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The map label for this gene is hemL [H]

Identifier: 197105572

GI number: 197105572

Start: 2368450

End: 2369727

Strand: Direct

Name: hemL [H]

Synonym: PHZ_c2109

Alternate gene names: 197105572

Gene position: 2368450-2369727 (Clockwise)

Preceding gene: 197105568

Following gene: 197105574

Centisome position: 59.27

GC content: 69.56

Gene sequence:

>1278_bases
ATGTCCTGGACGAACAGCAAGAACACGGACCTCGTCGAACGGGCCCAGGCGGTGATCCCGATGGGCATGTACGGGCACCA
GTCCGTGCTCCTGCTGCCGGACGACTATCCGCAGTTCTTCCGCCGGGCGAAAGGCGTCCATCTCTGGGACGTCGACGGCA
ACCGCTATCTCGATTTCCTCTGCGGCTACGGGCCGAACCTGTTCGGCTACGGCGACCCCGAGATCGACGACGCCTACATC
GCCCAGCTGCGCGAGGGCGACACCATGACCGGGCCGGGCGAGGTCATGGTCGAGCTGGCCGAGGCGATGGTCGGCCTCAT
CGCTCACGCCGACTGGGCCATGTTCTGCAAGAACGGCACCGACGCCACCACCATGGCGCTGATGATCGCGCGGAACCACA
CCGGCCGGAACACCGTCGTGCTGGCGCGGGGCGCCTACCACGGTGCCGCGCCCTGGTGCACCCCGCTGAAGAAGGGGGTC
GCGCCCGGCGACCGGGCGAACCAGGTGTTCTACGACTACAACGACGTCGAGAGCCTCGAGGCGGCGGTGCGCGAGGCCGG
CGACGACCTGGCGGCGATCTTCGCCTCGCCGATCAAGCACGACACCTTCGTCGACCAGGAGCTGCCCGATCCGGCGTACG
CCCGCCGGGCCCGCGAGCTGTGCGACGAGCGCGGCGCGCTGCTGATCGTCGACGACGTGCGGGCCGGCTTCCGCCTCGCG
CGCGACTCGAGCTGGTCGCTGGTGGGCGTGAAGCCCGACCTGTCGAGCTGGGGCAAGGCGATCGCCAACGGCCACCCGAT
CTCGGCCCTGCTGGGCGCGGACATCTGCCGGATGGCGGCGGCGACCATCTACGCCACCGGCTCGTACTGGTTCTCGGCGG
CGCCTATGGCGGCGGCGCTGAAGACCCTGGCCCGCATCCGCGACACCGACTACCTGGAGCGCACGCAGGCGCTCGGCCGG
CGCCTGCGCGAGGGGCTGGACGAGAGCGCCGCCCGACATGGACTGGCGCTCCGTCAGACCGGCCCGGCCGAGCTGCCGCT
GATCATGGTGGACGACGATCCGACGCTCGCGAAGGGCTATTTCTGGACCCAGGCGCTGATGAAGCGCGGGGTCTACTTCC
ACCCCTGGCACAACATGTTCATCTGCGCGGCCATGACCGAGGCCGACATCGACTTCGCCGTCGAGGCGGCGGACGAGGCG
TTCAAGCTGCTGAAGGCCGCCGGTCCGCTGGAGGCGCCCGCCAAGCTGGGCTTCATGAACCAGATGCTCGACCACTAG

Upstream 100 bases:

>100_bases
GAAGCCCGTGACCCATGATCCCCCCTGATGAACTCCGGTTGATTTGTACCCACGCGGCGATAAGCTAGTCAAAACTATCT
TTCTGCCTGGGGGCTGACCG

Downstream 100 bases:

>100_bases
GTCCGGCGGGAGGGGCTTGCGCGCCCCTCCTGCGGCCGTCCTCGCCGCTCACGCCGGCCGTCCGGGCCGGCTCACCCCGA
ACCGGCGCAGCACGTTGTGG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSWTNSKNTDLVERAQAVIPMGMYGHQSVLLLPDDYPQFFRRAKGVHLWDVDGNRYLDFLCGYGPNLFGYGDPEIDDAYI
AQLREGDTMTGPGEVMVELAEAMVGLIAHADWAMFCKNGTDATTMALMIARNHTGRNTVVLARGAYHGAAPWCTPLKKGV
APGDRANQVFYDYNDVESLEAAVREAGDDLAAIFASPIKHDTFVDQELPDPAYARRARELCDERGALLIVDDVRAGFRLA
RDSSWSLVGVKPDLSSWGKAIANGHPISALLGADICRMAAATIYATGSYWFSAAPMAAALKTLARIRDTDYLERTQALGR
RLREGLDESAARHGLALRQTGPAELPLIMVDDDPTLAKGYFWTQALMKRGVYFHPWHNMFICAAMTEADIDFAVEAADEA
FKLLKAAGPLEAPAKLGFMNQMLDH

Sequences:

>Translated_425_residues
MSWTNSKNTDLVERAQAVIPMGMYGHQSVLLLPDDYPQFFRRAKGVHLWDVDGNRYLDFLCGYGPNLFGYGDPEIDDAYI
AQLREGDTMTGPGEVMVELAEAMVGLIAHADWAMFCKNGTDATTMALMIARNHTGRNTVVLARGAYHGAAPWCTPLKKGV
APGDRANQVFYDYNDVESLEAAVREAGDDLAAIFASPIKHDTFVDQELPDPAYARRARELCDERGALLIVDDVRAGFRLA
RDSSWSLVGVKPDLSSWGKAIANGHPISALLGADICRMAAATIYATGSYWFSAAPMAAALKTLARIRDTDYLERTQALGR
RLREGLDESAARHGLALRQTGPAELPLIMVDDDPTLAKGYFWTQALMKRGVYFHPWHNMFICAAMTEADIDFAVEAADEA
FKLLKAAGPLEAPAKLGFMNQMLDH
>Mature_424_residues
SWTNSKNTDLVERAQAVIPMGMYGHQSVLLLPDDYPQFFRRAKGVHLWDVDGNRYLDFLCGYGPNLFGYGDPEIDDAYIA
QLREGDTMTGPGEVMVELAEAMVGLIAHADWAMFCKNGTDATTMALMIARNHTGRNTVVLARGAYHGAAPWCTPLKKGVA
PGDRANQVFYDYNDVESLEAAVREAGDDLAAIFASPIKHDTFVDQELPDPAYARRARELCDERGALLIVDDVRAGFRLAR
DSSWSLVGVKPDLSSWGKAIANGHPISALLGADICRMAAATIYATGSYWFSAAPMAAALKTLARIRDTDYLERTQALGRR
LREGLDESAARHGLALRQTGPAELPLIMVDDDPTLAKGYFWTQALMKRGVYFHPWHNMFICAAMTEADIDFAVEAADEAF
KLLKAAGPLEAPAKLGFMNQMLDH

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786349, Length=430, Percent_Identity=30, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1789016, Length=352, Percent_Identity=27.8409090909091, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788044, Length=315, Percent_Identity=28.2539682539683, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787560, Length=316, Percent_Identity=30.379746835443, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693181, Length=310, Percent_Identity=26.4516129032258, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789759, Length=320, Percent_Identity=26.5625, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46685; Mature: 46553

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWTNSKNTDLVERAQAVIPMGMYGHQSVLLLPDDYPQFFRRAKGVHLWDVDGNRYLDFL
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEECCCCHHHHHH
CGYGPNLFGYGDPEIDDAYIAQLREGDTMTGPGEVMVELAEAMVGLIAHADWAMFCKNGT
HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCC
DATTMALMIARNHTGRNTVVLARGAYHGAAPWCTPLKKGVAPGDRANQVFYDYNDVESLE
CHHHHEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHH
AAVREAGDDLAAIFASPIKHDTFVDQELPDPAYARRARELCDERGALLIVDDVRAGFRLA
HHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEE
RDSSWSLVGVKPDLSSWGKAIANGHPISALLGADICRMAAATIYATGSYWFSAAPMAAAL
CCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHCCHHHHHH
KTLARIRDTDYLERTQALGRRLREGLDESAARHGLALRQTGPAELPLIMVDDDPTLAKGY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCHHHH
FWTQALMKRGVYFHPWHNMFICAAMTEADIDFAVEAADEAFKLLKAAGPLEAPAKLGFMN
HHHHHHHHCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
QMLDH
HHHCC
>Mature Secondary Structure 
SWTNSKNTDLVERAQAVIPMGMYGHQSVLLLPDDYPQFFRRAKGVHLWDVDGNRYLDFL
CCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEECCCCHHHHHH
CGYGPNLFGYGDPEIDDAYIAQLREGDTMTGPGEVMVELAEAMVGLIAHADWAMFCKNGT
HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCC
DATTMALMIARNHTGRNTVVLARGAYHGAAPWCTPLKKGVAPGDRANQVFYDYNDVESLE
CHHHHEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHH
AAVREAGDDLAAIFASPIKHDTFVDQELPDPAYARRARELCDERGALLIVDDVRAGFRLA
HHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEE
RDSSWSLVGVKPDLSSWGKAIANGHPISALLGADICRMAAATIYATGSYWFSAAPMAAAL
CCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHCCHHHHHH
KTLARIRDTDYLERTQALGRRLREGLDESAARHGLALRQTGPAELPLIMVDDDPTLAKGY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCHHHH
FWTQALMKRGVYFHPWHNMFICAAMTEADIDFAVEAADEAFKLLKAAGPLEAPAKLGFMN
HHHHHHHHCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
QMLDH
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA