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The map label for this gene is mfnA [H]

Identifier: 197105702

GI number: 197105702

Start: 2535424

End: 2536650

Strand: Reverse

Name: mfnA [H]

Synonym: PHZ_c2240

Alternate gene names: 197105702

Gene position: 2536650-2535424 (Counterclockwise)

Preceding gene: 197105703

Following gene: 197105701

Centisome position: 63.48

GC content: 72.21

Gene sequence:

>1227_bases
ATGGCCGCAGCCCTTCCGCAGACCGGCGCCGACTGGCCGGACCTGAAGGCCCGTATGCAGGAGATGGGCGCCGGCGACGT
CCACTGGCGCGAGGGCAAGACCGCCGTCTACGTCTTCAACGCCGGCCCCGAGGTGGAGCAGGTCCAGAAGGAGGCCTACG
CCCTCTTCATGTCCGAGAACGGGCTGGGGCCCGCCGCCTTCCCGAGCCTGGCGCGGATGGAGGCCGAGGTCGTCGGCTAC
GGCCTGTCGCTGCTGAACGCGCCCGAGGGGGCGGCCGGAACGATCACTTCGGGCGGGACCGATTCCATCACCATGGCGGT
GAAGGCCGCGCGCGACCACGCCCGGAAGGTGCGCGGGGTGACGGGTCCGCTCAACCTCGTCCTGCCGCGCTCGGCGCATC
CGGCGTTCGACAAGGCCTGCGCGGTCATGGAGATCGAGGTCCGCCGGACGCCGCTGAAGGACTGGCTGGCCGATCCCGAG
GCCATGGCCGCGGCGGCTGACGACCGCACGGTGATGATCGTCGGCTCGGCGCCGAACTTCCCCTACGGCCTGATCGATCC
CATCGGGGCGCTCTCTGACCTGGCGACGGCGCGGGACCTGTGGCTGCACGTGGACGCCTGCGTCGGGGGCTACATCGCCC
CCTTCGTGCGGATGAACGGCGGCGACATCCCGCCTTTCGACTTCAAGCTGCCGGGCGTTCGCTCGATCTCGGCCGACCTG
CACAAGTACGGCTACTGCGCCAAGGGCGCCTCGACGGTGCTCTTCCGTTCGGCCGAGCTGCACCGGCTGATGGTCTTCGA
CTTCAACGACTGGCCGGGCGGCCGGATGGTGACGCCGACGCTCGCCGGCACGCGGCCGGGCGGGGCGATCGCAGCGGCCT
GGGCGGTGATGACGTTCCTGGGCGTCGAGGGCTACCGGCGCAAGCACGGGCAGGTGACGCGGGCGCGGGAGCGGATCGAG
GCCGGCGTGCGCGAGCTGGGCTTTTCGGTGATCGGCCGCCCGCAGCTGGGGCTGCTCGCCTTCGCCCGCCAGGACGTCGA
CTGCCTGGCCGTCTGGGCCAAGCTGCGCGAGCGGGGCTGGTTCACCAGCGTGACCACCGAGCCGCGCGGGCTGCACCTGA
TGCTCTCGCCCGTGCACGCCGAGATCGCCGACAGCTATCTCGCCGACCTCGCCTGGGCCGTGGAGGCGGCGCGCGGCGCC
GCCGGCGGCGAGGCGCGGTATTCGTAG

Upstream 100 bases:

>100_bases
GGCGTTTCCTCCCTAACTGGCCGCGCCGAAAGGCGCGGCTTTTTGTTTGTCCGAGCGTCCGGCTAAGGTCCTTCCCCGCT
CATCGACCCGGGGGACCTCC

Downstream 100 bases:

>100_bases
ACGCTCCGTCGCGCTTGAGCTTGCGGCGAAGTCGCGAGAGCTTCGCCGGATGGATCGTCGAATCTTCCTCACCGGCGCCT
CGGCGCTGATCGCGGCCGCG

Product: putative sphingosine-1-phosphate lyase

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MAAALPQTGADWPDLKARMQEMGAGDVHWREGKTAVYVFNAGPEVEQVQKEAYALFMSENGLGPAAFPSLARMEAEVVGY
GLSLLNAPEGAAGTITSGGTDSITMAVKAARDHARKVRGVTGPLNLVLPRSAHPAFDKACAVMEIEVRRTPLKDWLADPE
AMAAAADDRTVMIVGSAPNFPYGLIDPIGALSDLATARDLWLHVDACVGGYIAPFVRMNGGDIPPFDFKLPGVRSISADL
HKYGYCAKGASTVLFRSAELHRLMVFDFNDWPGGRMVTPTLAGTRPGGAIAAAWAVMTFLGVEGYRRKHGQVTRARERIE
AGVRELGFSVIGRPQLGLLAFARQDVDCLAVWAKLRERGWFTSVTTEPRGLHLMLSPVHAEIADSYLADLAWAVEAARGA
AGGEARYS

Sequences:

>Translated_408_residues
MAAALPQTGADWPDLKARMQEMGAGDVHWREGKTAVYVFNAGPEVEQVQKEAYALFMSENGLGPAAFPSLARMEAEVVGY
GLSLLNAPEGAAGTITSGGTDSITMAVKAARDHARKVRGVTGPLNLVLPRSAHPAFDKACAVMEIEVRRTPLKDWLADPE
AMAAAADDRTVMIVGSAPNFPYGLIDPIGALSDLATARDLWLHVDACVGGYIAPFVRMNGGDIPPFDFKLPGVRSISADL
HKYGYCAKGASTVLFRSAELHRLMVFDFNDWPGGRMVTPTLAGTRPGGAIAAAWAVMTFLGVEGYRRKHGQVTRARERIE
AGVRELGFSVIGRPQLGLLAFARQDVDCLAVWAKLRERGWFTSVTTEPRGLHLMLSPVHAEIADSYLADLAWAVEAARGA
AGGEARYS
>Mature_407_residues
AAALPQTGADWPDLKARMQEMGAGDVHWREGKTAVYVFNAGPEVEQVQKEAYALFMSENGLGPAAFPSLARMEAEVVGYG
LSLLNAPEGAAGTITSGGTDSITMAVKAARDHARKVRGVTGPLNLVLPRSAHPAFDKACAVMEIEVRRTPLKDWLADPEA
MAAAADDRTVMIVGSAPNFPYGLIDPIGALSDLATARDLWLHVDACVGGYIAPFVRMNGGDIPPFDFKLPGVRSISADLH
KYGYCAKGASTVLFRSAELHRLMVFDFNDWPGGRMVTPTLAGTRPGGAIAAAWAVMTFLGVEGYRRKHGQVTRARERIEA
GVRELGFSVIGRPQLGLLAFARQDVDCLAVWAKLRERGWFTSVTTEPRGLHLMLSPVHAEIADSYLADLAWAVEAARGAA
GGEARYS

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31982936, Length=396, Percent_Identity=36.1111111111111, Blast_Score=256, Evalue=4e-68,
Organism=Escherichia coli, GI1787769, Length=341, Percent_Identity=28.1524926686217, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1789934, Length=341, Percent_Identity=28.1524926686217, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17543922, Length=360, Percent_Identity=37.2222222222222, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17557272, Length=383, Percent_Identity=34.4647519582245, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25148342, Length=353, Percent_Identity=33.7110481586402, Blast_Score=201, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6320500, Length=408, Percent_Identity=31.3725490196078, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI21355963, Length=395, Percent_Identity=35.9493670886076, Blast_Score=267, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24654344, Length=395, Percent_Identity=35.9493670886076, Blast_Score=267, Evalue=8e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 43748; Mature: 43616

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAALPQTGADWPDLKARMQEMGAGDVHWREGKTAVYVFNAGPEVEQVQKEAYALFMSEN
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHHHEEEEECC
GLGPAAFPSLARMEAEVVGYGLSLLNAPEGAAGTITSGGTDSITMAVKAARDHARKVRGV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCC
TGPLNLVLPRSAHPAFDKACAVMEIEVRRTPLKDWLADPEAMAAAADDRTVMIVGSAPNF
CCCEEEEECCCCCCCHHHCEEEEEEEECCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCC
PYGLIDPIGALSDLATARDLWLHVDACVGGYIAPFVRMNGGDIPPFDFKLPGVRSISADL
CCCHHCHHHHHHHHHHHHHHHEEHHHHHCCHHHHHEEECCCCCCCCCCCCCCCHHHHHHH
HKYGYCAKGASTVLFRSAELHRLMVFDFNDWPGGRMVTPTLAGTRPGGAIAAAWAVMTFL
HHCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
GVEGYRRKHGQVTRARERIEAGVRELGFSVIGRPQLGLLAFARQDVDCLAVWAKLRERGW
CCCHHHHHCCHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCC
FTSVTTEPRGLHLMLSPVHAEIADSYLADLAWAVEAARGAAGGEARYS
EEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AAALPQTGADWPDLKARMQEMGAGDVHWREGKTAVYVFNAGPEVEQVQKEAYALFMSEN
CCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHHHEEEEECC
GLGPAAFPSLARMEAEVVGYGLSLLNAPEGAAGTITSGGTDSITMAVKAARDHARKVRGV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCC
TGPLNLVLPRSAHPAFDKACAVMEIEVRRTPLKDWLADPEAMAAAADDRTVMIVGSAPNF
CCCEEEEECCCCCCCHHHCEEEEEEEECCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCC
PYGLIDPIGALSDLATARDLWLHVDACVGGYIAPFVRMNGGDIPPFDFKLPGVRSISADL
CCCHHCHHHHHHHHHHHHHHHEEHHHHHCCHHHHHEEECCCCCCCCCCCCCCCHHHHHHH
HKYGYCAKGASTVLFRSAELHRLMVFDFNDWPGGRMVTPTLAGTRPGGAIAAAWAVMTFL
HHCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
GVEGYRRKHGQVTRARERIEAGVRELGFSVIGRPQLGLLAFARQDVDCLAVWAKLRERGW
CCCHHHHHCCHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCC
FTSVTTEPRGLHLMLSPVHAEIADSYLADLAWAVEAARGAAGGEARYS
EEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA