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The map label for this gene is cpg2 [H]

Identifier: 197105529

GI number: 197105529

Start: 2308487

End: 2309806

Strand: Reverse

Name: cpg2 [H]

Synonym: PHZ_c2066

Alternate gene names: 197105529

Gene position: 2309806-2308487 (Counterclockwise)

Preceding gene: 197105530

Following gene: 197105527

Centisome position: 57.8

GC content: 73.41

Gene sequence:

>1320_bases
ATGAAGACCGCCTGCGCCGCCCTCCTGGGGGCGTTCGCCCTCGCGTCCGCCGCGCCGGCGCAGGCCGCGCCGCCCACGCC
GGCCGAGCGCGCGATGATCGCCGCCGTCGAGGCCGAGCGCGAGCGCAGCGTGAAGCTGCTGGAAGACCTGGTGAAGGTGA
ACTCCGGCACCATGAACCTGCCCGGCGTCGAGCAGGTTGGGCGGATGATGCGCGCCGAGCTGGAGCCGCTGGGCTTCGAC
GTGCGCTGGGTCCCCATGAAGGCGACCGACCGGGCCGGCCACATCGTGGCCGTCCACAAGGGGAACGGGCGCGGCAAGCG
GCTGCTGCTGATCGGCCACCTCGACACCGTCTTCGAACCCGACAGCCCGTTCCAGGCCTGGACCCGCCGCGGCGACGTGG
CCGAGGGGCCGGGGGTGGGCGACGACAAGGGCGGCATGGTCGTGATGATCGCGGCGCTGCGGGCGATGCAGGCGGCCGGG
ACGCTGAAGGACGCCGACATCACCGTCGTGCTGACGGGCGACGAGGAGAAGCCGGGCGCGCCGCTGTCGATCGGCCGGGC
CGACCTGATCGCCGCCGGCCGCGCCAGCGACGTGGCGCTGGACTTCGAGGGCCTCTCGCGCGAGGGCGGCCGGGACATCG
GGGCGATCGCCCGCCGCTCGGCGACGTCCTGGACGCTGCGGGCCACGGCGCGCTCGGGCCACTCTTCGGGGGTCTGCATG
GAGGGGCCCGGCTGCGGCGCGGTCTACGAGCTGACCCGGATCCTCGATGCGTTCCGGCGCGAACTGGCCGAGCCGAACCT
GACCTACAACGTGGGCATCCTCGTCGGCGGCGCGAACGCCTCGGTCAACGAAGGCCGGACCGGCGGCCAGGCCAGCGGCA
AGTCCAACATCATCGCGGCCGAGGCGGTCGCCGTGGGCGACATCCGCACGCTGTCCAACGAGCAGGAGGCCCGGGTGCGG
GCGAAGATGCAGGCGATCGTGGCCCGCCACCTGCCGAAGACCGAGGCCGTCCTGACCTTCGAGGAGACCGGCTATCCGCC
GATGGCCCCGACCGAGGGGAACAAGGCCCTGCTGGCCAGGCTGAATGAGGTGAACCGCACCCTCGGCCTTGCCGAGATGC
CGCAGGGCGACCCCGCCAGACGCGGGGCGGGGGACATCGCCTTCGTCTCGTTCATCGACGGGCTGGTCGGCCTGGGTCCG
GCCGGCGAGAACAGCCACGCCCCGGGCGAGACGATCGACCTCACGAGCCTCGAGGTCCAGGCCAAGCGGGCCGCGCTGCT
GATGACCCGCCTGTCGCGCGAACCGCGCGGCAGCCGCTAG

Upstream 100 bases:

>100_bases
AGGCCTACGCCGACCTGCCGCGCGGCGCCTCGCGCTCGGCCCTTGTCGAATTCGTCCGCAGCCTGCGTAGTCAGCCGGGC
TGAAACCCGGAGCCATTCCC

Downstream 100 bases:

>100_bases
GCCCCTCGGCTAGGCCCCTCGGCTAGGCCCCTCGGCTAGGCCGGCGTCCCCAGCTCGGCCAGGGCGCGCTCCTTCACGGC
CTTGTAGTCCACCTTGCCGT

Product: peptidase, M20/M25/M40 family

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKTACAALLGAFALASAAPAQAAPPTPAERAMIAAVEAERERSVKLLEDLVKVNSGTMNLPGVEQVGRMMRAELEPLGFD
VRWVPMKATDRAGHIVAVHKGNGRGKRLLLIGHLDTVFEPDSPFQAWTRRGDVAEGPGVGDDKGGMVVMIAALRAMQAAG
TLKDADITVVLTGDEEKPGAPLSIGRADLIAAGRASDVALDFEGLSREGGRDIGAIARRSATSWTLRATARSGHSSGVCM
EGPGCGAVYELTRILDAFRRELAEPNLTYNVGILVGGANASVNEGRTGGQASGKSNIIAAEAVAVGDIRTLSNEQEARVR
AKMQAIVARHLPKTEAVLTFEETGYPPMAPTEGNKALLARLNEVNRTLGLAEMPQGDPARRGAGDIAFVSFIDGLVGLGP
AGENSHAPGETIDLTSLEVQAKRAALLMTRLSREPRGSR

Sequences:

>Translated_439_residues
MKTACAALLGAFALASAAPAQAAPPTPAERAMIAAVEAERERSVKLLEDLVKVNSGTMNLPGVEQVGRMMRAELEPLGFD
VRWVPMKATDRAGHIVAVHKGNGRGKRLLLIGHLDTVFEPDSPFQAWTRRGDVAEGPGVGDDKGGMVVMIAALRAMQAAG
TLKDADITVVLTGDEEKPGAPLSIGRADLIAAGRASDVALDFEGLSREGGRDIGAIARRSATSWTLRATARSGHSSGVCM
EGPGCGAVYELTRILDAFRRELAEPNLTYNVGILVGGANASVNEGRTGGQASGKSNIIAAEAVAVGDIRTLSNEQEARVR
AKMQAIVARHLPKTEAVLTFEETGYPPMAPTEGNKALLARLNEVNRTLGLAEMPQGDPARRGAGDIAFVSFIDGLVGLGP
AGENSHAPGETIDLTSLEVQAKRAALLMTRLSREPRGSR
>Mature_439_residues
MKTACAALLGAFALASAAPAQAAPPTPAERAMIAAVEAERERSVKLLEDLVKVNSGTMNLPGVEQVGRMMRAELEPLGFD
VRWVPMKATDRAGHIVAVHKGNGRGKRLLLIGHLDTVFEPDSPFQAWTRRGDVAEGPGVGDDKGGMVVMIAALRAMQAAG
TLKDADITVVLTGDEEKPGAPLSIGRADLIAAGRASDVALDFEGLSREGGRDIGAIARRSATSWTLRATARSGHSSGVCM
EGPGCGAVYELTRILDAFRRELAEPNLTYNVGILVGGANASVNEGRTGGQASGKSNIIAAEAVAVGDIRTLSNEQEARVR
AKMQAIVARHLPKTEAVLTFEETGYPPMAPTEGNKALLARLNEVNRTLGLAEMPQGDPARRGAGDIAFVSFIDGLVGLGP
AGENSHAPGETIDLTSLEVQAKRAALLMTRLSREPRGSR

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 46000; Mature: 46000

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTACAALLGAFALASAAPAQAAPPTPAERAMIAAVEAERERSVKLLEDLVKVNSGTMNL
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
PGVEQVGRMMRAELEPLGFDVRWVPMKATDRAGHIVAVHKGNGRGKRLLLIGHLDTVFEP
CCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCHHHCCC
DSPFQAWTRRGDVAEGPGVGDDKGGMVVMIAALRAMQAAGTLKDADITVVLTGDEEKPGA
CCCHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
PLSIGRADLIAAGRASDVALDFEGLSREGGRDIGAIARRSATSWTLRATARSGHSSGVCM
CCCCCCHHEEECCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCEEE
EGPGCGAVYELTRILDAFRRELAEPNLTYNVGILVGGANASVNEGRTGGQASGKSNIIAA
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEE
EAVAVGDIRTLSNEQEARVRAKMQAIVARHLPKTEAVLTFEETGYPPMAPTEGNKALLAR
HEEEECCHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHH
LNEVNRTLGLAEMPQGDPARRGAGDIAFVSFIDGLVGLGPAGENSHAPGETIDLTSLEVQ
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHH
AKRAALLMTRLSREPRGSR
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKTACAALLGAFALASAAPAQAAPPTPAERAMIAAVEAERERSVKLLEDLVKVNSGTMNL
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
PGVEQVGRMMRAELEPLGFDVRWVPMKATDRAGHIVAVHKGNGRGKRLLLIGHLDTVFEP
CCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCHHHCCC
DSPFQAWTRRGDVAEGPGVGDDKGGMVVMIAALRAMQAAGTLKDADITVVLTGDEEKPGA
CCCHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
PLSIGRADLIAAGRASDVALDFEGLSREGGRDIGAIARRSATSWTLRATARSGHSSGVCM
CCCCCCHHEEECCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCEEE
EGPGCGAVYELTRILDAFRRELAEPNLTYNVGILVGGANASVNEGRTGGQASGKSNIIAA
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEE
EAVAVGDIRTLSNEQEARVRAKMQAIVARHLPKTEAVLTFEETGYPPMAPTEGNKALLAR
HEEEECCHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHH
LNEVNRTLGLAEMPQGDPARRGAGDIAFVSFIDGLVGLGPAGENSHAPGETIDLTSLEVQ
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHH
AKRAALLMTRLSREPRGSR
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]