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The map label for this gene is cya [H]

Identifier: 197105753

GI number: 197105753

Start: 2595888

End: 2597069

Strand: Direct

Name: cya [H]

Synonym: PHZ_c2291

Alternate gene names: 197105753

Gene position: 2595888-2597069 (Clockwise)

Preceding gene: 197105741

Following gene: 197105754

Centisome position: 64.96

GC content: 72.34

Gene sequence:

>1182_bases
ATGGAATATGCGTTCGAGACGATCACGGCCGAGCAGGCGGCGGGCGTCCAGCTCGGCGACACGCTGACGTTCAACGGCGG
GCCGGCCAGCGCCGTCTCCGTCGTCTACCAGTCCTACGAGCCCCTGGCCCTGACGCCGGAAGTTCCCAGCATCCTCGTCA
CCTTCGCCGGGCGGACCGTGAAGTTCGGCGTCGGCCTGACCCAGCTCTCCGACGCGGGCGCCATCGTGATGGCCGACGGC
TCCAAGCTGTTCGTGGGCGACGCGGGCGACGAGCGGACCTCGGGCTCCGACCTGGGCGACGGCCTCTACGGCGGCCCCGG
CCACGACGTCCTGGCGGGCTTGGGGGGCGACGACCTGATCCACGGCGGAAGCGGCGACGACCAGCTCGCCGGCGGCGCGG
GCTACGACGTGATCTACGGCGGCCAGGGCGACGACGTGATCTACGGCGGCTCCACCGCGGCGGGAGAGCCCGGCGAGGCG
GGCAACTTCGCCCACGGCAACCTCGGCGACGACCACGTGGTCGGCGGCGGCGGCGACGACTGGCTCTACGGCGGCCAGGG
GGCCGACTTCATTGCCGGCCTGGATGGCGACGACTACCTCAGCGGCGACCTGGGCGACGACGAACTGCACGGCGGCCTCG
GCGACGACAGCCTGGTCGGCGGCGGCGGGAACGACACCCTGCAGGGCGGCTTCGGGGCGGACCGCTTCGGCGGCGGCGCC
GGCGACGACCTGCTGGTCGCCCAGGGTCCGGAGGGCGCCTGGATGCGGGGCGACGAGGGGAACGACACCCTCGTCACGGC
CACCGCGGGCCGCGACACGCTCTACGGCGGCGAGGGGCGCGACCGGTTCGAGTTCGTGGCCAGGACCCCGCCGGGCGAAG
GCGTCGATGCGGTCATCATGGACTGGGAGGCCCACGATACCCTGAACTTCGCGGACGTCAGCATCCTGTCCTCCTCGATC
CTGCCGACCTCGTATTCGGAGTTCACGGCCGACAGCTACGAGCAGGCCCTCGCCATCGCCAACCAGCACATCTCGGCGGC
GGGCGCGAAGTACGTGGCCGCGCAGGTGGGGGATTCCGTGGTCGTCTTCGTCGATGCGGGCGACCCGGCCGACGGGGCGG
ACTCGGCCGTCCTGCTGGTCGGCCGCACCCTGGCCGACATCGGCCTGGAGAACTTCGTCTAG

Upstream 100 bases:

>100_bases
CCTCCGCCTCGCCGAACATCGTTTCTCGTAAGTTGCGTTTTTACGCAACATGCGTCATCTAGGCCGTAGAGGGGCGATCG
CCCAGGAGACACCGACCTTG

Downstream 100 bases:

>100_bases
CCCGGATCGCCTAGCCCGGATCGTTAGCCCGGATCGCTAGCCCGGGCAGCGCATCAGGGTGATGGGGCCCGCCCAGGGGC
CGCCGCTGACGGTCATGCTC

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MEYAFETITAEQAAGVQLGDTLTFNGGPASAVSVVYQSYEPLALTPEVPSILVTFAGRTVKFGVGLTQLSDAGAIVMADG
SKLFVGDAGDERTSGSDLGDGLYGGPGHDVLAGLGGDDLIHGGSGDDQLAGGAGYDVIYGGQGDDVIYGGSTAAGEPGEA
GNFAHGNLGDDHVVGGGGDDWLYGGQGADFIAGLDGDDYLSGDLGDDELHGGLGDDSLVGGGGNDTLQGGFGADRFGGGA
GDDLLVAQGPEGAWMRGDEGNDTLVTATAGRDTLYGGEGRDRFEFVARTPPGEGVDAVIMDWEAHDTLNFADVSILSSSI
LPTSYSEFTADSYEQALAIANQHISAAGAKYVAAQVGDSVVVFVDAGDPADGADSAVLLVGRTLADIGLENFV

Sequences:

