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The map label for this gene is ilvD [H]

Identifier: 197105537

GI number: 197105537

Start: 2319121

End: 2320845

Strand: Reverse

Name: ilvD [H]

Synonym: PHZ_c2074

Alternate gene names: 197105537

Gene position: 2320845-2319121 (Counterclockwise)

Preceding gene: 197105538

Following gene: 197105536

Centisome position: 58.08

GC content: 70.61

Gene sequence:

>1725_bases
ATGGCCAGGAAGCCGCTGCGCAGCCAACGGAGCTACGGCAAGCACGACCGCGACGGCTTCATCCACCGGAGCTGGATCAA
GGGCACGGGCCTGCCGGACCACGTCTTCGACGGCCGGCCGATCATCGGCGTCTGCAACACCTGGTCCGAGCTGGTCACCT
GCCAGTTCCACCTGCGCGACCTGGCCGAGTACGTGAAGCGCGGCGTCTGGGAGGCGGGCGGGGTGCCGATCGAGTTCCCG
GCCATGAGCCTGCCCGAGACCCAGATGCGGCCTACGGCCATGCTGTTCCGCAACCTCCTGGCCATGGAGGTGGAGGAGAG
CATCCGCGCCAACCCCATCGACGGGGTGGTCCTGCTGGGCGGCTGCGACAAGACCACGCCCGGCCAGCTCATGGGCGCGG
CCAGCGTCGACCTGCCGACCATGGTGGTCTCGTCCGGCCCGATGCTGAACGGCAAGTGGCACGGCCGCGACATCGGCTCG
GGCACCGATGTGTGGCGCTTCTCCGAGGCGGTGCGGGCGGGCGAGATGAGCCTGACGGACTTCCTCTCGGCCGAGAGCTC
GATGAGCCGCAGCCACGGGACCTGCAACACCATGGGCACGGCCTCGACCATGGCCAGCCTGATGGAGGCTCTGGGCGTCT
GCCTGCCGAACAACGCCGCGCTGCCCGGCGTGGACTCCCGCCGCAAGACGCTCGCTCACCTCACGGGCAACCGCATCGTC
CAGCTCGTCAAGGACGACGTCAGGCTCTCGCAGATTCTCACCCGCGAGGCGTTCGAGAACGCCATCCTGATGCACGCCGC
GATCGGCGGCTCGACCAACGCGGTGGTCCACCTGCTGGCCCTGGCCGGGCGGGTCGGGATCGAGCTGTCGCTGGAGGATT
TCGACCGCATCGGCCGCGAGGTCCCGCTGCTGGTGAACCTGATGCCGTCGGGCAAATACCTGATGGAGGAGTTCTGCTAC
GCCGGCGGCTGCCCGGCGGTGATGAAAGAGCTGGGGCCGCTGCTGCGGCGCGAGGCGATCACCGTCTCGGGCCATACCCA
GGGCCAGATCGCCGAGGCCGCCGAGGTCTGGAACCGCGAGGTGATCGGCACGCGGGAGGCGCCGGTCGGGCCGTCCTCGG
GCGTGTGGGTGCTGCGCGGCAACCTCTGTCCCGGCGGGGCGATCCTGAAGCCCAGCGCCGCGACGCCGGCCCTGCTGACC
CACCGCGGCCGCGCGGTCGTCTTCGAGGACATCGAGGACTACCACGCCCGCATTGACGATCCGGACCTGCCCGTGGACGA
GACCTCGATCCTGGTGCTCAAGGGCTGCGGCCCCAAGGGCTACCCCGGCATGCCCGAGGTGGGGAACATGGCCCTGCCGC
CCAAGCTGCTGCACAGAGGCGTGCGCGACATGGTCCGAATCTCGGACGCGCGGATGAGCGGCACGGCCTACGGCACGGTG
ATCCTGCACGTCTCGCCCGAGGCCGAGGCGGGCGGGCCGCTGGCGCTGGTGCGGAACGGTGACGAGATCGCCTTCGACGG
CCCCAGCCGCACCCTCGACCTGCTGGTGGACGAGGCCGAGCTGGCCCGCCGCCGCGCCGAGTGGGAGGCCGCCCGCACGC
CCTCGCAGTTCGACCGCGGCTGGTACAAGCTCTACATCGACACCGTGCTGCAGGCGGACCGCGGCGCCGACCTCGACTTC
CTGGTCGGCAAGTCCAGCCCCGACGTCACCCGCGAGTCCCACTGA

Upstream 100 bases:

>100_bases
GGGGGTGAAGGGCCTGCCGCTGCCGGTGTTCGAGGGCTGAACCCCGGCCCCGCTCGGGGGTTTATCTCTCGGGCATCACG
GGAACGCCGAGGGGTCGGGA

Downstream 100 bases:

>100_bases
TGGCGGGGGCGATCTATCCCGGCATGAAGGACCGCGTGGTCTTCGTCACCGGCGGCGCCTCGGGCATCGGGGCCGCCTTC
GTCGAGCAGTTCCACGCCCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MARKPLRSQRSYGKHDRDGFIHRSWIKGTGLPDHVFDGRPIIGVCNTWSELVTCQFHLRDLAEYVKRGVWEAGGVPIEFP
AMSLPETQMRPTAMLFRNLLAMEVEESIRANPIDGVVLLGGCDKTTPGQLMGAASVDLPTMVVSSGPMLNGKWHGRDIGS
GTDVWRFSEAVRAGEMSLTDFLSAESSMSRSHGTCNTMGTASTMASLMEALGVCLPNNAALPGVDSRRKTLAHLTGNRIV
QLVKDDVRLSQILTREAFENAILMHAAIGGSTNAVVHLLALAGRVGIELSLEDFDRIGREVPLLVNLMPSGKYLMEEFCY
AGGCPAVMKELGPLLRREAITVSGHTQGQIAEAAEVWNREVIGTREAPVGPSSGVWVLRGNLCPGGAILKPSAATPALLT
HRGRAVVFEDIEDYHARIDDPDLPVDETSILVLKGCGPKGYPGMPEVGNMALPPKLLHRGVRDMVRISDARMSGTAYGTV
ILHVSPEAEAGGPLALVRNGDEIAFDGPSRTLDLLVDEAELARRRAEWEAARTPSQFDRGWYKLYIDTVLQADRGADLDF
LVGKSSPDVTRESH

Sequences:

>Translated_574_residues
MARKPLRSQRSYGKHDRDGFIHRSWIKGTGLPDHVFDGRPIIGVCNTWSELVTCQFHLRDLAEYVKRGVWEAGGVPIEFP
AMSLPETQMRPTAMLFRNLLAMEVEESIRANPIDGVVLLGGCDKTTPGQLMGAASVDLPTMVVSSGPMLNGKWHGRDIGS
GTDVWRFSEAVRAGEMSLTDFLSAESSMSRSHGTCNTMGTASTMASLMEALGVCLPNNAALPGVDSRRKTLAHLTGNRIV
QLVKDDVRLSQILTREAFENAILMHAAIGGSTNAVVHLLALAGRVGIELSLEDFDRIGREVPLLVNLMPSGKYLMEEFCY
AGGCPAVMKELGPLLRREAITVSGHTQGQIAEAAEVWNREVIGTREAPVGPSSGVWVLRGNLCPGGAILKPSAATPALLT
HRGRAVVFEDIEDYHARIDDPDLPVDETSILVLKGCGPKGYPGMPEVGNMALPPKLLHRGVRDMVRISDARMSGTAYGTV
ILHVSPEAEAGGPLALVRNGDEIAFDGPSRTLDLLVDEAELARRRAEWEAARTPSQFDRGWYKLYIDTVLQADRGADLDF
LVGKSSPDVTRESH
>Mature_573_residues
ARKPLRSQRSYGKHDRDGFIHRSWIKGTGLPDHVFDGRPIIGVCNTWSELVTCQFHLRDLAEYVKRGVWEAGGVPIEFPA
MSLPETQMRPTAMLFRNLLAMEVEESIRANPIDGVVLLGGCDKTTPGQLMGAASVDLPTMVVSSGPMLNGKWHGRDIGSG
TDVWRFSEAVRAGEMSLTDFLSAESSMSRSHGTCNTMGTASTMASLMEALGVCLPNNAALPGVDSRRKTLAHLTGNRIVQ
LVKDDVRLSQILTREAFENAILMHAAIGGSTNAVVHLLALAGRVGIELSLEDFDRIGREVPLLVNLMPSGKYLMEEFCYA
GGCPAVMKELGPLLRREAITVSGHTQGQIAEAAEVWNREVIGTREAPVGPSSGVWVLRGNLCPGGAILKPSAATPALLTH
RGRAVVFEDIEDYHARIDDPDLPVDETSILVLKGCGPKGYPGMPEVGNMALPPKLLHRGVRDMVRISDARMSGTAYGTVI
LHVSPEAEAGGPLALVRNGDEIAFDGPSRTLDLLVDEAELARRRAEWEAARTPSQFDRGWYKLYIDTVLQADRGADLDFL
VGKSSPDVTRESH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=605, Percent_Identity=33.2231404958678, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI1788157, Length=515, Percent_Identity=30.2912621359223, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI2367371, Length=455, Percent_Identity=31.4285714285714, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1786464, Length=453, Percent_Identity=32.2295805739514, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322476, Length=556, Percent_Identity=32.0143884892086, Blast_Score=261, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62212; Mature: 62081

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKPLRSQRSYGKHDRDGFIHRSWIKGTGLPDHVFDGRPIIGVCNTWSELVTCQFHLRD
CCCCCCHHHHHCCCCCCCCCEEEHECCCCCCCCHHCCCCCEEEECCCHHHHHHHHHHHHH
LAEYVKRGVWEAGGVPIEFPAMSLPETQMRPTAMLFRNLLAMEVEESIRANPIDGVVLLG
HHHHHHHCCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
GCDKTTPGQLMGAASVDLPTMVVSSGPMLNGKWHGRDIGSGTDVWRFSEAVRAGEMSLTD
CCCCCCCHHEEECCCCCCCEEEECCCCEECCEECCCCCCCCCCHHHHHHHHHCCCCHHHH
FLSAESSMSRSHGTCNTMGTASTMASLMEALGVCLPNNAALPGVDSRRKTLAHLTGNRIV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QLVKDDVRLSQILTREAFENAILMHAAIGGSTNAVVHLLALAGRVGIELSLEDFDRIGRE
HHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHHCCCC
VPLLVNLMPSGKYLMEEFCYAGGCPAVMKELGPLLRREAITVSGHTQGQIAEAAEVWNRE
CCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHCCH
VIGTREAPVGPSSGVWVLRGNLCPGGAILKPSAATPALLTHRGRAVVFEDIEDYHARIDD
HCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCHHHHCCCCEEEEECHHHHHHCCCC
PDLPVDETSILVLKGCGPKGYPGMPEVGNMALPPKLLHRGVRDMVRISDARMSGTAYGTV
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
ILHVSPEAEAGGPLALVRNGDEIAFDGPSRTLDLLVDEAELARRRAEWEAARTPSQFDRG
EEEECCCCCCCCCEEEEECCCEEEECCCCCEEHHEECHHHHHHHHHHHHHHCCCHHHCCC
WYKLYIDTVLQADRGADLDFLVGKSSPDVTRESH
CEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
ARKPLRSQRSYGKHDRDGFIHRSWIKGTGLPDHVFDGRPIIGVCNTWSELVTCQFHLRD
CCCCCHHHHHCCCCCCCCCEEEHECCCCCCCCHHCCCCCEEEECCCHHHHHHHHHHHHH
LAEYVKRGVWEAGGVPIEFPAMSLPETQMRPTAMLFRNLLAMEVEESIRANPIDGVVLLG
HHHHHHHCCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
GCDKTTPGQLMGAASVDLPTMVVSSGPMLNGKWHGRDIGSGTDVWRFSEAVRAGEMSLTD
CCCCCCCHHEEECCCCCCCEEEECCCCEECCEECCCCCCCCCCHHHHHHHHHCCCCHHHH
FLSAESSMSRSHGTCNTMGTASTMASLMEALGVCLPNNAALPGVDSRRKTLAHLTGNRIV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QLVKDDVRLSQILTREAFENAILMHAAIGGSTNAVVHLLALAGRVGIELSLEDFDRIGRE
HHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHHCCCC
VPLLVNLMPSGKYLMEEFCYAGGCPAVMKELGPLLRREAITVSGHTQGQIAEAAEVWNRE
CCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHCCH
VIGTREAPVGPSSGVWVLRGNLCPGGAILKPSAATPALLTHRGRAVVFEDIEDYHARIDD
HCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCHHHHCCCCEEEEECHHHHHHCCCC
PDLPVDETSILVLKGCGPKGYPGMPEVGNMALPPKLLHRGVRDMVRISDARMSGTAYGTV
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
ILHVSPEAEAGGPLALVRNGDEIAFDGPSRTLDLLVDEAELARRRAEWEAARTPSQFDRG
EEEECCCCCCCCCEEEEECCCEEEECCCCCEEHHEECHHHHHHHHHHHHHHCCCHHHCCC
WYKLYIDTVLQADRGADLDFLVGKSSPDVTRESH
CEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA