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The map label for this gene is kbl [C]

Identifier: 197105516

GI number: 197105516

Start: 2294971

End: 2296188

Strand: Direct

Name: kbl [C]

Synonym: PHZ_c2053

Alternate gene names: 197105516

Gene position: 2294971-2296188 (Clockwise)

Preceding gene: 197105515

Following gene: 197105520

Centisome position: 57.43

GC content: 70.77

Gene sequence:

>1218_bases
ATGGGGCTTCTCGACAAGCACCTGGGCTATCGCGCCCCCCTGGAAGGCATCCGCGCTGCGGGCGCCGACCCGTCCAACGT
CCGGTTCGACGCCGTGCTCTCGCCCACTGAGGGCGTGCTGGCCGGCCAACCGGTGATCCTGCTGGGCACCAACAACTATC
TCGGGCTGACCTTCGACCCGGCCTGCATCGAGGCCTCGGCCGAGGCGGTGCGCGAATGGGGCACGGGCACGACCGGCTCG
CGGTTCGCCAACGGCACCTTCGCCGGCCACACGGCGCTGGAGCAGGCCCTGGCCGGCTTCTACGGCCGCAAGCACGCGAT
GGTCTTCACGACCGGCTACCAGGCCAACCTGGGCACGATCTCGGGCCTCGTCGGCCGCGGCGACCATCTGATCCTGGACG
CCGACAGCCACGCCTCGATCTATGACGCGGCCAAGCTGTCGGGCGCCGAAGTCATCCGCTTCCGCCACAACGACCCGGAC
GACCTGCACAAGCGCCTGCGGCGCCTGGGCGACGCGCCCGGCGGACGGCTGATCGTCGTCGAGGGCATCTACTCGATGAT
CGGCGACGTGGCCCCGCTGAAGGAGTTCGTCGACGTCAAGCGCGAGATGGGCGGCCACCTGCTGGTGGACGAGGCCCACT
CCATGGGCGTGCTGGGCGAGAAGGGCCGCGGCCTGGCCGAAGCGGCCGGCGTCGAGGACGGCGTCGACTTCATCGTCGGC
ACCTTCTCCAAGAGCCTGGGCTCGGTCGGCGGCTTCCTCGTCTCGGACGAGGAGAACTTCGACCTGCTGCGCATCGTCAG
CCGGCCCTACATGTTCACCGCCTCGCTGCCGCCGGCGGTGATCGCCTCGACCCTCACCGCCCTGAAGCGGCTGGAAGACG
AGCCCGGTCTGCGCGCGCGGCTGTCGGCCAACGCCGACCGGCTCTACGAGGGCCTGCGCGACATGGGCTATGCGGTCGGC
CCGCACGCCAGCCCGATCACCGCCGTCGAGATGCCCGACCAGGCCACCGCCGTCGGCATGTGGAACGCGCTGCTGCAGAA
CGGCGTCTACCTGAACCTCGCCATCCCGCCGGCCACGCCCGAGAACAAGTCGCTGCTGCGCTCCAGCGTCAGCGCGGCCC
ACACGACCGAGCAGATCGACACCGTCCTCGGCGTCTTCGAGCAACTGGGCCAGGAATTCGGCCTGCTGGCCGGCCGCCGC
CGCGCCGCCACCGCCTAG

Upstream 100 bases:

>100_bases
ATCGATTCGACCTGTCGATCCCGCTCGACCGGCTGGCCACGGTGCAGACCGTCGGCGACCTTTCCGAACTGATCAACACG
CTGCGGATGAAGGCTTAAGG

Downstream 100 bases:

>100_bases
CCCACGCTAGCCTCGGGGCCGGCGCGCCCGCCGCAGTCGCCACAGCACGCCGGGCGCCGCCAGGATCGGGTGGCGCTCGC
GGAACGGCGTGACCTCCAGG

Product: aminotransferase, class II

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MGLLDKHLGYRAPLEGIRAAGADPSNVRFDAVLSPTEGVLAGQPVILLGTNNYLGLTFDPACIEASAEAVREWGTGTTGS
RFANGTFAGHTALEQALAGFYGRKHAMVFTTGYQANLGTISGLVGRGDHLILDADSHASIYDAAKLSGAEVIRFRHNDPD
DLHKRLRRLGDAPGGRLIVVEGIYSMIGDVAPLKEFVDVKREMGGHLLVDEAHSMGVLGEKGRGLAEAAGVEDGVDFIVG
TFSKSLGSVGGFLVSDEENFDLLRIVSRPYMFTASLPPAVIASTLTALKRLEDEPGLRARLSANADRLYEGLRDMGYAVG
PHASPITAVEMPDQATAVGMWNALLQNGVYLNLAIPPATPENKSLLRSSVSAAHTTEQIDTVLGVFEQLGQEFGLLAGRR
RAATA

Sequences:

>Translated_405_residues
MGLLDKHLGYRAPLEGIRAAGADPSNVRFDAVLSPTEGVLAGQPVILLGTNNYLGLTFDPACIEASAEAVREWGTGTTGS
RFANGTFAGHTALEQALAGFYGRKHAMVFTTGYQANLGTISGLVGRGDHLILDADSHASIYDAAKLSGAEVIRFRHNDPD
DLHKRLRRLGDAPGGRLIVVEGIYSMIGDVAPLKEFVDVKREMGGHLLVDEAHSMGVLGEKGRGLAEAAGVEDGVDFIVG
TFSKSLGSVGGFLVSDEENFDLLRIVSRPYMFTASLPPAVIASTLTALKRLEDEPGLRARLSANADRLYEGLRDMGYAVG
PHASPITAVEMPDQATAVGMWNALLQNGVYLNLAIPPATPENKSLLRSSVSAAHTTEQIDTVLGVFEQLGQEFGLLAGRR
RAATA
>Mature_404_residues
GLLDKHLGYRAPLEGIRAAGADPSNVRFDAVLSPTEGVLAGQPVILLGTNNYLGLTFDPACIEASAEAVREWGTGTTGSR
FANGTFAGHTALEQALAGFYGRKHAMVFTTGYQANLGTISGLVGRGDHLILDADSHASIYDAAKLSGAEVIRFRHNDPDD
LHKRLRRLGDAPGGRLIVVEGIYSMIGDVAPLKEFVDVKREMGGHLLVDEAHSMGVLGEKGRGLAEAAGVEDGVDFIVGT
FSKSLGSVGGFLVSDEENFDLLRIVSRPYMFTASLPPAVIASTLTALKRLEDEPGLRARLSANADRLYEGLRDMGYAVGP
HASPITAVEMPDQATAVGMWNALLQNGVYLNLAIPPATPENKSLLRSSVSAAHTTEQIDTVLGVFEQLGQEFGLLAGRRR
AATA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=387, Percent_Identity=33.8501291989664, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI284448556, Length=366, Percent_Identity=33.879781420765, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4758668, Length=376, Percent_Identity=34.3085106382979, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI83977440, Length=350, Percent_Identity=32, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI83977442, Length=350, Percent_Identity=32, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI83977444, Length=350, Percent_Identity=32, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI119220554, Length=381, Percent_Identity=31.758530183727, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4502025, Length=367, Percent_Identity=29.700272479564, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI40316939, Length=367, Percent_Identity=29.700272479564, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI5454084, Length=376, Percent_Identity=28.1914893617021, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1790046, Length=362, Percent_Identity=35.9116022099448, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=32.5513196480938, Blast_Score=178, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=394, Percent_Identity=33.248730964467, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=31.6353887399464, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17560912, Length=366, Percent_Identity=30.6010928961749, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=366, Percent_Identity=30.6010928961749, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71982617, Length=285, Percent_Identity=27.0175438596491, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=285, Percent_Identity=27.0175438596491, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320267, Length=372, Percent_Identity=31.7204301075269, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=26.8421052631579, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=259, Percent_Identity=31.6602316602317, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24662918, Length=386, Percent_Identity=32.1243523316062, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI17137420, Length=354, Percent_Identity=30.5084745762712, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=31.5363881401617, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24653280, Length=378, Percent_Identity=28.3068783068783, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24653276, Length=378, Percent_Identity=28.3068783068783, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24653278, Length=378, Percent_Identity=28.3068783068783, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42934; Mature: 42803

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00599 AA_TRANSFER_CLASS_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLDKHLGYRAPLEGIRAAGADPSNVRFDAVLSPTEGVLAGQPVILLGTNNYLGLTFDP
CCCCHHHCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEEEECH
ACIEASAEAVREWGTGTTGSRFANGTFAGHTALEQALAGFYGRKHAMVFTTGYQANLGTI
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHH
SGLVGRGDHLILDADSHASIYDAAKLSGAEVIRFRHNDPDDLHKRLRRLGDAPGGRLIVV
HHHHCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEH
EGIYSMIGDVAPLKEFVDVKREMGGHLLVDEAHSMGVLGEKGRGLAEAAGVEDGVDFIVG
HHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCHHHHHH
TFSKSLGSVGGFLVSDEENFDLLRIVSRPYMFTASLPPAVIASTLTALKRLEDEPGLRAR
HHHHHHHCCCCEEEECCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEE
LSANADRLYEGLRDMGYAVGPHASPITAVEMPDQATAVGMWNALLQNGVYLNLAIPPATP
ECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEECCCCC
ENKSLLRSSVSAAHTTEQIDTVLGVFEQLGQEFGLLAGRRRAATA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
GLLDKHLGYRAPLEGIRAAGADPSNVRFDAVLSPTEGVLAGQPVILLGTNNYLGLTFDP
CCCHHHCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEEEECH
ACIEASAEAVREWGTGTTGSRFANGTFAGHTALEQALAGFYGRKHAMVFTTGYQANLGTI
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHH
SGLVGRGDHLILDADSHASIYDAAKLSGAEVIRFRHNDPDDLHKRLRRLGDAPGGRLIVV
HHHHCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEH
EGIYSMIGDVAPLKEFVDVKREMGGHLLVDEAHSMGVLGEKGRGLAEAAGVEDGVDFIVG
HHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCHHHHHH
TFSKSLGSVGGFLVSDEENFDLLRIVSRPYMFTASLPPAVIASTLTALKRLEDEPGLRAR
HHHHHHHCCCCEEEECCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEE
LSANADRLYEGLRDMGYAVGPHASPITAVEMPDQATAVGMWNALLQNGVYLNLAIPPATP
ECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEECCCCC
ENKSLLRSSVSAAHTTEQIDTVLGVFEQLGQEFGLLAGRRRAATA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA