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The map label for this gene is manC [H]

Identifier: 197105703

GI number: 197105703

Start: 2536878

End: 2539034

Strand: Reverse

Name: manC [H]

Synonym: PHZ_c2241

Alternate gene names: 197105703

Gene position: 2539034-2536878 (Counterclockwise)

Preceding gene: 197105704

Following gene: 197105702

Centisome position: 63.54

GC content: 76.03

Gene sequence:

>2157_bases
GTGGCCGTCTATCCGGTGATCATGTGCGGCGGGTCGGGGACGCGGCTGTGGCCGGCCTCGCGCCCCTGGCGGCCCAAGCA
GTTCATTCCGCTGACCGGGGCCCGCTCCAGCTTCCAGGAGACGCTGGTCCGGGTGGCGCCGCTGGCCGAGGCCGGCCCCG
TGCTGGTCGTCGCGGGGATCGCCCACCAGGCCCTCATCGAGGCCCAGCTTGCCGAGATCGGCGGACAGGCGGTGGTGCTG
CTGGAGCCTGAGCCGCGGGACTCGGCCGCCGCCATCGCCGCGGCCTGCGCCTGGATCGAAGCGCGCGATCCGGACGCCGT
GGCGGTCATCGTCTCGGCCGACCACCACATCCCCGACGCCGACGCCTTCCGTGCGGCCGTGGCGCAGACCCTGCCGGCGG
CCTGCGAGGGCGCGGTCGTGACGCTGGGCGTAGAGCCGACCGAGCCCGCCACGGCCTACGGCTACATCCGGCCGGGCGCA
GGGGCCGAGGCCGTGAAGCCGGTCGCGGCCTTCGTCGAGAAGCCCGACGCCGAACGGGCCCGGGCCTATGTGGCGGACGG
CTACCTGTGGAACAGCGGCAATTTCGTCGCCACGGCGCGGACGCTGATGGACGAGCTCGGCGCCCATGCGCCCGGCGTGG
CGAAGGCCGCGCGGGCCGGGGTCGCCGACCTGGAAGCGAACGGCGCGGCCTGGATCCTCGGCCGGCCGTTCCGCCAGGCG
CCGAAGATATCCATCGACTACGCGGTGATGGAGAAGACCGCCCGGGCCGCCGTGCTGCCGGTCGCCTTCGAATGGTCGGA
CGTCGGCGCGTGGGACGCGGTCCTGGCGGGCTCGGACCGCGACGCCGACGGCAACAGCCTGAGCGGCAACGTGCAGGCGG
TGGGCGCGCGCGACCTGCTGGTCCGGGCCTCGGACGACCTGCACGTGGCGGTGGTCGGCGCCTCCAACCTGGCGGTGATC
GTCGAGCCGGACGTGGTGCTGGTCTGCGACCTCGCCGCCAGCCAGGACGTCAAGGCCGCGGCGGCCGCGGCCCCGCCCGG
CGGCCGGGGCCGGCGCTTCACCACCCTGGAGGCCGCCGCCGACTGGTACGACCTGTGGTTCCGCACCGCCGCCCTGCCGC
TGTGGAGCACCCTGGGGGCCGATCCCGTCAACGGCGGTTTCCGCGAGGCGCTGACCGCCGAGGGCGAGGCGGTCGACCCG
CGGCGGCGCGCCCGCACCCAGGCCCGGCAGGTCTTCGTCTTCGCCACGGCGGCGGCGATCGGCGCCCCCGGCCCCTGGCT
GGAGGTCGCCAAGCGCGGCTGGGAGTTCTACGCCGCCCGGGGACTGCGCAAGGACGGGCGGACGGTGTCGGTGCTGACCG
TGGACGGCGCGCCGCTGGACGAGACCGCCTGCCTGTACGAGCACGCCTTCCTGCTGCTGGCCCTGAGCGCGCTCGCCCGT
GCCGAGCCCGGGGACGCCCGCTGGCGGACCGAGGGCGCCCGCGCCCGCGCGGCCCTGGAGATCTTCCGCCATCCGGCCGG
CGGCTTCCGCGAGGCGGGGCCCCAGCCCTACCAGGCCAACGCCCACATGCACCTCTTCGAGGCGGCCCTCGCCTGGGAGG
CGGTGGAGCCCGACGGCGGCTGGGGGCGGCTGGCGGACGAGGTGGCCGATCTCGCCCTCGAGCGGTTCATCGATCCCGAC
AGCGGCGTGCTGCGCGAGTTCTTCGACGCGGGCTGGGCCCCTCTGACGGGCGAGGCGGGCCTGGTGGAGCCGGGGCACCA
GTTCGAATGGGCCTGGTTGCTGGAGCGCTGGGGCCGGGCCCGCGGCGCCGAGCGCGGGCTGCACACGGCGCGCCGCCTCT
ACGAGGTCGGCCGGGCGGGCGTCGACGCCTCGCGCGAGGTGGCGGTCAACGCCCTGTGGGACGACCTGGCGGTGCGCGAC
GGCTATGCACGCCTGTGGCCTCAGACCGAGCGCCTGAAGGCCGCCGTCCTGCTGGGCGAGGAGGCCGACGCCATCTCGGC
CGCGCGGGGGCTGGCGCGCTATCTGGAGACCCCCGCCCGGGGCGCCTGGCGCGACAAGCTGCGGCCCGACGGCGGCTTCG
TGGACGAGCCGGCGCCGGCGACCTCGCTGTACCACCTGACCATGGCGGTGCTGGAGCTGACCGGCCGCGCCGGATGA

Upstream 100 bases:

>100_bases
GGGCGAGATCGCGCTTCTGCGCACGCTGGCCCTAGTCTGCCTTGGCCGATTCAACCCGCCTCGGGTTAGTTAGCGGTTCG
GCGAGGGGGAGGGGCGCGGC

Downstream 100 bases:

>100_bases
CACCCGGCGCCCGGATTCCGGGCAGGCTGCCCAGGCTGCGGGCGCCTGTCGAACCGGGTTTCGCAATTGAAGCGATGACG
TCTTCGCGCTGACACAAATC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 718; Mature: 717

Protein sequence:

>718_residues
MAVYPVIMCGGSGTRLWPASRPWRPKQFIPLTGARSSFQETLVRVAPLAEAGPVLVVAGIAHQALIEAQLAEIGGQAVVL
LEPEPRDSAAAIAAACAWIEARDPDAVAVIVSADHHIPDADAFRAAVAQTLPAACEGAVVTLGVEPTEPATAYGYIRPGA
GAEAVKPVAAFVEKPDAERARAYVADGYLWNSGNFVATARTLMDELGAHAPGVAKAARAGVADLEANGAAWILGRPFRQA
PKISIDYAVMEKTARAAVLPVAFEWSDVGAWDAVLAGSDRDADGNSLSGNVQAVGARDLLVRASDDLHVAVVGASNLAVI
VEPDVVLVCDLAASQDVKAAAAAAPPGGRGRRFTTLEAAADWYDLWFRTAALPLWSTLGADPVNGGFREALTAEGEAVDP
RRRARTQARQVFVFATAAAIGAPGPWLEVAKRGWEFYAARGLRKDGRTVSVLTVDGAPLDETACLYEHAFLLLALSALAR
AEPGDARWRTEGARARAALEIFRHPAGGFREAGPQPYQANAHMHLFEAALAWEAVEPDGGWGRLADEVADLALERFIDPD
SGVLREFFDAGWAPLTGEAGLVEPGHQFEWAWLLERWGRARGAERGLHTARRLYEVGRAGVDASREVAVNALWDDLAVRD
GYARLWPQTERLKAAVLLGEEADAISAARGLARYLETPARGAWRDKLRPDGGFVDEPAPATSLYHLTMAVLELTGRAG

Sequences:

>Translated_718_residues
MAVYPVIMCGGSGTRLWPASRPWRPKQFIPLTGARSSFQETLVRVAPLAEAGPVLVVAGIAHQALIEAQLAEIGGQAVVL
LEPEPRDSAAAIAAACAWIEARDPDAVAVIVSADHHIPDADAFRAAVAQTLPAACEGAVVTLGVEPTEPATAYGYIRPGA
GAEAVKPVAAFVEKPDAERARAYVADGYLWNSGNFVATARTLMDELGAHAPGVAKAARAGVADLEANGAAWILGRPFRQA
PKISIDYAVMEKTARAAVLPVAFEWSDVGAWDAVLAGSDRDADGNSLSGNVQAVGARDLLVRASDDLHVAVVGASNLAVI
VEPDVVLVCDLAASQDVKAAAAAAPPGGRGRRFTTLEAAADWYDLWFRTAALPLWSTLGADPVNGGFREALTAEGEAVDP
RRRARTQARQVFVFATAAAIGAPGPWLEVAKRGWEFYAARGLRKDGRTVSVLTVDGAPLDETACLYEHAFLLLALSALAR
AEPGDARWRTEGARARAALEIFRHPAGGFREAGPQPYQANAHMHLFEAALAWEAVEPDGGWGRLADEVADLALERFIDPD
SGVLREFFDAGWAPLTGEAGLVEPGHQFEWAWLLERWGRARGAERGLHTARRLYEVGRAGVDASREVAVNALWDDLAVRD
GYARLWPQTERLKAAVLLGEEADAISAARGLARYLETPARGAWRDKLRPDGGFVDEPAPATSLYHLTMAVLELTGRAG
>Mature_717_residues
AVYPVIMCGGSGTRLWPASRPWRPKQFIPLTGARSSFQETLVRVAPLAEAGPVLVVAGIAHQALIEAQLAEIGGQAVVLL
EPEPRDSAAAIAAACAWIEARDPDAVAVIVSADHHIPDADAFRAAVAQTLPAACEGAVVTLGVEPTEPATAYGYIRPGAG
AEAVKPVAAFVEKPDAERARAYVADGYLWNSGNFVATARTLMDELGAHAPGVAKAARAGVADLEANGAAWILGRPFRQAP
KISIDYAVMEKTARAAVLPVAFEWSDVGAWDAVLAGSDRDADGNSLSGNVQAVGARDLLVRASDDLHVAVVGASNLAVIV
EPDVVLVCDLAASQDVKAAAAAAPPGGRGRRFTTLEAAADWYDLWFRTAALPLWSTLGADPVNGGFREALTAEGEAVDPR
RRARTQARQVFVFATAAAIGAPGPWLEVAKRGWEFYAARGLRKDGRTVSVLTVDGAPLDETACLYEHAFLLLALSALARA
EPGDARWRTEGARARAALEIFRHPAGGFREAGPQPYQANAHMHLFEAALAWEAVEPDGGWGRLADEVADLALERFIDPDS
GVLREFFDAGWAPLTGEAGLVEPGHQFEWAWLLERWGRARGAERGLHTARRLYEVGRAGVDASREVAVNALWDDLAVRDG
YARLWPQTERLKAAVLLGEEADAISAARGLARYLETPARGAWRDKLRPDGGFVDEPAPATSLYHLTMAVLELTGRAG

Specific function: Involved In The Biosynthesis Of The Capsular Polysaccharide Colanic Acid. [C]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=374, Percent_Identity=38.2352941176471, Blast_Score=211, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR012341
- InterPro:   IPR010819 [H]

Pfam domain/function: PF07221 GlcNAc_2-epim [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 76282; Mature: 76150

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYPVIMCGGSGTRLWPASRPWRPKQFIPLTGARSSFQETLVRVAPLAEAGPVLVVAGI
CCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECH
AHQALIEAQLAEIGGQAVVLLEPEPRDSAAAIAAACAWIEARDPDAVAVIVSADHHIPDA
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCH
DAFRAAVAQTLPAACEGAVVTLGVEPTEPATAYGYIRPGAGAEAVKPVAAFVEKPDAERA
HHHHHHHHHHCCHHCCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHH
RAYVADGYLWNSGNFVATARTLMDELGAHAPGVAKAARAGVADLEANGAAWILGRPFRQA
HEEEECCEEECCCCEEEHHHHHHHHHCCCCCCHHHHHHCCCCEECCCCCEEEECCCCCCC
PKISIDYAVMEKTARAAVLPVAFEWSDVGAWDAVLAGSDRDADGNSLSGNVQAVGARDLL
CCCEEEHHHHHHHHHHEEEEEEEECCCCCCCHHEEECCCCCCCCCCCCCCEEEECCEEEE
VRASDDLHVAVVGASNLAVIVEPDVVLVCDLAASQDVKAAAAAAPPGGRGRRFTTLEAAA
EECCCCEEEEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCCCEEEEHHHHH
DWYDLWFRTAALPLWSTLGADPVNGGFREALTAEGEAVDPRRRARTQARQVFVFATAAAI
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHEEEEEEEHHHH
GAPGPWLEVAKRGWEFYAARGLRKDGRTVSVLTVDGAPLDETACLYEHAFLLLALSALAR
CCCCHHHHHHHCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
AEPGDARWRTEGARARAALEIFRHPAGGFREAGPQPYQANAHMHLFEAALAWEAVEPDGG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
WGRLADEVADLALERFIDPDSGVLREFFDAGWAPLTGEAGLVEPGHQFEWAWLLERWGRA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RGAERGLHTARRLYEVGRAGVDASREVAVNALWDDLAVRDGYARLWPQTERLKAAVLLGE
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHEEEEEECC
EADAISAARGLARYLETPARGAWRDKLRPDGGFVDEPAPATSLYHLTMAVLELTGRAG
CHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVYPVIMCGGSGTRLWPASRPWRPKQFIPLTGARSSFQETLVRVAPLAEAGPVLVVAGI
CEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECH
AHQALIEAQLAEIGGQAVVLLEPEPRDSAAAIAAACAWIEARDPDAVAVIVSADHHIPDA
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCH
DAFRAAVAQTLPAACEGAVVTLGVEPTEPATAYGYIRPGAGAEAVKPVAAFVEKPDAERA
HHHHHHHHHHCCHHCCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHH
RAYVADGYLWNSGNFVATARTLMDELGAHAPGVAKAARAGVADLEANGAAWILGRPFRQA
HEEEECCEEECCCCEEEHHHHHHHHHCCCCCCHHHHHHCCCCEECCCCCEEEECCCCCCC
PKISIDYAVMEKTARAAVLPVAFEWSDVGAWDAVLAGSDRDADGNSLSGNVQAVGARDLL
CCCEEEHHHHHHHHHHEEEEEEEECCCCCCCHHEEECCCCCCCCCCCCCCEEEECCEEEE
VRASDDLHVAVVGASNLAVIVEPDVVLVCDLAASQDVKAAAAAAPPGGRGRRFTTLEAAA
EECCCCEEEEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCCCEEEEHHHHH
DWYDLWFRTAALPLWSTLGADPVNGGFREALTAEGEAVDPRRRARTQARQVFVFATAAAI
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHEEEEEEEHHHH
GAPGPWLEVAKRGWEFYAARGLRKDGRTVSVLTVDGAPLDETACLYEHAFLLLALSALAR
CCCCHHHHHHHCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
AEPGDARWRTEGARARAALEIFRHPAGGFREAGPQPYQANAHMHLFEAALAWEAVEPDGG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
WGRLADEVADLALERFIDPDSGVLREFFDAGWAPLTGEAGLVEPGHQFEWAWLLERWGRA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RGAERGLHTARRLYEVGRAGVDASREVAVNALWDDLAVRDGYARLWPQTERLKAAVLLGE
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHEEEEEECC
EADAISAARGLARYLETPARGAWRDKLRPDGGFVDEPAPATSLYHLTMAVLELTGRAG
CHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1452036; 11481430 [H]