>Translated_393_residues
MEYAFETITAEQAAGVQLGDTLTFNGGPASAVSVVYQSYEPLALTPEVPSILVTFAGRTVKFGVGLTQLSDAGAIVMADG
SKLFVGDAGDERTSGSDLGDGLYGGPGHDVLAGLGGDDLIHGGSGDDQLAGGAGYDVIYGGQGDDVIYGGSTAAGEPGEA
GNFAHGNLGDDHVVGGGGDDWLYGGQGADFIAGLDGDDYLSGDLGDDELHGGLGDDSLVGGGGNDTLQGGFGADRFGGGA
GDDLLVAQGPEGAWMRGDEGNDTLVTATAGRDTLYGGEGRDRFEFVARTPPGEGVDAVIMDWEAHDTLNFADVSILSSSI
LPTSYSEFTADSYEQALAIANQHISAAGAKYVAAQVGDSVVVFVDAGDPADGADSAVLLVGRTLADIGLENFV
>Mature_393_residues
MEYAFETITAEQAAGVQLGDTLTFNGGPASAVSVVYQSYEPLALTPEVPSILVTFAGRTVKFGVGLTQLSDAGAIVMADG
SKLFVGDAGDERTSGSDLGDGLYGGPGHDVLAGLGGDDLIHGGSGDDQLAGGAGYDVIYGGQGDDVIYGGSTAAGEPGEA
GNFAHGNLGDDHVVGGGGDDWLYGGQGADFIAGLDGDDYLSGDLGDDELHGGLGDDSLVGGGGNDTLQGGFGADRFGGGA
GDDLLVAQGPEGAWMRGDEGNDTLVTATAGRDTLYGGEGRDRFEFVARTPPGEGVDAVIMDWEAHDTLNFADVSILSSSI
LPTSYSEFTADSYEQALAIANQHISAAGAKYVAAQVGDSVVVFVDAGDPADGADSAVLLVGRTLADIGLENFV

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 39467; Mature: 39467

Theoretical pI: Translated: 3.58; Mature: 3.58

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYAFETITAEQAAGVQLGDTLTFNGGPASAVSVVYQSYEPLALTPEVPSILVTFAGRTV
CCCCCCCHHHHHHCCEEECCEEEECCCCHHHHHHHHHCCCCEEECCCCCEEEEEECCCEE
KFGVGLTQLSDAGAIVMADGSKLFVGDAGDERTSGSDLGDGLYGGPGHDVLAGLGGDDLI
EECCCCEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCEE
HGGSGDDQLAGGAGYDVIYGGQGDDVIYGGSTAAGEPGEAGNFAHGNLGDDHVVGGGGDD
ECCCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC
WLYGGQGADFIAGLDGDDYLSGDLGDDELHGGLGDDSLVGGGGNDTLQGGFGADRFGGGA
CEECCCCCCEEEECCCCCCCCCCCCCHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
GDDLLVAQGPEGAWMRGDEGNDTLVTATAGRDTLYGGEGRDRFEFVARTPPGEGVDAVIM
CCCEEEEECCCCCEECCCCCCCEEEEEECCCCEEECCCCCCEEEEEEECCCCCCCEEEEE
DWEAHDTLNFADVSILSSSILPTSYSEFTADSYEQALAIANQHISAAGAKYVAAQVGDSV
ECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCEE
VVFVDAGDPADGADSAVLLVGRTLADIGLENFV
EEEEECCCCCCCCCCEEEEECHHHHHHHHHHCC
>Mature Secondary Structure
MEYAFETITAEQAAGVQLGDTLTFNGGPASAVSVVYQSYEPLALTPEVPSILVTFAGRTV
CCCCCCCHHHHHHCCEEECCEEEECCCCHHHHHHHHHCCCCEEECCCCCEEEEEECCCEE
KFGVGLTQLSDAGAIVMADGSKLFVGDAGDERTSGSDLGDGLYGGPGHDVLAGLGGDDLI
EECCCCEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCEE
HGGSGDDQLAGGAGYDVIYGGQGDDVIYGGSTAAGEPGEAGNFAHGNLGDDHVVGGGGDD
ECCCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC
WLYGGQGADFIAGLDGDDYLSGDLGDDELHGGLGDDSLVGGGGNDTLQGGFGADRFGGGA
CEECCCCCCEEEECCCCCCCCCCCCCHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
GDDLLVAQGPEGAWMRGDEGNDTLVTATAGRDTLYGGEGRDRFEFVARTPPGEGVDAVIM
CCCEEEEECCCCCEECCCCCCCEEEEEECCCCEEECCCCCCEEEEEEECCCCCCCEEEEE
DWEAHDTLNFADVSILSSSILPTSYSEFTADSYEQALAIANQHISAAGAKYVAAQVGDSV
ECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCEE
VVFVDAGDPADGADSAVLLVGRTLADIGLENFV
EEEEECCCCCCCCCCEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]