEEEEECCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
FPEANARHYDFMLRGLAEVERALAARGIGFVIRKRPPHELVRELAADAALVVADRGYLRI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCEEEEECCCHHHH
QRAWRERLAEGLARRLVQVEGDVVVPVEAASNKHEYAARTIRPKLHRLWDDYLHPLAERP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNHPALGLRVAGDVDLSKVDAVLAGLKIDRSVPPVRRFAAGEGAARAALAAFLDRGLARY
CCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
EADRSRPEAGAVSHLSPYLHFGQISPVEIALAVREAGVVSGVATYLEELIVRRELAMNHA
HHHCCCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FQAPAYDRYEVLPEWARQTLADHASDPRPHLYTRDQFEAAETHDSYWNAAMLEMRATGYM
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HNRLRMYWGKKILHWSASPEEAWETALALNNRWFLDGRDPNSFTNVGWLFGLHDRPWGPQ
HHHHHHHHCCEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCCCCC
PVFGTVRSMGPNTFKKFDAEAYVRQVRALADAEAV
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPSSRLKVLVDAPPRPGARYVLYWMQQSQRAGGNPALEYAVEQANALKLPLLVCFGLAA
CCCCCCEEEEEECCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
FPEANARHYDFMLRGLAEVERALAARGIGFVIRKRPPHELVRELAADAALVVADRGYLRI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCEEEEECCCHHHH
QRAWRERLAEGLARRLVQVEGDVVVPVEAASNKHEYAARTIRPKLHRLWDDYLHPLAERP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNHPALGLRVAGDVDLSKVDAVLAGLKIDRSVPPVRRFAAGEGAARAALAAFLDRGLARY
CCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
EADRSRPEAGAVSHLSPYLHFGQISPVEIALAVREAGVVSGVATYLEELIVRRELAMNHA
HHHCCCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FQAPAYDRYEVLPEWARQTLADHASDPRPHLYTRDQFEAAETHDSYWNAAMLEMRATGYM
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HNRLRMYWGKKILHWSASPEEAWETALALNNRWFLDGRDPNSFTNVGWLFGLHDRPWGPQ
HHHHHHHHCCEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCCCCC
PVFGTVRSMGPNTFKKFDAEAYVRQVRALADAEAV
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]