Click here to switch to the map view.

The map label for this gene is hemL [H]

Identifier: 197105735

GI number: 197105735

Start: 2575124

End: 2576401

Strand: Direct

Name: hemL [H]

Synonym: PHZ_c2273

Alternate gene names: 197105735

Gene position: 2575124-2576401 (Clockwise)

Preceding gene: 197105729

Following gene: 197105736

Centisome position: 64.44

GC content: 71.67

Gene sequence:

>1278_bases
ATGGCTGGAACAGGCAGCCGGGACCGGGCGCTGCGCGAGCGGGCCCAGGCGGTGATCCCGGGCGGGATGTACGGGCACCA
GTCCGTGGGCCTGCTGCCCGACGACTACCCGCAGTTCTTCGAGAAGGGCGAAGGCGCCCACCTGTGGGACGTGGACGGCC
GGCGCTACCTCGACTTCATGTGCGCCTATGGCCCGAACCTGTTCGGCTACGCCCATCCCGAGATCGACGCCGCCTTCGTC
CGCCAGCTCGGCCAGGGCGACACCCTGACCGGACCGACCGCCCTGATGGTCCAGCTGGCCGAGGCCCTCACCGGCATGGT
CAGCCACGCCGACTGGGCGATCTTCTGCAAGAATGGGACGGACGCCACGTCCATGGCCCTGACCGTCGCCCGCGCCCACA
CGAAGCGCCGCGTGGTCGTCCGGGCCAAGGGCGCCTACCACGGCGCCGCGCCCTGGTGCACCCCGAGGCCCGCGGGCGTG
ATCGACACCGACCGGGCGCACCAGATCTTCTACGACTACAACGACGTGGGAAGCCTCGAGGCGGCCGTCGCCCAGGCGGG
AGACGACCTCGCCTGCATCTTCGCCGCCCCGTTCAAGCACGACGCCTTCGTTGATCAGGCCGAGCCCGACCCGGCCTACG
CCCGCCGGGCGCGCGAGCTGTGCGACGAACGCGGCGCGCTGCTGGTGGTGGACGAGGTGCGGGCGGGCTTTCGGCTGTCG
CGCGACTGCTCGTGGAGCCGGATCGGCGTCCAGCCCGACCTCTCCACCTGGGGCAAGTGCGTGGCCAACGGCCACCCGAT
CTCGGTGCTGCTGGGATCGGACAAGGCCCGCGCGGCGGCGGCGTCGGTCTATGTGACCGGCTCGTTCTGGTACCAGGCCG
CCCCCATGGCCGCCGCGCTGGAGACCCTGCGGCTGGTGCGCGAGACCGACTATCTGGAGCGCATGACCGCGCTGGGCGAG
CGGCTGCGGCAAGGCCTTGCCGAACGCGCGGCGGCGGCCGGCTTCGGCTTCCGCCAGACCGGGCCCGCCACCATGCCCCT
CTTCCTGTTCGACGACGATCCGGACCTTCGCAGGGGCTTCTGCTTTTCCAGCGAGATGCTGGCGCGGGGGGTCTATGTGC
ACCCCTGGCACAACATGTTCCTGTGCGCCGCCATGACCGAGGCCGACATCGACGCGGCGCTCGACGCGGCCGAGGACGCG
TTCGCCGCCCTGAAGCGCCAGGCGGGCGCCCTGCCGCCCGTCGAGAAACTCGCCTTCCTCACCGCCGGAGCCCATTGA

Upstream 100 bases:

>100_bases
CCCAGCCGGACGGGGAGCGACATGGCCGCGATCTACAGGGAGTCGCGGTCGCCCGCGCGGCGACGTAAGCTCGCGCCAAC
GACAAGCGAGGGAGGCGCGG

Downstream 100 bases:

>100_bases
TGGACGACTATTCCGACTACGACGGCCTGGGCCTGGCCGAGCTGGTCCGCACGAAGCAGGTGACGCCTGCCGAGCTGGTC
GAGGCCGCCATCGTCCGCAT

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAGTGSRDRALRERAQAVIPGGMYGHQSVGLLPDDYPQFFEKGEGAHLWDVDGRRYLDFMCAYGPNLFGYAHPEIDAAFV
RQLGQGDTLTGPTALMVQLAEALTGMVSHADWAIFCKNGTDATSMALTVARAHTKRRVVVRAKGAYHGAAPWCTPRPAGV
IDTDRAHQIFYDYNDVGSLEAAVAQAGDDLACIFAAPFKHDAFVDQAEPDPAYARRARELCDERGALLVVDEVRAGFRLS
RDCSWSRIGVQPDLSTWGKCVANGHPISVLLGSDKARAAAASVYVTGSFWYQAAPMAAALETLRLVRETDYLERMTALGE
RLRQGLAERAAAAGFGFRQTGPATMPLFLFDDDPDLRRGFCFSSEMLARGVYVHPWHNMFLCAAMTEADIDAALDAAEDA
FAALKRQAGALPPVEKLAFLTAGAH

Sequences:

>Translated_425_residues
MAGTGSRDRALRERAQAVIPGGMYGHQSVGLLPDDYPQFFEKGEGAHLWDVDGRRYLDFMCAYGPNLFGYAHPEIDAAFV
RQLGQGDTLTGPTALMVQLAEALTGMVSHADWAIFCKNGTDATSMALTVARAHTKRRVVVRAKGAYHGAAPWCTPRPAGV
IDTDRAHQIFYDYNDVGSLEAAVAQAGDDLACIFAAPFKHDAFVDQAEPDPAYARRARELCDERGALLVVDEVRAGFRLS
RDCSWSRIGVQPDLSTWGKCVANGHPISVLLGSDKARAAAASVYVTGSFWYQAAPMAAALETLRLVRETDYLERMTALGE
RLRQGLAERAAAAGFGFRQTGPATMPLFLFDDDPDLRRGFCFSSEMLARGVYVHPWHNMFLCAAMTEADIDAALDAAEDA
FAALKRQAGALPPVEKLAFLTAGAH
>Mature_424_residues
AGTGSRDRALRERAQAVIPGGMYGHQSVGLLPDDYPQFFEKGEGAHLWDVDGRRYLDFMCAYGPNLFGYAHPEIDAAFVR
QLGQGDTLTGPTALMVQLAEALTGMVSHADWAIFCKNGTDATSMALTVARAHTKRRVVVRAKGAYHGAAPWCTPRPAGVI
DTDRAHQIFYDYNDVGSLEAAVAQAGDDLACIFAAPFKHDAFVDQAEPDPAYARRARELCDERGALLVVDEVRAGFRLSR
DCSWSRIGVQPDLSTWGKCVANGHPISVLLGSDKARAAAASVYVTGSFWYQAAPMAAALETLRLVRETDYLERMTALGER
LRQGLAERAAAAGFGFRQTGPATMPLFLFDDDPDLRRGFCFSSEMLARGVYVHPWHNMFLCAAMTEADIDAALDAAEDAF
AALKRQAGALPPVEKLAFLTAGAH

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786349, Length=427, Percent_Identity=30.9133489461358, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1789016, Length=453, Percent_Identity=26.7108167770419, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788044, Length=314, Percent_Identity=29.6178343949045, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789759, Length=315, Percent_Identity=27.6190476190476, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787560, Length=316, Percent_Identity=28.7974683544304, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI145693181, Length=347, Percent_Identity=24.4956772334294, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71992977, Length=360, Percent_Identity=23.6111111111111, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=318, Percent_Identity=26.1006289308176, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356575, Length=323, Percent_Identity=24.4582043343653, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46098; Mature: 45966

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTGSRDRALRERAQAVIPGGMYGHQSVGLLPDDYPQFFEKGEGAHLWDVDGRRYLDFM
CCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCHHHHHHH
CAYGPNLFGYAHPEIDAAFVRQLGQGDTLTGPTALMVQLAEALTGMVSHADWAIFCKNGT
HHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
DATSMALTVARAHTKRRVVVRAKGAYHGAAPWCTPRPAGVIDTDRAHQIFYDYNDVGSLE
CHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHH
AAVAQAGDDLACIFAAPFKHDAFVDQAEPDPAYARRARELCDERGALLVVDEVRAGFRLS
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEC
RDCSWSRIGVQPDLSTWGKCVANGHPISVLLGSDKARAAAASVYVTGSFWYQAAPMAAAL
CCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEEEECHHHHHCHHHHHH
ETLRLVRETDYLERMTALGERLRQGLAERAAAAGFGFRQTGPATMPLFLFDDDPDLRRGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHCC
CFSSEMLARGVYVHPWHNMFLCAAMTEADIDAALDAAEDAFAALKRQAGALPPVEKLAFL
CCCHHHHHCCCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TAGAH
HCCCC
>Mature Secondary Structure 
AGTGSRDRALRERAQAVIPGGMYGHQSVGLLPDDYPQFFEKGEGAHLWDVDGRRYLDFM
CCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCHHHHHHH
CAYGPNLFGYAHPEIDAAFVRQLGQGDTLTGPTALMVQLAEALTGMVSHADWAIFCKNGT
HHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
DATSMALTVARAHTKRRVVVRAKGAYHGAAPWCTPRPAGVIDTDRAHQIFYDYNDVGSLE
CHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHH
AAVAQAGDDLACIFAAPFKHDAFVDQAEPDPAYARRARELCDERGALLVVDEVRAGFRLS
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEC
RDCSWSRIGVQPDLSTWGKCVANGHPISVLLGSDKARAAAASVYVTGSFWYQAAPMAAAL
CCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEEEECHHHHHCHHHHHH
ETLRLVRETDYLERMTALGERLRQGLAERAAAAGFGFRQTGPATMPLFLFDDDPDLRRGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHCC
CFSSEMLARGVYVHPWHNMFLCAAMTEADIDAALDAAEDAFAALKRQAGALPPVEKLAFL
CCCHHHHHCCCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TAGAH
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA