Click here to switch to the map view.

The map label for this gene is capL [H]

Identifier: 197105628

GI number: 197105628

Start: 2439484

End: 2440827

Strand: Direct

Name: capL [H]

Synonym: PHZ_c2165

Alternate gene names: 197105628

Gene position: 2439484-2440827 (Clockwise)

Preceding gene: 197105626

Following gene: 197105630

Centisome position: 61.04

GC content: 70.09

Gene sequence:

>1344_bases
ATGGACGACGCTGACGCGACCCCCTTCGACCGCCTGCGCGCCGTGCTCGCCGACCGAAGCGCCGTAGTGGGCGTGATCGG
GCTGGGCTATGTCGGCCTGCCGCTGGCCGTGGCGGCCGCCCGGCGGGGGCTGTCCACCATCGGCTTCGACATCGATCCGG
CGAAAGAGGCCCGCATCAAGGCGGGCCGCTCGTACATCGACGCGGTCGCGAGCGATGAGCTCGCCGCGCTGGTGAAGGCC
GGACAGCTCACCGCCACCACCGCCTACGACCGCCTGGCGGAGTGCGACGTCATCGTCATCTGCGTGCCCACCCCGCTCAG
CCGGCACCGAGATCCGGACCTGTCCTACATCGAGACCACCGGCCGCGAGATCGCCCGGCGCCTGCGCCCGGGTCAGCTGG
TCGTGCTGGAGTCCACCACCTACCCCGGCACGACGCGCGAGGTTCTGAAGCCGATCCTGGAAAGCTCGGGCCTCGTCTGC
GGCCGCGACGTCTTCGTGGGCTTCTCGCCCGAGCGGGAGGATCCCGGCAACGCAGCCTTCGACACCGCGTCCATCCCCAA
GGTCGTCGCCGGCGACGGGCCGCAGGCCTCGGAGCTGGTGCAGGCGTTCTACGGCGCCGTCGTGCAGCAGGTGGTGCCCG
TCTCCTCGCCCGACGTGGCCGAGGCGGTGAAGATCACGGAGAACGTCTTCCGGGCCGTGAACATCGCGCTCGTCAACGAG
CTGAAGCTGATCTACGGCGCGATGGGCATCGACGTTTGGGAGGTCATCGAGGCGGCCAAGACCAAGCCGTTCGGCTACAT
GCCCTTCTATCCGGGCCCGGGGCTGGGCGGCCACTGCATCCCCATCGACCCCTTCTATCTCACCTGGCGCTCCCGCGAGT
TCGAGGTGCCTACGCGCTTCATCGAGCTGGCGGGCGAGATCAACACCGCCATGCCGAACCATGTCGTCGACGTGCTGGCC
CGCGCGCTGGACGAGCGGCTCCGGCTGGCGGTCAGCGCCTCGCGGGTGCTCGTCGTCGGCCTGGCGTACAAGAAGAACGT
CGAGGACGTGCGCGAGAGCCCGTCCTTCAAGCTGATGTCGCTGCTCGAGGCGCGCGGCGCCAAGGTCGCGTTCCACGACC
CGCACGTTCCCGAGGCGCCCGTCACCCGCGAGCACCCCGAGTTCGCGGGCCGCAGGTCCGTGGCGCTGTCGGCGGAGACG
CTCAAGGACTTCGACGCCGTCCTGATCGCCACCGACCACGACGCCGTCGACTACCGCCTCCTCGCCGAGGCCCCGCTGGT
CGTGGACACCCGCAACGCCATGGCCCGCCACGGCGTCCAGGGCGAACACATCATCAAGGCGTAG

Upstream 100 bases:

>100_bases
CGGGCTCCTCGATGCGGCCTCGCCGTCGGCGGGCGGGCGAGCGTCCGCTGGCGCTCGATGCGGGTTTGTGCAGACGAGCG
TACGCCTTTAAAGGCGCGTC

Downstream 100 bases:

>100_bases
AGCGAAGCCGCTAGAAGAACCGTTCGCCGATGCGGATGGTGTCGCCGGGCGCGACCTGGGTGGTGCTGGTCAGGGGGAAG
GATTCCTCCTCGTCCCCGTC

Product: UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDDADATPFDRLRAVLADRSAVVGVIGLGYVGLPLAVAAARRGLSTIGFDIDPAKEARIKAGRSYIDAVASDELAALVKA
GQLTATTAYDRLAECDVIVICVPTPLSRHRDPDLSYIETTGREIARRLRPGQLVVLESTTYPGTTREVLKPILESSGLVC
GRDVFVGFSPEREDPGNAAFDTASIPKVVAGDGPQASELVQAFYGAVVQQVVPVSSPDVAEAVKITENVFRAVNIALVNE
LKLIYGAMGIDVWEVIEAAKTKPFGYMPFYPGPGLGGHCIPIDPFYLTWRSREFEVPTRFIELAGEINTAMPNHVVDVLA
RALDERLRLAVSASRVLVVGLAYKKNVEDVRESPSFKLMSLLEARGAKVAFHDPHVPEAPVTREHPEFAGRRSVALSAET
LKDFDAVLIATDHDAVDYRLLAEAPLVVDTRNAMARHGVQGEHIIKA

Sequences:

>Translated_447_residues
MDDADATPFDRLRAVLADRSAVVGVIGLGYVGLPLAVAAARRGLSTIGFDIDPAKEARIKAGRSYIDAVASDELAALVKA
GQLTATTAYDRLAECDVIVICVPTPLSRHRDPDLSYIETTGREIARRLRPGQLVVLESTTYPGTTREVLKPILESSGLVC
GRDVFVGFSPEREDPGNAAFDTASIPKVVAGDGPQASELVQAFYGAVVQQVVPVSSPDVAEAVKITENVFRAVNIALVNE
LKLIYGAMGIDVWEVIEAAKTKPFGYMPFYPGPGLGGHCIPIDPFYLTWRSREFEVPTRFIELAGEINTAMPNHVVDVLA
RALDERLRLAVSASRVLVVGLAYKKNVEDVRESPSFKLMSLLEARGAKVAFHDPHVPEAPVTREHPEFAGRRSVALSAET
LKDFDAVLIATDHDAVDYRLLAEAPLVVDTRNAMARHGVQGEHIIKA
>Mature_447_residues
MDDADATPFDRLRAVLADRSAVVGVIGLGYVGLPLAVAAARRGLSTIGFDIDPAKEARIKAGRSYIDAVASDELAALVKA
GQLTATTAYDRLAECDVIVICVPTPLSRHRDPDLSYIETTGREIARRLRPGQLVVLESTTYPGTTREVLKPILESSGLVC
GRDVFVGFSPEREDPGNAAFDTASIPKVVAGDGPQASELVQAFYGAVVQQVVPVSSPDVAEAVKITENVFRAVNIALVNE
LKLIYGAMGIDVWEVIEAAKTKPFGYMPFYPGPGLGGHCIPIDPFYLTWRSREFEVPTRFIELAGEINTAMPNHVVDVLA
RALDERLRLAVSASRVLVVGLAYKKNVEDVRESPSFKLMSLLEARGAKVAFHDPHVPEAPVTREHPEFAGRRSVALSAET
LKDFDAVLIATDHDAVDYRLLAEAPLVVDTRNAMARHGVQGEHIIKA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=435, Percent_Identity=25.7471264367816, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI296040438, Length=328, Percent_Identity=26.219512195122, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI48994968, Length=408, Percent_Identity=33.3333333333333, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788340, Length=400, Percent_Identity=23.5, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=386, Percent_Identity=26.4248704663212, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136908, Length=464, Percent_Identity=25.8620689655172, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48312; Mature: 48312

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDADATPFDRLRAVLADRSAVVGVIGLGYVGLPLAVAAARRGLSTIGFDIDPAKEARIK
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHH
AGRSYIDAVASDELAALVKAGQLTATTAYDRLAECDVIVICVPTPLSRHRDPDLSYIETT
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCEEEEECCCCHHCCCCCCCHHHHHH
GREIARRLRPGQLVVLESTTYPGTTREVLKPILESSGLVCGRDVFVGFSPEREDPGNAAF
HHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEECCEEEEECCCCCCCCCCCCC
DTASIPKVVAGDGPQASELVQAFYGAVVQQVVPVSSPDVAEAVKITENVFRAVNIALVNE
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKLIYGAMGIDVWEVIEAAKTKPFGYMPFYPGPGLGGHCIPIDPFYLTWRSREFEVPTRF
HHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCHHHH
IELAGEINTAMPNHVVDVLARALDERLRLAVSASRVLVVGLAYKKNVEDVRESPSFKLMS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCHHHHHCCCCHHHHH
LLEARGAKVAFHDPHVPEAPVTREHPEFAGRRSVALSAETLKDFDAVLIATDHDAVDYRL
HHHHCCCEEEECCCCCCCCCCCCCCCHHCCCCEEEEEHHHHHCCCEEEEEECCCCCCEEE
LAEAPLVVDTRNAMARHGVQGEHIIKA
EECCCEEEECHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDDADATPFDRLRAVLADRSAVVGVIGLGYVGLPLAVAAARRGLSTIGFDIDPAKEARIK
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHH
AGRSYIDAVASDELAALVKAGQLTATTAYDRLAECDVIVICVPTPLSRHRDPDLSYIETT
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCEEEEECCCCHHCCCCCCCHHHHHH
GREIARRLRPGQLVVLESTTYPGTTREVLKPILESSGLVCGRDVFVGFSPEREDPGNAAF
HHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEECCEEEEECCCCCCCCCCCCC
DTASIPKVVAGDGPQASELVQAFYGAVVQQVVPVSSPDVAEAVKITENVFRAVNIALVNE
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKLIYGAMGIDVWEVIEAAKTKPFGYMPFYPGPGLGGHCIPIDPFYLTWRSREFEVPTRF
HHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCHHHH
IELAGEINTAMPNHVVDVLARALDERLRLAVSASRVLVVGLAYKKNVEDVRESPSFKLMS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCHHHHHCCCCHHHHH
LLEARGAKVAFHDPHVPEAPVTREHPEFAGRRSVALSAETLKDFDAVLIATDHDAVDYRL
HHHHCCCEEEECCCCCCCCCCCCCCCHHCCCCEEEEEHHHHHCCCEEEEEECCCCCCEEE
LAEAPLVVDTRNAMARHGVQGEHIIKA
EECCCEEEECHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]